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Triple quadrupole linear ion trap mass spectrometer for the analysis of small molecules and macromolecules
Open accessAbstract
Recently, linear ion traps (LITs) have been combined with quadrupole (Q), time‐of‐flight (TOF) and Fourier transform ion cyclotron resonance (FT‐ICR) mass spectrometery (MS). LITs can be used either as ion accumulation devices or as commercially available, stand‐alone mass spectrometers with MSn capabilities. The combination of triple quadrupole MS with LIT technology in the form of an instrument of configuration QqLIT, using axial ejection, is particularly interesting, because this instrument retains the classical triple quadrupole scan functions such as selected reaction monitoring (SRM), product ion (PI), neutral loss (NL) and precursor ion (PC) while also providing access to sensitive ion trap experiments. For small molecules, quantitative and qualitative analysis can be performed using the same instrument. In addition, for peptide analysis, the enhanced multiply charged (EMC) scan allows an increase in selectivity, while the time‐delayed fragmentation (TDF) scan provides additional structural information. Various methods of operating the hybrid instrument are described for the case of the commercial Q TRAP (AB/MDS Sciex) and applications to drug metabolism analysis, quantitative confirmatory analysis, peptides analysis and automated nanoelectrospray (ESI‐chip‐MS) analysis are discussed. Copyright © 2004 John Wiley & Sons, Ltd.
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Cites
Mass spectrometry-based proteomics
Aebersold, R., & Mann, M. (2003) · Nature · doi:10.1038/nature01511 · Cited by 6,955
Cited by
Mass spectrometry–based proteomics turns quantitative
Ong, S.-E., & Mann, M. (2005) · Nature Chemical Biology · doi:10.1038/nchembio736 · Cited by 1,572
Farré, M. L., Pérez, S., Kantiani, L., & Barceló, D. (2008) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2008.09.010 · Cited by 1,009
Zubarev, R. A., & Makarov, A. (2013) · Analytical Chemistry · doi:10.1021/ac4001223 · Cited by 658
Rauniyar, N. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms161226120 · Cited by 406
“Targeted experiments are primarily performed on a triple-quadrupole (QQQ) and hybrid quadrupole-linear ion trap (QTrap) mass spectrometers using a data acquisition method known as Selected Reaction Monitoring (SRM) [1,2].”
MethodCatch me if you can: Mass spectrometry‐based phosphoproteomics and quantification strategies
Eyrich, B., Sickmann, A., & Zahedi, R. P. (2011) · PROTEOMICS · doi:10.1002/pmic.201000489 · Cited by 104
Metadata
- Authors
- Hopfgartner, G., Varesio, E., Tschäppät, V., Grivet, C., Bourgogne, E., & Leuthold, L. A.
- Venue
- Journal of Mass Spectrometry
- Publisher
- Wiley
- Published
- 2004-08
- Volume
- 39
- Issue
- 8
- Pages
- 845-855
- ISSN
- 1076-5174 (ISSN-L)
- 1096-9888
- OpenAlex
- W2109474157
- Cited by
- 287
- References
- 1
- FWCI
- 6.38
- Type
- journal article
- Language
- en
- Open access
- green
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- Hopfgartner, G., Varesio, E., Tschäppät, V., Grivet, C., Bourgogne, E., & Leuthold, L. A. (2004). Triple quadrupole linear ion trap mass spectrometer for the analysis of small molecules and macromolecules. Journal of Mass Spectrometry. https://doi.org/10.1002/jms.659
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