The oxidative damage theory of aging

Sequence and organization of the human mitochondrial genome

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Oxidants, antioxidants, and the degenerative diseases of aging.

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Hydroperoxide metabolism in mammalian organs.

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Chronic Parkinsonism in Humans Due to a Product of Meperidine-Analog Synthesis

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Chronic systemic pesticide exposure reproduces features of Parkinson's disease

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Protein Oxidation in Aging, Disease, and Oxidative Stress

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Plasma Homocysteine as a Risk Factor for Dementia and Alzheimer's Disease

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Oxidative Stress, Caloric Restriction, and Aging

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The mitochondrial generation of hydrogen peroxide. General properties and effect of hyperbaric oxygen

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Mitochondrial DNA mutation associated with Leber’s hereditary optic neuropathy

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The Biologic Clock: The Mitochondria?

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Deletions of muscle mitochondrial DNA in patients with mitochondrial myopathies

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8-Hydroxyguanine, an abundant form of oxidative DNA damage, causes G-T and A-C substitutions.

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Normal oxidative damage to mitochondrial and nuclear DNA is extensive.

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Oxidative Damage Linked to Neurodegeneration by Selective α-Synuclein Nitration in Synucleinopathy Lesions

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Age-related changes in oxidized proteins.

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Excess brain protein oxidation and enzyme dysfunction in normal aging and in Alzheimer disease.

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Inhibition of NADH-linked oxidation in brain mitochondria by 1-methyl-4-phenyl-pyridine, a metabolite of the neurotoxin, 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine

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MITOCHONDRIAL DNA MUTATIONS AS AN IMPORTANT CONTRIBUTOR TO AGEING AND DEGENERATIVE DISEASES

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Dietary Intake of Antioxidants and Risk of Alzheimer Disease

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Oxidative damage to mitochondrial DNA is increased in Alzheimer’s disease

Mecocci, P., MacGarvey, U., & Beal, M. F. (1994) · Annals of Neurology · doi:10.1002/ana.410360510 · Cited by 1,037 · see citing works

Biological Tyrosine Nitration: A Pathophysiological Function of Nitric Oxide and Reactive Oxygen Species

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Effects of Coenzyme Q10 in Early Parkinson Disease: Evidence of Slowing of the Functional Decline

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Extension of Life-Span with Superoxide Dismutase/Catalase Mimetics

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Mitochondrial DNA deletions in human brain: regional variability and increase with advanced age

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Human mitochondrial DNA deletions associated with mutations in the gene encoding twinkle, a phage T7 gene 4-like protein localized in mitochondria

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Extension of Drosophila lifespan by overexpression of human SOD1 in motorneurons

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Mutation of POLG is associated with progressive external ophthalmoplegia characterized by mtDNA deletions

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Somatic mutations of the mitochondrial genome in human colorectal tumours

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Facile Detection of Mitochondrial DNA Mutations in Tumors and Bodily Fluids

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Oxidative damage, mitochondrial oxidant generation and antioxidant defenses during aging and in response to food restriction in the mouse

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Nitration and inactivation of manganese superoxide dismutase in chronic rejection of human renal allografts.

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Oxidatively modified proteins in aging and disease1, 2 1Guest Editor: Earl Stadtman 2This article is part of a series of reviews on “Oxidatively Modified Proteins in Aging and Disease” The full list of papers may be found on the homepage of the journal

Beal, M. F. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)00780-3 · Cited by 763 · see citing works

Oxidative damage to mitochondrial DNA shows marked age-dependent increases in human brain

Mecocci, P., MacGarvey, U., Kaufman, A. E., Koontz, D., Shoffner, J. M., Wallace, D. C., & Beal, M. F. (1993) · Annals of Neurology · doi:10.1002/ana.410340416 · Cited by 757 · see citing works

Aging-Dependent Large Accumulation of Point Mutations in the Human mtDNA Control Region for Replication

Michikawa, Y., Mazzucchelli, F., Bresolin, N., Scarlato, G., & Attardi, G. M. (1999) · Science · doi:10.1126/science.286.5440.774 · Cited by 725 · see citing works

Dietary Intake of Antioxidant Nutrients and the Risk of Incident Alzheimer Disease in a Biracial Community Study

Morris, M. C. (2002) · JAMA · doi:10.1001/jama.287.24.3230 · Cited by 678 · see citing works

Methionine sulfoxide reductase (MsrA) is a regulator of antioxidant defense and lifespan in mammals

Moskovitz, J., Barnoy, S., Williams, W. M., Requena, J. R., Berlett, B. S., & Stadtman, E. R. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.231472998 · Cited by 677 · see citing works

Intake of flavonoids and risk of dementia

Commenges, D., Scotet, V., Renaud, S., Jacqmin‐Gadda, H., Barberger‐Gateau, P., & Dartigues, J. (2000) · European Journal of Epidemiology · doi:10.1023/a:1007614613771 · Cited by 647 · see citing works

A pattern of accumulation of a somatic deletion of mitochondrial DNA in aging human tissues.

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Origin and functional consequences of the complex I defect in Parkinson's disease

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Permanent human parkinsonism due to 1‐methy 1–4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP)

Ballard, P., Tetrud, J. W., & Langston, J. W. (1985) · Neurology · doi:10.1212/wnl.35.7.949 · Cited by 630 · see citing works

Oxidative damage during aging targets mitochondrial aconitase

Yan, L., Levine, R. L., & Sohal, R. S. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.21.11168 · Cited by 620 · see citing works

Mechanisms of aging: an appraisal of the oxidative stress hypothesis1,2 1This article is part of a series of reviews on “Oxidative Stress and Aging.” The full list of papers may be found on the homepage of the journal. 2Guest Editor: Rajindar S. Sohal

Sohal, R. S., Mockett, R. J., & Orr, W. C. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)00886-9 · Cited by 593 · see citing works

Protein Nitration in Parkinsonʼs Disease

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Oxidative damage to mitochondrial DNA is inversely related to maximum life span in the heart and brain of mammals

Barja, G., & Herrero, A. (2000) · The FASEB Journal · doi:10.1096/fasebj.14.2.312 · Cited by 540 · see citing works

Chronic mitochondrial energy impairment produces selective striatal degeneration and abnormal choreiform movements in primates.

Brouillet, E., Hantraye, P., Ferrante, R. J., Dolan, R., Leroy‐Willig, A., Kowall, N. W., & Beal, M. F. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.15.7105 · Cited by 485 · see citing works

FLP Recombinase-Mediated Induction of Cu/Zn-Superoxide Dismutase Transgene Expression Can Extend the Life Span of Adult Drosophila melanogaster Flies

Sun, J., & Tower, J. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.1.216 · Cited by 467 · see citing works

Age-dependent increases in oxidative damage to DNA, lipids, and proteins in human skeletal muscle

Mecocci, P., Fanò, G., Fulle, S., MacGarvey, U. M., Shinobu, L. A., Polidori, M. C., Cherubini, A., Vecchiet, J., Senin, U., & Beal, M. F. (1999) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(98)00208-1 · Cited by 461 · see citing works

High-quality life extension by the enzyme peptide methionine sulfoxide reductase

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Mitochondrial DNA Variants Observed in Alzheimer Disease and Parkinson Disease Patients

Shoffner, J. M., Brown, M. D., Torroni, A., Lott, M. T., Cabell, M. F., Mirra, S. S., Beal, M. F., Yang, C.-C., Gearing, M., Salvo, R., et al. (1993) · Genomics · doi:10.1006/geno.1993.1299 · Cited by 450 · see citing works

Human cells are protected from mitochondrial dysfunction by complementation of DNA products in fused mitochondria

Ono, T., Isobe, K., Nakada, K., & Hayashi, J.-I. (2001) · Nature Genetics · doi:10.1038/90116 · Cited by 420 · see citing works

Mitochondrial adenine nucleotide translocase is modified oxidatively during aging

Yan, L.-J., & Sohal, R. S. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.22.12896 · Cited by 414 · see citing works

Induced Overexpression of Mitochondrial Mn-Superoxide Dismutase Extends the Life Span of Adult Drosophila melanogaster

Sun, J., Folk, D. G., Bradley, T. J., & Tower, J. (2002) · Genetics · doi:10.1093/genetics/161.2.661 · Cited by 381 · see citing works

High aggregate burden of somatic mtDNA point mutations in aging and Alzheimer's disease brain

Lin, M. T. (2002) · Human Molecular Genetics · doi:10.1093/hmg/11.2.133 · Cited by 366 · see citing works

Association of mitochondrial DNA damage with aging and coronary atherosclerotic heart disease

Corral‐Debrinski, M., Shoffner, J. M., Lott, M. T., & Wallace, D. C. (1992) · Mutation Research/DNAging · doi:10.1016/0921-8734(92)90021-g · Cited by 360 · see citing works

Protein oxidative damage is associated with life expectancy of houseflies.

Sohal, R. S., Agarwal, S., Dubey, A., & Orr, W. C. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.15.7255 · Cited by 354 · see citing works

Proteomic method identifies proteins nitrated <i>in vivo</i> during inflammatory challenge

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Vitamin E and Cognitive Decline in Older Persons

Morris, M. C., Evans, D. A., Bienias, J. L., Tangney, C. C., & Wilson, R. S. (2002) · Archives of Neurology · doi:10.1001/archneur.59.7.1125 · Cited by 346 · see citing works

Association of vitamin E and C supplement use with cognitive function and dementia in elderly men

Olson, D. A. (2000) · Neurology · doi:10.1212/wnl.55.6.901-a · Cited by 342 · see citing works

Decline with age of the respiratory chain activity in human skeletal muscle

Boffoli, D., Scacco, S. C., Vergari, R., Solarino, G., Santacroce, G., & Papa, S. (1994) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/0925-4439(94)90061-2 · Cited by 341 · see citing works

Analyses of mitochondrial respiratory chain function and mitochondrial DNA deletion in human skeletal muscle: Effect of ageing

Cooper, J. A. D., Mann, V. M., & Schapira, A. H. V. (1992) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(92)90270-u · Cited by 335 · see citing works

Peroxynitrite disables the tyrosine phosphorylation regulatory mechanism: Lymphocyte-specific tyrosine kinase fails to phosphorylate nitrated cdc2(6-20)NH2 peptide.

Kong, S. K., Yim, M. B., Stadtman, E. R., & Chock, P. B. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.8.3377 · Cited by 335 · see citing works

Increased oxidative damage to DNA in ALS patients

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Association of vitamin E and C supplement use with cognitive function and dementia in elderly men

Masaki, K. H., Losonczy, K. G., Izmirlian, G., Foley, D. J., Ross, G. W., Petrovitch, H., Havlik, R., & White, L. R. (2000) · Neurology · doi:10.1212/wnl.54.6.1265 · Cited by 330 · see citing works

Mitochondrial DNA transmission of the mitochondrial defect in Parkinson's disease

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Is oxidative damage the fundamental pathogenic mechanism of Alzheimer’s and other neurodegenerative diseases?

Perry, G. L., Nunomura, A., Hirai, K., Zhu, X., Prez, M. D. F., Ávila, J., Castellani, R. J., Atwood, C., Aliev, G., Sayre, L. M., et al. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)01113-9 · Cited by 297 · see citing works

Life extension in Drosophila by feeding a drug

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High frequency of homoplasmic mitochondrial DNA mutations in human tumors can be explained without selection

Coller, H. A., Khrapko, K., Bodyak, N. D., Nekhaeva, E., Herrero-Jimenez, P., & Thilly, W. G. (2001) · Nature Genetics · doi:10.1038/88859 · Cited by 288 · see citing works

Role of mitochondrial DNA mutations in human aging: Implications for the central nervous system and muscle

Brierley, E. J., Johnson, M. A., Lightowlers, R. N., James, O., & Turnbull, D. M. (1998) · Annals of Neurology · doi:10.1002/ana.410430212 · Cited by 282 · see citing works

Muscle-specific mutations accumulate with aging in critical human mtDNA control sites for replication

Wang, Y., Michikawa, Y., Mallidis, C., Bai, Y., Woodhouse, L. J., Yarasheski, K. E., Miller, C. A., Askanas, V., Engel, W. K., Bhasin, S., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.061013598 · Cited by 272 · see citing works

Cybrids in Alzheimer's disease: a cellular model of the disease?

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Age‐Dependent Impairment of Mitochondrial Function in Primate Brain

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Cybrids in Alzheimer's disease: A cellular model of the disease?

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Differential accumulations of 4,977 bp deletion in mitochondrial DNA of various tissues in human ageing

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Is Cell Aging Caused by Respiration-Dependent Injury to the Mitochondrial Genome?

Fleming, J. E., Miquel, J., Cottrell, S. F., Yengoyan, L. S., & Economos, A. C. (2009) · Gerontology · doi:10.1159/000212510 · Cited by 242 · see citing works

Rate of generation of oxidative stress-related damage and animal longevity

Barja, G. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)00910-3 · Cited by 232 · see citing works

Lymphocyte oxidative DNA damage and plasma antioxidants in Alzheimer disease

Mecocci, P. (2002) · Archives of Neurology · doi:10.1001/archneur.59.5.794 · Cited by 229 · see citing works

Low Reserve of Cytochrome c Oxidase Capacity in Vivo in the Respiratory Chain of a Variety of Human Cell Types

Villani, G., Greco, M., Papa, S., & Attardi, G. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.48.31829 · Cited by 225 · see citing works

Mitochondrial DNA in Aging and Disease

Wallace, D. C. (1997) · Scientific American · doi:10.1038/scientificamerican0897-40 · Cited by 222 · see citing works

Ancient mtDNA sequences in the human nuclear genome: A potential source of errors in identifying pathogenic mutations

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Cloning the expression of a mammalian gene involved in the reduction of methionine sulfoxide residues in proteins.

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Age-associated accumulation of 8-hydroxydeoxyguanosine in mitochondrial DNA of human diaphragm

Hayakawa, M., Torii, K., Sugiyama, S., Tanaka, M., & Ozawa, T. (1991) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(91)91921-x · Cited by 199 · see citing works

Chronic mitochondrial energy impairment produces selective striatal degeneration and abnormal choreiform movements in primates

Brouillet, M. (1995) · Medical Entomology and Zoology · Cited by 190 · see citing works

Mitochondrial Creatine Kinase Is a Prime Target of Peroxynitrite-induced Modification and Inactivation

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Oxidative stress and aging in the Mongolian gerbil (Meriones unguiculatus)

Sohal, R. S., Agarwal, S., & Sohal, B. H. (1995) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(94)01578-a · Cited by 171 · see citing works

Mitochondrial enzyme-deficient hippocampal neurons and choroidal cells in AD

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Coenzyme Q 10 as a Possible Treatment for Neurodegenerative Diseases

Beal, M. F. (2002) · Free Radical Research · doi:10.1080/10715760290021315 · Cited by 160 · see citing works

Repair of DNA damage in mitochondria

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Human brain contains high levels of heteroplasmy in the noncoding regions of mitochondrial DNA.

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Familial multisystem degeneration with parkinsonism associated with the 11778 mitochondrial DNA mutation

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Detection of point mutations in codon 331 of mitochondrial NADH dehydrogenase subunit 2 in alzheimer's brains

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