Prevalence of human papillomavirus types in cervical lesions from women in rural Western India
Open accessAbstract
Cervical cancer is the most common cancer among women in many areas of India which contributes for a fifth of the global burden of disease. Persistent infection with one of the high-risk human papillomaviruses (HPV) has been established as the cause for cervical cancer and the documentation of the prevalence of HPV types in cervical cancer in different regions of India is useful for a prevention program combining both screening and vaccination. In this study, the HPV type distribution and the frequency of p16(INK4a) immunoexpression have been determined in 125 cases of inflammatory lesions or grade 1 cervical intraepithelial neoplasia, 74 cases of grade 2, 72 cases of grade 3, and 113 cervical cancer cases diagnosed among women from rural Solapur and Osmanabad districts, Maharashtra. The overall prevalence of high-risk HPV was 37.6% in inflammatory lesions or grade 1 cervical intraepithelial neoplasia, 63.5% in grade 2, 97.2% in grade 3 and 92% in cervical cancer cases. HPV 16 and HPV 18 were detected in 80.6% of grade 3 cervical intraepithelial neoplasia and 86.5% of cervical cancer cases. 94.7% of the cervical cancer and 84.4% of the high grade lesions with a strong and full thickness staining for p16(INK4a) were positive for HPV infection; p16(INK4a) immunoexpression increased with worsening grade of cervical intraepithelial neoplasia. The HPV genotyping data showing a high HPV 16 and 18 prevalence in cancer specimens indicate that prophylactic HPV 16/18 vaccination would…
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Available reports from studies covering few parts of India show a wide variation in HPV infection prevalence and genotype distribution, attributed to diversified socio-economic and geo-climatic conditions.
“Available reports from studies covering few parts of India show a wide variation in the prevalence of HPV infection and genotypes distribution which is attributed to diversified socio-economic and geo-climatic condition [5–9].”
From HPV Genotypes distribution in Indian women with and without cervical carcinoma: Implication for HPV vaccination program in Odisha, Eastern India (2017) · cites this paper as [8]
Epidemiology of HPV infection and pattern of HPV genotype distribution are not well documented in the entire Indian subcontinent, which limits implementation of cervical cancer prevention programs.
“Epidemiology of HPV infection and pattern of HPV genotype distribution are not well documented in the entire Indian subcontinent which limits the implementation of cervical cancer prevention programs.”
From HPV Genotypes distribution in Indian women with and without cervical carcinoma: Implication for HPV vaccination program in Odisha, Eastern India (2017) · cites this paper as [8]
The overall prevalence of HPV 16 and 18 in cancer cases is much higher in the present work than in other studies.
“As compared to other studies, the overall prevalence of HPV 16 and 18 in cancer cases (82.3%) is much higher in the present work [7, 8, 16].”
From HPV Genotypes distribution in Indian women with and without cervical carcinoma: Implication for HPV vaccination program in Odisha, Eastern India (2017) · cites this paper as [8]
The genotype distribution with HPV 16 followed by HPV 18 as most prevalent in cervical cancer is in accordance with international and local data.
“The most prevalent genotype in cervical cancer was HPV 16 followed by18 is in accordance with international and local data [7, 8, 16].”
From HPV Genotypes distribution in Indian women with and without cervical carcinoma: Implication for HPV vaccination program in Odisha, Eastern India (2017) · cites this paper as [8]
Synergistic effect of multiple infections by HPV genotypes on carcinogenesis is supported by many studies.
“Synergistic effect of multiple infections by HPV genotypes on carcinogenesis is supported by many studies [7–9, 17, 26], while contradicting studies [25, 29, 31, 32, 35] invoke confusion.”
From HPV Genotypes distribution in Indian women with and without cervical carcinoma: Implication for HPV vaccination program in Odisha, Eastern India (2017) · cites this paper as [8]
Data on prevalence and distribution of three most prominent genotypes in cancer cases from different geographical regions of India shows a great regional variation.
“Data on the prevalence and distribution of three most prominent genotypes in the cancer cases from different geographical regions of India shows a great regional variation [5–9, 15–17].”
From HPV Genotypes distribution in Indian women with and without cervical carcinoma: Implication for HPV vaccination program in Odisha, Eastern India (2017) · cites this paper as [8]
HPV16 alone causes around 63-81% of cervical cancers in the general population and HPV18 accounts for another 10-15% in India.
“Among the oncogenic HPV types, HPV16 alone causes around 63-81% of cervical cancers in the general population and HPV18 accounts for another 10 to 15% in India [3–5].”
From HPV Screening in Women Living with HIV (WLHIV) in Karnataka, India: Can it be Integrated into ART Centres? (2025) · cites this paper as [4]
Cited by
Sorted by citations
Current status of human papillomavirus vaccination in India's cervical cancer prevention efforts
Sankaranarayanan, R., Basu, P., Kaur, P., Bhaskar, R., Singh, G. B., Denzongpa, P., Grover, R. K., Sebastian, P., Saikia, T., Oswal, K., et al. (2019) · The Lancet Oncology · doi:10.1016/s1470-2045(19)30531-5 · Cited by 136 · see citing works
Self-citationSenapati, R., Nayak, B., Kar, S. K., & Dwibedi, B. (2017) · BMC Infectious Diseases · doi:10.1186/s12879-016-2136-4 · Cited by 95 · see citing works
“3%) is much higher in the present work [7, 8, 16].”
BackgroundRao, S., R, S., Sarma, D., Nath, A., R, A., Jagannathan, L., Rao, A., Suhas, G., Iyengar, S., V, R., et al. (2025) · Asian Pacific Journal of Cancer Prevention · doi:10.31557/apjcp.2025.26.12.4513
- Authors
- Deodhar, K., Gheit, T., Vaccarella, S., Romao, C. C., Tenet, V., Nene, B. M., Jayant, K., Kelkar, R., Malvi, S. G., Sylla, B. S., Franceschi, S., Jeronimo, J., Shastri, S., Sankaranarayanan, R., & Tommasino, M.
- Affiliations
- Tata Memorial Hospital (IN)
- Centre international de recherche sur le cancer (FR)
- Nargis Dutt Memorial Cancer Hospital (IN)
- Corresponding author
- Tommasino, Massimo
- ORCID
- Venue
- Journal of Medical Virology
- Publisher
- Wiley
- Published
- 2012-05-14
- Volume
- 84
- Issue
- 7
- Pages
- 1054-1060
- ISSN
- 0146-6615 (ISSN-L)
- 1096-9071
- OpenAlex
- W2122371978
- Cited by
- 34
- References
- 0
- Citations by year
- 2025: 1 · 2024: 3 · 2022: 2 · 2021: 2 · 2020: 3 · 2019: 2 · 2018: 2 · 2017: 3 · 2016: 4 · 2015: 3 · 2014: 5 · 2013: 3 · 2012: 1
- FWCI
- 2.86
- Type
- journal article
- Language
- en
- Open access
- Licence
- Locations
- Journal of Medical Virology (publishedVersion)
- PubMed (publishedVersion)
- INFM-OAR (INFN Catania) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Epidemiology › Cervical Cancer and HPV Research
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Women's cancer prevention and management
- Life Sciences › Immunology and Microbiology › Microbiology › Reproductive tract infections research
- Keywords
- human papillomavirus, HPV prevalence, cervical intraepithelial neoplasia, cervical cancer, HPV16, HPV 18, high-risk HPV genotyping, rural women, cervical cancer prevention, HPV vaccination, Maharashtra
- MeSH terms
- Adult, Carcinoma, Uterine Cervical Neoplasms, Female, Genotype, Humans, India, Middle Aged, Rural Population, Prevalence, Papillomaviridae, Papillomavirus Infections
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
