Cited by 75Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchAntioxidant Activity and Oxidative Stress

Oxidative challenge in Alzheimer's disease: state of knowledge and future needs

Cervellati, Carlo, Wood, Paul L, Romani, Arianna, Valacchi, Giuseppe, Squerzanti, Monica, Sanz, Juana Maria, Ortolani, Beatrice, Zuliani, Giovanni·2016·Journal of Investigative Medicine

Abstract

A large body of experimental and postmortem findings indicate that Alzheimer's disease (AD) is associated with increased oxidative stress (OxS) levels in the brain. Despite the current limitations of OxS assessment in living subjects, recent data suggest that oxidative challenge might increase early both in the central nervous system and peripheral fluids. The aim of this review was to provide an overview of the existing literature linking systemic OxS to brain OxS in AD. We firmly believe that continued research aimed at overcoming the methodological and design issues affecting the body of studies in this field is mandatory for successful development of an effective antioxidant-based treatment of AD.

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Crossref · 10.1136/jim-2015-000017

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164 of 164 references verified0 citation errors · 0 not checkable

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Authors
Cervellati, C., Wood, P. L., Romani, A., Valacchi, G., Squerzanti, M., Sanz, J. M., Ortolani, B., & Zuliani, G.
Affiliations
  • University of Ferrara (IT)
  • Lincoln Memorial University (US)
  • Department of Medical Science, Section of Internal and CardioRespiratory Medicine, University of Ferrara, Ferrara, Italy
Corresponding author
Cervellati, Carlo
Venue
Journal of Investigative Medicine
Published
2016-01
Volume
64
Issue
1
Pages
21-32
ISSN
  • 1081-5589 (ISSN-L)
  • 1708-8267
OpenAlex
W2233978156
Cited by
75
References
164
Citations by year
2026: 1 · 2025: 5 · 2024: 6 · 2023: 5 · 2022: 3 · 2021: 9 · 2020: 10 · 2019: 8 · 2018: 9 · 2017: 10 · 2016: 9
FWCI
1.45
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Investigative Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • Institutional Research Information System University of Ferrara (University of Ferrara) (submittedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
Keywords
Alzheimer's disease, oxidative stress, systemic oxidative stress, brain oxidative stress, antioxidant therapy, central nervous system
MeSH terms
Alzheimer Disease, Antioxidants, Humans, Models, Biological, Biomarkers, Oxidative Stress

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