The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Distribution of divalent metal transporter 1 and metal transport protein 1 in the normal and Belgrade rat
Abstract
Iron accumulation in the brain occurs in a number of neurodegenerative diseases. Two new iron transport proteins have been identified that may help elucidate the mechanism of abnormal iron accumulation. The Divalent Metal Transporter 1 (DMT1), is responsible for iron uptake from the gut and transport from endosomes. The Metal Transport Protein 1 (MTP1) promotes iron export. In this study we determined the cellular and regional expression of these two transporters in the brains of normal adult and Belgrade rats. Belgrade rats have a defect in DMT1 that is associated with lower levels of iron in the brain. In the normal rat, DMT1 expression is highest in neurons in the striatum, cerebellum, thalamus, ependymal cells lining the third ventricle, and vascular cells throughout the brain. The staining in the ependymal cells and endothelial cells suggests that DMT1 has an important role in iron transport into the brain. In Belgrade rats, there is generalized decrease in immunodetectable DMT1 compared to normal rats except in the ependymal cells. This decrease in immunoreactivity, however, was absent on immunoblots. The immunoblot analysis indicates that this protein did not upregulate to compensate for the chronic defect in iron transport. MTP1 staining is found in most brain regions. MTP1 expression in the brain is robust in pyramidal neurons of the cerebral cortex but is not detected in the vascular endothelial cells and ependymal cells. MTP1 staining in Belgrade rats was decreased compared to normal, but similar to DMT1 this decrease was not corroborated by immunoblotting. These results indicate that DMT1 and MTP1 are involved in brain iron transport and this involvement is regionally and cellularly specific. J Neurosci. Res. 66:1198–1207, 2001. © 2001 Wiley‐Liss, Inc.
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Cites
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Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter
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BackgroundTransferrin and Iron in Normal, Alzheimer's Disease, and Parkinson's Disease Brain Regions
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I RON S TATUS AND N EURAL F UNCTIONING
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Self-citationIron neurochemistry in Alzheimer's disease and Parkinson's disease: targets for therapeutics
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Neuropathological examination suggests impaired brain iron acquisition in restless legs syndrome
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Metadata
- Authors
- Burdo, J. R., Menzies, S. L., Simpson, I. A., Garrick, L. M., Garrick, M. D., Dolan, K. G., Haile, D. J., Beard, J. L., & Connor, J. R.
- Venue
- Journal of Neuroscience Research
- Publisher
- Wiley
- Published
- 2001-11-30
- Volume
- 66
- Issue
- 6
- Pages
- 1198-1207
- ISSN
- 0360-4012 (ISSN-L)
- 1097-4547
- OpenAlex
- W2127695183
- Cited by
- 297
- References
- 11
- FWCI
- 6.78
- Type
- journal article
- Language
- en
- Open access
- closed
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