The DOI matches its Crossref record; 141 of the 141 references it cites were found in a registry or an index.
Extracellular proteolysis in brain injury and inflammation: Role for plasminogen activators and matrix metalloproteinases
Abstract
The role of intracellular proteases (e.g., calpains and caspases) in the pathophysiology of neuronal cell death has been extensively investigated. More recently, accumulating data have suggested that extracellular proteolysis also plays a critical role. The two major systems that modify the extracellular matrix in brain are the plasminogen activator (PA) and matrix metalloproteinase (MMP) axes. This Mini‐Review delineates major pathways of PA and MMP action after stroke, brain trauma, and chronic inflammation. Deleterious effects include the disruption of blood–brain barrier integrity, amplification of inflammatory infiltrates, demyelination, and possibly interruption of cell–cell and cell–matrix interactions that may trigger cell death. In contrast, PA‐MMP actions may contribute to extracellular proteolysis that mediates parenchymal and angiogenic recovery after brain injury. As the mechanisms of deleterious vs. potentially beneficial PA and MMP actions become better defined, it is hoped that new therapeutic targets will emerge for ameliorating the sequelae of brain injury and inflammation. © 2002 Wiley‐Liss, Inc.
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Cites
Tissue Plasminogen Activator for Acute Ischemic Stroke
(1995) · New England Journal of Medicine · doi:10.1056/nejm199512143332401 · Cited by 11,654
Axonal transection in the lesions of multiple sclerosis
Trapp, B. D., Peterson, J., Ransohoff, R. M., Rudick, R., Mörk, S., & Bö, L. (1998) · New England Journal of Medicine · doi:10.1056/nejm199801293380502 · Cited by 4,029
Excitatory Amino Acids as a Final Common Pathway for Neurologic Disorders
Epstein, F. H., Lipton, S. A., & Rosenberg, P. A. (1994) · New England Journal of Medicine · doi:10.1056/nejm199403033300907 · Cited by 2,658
The Role of Glutamate Neurotoxicity in Hypoxic-Ischemic Neuronal Death
Choi, D. W., & Rothman, S. M. (1990) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.13.030190.001131 · Cited by 2,223
The glial scar and central nervous system repair
Fawcett, J. W., & Asher, R. A. (1999) · Brain Research Bulletin · doi:10.1016/s0361-9230(99)00072-6 · Cited by 1,803
The matrix‐degrading metalloproteinases
Matrisian, L. M. (1992) · BioEssays · doi:10.1002/bies.950140705 · Cited by 1,364
ECM and Cell Surface Proteolysis: Regulating Cellular Ecology
Werb, Z. (1997) · Cell · doi:10.1016/s0092-8674(00)80429-8 · Cited by 1,307
The Handbook of proteolytic enzymes
Barrett, A. J., Rawlings, N. D., & Woessner, J. F. (1998) · Cited by 1,119
Proteolytic remodeling of extracellular matrix
Birkedal-Hansen, H. (1995) · Current Opinion in Cell Biology · doi:10.1016/0955-0674(95)80116-2 · Cited by 1,074
Cited by
Keel, M., & Trentz, O. (2005) · Injury · doi:10.1016/j.injury.2004.12.037 · Cited by 885
Matrix metalloproteinases in the brain and blood–brain barrier: Versatile breakers and makers
Rempe, R. G., Hartz, A. M., & Bauer, B. (2016) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x16655551 · Cited by 721
Metalloproteinases: Mediators of Pathology and Regeneration in the CNS
Yong, V. W. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1807 · Cited by 582
Matrix Metalloproteinases Expressed by Astrocytes Mediate Extracellular Amyloid-β Peptide Catabolism
Yin, K.-J., Cirrito, J. R., Yan, P., Hu, X., Xiao, Q., Pan, X., Bateman, R., Song, H., Hsu, F.-F., Turk, J., et al. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.2085-06.2006 · Cited by 381
Castellanos, M., Leira, R., Serena, J., Pumar, J. M., Lizasoain, I., Castillo, J., & Dávalos, A. (2003) · Stroke · doi:10.1161/01.str.0000046764.57344.31 · Cited by 361
Metadata
- Authors
- Lo, E. H., Wang, X., & Cuzner, M. L.
- Venue
- Journal of Neuroscience Research
- Publisher
- Wiley
- Published
- 2002-05-14
- Volume
- 69
- Issue
- 1
- Pages
- 1-9
- ISSN
- 0360-4012 (ISSN-L)
- 1097-4547
- OpenAlex
- W2036489895
- Cited by
- 310
- References
- 141
- FWCI
- 6.81
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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