The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Plasma Metalloproteinase-9 Concentration Predicts Hemorrhagic Transformation in Acute Ischemic Stroke
Open accessAbstract
Background and Purpose— Matrix metalloproteinase-9 (MMP-9) activity has been associated with hemorrhagic transformation (HT) in experimental models of cerebral ischemia. Our aim was to investigate the relationship between MMP-9 concentrations in blood within 24 hours of stroke onset and subsequent HT of cerebral infarction. Methods— We studied 250 patients with a hemispheric ischemic stroke of 7.8±4.5 hours’ duration. Early CT signs of cerebral infarction were evaluated on admission. The HT and infarct volume were analyzed from the CT performed on days 4 through 7. MMP-9 levels were determined by enzyme-linked immunosorbent assay in blood samples obtained on admission. Results— HT was observed in 38 patients (15.2%): 24 (63.2%) had a hemorrhagic infarction, and 14 (36.8%) had a parenchymal hematoma. A total of 108 patients (43%) received anticoagulants before the second CT scan. Systolic and diastolic blood pressures, body temperature, frequency of early CT signs of ischemia (92% versus 22%), and treatment with anticoagulants (79% versus 37%) were significantly higher in the group with HT ( P <0.001). Mean infarct volume was 126±60 cm 3 in the HT group and 90±68 cm 3 in the group without HT ( P =0.003). Median (quartiles) plasma MMP-9 concentrations were higher in the HT group (193 [163, 213] versus 62 [40, 93] ng/mL, P <0.001), even in the 24 patients seen within 3 hours of symptom onset ( P =0.014). MMP-9 levels ≥140 ng/mL had a positive and negative predictive value of HT of 61% and 97%, respectively. MMP-9 ≥140 ng/mL was associated with HT (odds ratio, 12; 95% confidence interval, 3 to 51; P <0.001) after adjustment for potential confounders and final infarct volume. Conclusions— High plasma MMP-9 concentration in the acute phase of a cerebral infarct is an independent biochemical predictor of HT in all stroke subtypes.
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Self-citationProcessing of tumour necrosis factor-α precursor by metalloproteinases
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Cited by
Turner, R. J., & Sharp, F. R. (2016) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2016.00056 · Cited by 533
Wijdicks, E. F. M., Sheth, K. N., Carter, B. S., Greer, D. M., Kasner, S. E., Kimberly, W. T., Schwab, S., Smith, E. E., Tamargo, R. J., & Wintermark, M. (2014) · Stroke · doi:10.1161/01.str.0000441965.15164.d6 · Cited by 522
Blood–brain barrier, reperfusion injury, and hemorrhagic transformation in acute ischemic stroke
Khatri, R., McKinney, A. M., Swenson, B., & Janardhan, V. (2012) · Neurology · doi:10.1212/wnl.0b013e3182697e70 · Cited by 478
Matrix Metalloproteinases and Blood-Brain Barrier Disruption in Acute Ischemic Stroke
Lakhan, S. E., Kirchgessner, A., Tepper, D., & Leonard, A. (2013) · Frontiers in Neurology · doi:10.3389/fneur.2013.00032 · Cited by 384
Wang, X., Tsuji, K., Lee, S.-R., Ning, M., Furie, K. L., Buchan, A. M., & Lo, E. H. (2004) · Stroke · doi:10.1161/01.str.0000143219.16695.af · Cited by 334
Metadata
- Authors
- Castellanos, M., Leira, R., Serena, J., Pumar, J. M., Lizasoain, I., Castillo, J., & Dávalos, A.
- Venue
- Stroke
- Published
- 2003-01
- Volume
- 34
- Issue
- 1
- Pages
- 40-46
- ISSN
- 0039-2499 (ISSN-L)
- 1524-4628
- OpenAlex
- W4296234323
- Cited by
- 361
- References
- 27
- FWCI
- 11.21
- Type
- journal article
- Language
- en
- Open access
- bronze
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