Cited by 124Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchAntioxidant Activity and Oxidative Stress

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Remarkable increase in the concentration of 8-hydroxyguanosine in cerebrospinal fluid from patients with Alzheimer’s disease

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Abe, Takashi, Tohgi, Hideo, Isobe, Chiaki, Murata, Takahiko, Sato, Chigumi·2002·Journal of Neuroscience Research

DOI 10.1002/jnr.10349

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Abstract

To investigate the possible role of oxidative RNA damage in the pathogenesis of Alzheimer's disease (AD), the concentrations of the oxidative stress marker 8-hydroxyguanosine (8-OHG) were measured in the cerebrospinal fluid (CSF) and the serum of patients with AD and control subjects. The concentration of 8-OHG in CSF in AD patients was approximately fivefold that in controls (P < 0.001). The concentration of 8-OHG in CSF decreased significantly with the duration of illness (r(s) = -0.48, P < 0.05) and the progression of cognitive dysfunctions (r(s) = 0.67, P < 0.01). However, the concentration of 8-OHG in CSF showed no correlation with that in serum in both the controls and AD patients. In addition, the concentration of 8-OHG in serum was not significantly altered in AD patients compared to that in controls, suggesting that the 8-OHG concentrations in the CSF do not reflect those in serum and may be probably reflect those in brain tissue. These in vivo findings suggest a possible role of 8-OHG and increased oxidative RNA damage in the early stage of the development of AD.

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Authors: Abe, T., Tohgi, H., Isobe, C., Murata, T., & Sato, C.
Affiliations: Iwate Medical University (JP)
Corresponding author: Tohgi, Hideo
ORCID: Abe, Takashi
Venue: Journal of Neuroscience Research
Publisher: Wiley
Published: 2002-10-18
Volume: 70
Issue: 3
Pages: 447-450
ISSN: 0360-4012 (ISSN-L)
1097-4547
DOI: 10.1002/jnr.10349
OpenAlex: W2059334739
Cited by: 124
References: 32
Citations by year: 2026: 2 · 2025: 2 · 2024: 5 · 2023: 7 · 2022: 8 · 2021: 5 · 2020: 7 · 2019: 4 · 2018: 3 · 2017: 6 · 2016: 6 · 2015: 4 · 2014: 6 · 2013: 5 · 2012: 9
FWCI: 1.80
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Journal of Neuroscience Research (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Keywords: 8-hydroxyguanosine, Alzheimer's disease, cerebrospinal fluid biomarkers, oxidative RNA damage, oxidative stress, serum biomarkers, disease progression, cognitive decline
MeSH terms: Aged, Alzheimer Disease, Brain, Female, Guanosine, Humans, Male, Middle Aged, Neurons, RNA, Up-Regulation, Oxidative Stress

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Remarkable increase in the concentration of 8-hydroxyguanosine in cerebrospinal fluid from patients with Alzheimer’s disease

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