Oxidative challenge in Alzheimer's disease: state of knowledge and future needs
Abstract
A large body of experimental and postmortem findings indicate that Alzheimer's disease (AD) is associated with increased oxidative stress (OxS) levels in the brain. Despite the current limitations of OxS assessment in living subjects, recent data suggest that oxidative challenge might increase early both in the central nervous system and peripheral fluids. The aim of this review was to provide an overview of the existing literature linking systemic OxS to brain OxS in AD. We firmly believe that continued research aimed at overcoming the methodological and design issues affecting the body of studies in this field is mandatory for successful development of an effective antioxidant-based treatment of AD.
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Brain insulin resistance may take a role in AD.
“Emerging evidence has demonstrated that brain insulin resistance, as a key mediator in prediabetes and diabetes mellitus, may take a role in AD (Cervellati et al., 2016).”
From Effect of Probiotic Supplementation on Cognitive Function and Metabolic Status in Alzheimer's Disease: A Randomized, Double-Blind and Controlled Trial (2016) · cites this paper as Cervellati et al., 2016
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Akbari, E., Asemi, Z., Daneshvar Kakhaki, R., Bahmani, F., Kouchaki, E., Tamtaji, O. R., Hamidi, G. A., & Salami, M. (2016) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2016.00256 · Cited by 946 · see citing works
- Authors
- Cervellati, C., Wood, P. L., Romani, A., Valacchi, G., Squerzanti, M., Sanz, J. M., Ortolani, B., & Zuliani, G.
- Affiliations
- University of Ferrara (IT)
- Lincoln Memorial University (US)
- Department of Medical Science, Section of Internal and CardioRespiratory Medicine, University of Ferrara, Ferrara, Italy
- Corresponding author
- Cervellati, Carlo
- Venue
- Journal of Investigative Medicine
- Publisher
- SAGE Publications
- Published
- 2016-01
- Volume
- 64
- Issue
- 1
- Pages
- 21-32
- ISSN
- 1081-5589 (ISSN-L)
- 1708-8267
- OpenAlex
- W2233978156
- Cited by
- 75
- References
- 164
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 6 · 2023: 5 · 2022: 3 · 2021: 9 · 2020: 10 · 2019: 8 · 2018: 9 · 2017: 10 · 2016: 9
- FWCI
- 1.45
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Investigative Medicine (publishedVersion)
- PubMed (publishedVersion)
- Institutional Research Information System University of Ferrara (University of Ferrara) (submittedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Keywords
- Alzheimer's disease, oxidative stress, systemic oxidative stress, brain oxidative stress, antioxidant therapy, central nervous system
- MeSH terms
- Alzheimer Disease, Antioxidants, Humans, Models, Biological, Biomarkers, Oxidative Stress
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