The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Adult bone marrow stromal stem cells express germline, ectodermal, endodermal, and mesodermal genes prior to neurogenesis
Open accessAbstract
Bone marrow stromal stem cells (MSCs) normally differentiate into mesenchymal derivatives but recently have also been converted into neurons, classical ectodermal cells. To begin defining underlying mechanisms, we extended our characterization of MSCs and the differentiated neurons. In addition to expected mesodermal mRNAs, populations and clonal lines of MSCs expressed germinal, endodermal, and ectodermal genes. Thus, the MSCs are apparently “multidifferentiated” in addition to being multipotent. Conversely, the differentiating neurons derived from populations and clonal lines of MSCs expressed the specific markers β‐III tubulin, tau, neurofilament‐M, TOAD‐64, and synaptophysin de novo. The transmitter enzymes tyrosine hydroxylase and choline acetyltransferase were localized to neuronal subpopulations. Our observations suggest that MSCs are already multidifferentiated and that neural differentiation comprises quantitative modulation of gene expression rather than simple on–off switching of neural‐specific genes. © 2002 Wiley‐Liss, Inc.
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Multilineage potential of adult human mesenchymal stem cells
Pittenger, M. F., Mackay, A. M., Beck, S. C., Jaiswal, R. K., Douglas, R., Mosca, J. D., Moorman, M. A., Simonetti, D. W., Craig, S., & Marshak, D. R. (1999) · Science · doi:10.1126/science.284.5411.143 · Cited by 21,052
Subventricular zone astrocytes are neural stem cells in the adult mammalian brain
Doetsch, F., Caillé, I., Lim, D. A., García-Verdugo, J. M., & Alvarez-Buylla, A. (1999) · Cell · doi:10.1016/s0092-8674(00)80783-7 · Cited by 3,898
Morshead, C. M., Reynolds, B. A., Craig, C. G., McBurney, M. W., Staines, W. A., Morassutti, D., Weiss, S., & van der Kooy, D. (1994) · Neuron · doi:10.1016/0896-6273(94)90046-9 · Cited by 1,403
An acidic protein isolated from fibrous astrocytes
Eng, L. F., Vanderhaeghen, J. J., Bignami, A., & Gerstl, B. (1971) · Brain Research · doi:10.1016/0006-8993(71)90668-8 · Cited by 1,230
Conversion of Xenopus Ectoderm into Neurons by NeuroD, a Basic Helix-Loop-Helix Protein
Lee, J. E., Hollenberg, S. M., Snider, L., Turner, D. L., Lipnick, N., & Weintraub, H. (1995) · Science · doi:10.1126/science.7754368 · Cited by 1,023
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Engler, A. J., Sen, S., Sweeney, H. L., & Discher, D. E. (2006) · Cell · doi:10.1016/j.cell.2006.06.044 · Cited by 13,915
Phinney, D. G., & Prockop, D. J. (2007) · Stem Cells · doi:10.1634/stemcells.2007-0637 · Cited by 1,908
Antitumor effect of genetically engineered mesenchymal stem cells in a rat glioma model
Nakamura, K., Ito, Y., Kawano, Y., Kurozumi, K., Kobune, M., Tsuda, H., Bizen, A., Honmou, O., Niitsu, Y., & Hamada, H. (2004) · Gene Therapy · doi:10.1038/sj.gt.3302276 · Cited by 597
Mesenchymal stem cells: paradoxes of passaging
Javazon, E. H., Beggs, K. J., & Flake, A. W. (2004) · Experimental Hematology · doi:10.1016/j.exphem.2004.02.004 · Cited by 527
Lu, P., Blesch, A., & Tuszynski, M. H. (2004) · Journal of Neuroscience Research · doi:10.1002/jnr.20148 · Cited by 435
Metadata
- Authors
- Woodbury, D., Reynolds, K., & Black, I. B.
- Venue
- Journal of Neuroscience Research
- Publisher
- Wiley
- Published
- 2002-08-27
- Volume
- 69
- Issue
- 6
- Pages
- 908-917
- ISSN
- 0360-4012 (ISSN-L)
- 1097-4547
- OpenAlex
- W1970865563
- Cited by
- 460
- References
- 5
- FWCI
- 12.40
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Woodbury, D., Reynolds, K., & Black, I. B. (2002). Adult bone marrow stromal stem cells express germline, ectodermal, endodermal, and mesodermal genes prior to neurogenesis. Journal of Neuroscience Research. https://doi.org/10.1002/jnr.10365
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
