Cited by 311Parkinson's Disease Mechanisms and TreatmentsDeep Brain Stimulation and Movement DisordersNeurogenesis and neuroplasticity mechanisms

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Exercise-induced behavioral recovery and neuroplasticity in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned mouse basal ganglia

Fisher, Beth E., Petzinger, Giselle M., Nixon, Kerry, Hogg, Elizabeth, Bremmer, Samuel, Meshul, Charles K., Jakowec, Michael W.·2004·Journal of Neuroscience Research

DOI 10.1002/jnr.20162

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Abstract

Physical activity has been shown to be neuroprotective in lesions affecting the basal ganglia. Using a treadmill exercise paradigm, we investigated the effect of exercise on neurorestoration. The 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-lesioned mouse model provides a means to investigate the effect of exercise on neurorestoration because 30-40% of nigrostriatal dopaminergic neurons survive MPTP lesioning and may provide a template for neurorestoration to occur. MPTP-lesioned C57 BL/6J mice were administered MPTP (four injections of 20 mg/kg free-base, 2 hr apart) or saline and divided into the following groups: (1). saline; (2). saline + exercise; (3). MPTP; and (4) MPTP + exercise. Mice in exercise groups were run on a motorized treadmill for 30 days starting 4 days after MPTP lesioning (a period after which MPTP-induced cell death is complete). Initially, MPTP-lesioned + exercise mice ran at slower speeds for a shorter amount of time compared to saline + exercise mice. Both velocity and endurance improved in the MPTP + exercise group to near normal levels over the 30-day exercise period. The expression of proteins and genes involved in basal ganglia function including the dopamine transporter (DAT), tyrosine hydroxylase (TH), and the dopamine D1 and D2 receptors, as well as alterations on glutamate immunolabeling were determined. Exercise resulted in a significant downregulation of striatal DAT in the MPTP + exercise compared to MPTP nonexercised mice and to a lesser extent in the saline + exercised mice compared to their no-exercise counterparts. There was no significant difference in TH protein levels between MPTP and MPTP + exercise groups at the end of the study. The expression of striatal dopamine D1 and D2 receptor mRNA transcript was suppressed in the saline + exercise group; however, dopamine D2 transcript expression was increased in the MPTP + exercise mice. Immunoelectron microscopy indicated that treadmill exercise reversed the lesioned-induced increase in nerve terminal glutamate immunolabeling seen after MPTP administration. Our data demonstrates that exercise promotes behavioral recovery in the injured brain by modulating genes and proteins important to basal ganglia function.

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LAEMMLI, U. K. (1970) · Nature · doi:10.1038/227680a0 · Cited by 249,961
Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.
Towbin, H., Staehelin, T., & Gordon, J. (1979) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.76.9.4350 · Cited by 53,218
Exercise: a behavioral intervention to enhance brain health and plasticity
Cotman, C. (2002) · Trends in Neurosciences · doi:10.1016/s0166-2236(02)02143-4 · Cited by 2,739
Progressive degeneration of nigrostriatal dopamine neurons following intrastriatal terminal lesions with 6-hydroxydopamine: A combined retrograde tracing and immunocytochemical study in the rat
Sauer, H., & Oertel, W. H. (1994) · Neuroscience · doi:10.1016/0306-4522(94)90605-x · Cited by 817
Voluntary exercise induces a BDNF-mediated mechanism that promotes neuroplasticity
Gómez-Pinilla, F., Ying, Z., Roy, R. R., Molteni, R., & Edgerton, V. R. (2002) · Journal of Neurophysiology · doi:10.1152/jn.00152.2002 · Cited by 724
Time course and morphology of dopaminergic neuronal death caused by the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Jackson-Lewis, V. R., Jakowec, M. W., Burke, R. E., & Przedborski, S. (1995) · Neurodegeneration · doi:10.1016/1055-8330(95)90015-2 · Cited by 609
Neuromodulatory actions of dopamine in the neostriatum are dependent upon the excitatory amino acid receptor subtypes activated.
Cepeda, C., Buchwald, N. A., & Levine, M. S. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.20.9576 · Cited by 559
Regulation of the vascular extracellular superoxide dismutase by nitric oxide and exercise training
Fukai, T., Siegfried, M. R., Ushio‐Fukai, M., Cheng, Y., Kojda, G., & Harrison, D. G. (2000) · Journal of Clinical Investigation · doi:10.1172/jci9551 · Cited by 555
Behavioral phenotyping of the MPTP mouse model of Parkinson's disease
Sedelis, M., Schwarting, R. K. W., & Huston, J. P. (2001) · Behavioural Brain Research · doi:10.1016/s0166-4328(01)00309-6 · Cited by 436
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Tillerson, J. L., Caudle, W. M., Reverón, M. E., & Miller, G. W. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00096-4 · Cited by 399
Forced Limb-Use Effects on the Behavioral and Neurochemical Effects of 6-Hydroxydopamine
Tillerson, J. L., Cohen, A. D., Philhower, J., Miller, G. W., Zigmond, M. J., & Schallert, T. J. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-12-04427.2001 · Cited by 357
Molecular effects of dopamine on striatal-projection pathways
Gerfen, C. R. (2000) · Trends in Neurosciences · doi:10.1016/s1471-1931(00)00019-7 · Cited by 356
Dopamine and N-Methyl-D- Aspartate Receptor Interactions in the Neostriatum
Cepeda, C., & Levine, M. S. (1998) · Developmental Neuroscience · doi:10.1159/000017294 · Cited by 350
D1 and D2 dopamine receptor function in the striatum: coactivation of D1- and D2-dopamine receptors on separate populations of neurons results in potentiated immediate early gene response in D1-containing neurons
Gerfen, C., Keefe, K., & Gauda, E. (1995) · The Journal of Neuroscience · doi:10.1523/jneurosci.15-12-08167.1995 · Cited by 283
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Cohen, A. D., Tillerson, J. L., Smith, A. D., Schallert, T., & Zigmond, M. J. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01657.x · Cited by 243
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Starr, M. S. (1995) · Synapse · doi:10.1002/syn.890190405 · Cited by 214
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Hepler, J. R., Toomim, C. S., McCarthy, K. D., Conti, F., Battaglia, G. S., Rustioni, A., & Petrusz, P. (1988) · Journal of Histochemistry & Cytochemistry · doi:10.1177/36.1.2891743 · Cited by 205
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Dewey, S. L., Morgan, A. E., Ashby, C. R., Horan, B., Kushner, S. A., Logan, J., Volkow, N. D., Fowler, J. S., Gardner, E. L., & Brodie, J. D. (1998) · Synapse · doi:10.1002/(sici)1098-2396(199810)30:2 · Cited by 194
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Chapter 3 Activity-dependent regulation of neuronal plasticity and self repair
Kempermann, G., van Praag, H., & Gage, F. H. (2000) · Progress in brain research · doi:10.1016/s0079-6123(00)27004-0 · Cited by 191
Endurance training effects on neurotransmitter release in rat striatum: an in vivo microdialysis study
MEEUSEN, R. R., Smolders, I. J., Sarre, S., Meirleir, K. D., KEIZER, H. A., Serneels, M., Ebinger, G., & Michotte, Y. M. (1997) · Acta Physiologica Scandinavica · doi:10.1046/j.1365-201x.1997.00118.x · Cited by 191
Techniques to optimize post-embedding single and double staining for amino acid neurotransmitters.
Phend, K. D., Weinberg, R. J., & Rustioni, A. (1992) · Journal of Histochemistry & Cytochemistry · doi:10.1177/40.7.1376741 · Cited by 186
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Mortensen, O. V., & Amara, S. G. (2003) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2003.08.066 · Cited by 181
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Ricaurte, G. A., Langston, J. W., DeLanney, L. E., Irwin, I., Peroutka, S. J., & Forno, L. S. (1986) · Brain Research · doi:10.1016/0006-8993(86)90905-4 · Cited by 180
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Sasco, A. J., Paffenbarger, R. S., Gendre, I., & Wing, A. L. (1992) · Archives of Neurology · doi:10.1001/archneur.1992.00530280040020 · Cited by 147
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Kojda, G., Cheng, Y. C., Burchfield, J. S., & Harrison, D. G. (2001) · Circulation · doi:10.1161/01.cir.103.23.2839 · Cited by 143
Monoamine transporter pharmacology and mutant mice
Gainetdinov, R. R., Sotnikova, T. D., & Caron, M. G. (2002) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(02)02044-8 · Cited by 126
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Burke, R. E., Cadet, J. L., Kent, J. D., Karanas, A. L., & Jackson-Lewis, V. R. (1990) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(90)90095-w · Cited by 59
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Bland, S. T., Gonzales, R. A., & Schallert, T. J. (1999) · Neuroscience Letters · doi:10.1016/s0304-3940(99)00855-1 · Cited by 48
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Liste, I., Rodríguez‐Pallares, J., Caruncho, H. J., & Labandeira-García, J. L. (1999) · Molecular Brain Research · doi:10.1016/s0169-328x(99)00140-0 · Cited by 18
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Authors: Fisher, B. E., Petzinger, G. M., Nixon, K., Hogg, E., Bremmer, S., Meshul, C. K., & Jakowec, M. W.
Affiliations: University of Southern California (US)
Oregon Health & Science University (US)
Corresponding author: Jakowec, Michael W.
ORCID: Fisher, Beth E.
Petzinger, Giselle M.
Meshul, Charles K.
Jakowec, Michael W.
Venue: Journal of Neuroscience Research
Publisher: Wiley
Published: 2004-05-20
Volume: 77
Issue: 3
Pages: 378-390
ISSN: 0360-4012 (ISSN-L)
1097-4547
DOI: 10.1002/jnr.20162
OpenAlex: W2084445735
Cited by: 311
References: 41
Citations by year: 2026: 7 · 2025: 8 · 2024: 7 · 2023: 6 · 2022: 10 · 2021: 19 · 2020: 20 · 2019: 14 · 2018: 19 · 2017: 13 · 2016: 13 · 2015: 21 · 2014: 13 · 2013: 29 · 2012: 15
FWCI: 6.04
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Journal of Neuroscience Research (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Neurological Disorders and Stroke (R01NS044327, R01 NS44327-1)
Topics: Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
Health Sciences › Medicine › Clinical Neurology › Deep Brain Stimulation and Movement Disorders
Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords: physical activity, neuroplasticity, neurorestoration, MPTP lesion, basal ganglia, Parkinson's disease model, dopamine transporter, dopamine D1 receptor, dopamine D2 receptor, tyrosine hydroxylase, striatum, treadmill running, behavioral recovery, neuroprotection, gene expression changes, C57BL/6J mice, dopaminergic neurons
MeSH terms: Animals, Basal Ganglia, Behavior, Animal, Male, Membrane Glycoproteins, Mice, Inbred C57BL, Nerve Tissue Proteins, Neuronal Plasticity, Physical Conditioning, Animal, Tyrosine 3-Monooxygenase, MPTP Poisoning, Membrane Transport Proteins, Dopamine Plasma Membrane Transport Proteins, Mice

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Exercise-induced behavioral recovery and neuroplasticity in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned mouse basal ganglia

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