Prevalence of ventricular diastolic dysfunction in asymptomatic, normotensive patients with diabetes mellitus
Abstract
To determine the prevalence of left ventricular diastolic dysfunction in asymptomatic, normotensive patients with type 2 diabetes mellitus, we studied 61 consecutive normotensive patients with type 2 diabetes using conventional Doppler echocardiography at rest (deceleration time, isovolumic relaxation time, early diastolic velocity [E]/peak atrial systolic velocity [A] ratio), and during the Valsalva maneuver. In addition, mitral annular velocity and velocity of flow propagation were assessed in all patients using tissue Doppler imaging (TDI) and color M-mode echocardiography. A standard resting echocardiogram excluded significant valvular disease and stress echocardiography excluded significant coronary artery disease in those with diastolic dysfunction. Diastolic dysfunction was found in 43 of 57 patients (75%) when all of the above echocardiographic techniques were used. TDI detected diastolic dysfunction more often (63%) than any other echocardiographic approach. Thus, the prevalence of left ventricular diastolic dysfunction in asymptomatic, normotensive patients with type 2 diabetes without significant coronary artery disease is much higher than previously suspected. TDI markedly improved the echocardiographic detection of diastolic dysfunction in asymptomatic patients with type 2 diabetes.
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Diastolic dysfunction can develop early in T2DM course and be detected in 75% of asymptomatic patients, with a prevalence and severity that increase across the whole spectrum of glucose dysregulation from prediabetes to diabetes.
“A diastolic dysfunction can develop early in T2DM course and be detected in 75% of asymptomatic patients, with a prevalence and a severity that increase across the whole spectrum of glucose dysregulation from prediabetes to diabetes [79,80].”
From Dysregulated epicardial adipose tissue as a risk factor and potential therapeutic target of heart failure with preserved ejection fraction in diabetes (2022) · cites this paper as [79]
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- Authors
- Boyer, J. K., Thanigaraj, S., Schechtman, K. B., & Pérez, J. E.
- Affiliations
- Washington University in St. Louis (US)
- Corresponding author
- Thanigaraj, Srihari
- Venue
- The American Journal of Cardiology
- Publisher
- Elsevier BV
- Published
- 2004-04
- Volume
- 93
- Issue
- 7
- Pages
- 870-875
- ISSN
- 0002-9149 (ISSN-L)
- OpenAlex
- W2048199961
- Cited by
- 534
- References
- 22
- Citations by year
- 2026: 8 · 2025: 16 · 2024: 18 · 2023: 20 · 2022: 25 · 2021: 27 · 2020: 21 · 2019: 38 · 2018: 36 · 2017: 24 · 2016: 32 · 2015: 31 · 2014: 32 · 2013: 25 · 2012: 31
- FWCI
- 12.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The American Journal of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (2-T32-HL07081, T32HL007081)
- National Center for Research Resources (M01-RR00036, M01RR000036)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Keywords
- left ventricular diastolic dysfunction, type 2 diabetes, asymptomatic patients, normotensive subjects, prevalence, tissue Doppler imaging, Valsalva maneuver, mitral annular velocity, early diastolic filling velocity, coronary artery disease exclusion
- MeSH terms
- Adult, Blood Pressure, Diabetes Mellitus, Type 2, Diastole, Female, Humans, Male, Middle Aged, Valsalva Maneuver, Prevalence, Ventricular Dysfunction, Left, Echocardiography, Doppler, Color, Echocardiography, Stress
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