Cited by 534Cardiovascular Function and Risk FactorsDiabetes, Cardiovascular Risks, and LipoproteinsCardiovascular Health and Disease Prevention

Prevalence of ventricular diastolic dysfunction in asymptomatic, normotensive patients with diabetes mellitus

Boyer, John K, Thanigaraj, Srihari, Schechtman, Kenneth B, Pérez, Julio E·2004·The American Journal of Cardiology

Abstract

To determine the prevalence of left ventricular diastolic dysfunction in asymptomatic, normotensive patients with type 2 diabetes mellitus, we studied 61 consecutive normotensive patients with type 2 diabetes using conventional Doppler echocardiography at rest (deceleration time, isovolumic relaxation time, early diastolic velocity [E]/peak atrial systolic velocity [A] ratio), and during the Valsalva maneuver. In addition, mitral annular velocity and velocity of flow propagation were assessed in all patients using tissue Doppler imaging (TDI) and color M-mode echocardiography. A standard resting echocardiogram excluded significant valvular disease and stress echocardiography excluded significant coronary artery disease in those with diastolic dysfunction. Diastolic dysfunction was found in 43 of 57 patients (75%) when all of the above echocardiographic techniques were used. TDI detected diastolic dysfunction more often (63%) than any other echocardiographic approach. Thus, the prevalence of left ventricular diastolic dysfunction in asymptomatic, normotensive patients with type 2 diabetes without significant coronary artery disease is much higher than previously suspected. TDI markedly improved the echocardiographic detection of diastolic dysfunction in asymptomatic patients with type 2 diabetes.

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Crossref · 10.1016/j.amjcard.2003.12.026

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Authors
Boyer, J. K., Thanigaraj, S., Schechtman, K. B., & Pérez, J. E.
Affiliations
Washington University in St. Louis (US)
Corresponding author
Thanigaraj, Srihari
Venue
The American Journal of Cardiology
Publisher
Elsevier BV
Published
2004-04
Volume
93
Issue
7
Pages
870-875
ISSN
0002-9149 (ISSN-L)
OpenAlex
W2048199961
Cited by
534
References
22
Citations by year
2026: 8 · 2025: 16 · 2024: 18 · 2023: 20 · 2022: 25 · 2021: 27 · 2020: 21 · 2019: 38 · 2018: 36 · 2017: 24 · 2016: 32 · 2015: 31 · 2014: 32 · 2013: 25 · 2012: 31
FWCI
12.00
Type
journal article
Language
en
Open access
closed
Locations
  • The American Journal of Cardiology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Heart, Lung, and Blood Institute (2-T32-HL07081, T32HL007081)
  • National Center for Research Resources (M01-RR00036, M01RR000036)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
Keywords
left ventricular diastolic dysfunction, type 2 diabetes, asymptomatic patients, normotensive subjects, prevalence, tissue Doppler imaging, Valsalva maneuver, mitral annular velocity, early diastolic filling velocity, coronary artery disease exclusion
MeSH terms
Adult, Blood Pressure, Diabetes Mellitus, Type 2, Diastole, Female, Humans, Male, Middle Aged, Valsalva Maneuver, Prevalence, Ventricular Dysfunction, Left, Echocardiography, Doppler, Color, Echocardiography, Stress

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