Increased basal ganglia iron levels in Huntington disease

“Mini-mental state”

Folstein, M. F., Folstein, S. E., & McHugh, P. R. (1975) · Journal of Psychiatric Research · doi:10.1016/0022-3956(75)90026-6 · Cited by 88,282 · see citing works

Untitled work

(1976) · Medical Entomology and Zoology · Cited by 8,899 · see citing works

A Controlled Trial of Selegiline, Alpha-Tocopherol, or Both as Treatment for Alzheimer's Disease

Sano, M., Ernesto, C., Thomas, R. G., Klauber, M. R., Schafer, K., Grundman, M., Woodbury, P., Growdon, J., Cotman, C. W., Pfeiffer, E., et al. (1997) · New England Journal of Medicine · doi:10.1056/nejm199704243361704 · Cited by 2,380 · see citing works

The effect of age on the non-haemin iron in the human brain

Hallgren, B., & Sourander, P. (1958) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1958.tb12607.x · Cited by 1,427 · see citing works

Iron accumulation in Alzheimer disease is a source of redox-generated free radicals

Smith, M. A., Harris, P. L. R., Sayre, L. M., & Perry, G. L. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.18.9866 · Cited by 1,357 · see citing works

Neurochemical and histologic characterization of striatal excitotoxic lesions produced by the mitochondrial toxin 3-nitropropionic acid

Beal, M. F., Brouillet, E., Jenkins, B. G., Ferrante, R. J., Kowall, N. W., Miller, J., Storey, E., Srivastava, R., Rosen, B. R., & Hyman, B. T. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-10-04181.1993 · Cited by 1,026 · see citing works

Psychological Statistics.

Katz, L., & McNemar, Q. (1963) · Journal of the American Statistical Association · doi:10.2307/2283304 · Cited by 991 · see citing works

The importance of free radicals and catalytic metal ions in human diseases.

Halliwell, B., & Gutteridge, J. M. C. (1985) · Molecular Aspects of Medicine · doi:10.1016/0098-2997(85)90001-9 · Cited by 941 · see citing works

Oxidative damage and metabolic dysfunction in Huntington's disease: Selective vulnerability of the basal ganglia

Browne, S. E., Bowling, A. C., Macgarvey, U., Baik, M. J., Berger, S. C., Muquit, M. M. K., Bird, E. D., & Beal, M. F. (1997) · Annals of Neurology · doi:10.1002/ana.410410514 · Cited by 885 · see citing works

Intramuscular desferrioxamine in patients with Alzheimer's disease

MCLACHLAN, D. (1991) · The Lancet · doi:10.1016/0140-6736(91)92978-b · Cited by 764 · see citing works

Mitochondrial defect in Huntington's disease caudate nucleus

Gu, M., Gash, M. T., Mann, V. M., Javoy‐Agid, F., Cooper, J. M., & Schapira, A. H. V. (1996) · Annals of Neurology · doi:10.1002/ana.410390317 · Cited by 758 · see citing works

A histochemical study of iron, transferrin, and ferritin in Alzheimer's diseased brains

Connor, J. R., Menzies, S. L., Martin, S. M. S., & Mufson, E. J. (1992) · Journal of Neuroscience Research · doi:10.1002/jnr.490310111 · Cited by 468 · see citing works

Mitochondria, free radicals, and neurodegeneration

Beal, M. F. (1996) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(96)80100-0 · Cited by 422 · see citing works

Transverse relaxation of solvent protons induced by magnetized spheres: Application to ferritin, erythrocytes, and magnetite

Gillis, P., & Koenig, S. H. (1987) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910050404 · Cited by 353 · see citing works

Hydrogen peroxide-mediated neuronal cell death induced by an endogenous neurotoxin, 3-hydroxykynurenine.

Okuda, S., Nishiyama, N., Saitō, H., & Katsuki, H. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.22.12553 · Cited by 302 · see citing works

Alterations in levels of iron, ferritin, and other trace metals in neurodegenerative diseases affecting the basal ganglia

Dexter, D. T., Jenner, P. G., Schapira, A. H. V., & MARSDEN, C. D. (1992) · Annals of Neurology · doi:10.1002/ana.410320716 · Cited by 292 · see citing works

Genotypes at the GluR6 kainate receptor locus are associated with variation in the age of onset of Huntington disease

Rubinsztein, D. C., Leggo, J., Chiano, M. N., Dodge, A., Norbury, G., Rosser, E. M., & Craufurd, D. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.8.3872 · Cited by 238 · see citing works

Increased regional brain concentrations of ceruloplasmin in neurodegenerative disorders

Loeffler, D. A., LeWitt, P. A., Juneau, P. L., Sima, A. A. F., Nguyen, H.-U., DeMaggio, A. J., Brickman, C. M., Brewer, G. J., Dick, R. D., Troyer, M. D., et al. (1996) · Brain Research · doi:10.1016/s0006-8993(96)00782-2 · Cited by 237 · see citing works

MR evaluation of age-related increase of brain iron in young adult and older normal males

Bartzokis, G., Beckson, M., Hance, D. B., Marx, P., Foster, J., & Marder, S. R. (1997) · Magnetic Resonance Imaging · doi:10.1016/s0730-725x(96)00234-2 · Cited by 181 · see citing works

Use of desferrioxamine in the treatment of aceruloplasminemia

Miyajima, H., Takahashi, Y., Kamata, T., Shimizu, H., Sakai, N., & Gitlin, J. D. (1997) · Annals of Neurology · doi:10.1002/ana.410410318 · Cited by 173 · see citing works

The relation between brain iron and NMR relaxation times: An in vitro study

Vymazal, J., Brooks, R. A., Baumgarner, C. D., Tran, V., Katz, D., Bulte, J. W. M., Bauminger, E. R., & Chiro, G. D. (1996) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910350108 · Cited by 172 · see citing works

Field dependent transverse relaxation rate increase may be a specific measure of tissue iron stores

Bartzokis, G., Aravagiri, M., Oldendorf, W. H., Mintz, J., & Marder, S. R. (1993) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910290406 · Cited by 172 · see citing works

Desferrioxamine and vitamin E protect against iron and MPTP-induced neurodegeneration in mice

Lan, J., & Jiang, D. (1997) · Journal of Neural Transmission · doi:10.1007/bf01277665 · Cited by 160 · see citing works

MR of human postmortem brain tissue: correlative study between T2 and assays of iron and ferritin in Parkinson and Huntington disease.

Chen, J. C., Hardy, P., Kucharczyk, W., Clauberg, M., Joshi, J. G., Vourlas, A., Dhar, M. S., & Henkelman, R. M. (1993) · PubMed Central · Cited by 156 · see citing works

In vivo MR evaluation of age-related increases in brain iron.

Bartzokis, G., Mintz, J., Sultzer, D. L., Marx, P., Herzberg, J., Phelan, C., & Marder, S. R. (1994) · PubMed Central · Cited by 140 · see citing works

Trial of d-alpha-tocopherol in Huntington's disease

Peyser, C. E., Folstein, M. F., Chase, G. A., STARKSTEIN, S. E., Brandt, J., Cockrell, J. R., Bylsma, F., Coyle, J. T., McHugh, P. R., & Folstein, S. E. (1995) · American Journal of Psychiatry · doi:10.1176/ajp.152.12.1771 · Cited by 139 · see citing works

Age distribution and iron dependency of the T2 relaxation time in the globus pallidus and putamen

Schenker, C., Meier, D., Wichmann, W., Boesiger, P., & Valavanis, A. (1993) · Neuroradiology · doi:10.1007/bf00593967 · Cited by 137 · see citing works

In vivo evaluation of brain iron in Alzheimer's disease and normal subjects using MRI

Bartzokis, G., Sultzer, D. L., Mintz, J., Holt, L. E., Marx, P., Phelan, C., & Marder, S. R. (1994) · Biological Psychiatry · doi:10.1016/0006-3223(94)90047-7 · Cited by 137 · see citing works

Nuclear magnetic resonance relaxation in experimental brain edema: Effects of water concentration, protein concentration, and temperature

Kamman, R. L., Go, K. G., Brouwer, W., & Berendsen, H. J. C. (1988) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910060304 · Cited by 117 · see citing works

The CAG/Polyglutamine Tract Diseases: Gene Products and Molecular Pathogenesis

Koshy, B. T., & Zoghbi, H. Y. (1997) · Brain Pathology · doi:10.1111/j.1750-3639.1997.tb00894.x · Cited by 113 · see citing works

Hepatic hemosiderosis in non‐human primates: Quantification of liver iron using different field strengths

Bulte, J. W. M., Miller, G., Vymazal, J., Brooks, R. A., & Frank, J. A. (1997) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910370409 · Cited by 97 · see citing works

A Risk-Benefit Assessment of Iron-Chelation Therapy

Porter, J. B. (1997) · Drug Safety · doi:10.2165/00002018-199717060-00006 · Cited by 95 · see citing works

Brain iron homeostasis

Morris, C. M., Candy, J. M., Keith, A. B., Oakley, A. E., Taylor, G. A., Edwardson, J. A., Bloxham, C. A., Pullen, R. G. L., & Gocht, A. (1992) · Journal of Inorganic Biochemistry · doi:10.1016/0162-0134(92)84071-t · Cited by 90 · see citing works

Antioxidant treatment protects striatal neurons against excitotoxic insults

Nakao, N., Grasbon-Frodl, E. M., Widner, H., & Brundin, P. (1996) · Neuroscience · doi:10.1016/0306-4522(96)00034-6 · Cited by 90 · see citing works

Magnetic resonance imaging of brain iron in health and disease

Vymazal, J., Brooks, R. A., Patronas, N. J., Hájek, M., Bulte, J. W. M., & Chiro, G. D. (1995) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(95)00204-f · Cited by 88 · see citing works

Clinical Aspects of CAG Repeat Diseases

Nance, M. (1997) · Brain Pathology · doi:10.1111/j.1750-3639.1997.tb00892.x · Cited by 88 · see citing works

The quantitative Relation Between T1‐Weighted and T2‐Weighted MRI of Normal gray Matter and iron concentration

Vymazal, J., Hájek, M., Patronas, N., Giedd, J. N., Bulte, J. W. M., Baumgarner, C. D., Tran, V., & Brooks, R. A. (1995) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.1880050514 · Cited by 87 · see citing works

Free radicals and neurodegeneration

Cadet, J. L. (1994) · Trends in Neurosciences · doi:10.1016/0166-2236(94)90102-3 · Cited by 85 · see citing works

T1 and T2 of ferritin solutions: Effect of loading factor

Vymazal, J., Zak, O., Bulte, J. W. M., Aisen, P., & Brooks, R. A. (1996) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910360111 · Cited by 84 · see citing works

Differential Expression of Normal and Mutant Huntington's Disease Gene Alleles

Persichetti, F., Carlée, L., Faber, P. W., McNeil, S. M., Ambrose, C. M., Srinidhi, J., Anderson, M., Barnes, G. T., Gusella, J. F., & MacDonald, M. E. (1996) · Neurobiology of Disease · doi:10.1006/nbdi.1996.0018 · Cited by 82 · see citing works

Huntington's Disease and Dentatorubral‐Pallidoluysian Atrophy: Proteins, Pathogenesis and Pathology

Ross, C. A., Bêcher, M. W., Colomer, V., Engelender, S., Wood, J. D., & Sham, A. H. (1997) · Brain Pathology · doi:10.1111/j.1750-3639.1997.tb00898.x · Cited by 63 · see citing works

The Role of Metal Ions in Oxidative Processes and Aging

Floyd, R. A., & Carney, J. M. (1993) · Toxicology and Industrial Health · doi:10.1177/0748233793009001-214 · Cited by 58 · see citing works

Iodoacetate Produces Striatal Excitotoxic Lesions

Matthews, R. T., Ferrante, R. J., Jenkins, B. G., Browne, S. E., Goetz, K., Berger, S. A., Chen, Y. I., & Beal, M. F. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.69010285.x · Cited by 43 · see citing works

Selective Loss of [3H]Kainic Acid and [3H]AMPA Binding in Layer VI of Frontal Cortex in Huntington's Disease

Wagster, M. V., Hedreen, J. C., Peyser, C. E., Folstein, S. E., & Ross, C. A. (1994) · Experimental Neurology · doi:10.1006/exnr.1994.1081 · Cited by 40 · see citing works

MR microscopy at 7.0 T: Effects of brain iron

Malisch, T. W., Hedlund, L. W., Suddarth, S. A., & Johnson, G. A. (1991) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.1880010308 · Cited by 19 · see citing works

Clinical presentation and patterns of regional cerebral atrophy related to the length of trinucleotide repeat expansion in patients with adult onset Huntington's disease

Sieradzan, K. A., Mann, D. M. A., & Dodge, A. (1997) · Neuroscience Letters · doi:10.1016/s0304-3940(97)00182-1 · Cited by 17 · see citing works

Magnetic resonance imaging changes in putamen nuclei iron content and distribution in normal subjects

Steffens, D. C., McDonald, W. M., Tupler, L. A., Boyko, O. B., & Krishna, K. R. R. (1996) · Psychiatry Research Neuroimaging · doi:10.1016/0925-4927(96)02834-x · Cited by 12 · see citing works

Magnetic Resonance Imaging of Brain Iron

Bartzokis, G. (1997) · Springer eBooks · doi:10.1007/978-1-4899-0197-2_3 · Cited by 9 · see citing works

Nitric Oxide and Oxidative Damage in the CNS

Dawson, D. A. (1997) · Springer eBooks · doi:10.1007/978-1-4899-0197-2_11 · Cited by 3 · see citing works

Metals in Neurobiology: Probing Their Chemistry and Biology with Molecular Imaging

Que, E. L., Domaille, D. W., & Chang, C. J. (2008) · Chemical Reviews · doi:10.1021/cr078203u · Cited by 2,063 · see citing works

The role of iron in brain ageing and neurodegenerative disorders

Ward, R. J., Zucca, F. A., Duyn, J. H., Crichton, R. R., & Zecca, L. (2014) · The Lancet Neurology · doi:10.1016/s1474-4422(14)70117-6 · Cited by 1,819 · see citing works

Oxidative stress induced-neurodegenerative diseases: the need for antioxidants that penetrate the blood brain barrier

Gilgun‐Sherki, Y., Melamed, E., & Offen, D. (2001) · Neuropharmacology · doi:10.1016/s0028-3908(01)00019-3 · Cited by 839 · see citing works

The roles of iron in health and disease

Lieu, P. T., Heiskala, M. K., Peterson, P. A., & Yang, Y. M. (2001) · Molecular Aspects of Medicine · doi:10.1016/s0098-2997(00)00006-6 · Cited by 813 · see citing works

Targeting ferroptosis opens new avenues for the development of novel therapeutics

Sun, S., Shen, J., Jiang, J., Wang, F., & Min, J. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01606-1 · Cited by 632 · see citing works

Alzheimer's disease as homeostatic responses to age-related myelin breakdown

Bartzokis, G. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2009.08.007 · Cited by 546 · see citing works

Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases

Kell, D. B. (2009) · BMC Medical Genomics · doi:10.1186/1755-8794-2-2 · Cited by 554 · see citing works

Biological metals and metal-targeting compounds in major neurodegenerative diseases

Barnham, K. J., & Bush, A. I. (2014) · Chem. Soc. Rev. · doi:10.1039/c4cs00138a · Cited by 497 · see citing works

Clinical applications of neuroimaging with susceptibility‐weighted imaging

Sehgal, V., DelProposto, Z., Haacke, E. M., Tong, K. A., Wycliffe, N., Kido, D. K., Xu, Y., Neelavalli, J., Haddar, D., & Reichenbach, J. R. (2005) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.20404 · Cited by 424 · see citing works

Ferroptosis and cell death mechanisms in Parkinson's disease

Guiney, S. J., Adlard, P. A., Bush, A. I., Finkelstein, D. I., & Ayton, S. (2017) · Neurochemistry International · doi:10.1016/j.neuint.2017.01.004 · Cited by 337 · see citing works

High‐field magnetic resonance imaging of brain iron: birth of a biomarker?

Schenck, J. F., & Zimmerman, E. A. (2004) · NMR in Biomedicine · doi:10.1002/nbm.922 · Cited by 330 · see citing works

Proteomic and oxidative stress analysis in human brain samples of Huntington disease

Sorolla, M. A., Reverter‐Branchat, G., Tamarit, J., Ferrer, I., Ros, J., & Cabiscol, E. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.05.014 · Cited by 300 · see citing works

Distribution of divalent metal transporter 1 and metal transport protein 1 in the normal and Belgrade rat

Burdo, J. R., Menzies, S. L., Simpson, I. A., Garrick, L. M., Garrick, M. D., Dolan, K. G., Haile, D. J., Beard, J. L., & Connor, J. R. (2001) · Journal of Neuroscience Research · doi:10.1002/jnr.1256 · Cited by 297 · see citing works

Brain iron uptake and homeostatic mechanisms: An overview

Burdo, J. R., & Connor, J. R. (2003) · BioMetals · doi:10.1023/a:1020718718550 · Cited by 292 · see citing works

Microglial dystrophy in the aged and Alzheimer's disease brain is associated with ferritin immunoreactivity

Lopes, K. O., Sparks, D. L., & Streit, W. J. (2008) · Glia · doi:10.1002/glia.20678 · Cited by 262 · see citing works

Ferritin accumulation in dystrophic microglia is an early event in the development of Huntington's disease

Simmons, D. A., Casale, M., Alcon, B., Pham, N., Narayan, N., & LYNCH, G. S. (2007) · Glia · doi:10.1002/glia.20526 · Cited by 277 · see citing works

Metals and Neurodegeneration

Chen, P., Miah, M. R., & Aschner, M. (2016) · F1000Research · doi:10.12688/f1000research.7431.1 · Cited by 260 · see citing works

The transition metals copper and iron in neurodegenerative diseases

Rivera-Mancía, S., Pérez‐Neri, I., Rı́os, C., Tristán-López, L. A., Rivera-Espinosa, L., & Montes, S. (2010) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2010.04.010 · Cited by 243 · see citing works

Supplementation of Endothelial Cells with Mitochondria-targeted Antioxidants Inhibit Peroxide-induced Mitochondrial Iron Uptake, Oxidative Damage, and Apoptosis

Dhanasekaran, A., Kotamraju, S., Kalivendi, S. V., Matsunaga, T., Shang, T., Keszler, A., Joseph, J., & Kalyanaraman, B. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m404003200 · Cited by 241 · see citing works

Myelin breakdown and iron changes in Huntington's disease: pathogenesis and treatment implications

Bartzokis, G., Lu, P. H., Tishler, T. A., Fong, S. M., Oluwadara, B., Finn, J. P., Huang, D., Bordelon, Y., Mintz, J., & Perlman, S. (2007) · Neurochemical Research · doi:10.1007/s11064-007-9352-7 · Cited by 238 · see citing works

Iron and neurodegenerative disorders

Thompson, K. J., Shoham, S., & Connor, J. R. (2001) · Brain Research Bulletin · doi:10.1016/s0361-9230(01)00510-x · Cited by 235 · see citing works

In Vivo Evaluation of Brain Iron in Alzheimer Disease Using Magnetic Resonance Imaging

Bartzokis, G., Sultzer, D. L., Cummings, J. L., Holt, L. E., Hance, D. B., Henderson, V. W., & Mintz, J. (2000) · Archives of General Psychiatry · doi:10.1001/archpsyc.57.1.47 · Cited by 235 · see citing works

The Metabolism of Neuronal Iron and Its Pathogenic Role in Neurological Disease: Review

Moos, T., & Morgan, E. H. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1306.002 · Cited by 234 · see citing works

Role of Iron in Neurodegenerative Disorders

Berg, D., & Youdim, M. B. H. (2006) · Topics in Magnetic Resonance Imaging · doi:10.1097/01.rmr.0000245461.90406.ad · Cited by 227 · see citing works

Targeting dysregulation of brain iron homeostasis in Parkinson's disease by iron chelators

Weinreb, O., Mandel, S. A., Youdim, M. B. H., & Amit, T. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.01.017 · Cited by 190 · see citing works

Electron nanodiffraction and high-resolution electron microscopy studies of the structure and composition of physiological and pathological ferritin

Quintana, C., COWLEY, J. M., & Marhic, C. (2004) · Journal of Structural Biology · doi:10.1016/j.jsb.2004.03.001 · Cited by 189 · see citing works

Iron metabolism in Parkinsonian syndromes

Berg, D., & Hochstrasser, H. (2006) · Movement Disorders · doi:10.1002/mds.21020 · Cited by 185 · see citing works

Brain Ferritin Iron as a Risk Factor for Age at Onset in Neurodegenerative Diseases

Bartzokis, G., Tishler, T. A., Shin, I., Lu, P. H., & Cummings, J. L. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1306.019 · Cited by 184 · see citing works

Consequences of Disturbing Manganese Homeostasis

Baj, J., Flieger, W., Barbachowska, A., Kowalska, B., Flieger, M., Forma, A., Teresiński, G., Portincasa, P., Buszewicz, G., Radzikowska-Büchner, E., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241914959 · Cited by 184 · see citing works

Iron dysregulation in movement disorders

Dušek, P., Jankovic, J. J., & Le, W. (2012) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.12.054 · Cited by 172 · see citing works

Iron drives T helper cell pathogenicity by promoting RNA-binding protein PCBP1-mediated proinflammatory cytokine production

Wang, Z., Yin, W., Zhu, L., Li, J., Yao, Y., Chen, F., Sun, M., Zhang, J., Shen, N., Song, Y., et al. (2018) · Immunity · doi:10.1016/j.immuni.2018.05.008 · Cited by 156 · see citing works

Zebrafish as an Animal Model for Drug Discovery in Parkinson’s Disease and Other Movement Disorders: A Systematic Review

Vaz, R. L., Outeiro, T. F., & Ferreira, J. J. (2018) · Frontiers in Neurology · doi:10.3389/fneur.2018.00347 · Cited by 169 · see citing works

Metal‐Catalyzed Disruption of Membrane Protein and Lipid Signaling in the Pathogenesis of Neurodegenerative Disorders

Mattson, M. P. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1306.004 · Cited by 162 · see citing works

Development of biomarkers for Huntington's disease

Weir, D. W., Sturrock, A., & Leavitt, B. R. (2011) · The Lancet Neurology · doi:10.1016/s1474-4422(11)70070-9 · Cited by 159 · see citing works

Huntingtin-deficient zebrafish exhibit defects in iron utilization and development

Lumsden, A. L., Henshall, T. L., Dayan, S., Lardelli, M. T., & Richards, R. I. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddm138 · Cited by 156 · see citing works

Huntington disease arises from a combinatory toxicity of polyglutamine and copper binding

Xiao, G., Fan, Q., Wang, X., & Zhou, B. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1308535110 · Cited by 158 · see citing works

Mitochondrial iron homeostasis and its dysfunctions in neurodegenerative disorders

Mena, N. P., Urrutia, P. J., Lourido, F., Carrasco, C. M., & Núñez, M. T. (2015) · Mitochondrion · doi:10.1016/j.mito.2015.02.001 · Cited by 154 · see citing works

New Perspectives in Iron Chelation Therapy for the Treatment of Neurodegenerative Diseases

Núñez, M. T., & Chaná‐Cuevas, P. (2018) · Pharmaceuticals · doi:10.3390/ph11040109 · Cited by 150 · see citing works

Microglial degeneration in the aging brain - bad news for neurons?

Streit, W. (2008) · Frontiers in Bioscience · doi:10.2741/2937 · Cited by 150 · see citing works

Different Iron-Deposition Patterns of Multiple System Atrophy with Predominant Parkinsonism and Idiopathetic Parkinson Diseases Demonstrated by Phase-Corrected Susceptibility-Weighted Imaging

Wang, Y., Butros, S. R., Shuai, X., Dai, Y., Chen, C., Liu, M., Haacke, E. M., Hu, J., & Xu, H. (2011) · American Journal of Neuroradiology · doi:10.3174/ajnr.a2765 · Cited by 150 · see citing works

Quantitative Susceptibility Mapping Suggests Altered Brain Iron in Premanifest Huntington Disease

Bergen, J. M. G. V., Hua, J., Unschuld, P. G., Lim, I. A. L., Jones, C. K., Margolis, R. L., Ross, C. A., van Zijl, P. C. M., & Li, X. (2015) · American Journal of Neuroradiology · doi:10.3174/ajnr.a4617 · Cited by 140 · see citing works

Redox Mechanisms in Neurodegeneration: From Disease Outcomes to Therapeutic Opportunities

Sbodio, J. I., Snyder, S. H., & Paul, B. D. (2018) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7321 · Cited by 143 · see citing works

Intracellular Sources of ROS/H2O2 in Health and Neurodegeneration: Spotlight on Endoplasmic Reticulum

Konno, T., Melo, E. P., Chambers, J. E., & Avezov, E. (2021) · Cells · doi:10.3390/cells10020233 · Cited by 140 · see citing works

The influence of white matter fibre orientation on MR signal phase and decay

Denk, C., Hernández‐Torres, E., MacKay, A. L., & Rauscher, A. (2010) · NMR in Biomedicine · doi:10.1002/nbm.1581 · Cited by 135 · see citing works

Iron in the Brain: An Important Contributor in Normal and Diseased States

Piñero, D. J., & Connor, J. R. (2000) · The Neuroscientist · doi:10.1177/107385840000600607 · Cited by 131 · see citing works

Novel insights into ferroptosis: Implications for age-related diseases

Zhou, R., Chen, Y., Wei, X., Yu, B., Xiong, Z., Lu, C., & Hu, W. M. (2020) · Theranostics · doi:10.7150/thno.50663 · Cited by 132 · see citing works

Iron dysregulation in Huntington's disease

Müller, M., & Leavitt, B. R. (2014) · Journal of Neurochemistry · doi:10.1111/jnc.12739 · Cited by 122 · see citing works

Susceptibility weighted imaging with multiple echoes

Denk, C., & Rauscher, A. (2009) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.21995 · Cited by 123 · see citing works

Role of iron in neurodegenerative diseases

Li, K., & Reichmann, H. (2016) · Journal of Neural Transmission · doi:10.1007/s00702-016-1508-7 · Cited by 118 · see citing works

Volume and iron content in basal ganglia and thalamus

Péran, P., Cherubini, A., Luccichenti, G., Hagberg, G. E., Démonet, J., Rascol, O., Celsis, P., Caltagirone, C., Spalletta, G., & Sabatini, U. (2009) · Human Brain Mapping · doi:10.1002/hbm.20698 · Cited by 116 · see citing works

Mitochondrial iron metabolism and neurodegenerative diseases

Cheng, R., Dhorajia, V. V., Kim, J., & Kim, Y. (2021) · NeuroToxicology · doi:10.1016/j.neuro.2021.11.003 · Cited by 120 · see citing works

Hepcidin, an emerging and important player in brain iron homeostasis

Vela, D. (2018) · Journal of Translational Medicine · doi:10.1186/s12967-018-1399-5 · Cited by 104 · see citing works

Longitudinal Development of Brain Iron Is Linked to Cognition in Youth

Larsen, B., Bourque, J., Moore, T. M., Adebimpe, A., Calkins, M. E., Elliott, M. A., Gur, R. C., Gur, R. E., Moberg, P. J., Roalf, D. R., et al. (2020) · Journal of Neuroscience · doi:10.1523/jneurosci.2434-19.2020 · Cited by 102 · see citing works

Iron in neurodegenerative disorders

Berg, D., Becker, G., Riederer, P. F., & Rieß, O. (2002) · Neurotoxicity Research · doi:10.1080/1029842021000045444 · Cited by 98 · see citing works

Iron accumulation in the basal ganglia in Huntington's disease: cross-sectional data from the IMAGE-HD study

D, J. F. D., Ng, A., Poudel, G. R., Stout, J. C., Churchyard, A., Chua, P. M.-L., Egan, G. F., & Georgiou‐Karistianis, N. (2015) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2014-310183 · Cited by 99 · see citing works

Diffusion Tensor Imaging in Huntington’s disease reveals distinct patterns of white matter degeneration associated with motor and cognitive deficits

Bohanna, I., Georgiou‐Karistianis, N., Sritharan, A., Asadi, H., Johnston, L. A., Churchyard, A., & Egan, G. F. (2011) · Brain Imaging and Behavior · doi:10.1007/s11682-011-9121-8 · Cited by 94 · see citing works

Brain Iron Metabolism and Neurodegenerative Disorders

Sipe, J. C., Lee, P. L., & Beutler, E. (2002) · Developmental Neuroscience · doi:10.1159/000065701 · Cited by 94 · see citing works

Fueling neurodegeneration: metabolic insights into microglia functions

Sadeghdoust, M., Das, A., & Kaushik, D. K. (2024) · Journal of Neuroinflammation · doi:10.1186/s12974-024-03296-0 · Cited by 101 · see citing works

Quadratic trajectories of brain myelin content: unifying construct for neuropsychiatric disorders

Bartzokis, G. (2003) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2003.08.001 · Cited by 92 · see citing works

The neurotoxicity of iron, copper and cobalt in Parkinson’s disease through ROS-mediated mechanisms

Lan, A. P., Chen, J., Chai, Z., & Hu, Y. (2016) · BioMetals · doi:10.1007/s10534-016-9942-4 · Cited by 90 · see citing works

Voxel‐based analysis of R2* maps in the healthy human brain

Péran, P., Hagberg, G. E., Luccichenti, G., Cherubini, A., Brainovich, V., Celsis, P., Caltagirone, C., & Sabatini, U. (2007) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.21204 · Cited by 88 · see citing works

Iron and Brain Disorders

Sadrzadeh, S. M. H., & Saffari, Y. (2004) · Pathology Patterns Reviews · doi:10.1309/ew0121lg9n3n1yl4 · Cited by 88 · see citing works

Correlation of R2 with total iron concentration in the brains of rhesus monkeys

Hardy, P., Gash, D., Yokel, R., Andersen, A., Ai, Y., & Zhang, Z.-M. (2005) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.20244 · Cited by 93 · see citing works

Iron, Copper, and Zinc Distribution of the Cerebellum

Popescu, B. F. G., Robinson, C. A., Rajput, A. H., Rajput, A. H., Harder, S. L., & Nichol, H. K. (2009) · The Cerebellum · doi:10.1007/s12311-008-0091-3 · Cited by 83 · see citing works

Are There Common Biochemical and Molecular Mechanisms Controlling Manganism and Parkisonism

Roth, J. A. (2009) · NeuroMolecular Medicine · doi:10.1007/s12017-009-8088-8 · Cited by 82 · see citing works

A Critical Review of White Matter Changes in Huntington’s Disease

Casella, C., Lipp, I., Rosser, A., Jones, D. K., & Metzler‐Baddeley, C. (2020) · Movement Disorders · doi:10.1002/mds.28109 · Cited by 78 · see citing works

Is hemochromatosis a risk factor for Alzheimer's disease?

Connor, J. R., Milward, E. A., Moalem, S., Sampietro, M., Boyer, P. J., Percy, M. E., Vergani, C., Scott, R. J., & Chorney, M. J. (2001) · Journal of Alzheimer s Disease · doi:10.3233/jad-2001-3506 · Cited by 80 · see citing works

Cerebral Vitamin B5 (D-Pantothenic Acid) Deficiency as a Potential Cause of Metabolic Perturbation and Neurodegeneration in Huntington’s Disease

Patassini, S., Begley, P., Xu, J., Church, S. J., Kureishy, N., Reid, S. J., Waldvogel, H. J., Faull, R. L. M., Snell, R. G., Unwin, R. D., et al. (2019) · Metabolites · doi:10.3390/metabo9060113 · Cited by 79 · see citing works

Mineralization of the basal ganglia: implications for neuropsychiatry, pathology and neuroimaging

Casanova, M. F., & Araque, J. M. (2003) · Psychiatry Research · doi:10.1016/s0165-1781(03)00202-6 · Cited by 78 · see citing works

Trace metal regulation of neuronal apoptosis: From genes to behavior

Levenson, C. W. (2005) · Physiology & Behavior · doi:10.1016/j.physbeh.2005.08.010 · Cited by 77 · see citing works

Impaired Redox Signaling in Huntington’s Disease: Therapeutic Implications

Paul, B. D., & Snyder, S. H. (2019) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2019.00068 · Cited by 75 · see citing works

Seeking huntington disease biomarkers by multimodal, cross‐sectional basal ganglia imaging

Sánchez‐Castañeda, C., Cherubini, A., Elifani, F., Péran, P., Orobello, S., Capelli, G., Sabatini, U., & Squitieri, F. (2012) · Human Brain Mapping · doi:10.1002/hbm.22019 · Cited by 73 · see citing works

Iron and Neurodegeneration: From Cellular Homeostasis to Disease

Batista-Nascimento, L. S., Pimentel, C., Menezes, R., & Rodrigues‐Pousada, C. (2012) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2012/128647 · Cited by 70 · see citing works

Fast high resolution whole brain T2* weighted imaging using echo planar imaging at 7T

Zwanenburg, J. J. M., Versluis, M. J., Luijten, P. R., & Petridou, N. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2011.03.046 · Cited by 69 · see citing works

Prevalent Iron Metabolism Gene Variants Associated with Increased Brain Ferritin Iron in Healthy Older Men

Bartzokis, G., Lu, P. H., Tishler, T. A., Peters, D. G., Kosenko, A., Barrall, K. A., Finn, J. P., Villablanca, P. J., Laub, G. A., Altshuler, L. L., et al. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-1368 · Cited by 69 · see citing works

Elevated brain iron is independent from atrophy in Huntington's Disease

Dumas, E. M., Versluis, M. J., van den Bogaard, S. J. A., van Osch, M. J. P., Hart, E. P., van Roon‐Mom, W., van Buchem, M. A., WEBB, A. G., van der Grond, J., & Roos, R. A. C. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.03.056 · Cited by 62 · see citing works

Imaging of Iron

Dušek, P., Dezortová, M., & Wuerfel, J. T. (2013) · International review of neurobiology · doi:10.1016/b978-0-12-410502-7.00010-7 · Cited by 60 · see citing works

Altered Manganese Homeostasis and Manganese Toxicity in a Huntington's Disease Striatal Cell Model Are Not Explained by Defects in the Iron Transport System

Williams, B. B., Kwakye, G. F., Węgrzynowicz, M., Li, D. D., Aschner, M., Erikson, K. M., & Bowman, A. B. (2010) · Toxicological Sciences · doi:10.1093/toxsci/kfq174 · Cited by 60 · see citing works

Influence of chronic exercise on reserpine-induced oxidative stress in rats: Behavioral and antioxidant evaluations

TEIXEIRA, A., Trevizol, F., Colpo, G. D., García, S. C., Charão, M. F., Pereira, R. P., Fachinetto, R., da Rocha, J. B. T., & Bürger, M. E. (2007) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2007.10.004 · Cited by 55 · see citing works

Multiple Sclerosis and the Accumulation of Iron in the Basal Ganglia: Quantitative Assessment of Brain Iron Using MRI T2 Relaxometry

Burgetová, A., Seidl, Z., Krásenský, J., Horáková, D., & Vaněčková, M. (2010) · European Neurology · doi:10.1159/000279305 · Cited by 55 · see citing works

Reversion of age-related recognition memory impairment by iron chelation in rats

de Lima, M. N. M., Dias, C. P., Torres, J. P., Dornelles, A. D. S., Garcia, V. A., Scalco, F. S., Guimarães, M. R., Petry, R. C., Bromberg, E., Constantino, L. D. S., et al. (2007) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.02.006 · Cited by 55 · see citing works

Iron and Alzheimer’s Disease: From Pathology to Imaging

Tran, D. Q., DiGiacomo, P., Born, D. E., Georgiadis, M., & Zeineh, M. (2022) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2022.838692 · Cited by 57 · see citing works

Neurodegeneration With Brain Iron Accumulation: A Diagnostic Algorithm

Kruer, M. C., & Boddaert, N. (2012) · Seminars in Pediatric Neurology · doi:10.1016/j.spen.2012.04.001 · Cited by 54 · see citing works

Disturbance of Iron Metabolism as a Contributing Factor to SN Hyperechogenicity in Parkinson’s Disease: Implications for Idiopathic and Monogenetic Forms

Berg, D. (2007) · Neurochemical Research · doi:10.1007/s11064-007-9346-5 · Cited by 54 · see citing works

Correlations of Behavioral Deficits with Brain Pathology Assessed through Longitudinal MRI and Histopathology in the R6/2 Mouse Model of HD

Rattray, I., Smith, E. J., Gale, R., Matsumoto, K., Bates, G. P., & Modo, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0060012 · Cited by 52 · see citing works

7 T MRI reveals diffuse iron deposition in putamen and caudate nucleus in CADASIL

Liem, M. K., Lesnik Oberstein, S. A. J., Versluis, M. J., Maat-Schieman, M. L. C., Haan, J., Webb, A. G., Ferrari, M. D., van Buchem, M. A., & van der Grond, J. (2012) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp-2012-302545 · Cited by 50 · see citing works

MRI measures of corpus callosum iron and myelin in early Huntington's disease

Paola, M. D., Phillips, O. R., Sánchez‐Castañeda, C., Pardo, A. D., Maglione, V., Caltagirone, C., Sabatini, U., & Squitieri, F. (2013) · Human Brain Mapping · doi:10.1002/hbm.22391 · Cited by 49 · see citing works

Protein oxidation in Huntington disease

Sorolla, M. A., Colman, M. J. R., Vall‐llaura, N., Tamarit, J., Ros, J., & Cabiscol, E. (2012) · BioFactors · doi:10.1002/biof.1013 · Cited by 47 · see citing works

Free radical biology in neurological manifestations: mechanisms to therapeutics interventions

Tripathi, R. S., Gupta, R. V., Sahu, M., Srivastava, D., Das, A., Ambasta, R. K., & Kumar, P. (2021) · Environmental Science and Pollution Research · doi:10.1007/s11356-021-16693-2 · Cited by 52 · see citing works

Advances in Zebrafish as a Comprehensive Model of Mental Disorders

Wang, L., Liu, F., Fang, Y.-M., Ma, J.-H., Wang, J.-W., Qu, L., Yang, Q.-S., Wu, W., Jin, L.-B., & Sun, D. (2023) · Depression and Anxiety · doi:10.1155/2023/6663141 · Cited by 56 · see citing works

The role of iron in gray matter degeneration in Huntington's disease: A magnetic resonance imaging study

Sánchez‐Castañeda, C., Squitieri, F., Paola, M. D., Dayan, M., Petrollini, M., & Sabatini, U. (2014) · Human Brain Mapping · doi:10.1002/hbm.22612 · Cited by 46 · see citing works

The secret life of extracellular vesicles in metal homeostasis and neurodegeneration

Bellingham, S. A., Guo, B. B., & Hill, A. F. (2015) · Biology of the Cell · doi:10.1111/boc.201500030 · Cited by 45 · see citing works

MR relaxometry in Huntington's disease: Correlation between imaging, genetic and clinical parameters

Vymazal, J., Klempíř, J., Jech, R., Židovská, J., Syka, M., Růžička, E., & Roth, J. (2007) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2007.05.018 · Cited by 43 · see citing works

Desferoxamine reverses neonatal iron-induced recognition memory impairment in rats

de Lima, M. N. M., Presti-Torres, J., Caldana, F., Grazziotin, M. M., Scalco, F. S., Guimarães, M. R., Bromberg, E., Franke, S. I. R., Henriques, J. A. P., & Schröder, N. (2007) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.06.002 · Cited by 43 · see citing works

MRI T2 Hypointensities in basal ganglia of premanifest Huntington's disease

Jurgens, C. K., Jasinschi, R., Ekin, A., Witjes‐Ané, M. W., van der Grond, J., Middelkoop, H. A. M., & Roos, R. A. C. (2010) · PLoS Currents · doi:10.1371/currents.rrn1173 · Cited by 42 · see citing works

The Corticospinal Tract in Huntington's Disease

Phillips, O. R., Squitieri, F., Sánchez‐Castañeda, C., Elifani, F., Griguoli, A. M., Maglione, V., Caltagirone, C., Sabatini, U., & Paola, M. D. (2014) · Cerebral Cortex · doi:10.1093/cercor/bhu065 · Cited by 41 · see citing works

The role of ferroptosis in neurodegenerative diseases

Xu, Y., Zhao, J., Zhao, Y., Zhou, L., Qiao, H., Xu, Q., & Liu, Y. (2022) · Molecular Biology Reports · doi:10.1007/s11033-022-08048-y · Cited by 43 · see citing works

Altered iron and myelin in premanifest Huntington's Disease more than 20 years before clinical onset: Evidence from the cross-sectional HD Young Adult Study

Johnson, E. B., Parker, C. S., Scahill, R. I., Gregory, S., Papoutsi, M., Zeun, P., Osborne‐Crowley, K., Lowe, J., Nair, A., Estevez‐Fraga, C., et al. (2021) · EBioMedicine · doi:10.1016/j.ebiom.2021.103266 · Cited by 39 · see citing works

Determination of transverse relaxation rate for estimating iron deposits in central nervous system

Hikita, T., Abe, K., Sakoda, S., Tanaka, H., Murase, K., & Fujita, N. (2004) · Neuroscience Research · doi:10.1016/j.neures.2004.09.006 · Cited by 39 · see citing works

Heme Oxygenase-1 Induction and Dependent Increase in Ferritin

Gonzales, S., Erario, M., & Tomaro, M. L. (2002) · Developmental Neuroscience · doi:10.1159/000065686 · Cited by 38 · see citing works

Iron accumulation in the basal ganglia in Huntington's disease: Cross-sectional data from the IMAGE-HD study

(14451801), J. D. D., (15808028), A. N., (13437798), G. P., Stout, J. C., (10042406), A. C., (13518502), P. C., (14453715), G. E., & (13324965), N. G.-K. (2024) · Figshare

MRI evaluation of basal ganglia ferritin iron and neurotoxicity in Alzheimer's and Huntingon's disease.

Bartzokis, G., & Tishler, T. A. (2000) · PubMed · Cited by 196 · see citing works

The role of iron in gray matter degeneration in Huntington's disease: A magnetic resonance imaging study

Sánchez‐Castañeda, C., Squitieri, F., Paola, M. D., Dayan, M., Petrollini, M., & Sabatini, U. (2014) · Human Brain Mapping · doi:10.1002/hbm.22612 · Cited by 46 · see citing works

E07 Progressive Iron Accumulation In Huntington Disease Basal Ganglia: A Longitudinal Study

Sánchez‐Castañeda, C., Hagberg, G. E., Squitieri, F., & Sabatini, U. (2014) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2014-309032.110

E08 Iron Content in Brain Increases with Progression of Huntington's Disease: Longitudinal Study

Klempíř, J., Keller, J., Vymazal, J., Syka, M., Štochl, J., Jech, R., Židovská, J., & Roth, J. (2014) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2014-309032.111