The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
NMDA receptor function in mouse models of Huntington disease
Abstract
Huntington disease (HD) is an autosomal dominant disorder in which degeneration of medium‐sized spiny striatal neurons occurs. The HD gene and the protein it encodes, huntingtin, have been identified but their functions remain unknown. Transgenic mouse models for HD have been developed and we examined responses of medium‐sized striatal neurons recorded in vitro to application of N‐methyl‐D‐aspartate (NMDA) in two of these. The first model (R6/2) expresses exon 1 of the human HD gene with approximately 150 CAG repeats. In the R6/2 an enhancement of currents induced by selective activation of NMDA receptors as well as an enhancement of intracellular Ca 2+ flux occurred in both presymptomatic and symptomatic mice. These alterations appeared specific for the NMDA receptor because α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazole propionic acid (AMPA) receptor‐mediated currents were reduced in symptomatic R6/2s. In R6/2 animals there were parallel increases in NMDA‐R1 and decreases in NMDA‐R2A/B subunit proteins as established by immunohistochemistry. The second model (YAC72) contains human genomic DNA spanning the full‐length gene and all its regulatory elements with 72 CAG repeats. The phenotypical expression of the disorder develops more gradually than in the R6/2. In YAC72 mice we found similar but less marked increases in responses of medium‐sized striatal neurons to NMDA. These findings indicate that alterations in NMDA receptor function may predispose striatal neurons to excitotoxic damage, leading to subsequent neuronal degeneration and underscore the functional importance of NMDA receptors in HD. J. Neurosci. Res. 66:525–539, 2001. © 2001 Wiley‐Liss, Inc.
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Molecular Mechanisms and Potential Therapeutical Targets in Huntington's Disease
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Detection of Huntington's disease decades before diagnosis: the Predict-HD study
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Self-citationStructure, Function, and Pharmacology of Glutamate Receptor Ion Channels
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Metadata
- Authors
- Cepeda, C., Ariano, M. A., Calvert, C. R., Flores‐Hernández, J., Chandler, S. H., Leavitt, B. R., Hayden, M. R., & Levine, M. S.
- Venue
- Journal of Neuroscience Research
- Publisher
- Wiley
- Published
- 2001-11-02
- Volume
- 66
- Issue
- 4
- Pages
- 525-539
- ISSN
- 0360-4012 (ISSN-L)
- 1097-4547
- OpenAlex
- W2030258195
- Cited by
- 274
- References
- 45
- FWCI
- 4.18
- Type
- journal article
- Language
- en
- Open access
- closed
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