Current status of human papillomavirus vaccination in India's cervical cancer prevention efforts
Abstract
Efforts are being made to scale up human papillomavirus (HPV) vaccination for adolescent girls in India. Bivalent and quadrivalent HPV vaccines were licensed in the country in 2008, and a nonavalent vaccine was licensed in 2018. Demonstration projects initiated in Andhra Pradesh and Gujarat in 2009 introduced HPV vaccination in public health services in India. Following a few deaths in these projects, although subsequently deemed unrelated to vaccination, HPV vaccination in research projects was suspended. This suspension by default resulted in some participants in a trial evaluating two versus three doses receiving only one dose. Since 2016, the successful introduction of HPV vaccination in immunisation programmes in Punjab and Sikkim (with high coverage and safety), government-sponsored opportunistic vaccination in Delhi, prospects of a single dose providing protection, and future availability of an affordable Indian vaccine shows promise for future widespread implementation and evaluation of HPV vaccination in India.
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In India, access to preventive measures for cervical cancer, including HPV vaccination and cervical cancer screening, remains low.
“Despite the high burden of cervical cancer, access to preventive measures remains low in India.”
From Evidence-based impact projections of single-dose human papillomavirus vaccination in India: a modelling study (2022) · cites this paper as [9]
The success of HPV vaccination depends on securing political will and public acceptance.
“the success of HPV vaccination depends on securing political will and public acceptance.9”
From Evidence-based impact projections of single-dose human papillomavirus vaccination in India: a modelling study (2022) · cites this paper as [9]
Changing sexual behaviours related to an emerging economy (e.g., earlier sexual debut and later marriage) might make cervical cancer control in India more challenging than projected.
“changing sexual behaviours related to an emerging economy (eg sexual debut at earlier ages and marriage at older ages) might make control of cervical cancer more challenging than projected.9”
From Evidence-based impact projections of single-dose human papillomavirus vaccination in India: a modelling study (2022) · cites this paper as [9]
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“While HPV vaccines have been approved for Indian school-aged girls since 2008, the government of India temporarily halted vaccine studies in 2010 after the deaths of seven young girls who received HPV vaccination through implementation projects in the states of Gujarat and Andhra Pradesh [4].”
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Insights of Cisplatin Resistance in Cervical Cancer: A Decision Making for Cellular Survival
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Cervical Cancer and Human Papilloma Virus (HPV) Vaccines: A primer for General Physicians
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Experience of Human Papillomavirus Vaccination Project in a Community Set Up-An Indian Study
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Factors influencing HPV vaccine implementation in South Asia: a scoping review protocol
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CMTM6 as a candidate risk gene for cervical cancer: Comprehensive bioinformatics study
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Primary Prevention in Cervical Cancer—Current Status and Way Forward
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Cost-effectiveness of human papillomavirus (HPV) vaccination in Tunisia: a modelling study
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A questionnaire study on disparity of cervical cancer prevention programs in Asia‐Oceania
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Awareness of cervical cancer among women aged 18-25 years in rural areas
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Human papillomavirus vaccine: Success and challenges
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Self-citationA Novel Immune-Related Signature to Predict Prognosis and Immune Infiltration of Cervical Cancer
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FIGO guidance for sustainable implementation of vaccination programs for women: Pregnancy and HPV
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HPVsim: An agent-based model of HPV transmission and cervical cancerPreprint
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From hesitancy to hope: charting India’s path to widespread HPV immunisation
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Therapeutic HPV Vaccination: A Strategy for Cervical Cancer Elimination in India
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Universal Cervical Cancer Immunization: India Ready for a Quantum Leap
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Overcoming disparities to improve cancer care: The story of cervical cancer
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Self-citationSingle dose nonavalent HPV vaccine – need of the hour
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Self-citationNo Family Should Suffer From Cervical Cancer Twice–The Palliative Care Role in HPV Prevention
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- Authors
- Sankaranarayanan, R., Basu, P., Kaur, P., Bhaskar, R., Singh, G. B., Denzongpa, P., Grover, R. K., Sebastian, P., Saikia, T., Oswal, K., Kanodia, R., Dsouza, A., Mehrotra, R., Rath, G. K., Jaggi, V., Kashyap, S., Kataria, I., Hariprasad, R., Sasieni, P., Bhatla, N., Rajaraman, P., Trimble, E. L., Swaminathan, S., & Purushotham, A.
- Affiliations
- RTI International (US)
- World Health Organization (CH)
- Indian Council of Medical Research (IN)
- Government of Sikkim (IN)
- Delhi State Cancer Institute (IN)
- Tata Trusts (IN)
- Prince Aly Khan Hospital (IN)
- DR. B.R.A. Institute Rotary Cancer Hospital (IN)
- King's College London (GB)
- All India Institute of Medical Sciences (IN)
- United States Department of Health and Human Services (US)
- National Cancer Institute (US)
- Corresponding author
- Basu, Partha
- ORCID
- Venue
- The Lancet Oncology
- Publisher
- Elsevier BV
- Published
- 2019-11
- Volume
- 20
- Issue
- 11
- Pages
- e637-e644
- ISSN
- 1470-2045 (ISSN-L)
- OpenAlex
- W2982439965
- Cited by
- 136
- References
- 42
- Citations by year
- 2026: 13 · 2025: 16 · 2024: 27 · 2023: 18 · 2022: 24 · 2021: 21 · 2020: 17
- FWCI
- 2.26
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Lancet Oncology (publishedVersion)
- PubMed (publishedVersion)
- Research Portal (King's College London) (submittedVersion)
- Funders
- Indian Council of Medical Research
- Topics
- Health Sciences › Medicine › Epidemiology › Cervical Cancer and HPV Research
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Women's cancer prevention and management
- Social Sciences › Health › Vaccine Coverage and Hesitancy
- Keywords
- HPV vaccination, cervical cancer prevention, adolescent girls, immunization programs, bivalent HPV vaccine, quadrivalent HPV vaccine, nonavalent HPV vaccine, India
- MeSH terms
- Uterine Cervical Neoplasms, Female, Health Policy, Humans, India, Policy Making, Prognosis, Risk Factors, Vaccination, Immunization Programs, Risk Assessment, Papillomavirus Infections, Papillomavirus Vaccines, Disease Eradication
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