The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Detection of Huntington's disease decades before diagnosis: the Predict-HD study
Open accessAbstract
OBJECTIVE: The objective of the Predict-HD study is to use genetic, neurobiological and refined clinical markers to understand the early progression of Huntington's disease (HD), prior to the point of traditional diagnosis, in persons with a known gene mutation. Here we estimate the approximate onset and initial course of various measurable aspects of HD relative to the time of eventual diagnosis. METHODS: We studied 438 participants who were positive for the HD gene mutation, but did not yet meet the diagnostic criteria for HD and had no functional decline. Predictability of baseline cognitive, motor, psychiatric and imaging measures was modelled non-linearly using estimated time until diagnosis (based on CAG repeat length and current age) as the predictor. RESULTS: Estimated time to diagnosis was related to most clinical and neuroimaging markers. The patterns of association suggested the commencement of detectable changes one to two decades prior to the predicted time of clinical diagnosis. The patterns were highly robust and consistent, despite the varied types of markers and diverse measurement methodologies. CONCLUSIONS: These findings from the Predict-HD study suggest the approximate time scale of measurable disease development, and suggest candidate disease markers for use in preventive HD trials.
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Harrell, F. E. (2001) · Springer Series in Statistics · doi:10.1007/978-1-4757-3462-1 · Cited by 9,195
Harrell (2015) · Springer Series in Statistics · doi:10.1007/978-3-319-19425-7 · Cited by 6,878
Unified Huntington's disease rating scale: Reliability and consistency
(1996) · Movement Disorders · doi:10.1002/mds.870110204 · Cited by 2,079
The hopkins verbal learning test: Development of a new memory test with six equivalent forms
Brandt, J. (1991) · Clinical Neuropsychologist · doi:10.1080/13854049108403297 · Cited by 1,317
Unified Huntington's disease rating scale: reliability and consistency
Kremer, H. P. H. (1996) · Radboud Repository (Radboud University) · Cited by 1,059
Doty, R. L., Shaman, P., Kimmelman, C. P., & Dann, M. S. (1984) · The Laryngoscope · doi:10.1288/00005537-198402000-00004 · Cited by 878
Langbehn, D., Brinkman, R., Falush, D., Paulsen, J., Hayden, M., & on behalf of an International Huntington's Disease Collaborative Group (2004) · Clinical Genetics · doi:10.1111/j.1399-0004.2004.00241.x · Cited by 817
Self-citationOnset and rate of striatal atrophy in preclinical Huntington disease
Aylward, E. H., Sparks, B. F., Field, K. M., Yallapragada, V., Shpritz, B. D., Rosenblatt, A., Brandt, J., Gourley, L. M., Liang, K., Zhou, H., et al. (2004) · Neurology · doi:10.1212/01.wnl.0000132965.14653.d1 · Cited by 408
Self-citationBehavioral changes in Huntington Disease.
Craufurd, D., Thompson, J. C., & Snowden, J. S. (2001) · PubMed · Cited by 397
Psychiatric Symptoms in Huntington’s Disease before Diagnosis: The Predict-HD Study
Duff, K., Paulsen, J. S., Beglinger, L. J., Langbehn, D. R., & Stout, J. C. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.11.034 · Cited by 392
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Self-citationHuntington disease: natural history, biomarkers and prospects for therapeutics
Ross, C. A., Aylward, E. H., Wild, E. J., Langbehn, D. R., Long, J. D., Warner, J. H., Scahill, R. I., Leavitt, B. R., Stout, J. C., Paulsen, J. S., et al. (2014) · Nature Reviews Neurology · doi:10.1038/nrneurol.2014.24 · Cited by 1,016
Self-citationTabrizi, S. J., Langbehn, D. R., Leavitt, B. R., Roos, R. A., Durr, A., Craufurd, D., Kennard, C., Hicks, S. L., Fox, N. C., Scahill, R. I., et al. (2009) · The Lancet Neurology · doi:10.1016/s1474-4422(09)70170-x · Cited by 984
Self-citationStatistical physics of vaccination
Wang, Z., Bauch, C. T., Bhattacharyya, S., d'Onofrio, A., Manfredi, P., Perc, M., Perra, N., Salathé, M., & Zhao, D. (2016) · Physics Reports · doi:10.1016/j.physrep.2016.10.006 · Cited by 872
Molecular Mechanisms and Potential Therapeutical Targets in Huntington's Disease
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Metadata
- Authors
- Paulsen, J. S., Langbehn, D. R., Stout, J. C., Aylward, E., Ross, C. A., Nance, M., Guttman, M., Johnson, S., MacDonald, M., Beglinger, L. J., Duff, K., Kayson, E., Biglan, K., Shoulson, I., Oakes, D., Hayden, M., & The Predict-HD Investigators and Coordinators of the Huntington Study Group
- Venue
- Journal of Neurology, Neurosurgery & Psychiatry
- Publisher
- BMJ
- Published
- 2008-08-01
- Volume
- 79
- Issue
- 8
- Pages
- 874-880
- ISSN
- 0022-3050 (ISSN-L)
- OpenAlex
- W2162229008
- Cited by
- 804
- References
- 33
- FWCI
- 10.39
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Paulsen, J. S., Langbehn, D. R., Stout, J. C., Aylward, E., Ross, C. A., Nance, M., Guttman, M., Johnson, S., MacDonald, M., Beglinger, L. J., Duff, K., Kayson, E., Biglan, K., Shoulson, I., Oakes, D., Hayden, M., & The Predict-HD Investigators and Coordinators of the Huntington Study Group. (2008). Detection of Huntington's disease decades before diagnosis: the Predict-HD study. Journal of Neurology, Neurosurgery & Psychiatry. https://doi.org/10.1136/jnnp.2007.128728
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