Neuroprotective effects of prior limb use in 6-hydroxydopamine-treated rats: possible role of GDNF
Abstract
Unilateral administration of 6-hydroxydopamine (6-OHDA) into the medial forebrain bundle (MFB) causes a loss of dopamine (DA) in the ipsilateral striatum and contralateral motor deficits. However, if a cast is placed on the ipsilateral limb during the first 7 days following 6-OHDA infusion, forcing the animal to use its contralateral limb, both the behavioral and neurochemical deficits are reduced. Here, we examine the effect of forced reliance on a forelimb during the 7 days prior to ipsilateral infusion of 6-OHDA on the deficits characteristic of this lesion model. Casted animals displayed no behavioral asymmetries as measured 14-28 days postlesion and a marked attenuation in the loss of striatal DA and its metabolites at 30 days. In addition, animals receiving a unilateral cast alone had an increase in glial cell-line derived neurotrophic factor (GDNF) protein in the striatum corresponding to the overused limb. GDNF increased within 1 day after the onset of casting, peaked at 3 days, and returned to baseline within 7 days. These results suggest that preinjury forced limb-use can prevent the behavioral and neurochemical deficits to the subsequent administration of 6-OHDA and that this may be due in part to neuroprotective effects of GDNF.
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Restoration of DA-D2R, in combination with increased dopamine release, is critically important in the later phase of motor learning when automaticity is developed.
“Restoration of DA-D2R, in combination with increase DA release are known to be critically important in the later phase of motor learning when automaticity is developed 83.”
From Exercise-enhanced neuroplasticity targeting motor and cognitive circuitry in Parkinson's disease (2013) · cites this paper as [83]
Cites
GDNF: a Glial Cell Line-Derived Neurotrophic Factor for Midbrain Dopaminergic Neurons
Lin, L.-F. H., Doherty, D. H., Lile, J. D., Bektesh, S. L., & Collins, F. (1993) · Science · doi:10.1126/science.8493557 · Cited by 3,206 · see citing works
Ungerstedt, U. (1971) · Acta Physiologica Scandinavica · doi:10.1111/j.1365-201x.1971.tb11000.x · Cited by 1,926 · see citing works
Halliwell, B. (2001) · Drugs & Aging · doi:10.2165/00002512-200118090-00004 · Cited by 1,502 · see citing works
BDNF is a neurotrophic factor for dopaminergic neurons of the substantia nigra
Hyman, C., Hofer, M., Barde, Y., Juhasz, M., Yancopoulos, G. D., Squinto, S. P., & Lindsay, R. M. (1991) · Nature · doi:10.1038/350230a0 · Cited by 1,494 · see citing works
Neeper, S. A., Gómez‐Pinilla, F., Choi, J., & Cotman, C. W. (1996) · Brain Research · doi:10.1016/0006-8993(96)00273-9 · Cited by 1,015 · see citing works
Taub, E., Uswatte, G., & Pidikiti, R. D. (1999) · PubMed · Cited by 976 · see citing works
Environmental enrichment inhibits spontaneous apoptosis, prevents seizures and is neuroprotective
Young, D., Lawlor, P. A., Leone, P., Dragunow, M., & During, M. J. (1999) · Nature Medicine · doi:10.1038/7449 · Cited by 731 · see citing works
Nigrostriatal bundle damage and the lateral hypothalamic syndrome.
Marshall, J. F., Richardson, J. S., & Teitelbaum, P. (1974) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0037223 · Cited by 625 · see citing works
Carro, E., Trejo, J. L., Busiguina, S., & Torres-Aleman, I. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-15-05678.2001 · Cited by 601 · see citing works
Use-dependent growth of pyramidal neurons after neocortical damage
Jones, T. A., & Schallert, T. J. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-04-02140.1994 · Cited by 508 · see citing works
Animal models of neurological deficits: how relevant is the rat?
Cenci, M. A., Whishaw, I. Q., & Schallert, T. J. (2002) · Nature reviews. Neuroscience · doi:10.1038/nrn877 · Cited by 456 · see citing works
Hoffer, B. J., Hoffman, A. F., Bowenkamp, K., Huettl, P. F., Hudson, J., Martin, D., Lin, L.-F. H., & Gerhardt, G. A. (1994) · Neuroscience Letters · doi:10.1016/0304-3940(94)90218-6 · Cited by 453 · see citing works
Tillerson, J. L., Caudle, W. M., Reverón, M. E., & Miller, G. W. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00096-4 · Cited by 399 · see citing works
GDNF protects nigral dopamine neurons against 6-hydroxydopamine in vivo
Kearns, C. M., & Gash, D. M. (1995) · Brain Research · doi:10.1016/0006-8993(94)01366-p · Cited by 379 · see citing works
Forced Limb-Use Effects on the Behavioral and Neurochemical Effects of 6-Hydroxydopamine
Tillerson, J. L., Cohen, A. D., Philhower, J., Miller, G. W., Zigmond, M. J., & Schallert, T. J. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-12-04427.2001 · Cited by 357 · see citing works
Sterr, A., Elbert, T., Berthold, I., Kölbel, S., Rockstroh, B., & Taub, E. (2002) · Archives of Physical Medicine and Rehabilitation · doi:10.1053/apmr.2002.35108 · Cited by 276 · see citing works
Altar, C. A., Boylan, C. B., Jackson, C., Hershenson, S., Miller, J., Wiegand, S. J., Lindsay, R. M., & Hyman, C. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.23.11347 · Cited by 275 · see citing works
Levivier, M., Przedborski, S., Bencsics, C., & Kang, U. (1995) · The Journal of Neuroscience · doi:10.1523/jneurosci.15-12-07810.1995 · Cited by 274 · see citing works
Pham, T. M., Ickes, B. R., Albeck, D. S., Söderström, S., Granholm, A.-C., & Mohammed, A. H. (1999) · Neuroscience · doi:10.1016/s0306-4522(99)00316-4 · Cited by 262 · see citing works
Gómez‐Pinilla, F., So, V., & Kesslak, J. P. (1998) · Neuroscience · doi:10.1016/s0306-4522(97)00576-9 · Cited by 262 · see citing works
Winkler, C., Sauer, H., Lee, C. S., & Björklund, A. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-22-07206.1996 · Cited by 258 · see citing works
Marshall, J. F., & Ungerstedt, U. (1977) · European Journal of Pharmacology · doi:10.1016/0014-2999(77)90256-4 · Cited by 202 · see citing works
Choi-Lundberg, D. L., Lin, Q., Schallert, T., Crippens, D., Davidson, B. L., Chang, Y., Chiang, Y. L., Qian, J., Bardwaj, L., & Bohn, M. C. (1998) · Experimental Neurology · doi:10.1006/exnr.1998.6887 · Cited by 189 · see citing works
Brain‐derived neurotrophic factor mediates an excitoprotective effect of dietary restriction in mice
Duan, W., Guo, Z., & Mattson, M. P. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00071.x · Cited by 187 · see citing works
Constraint-induced movement therapy to enhance recovery after stroke
Taub, E., & Morris, D. M. (2001) · Current Atherosclerosis Reports · doi:10.1007/s11883-001-0020-0 · Cited by 186 · see citing works
Torasdotter, M., METSIS, M. L., Henriksson, B. G., Winblad, B. G., & Mohammed, A. H. S. (1998) · Behavioural Brain Research · doi:10.1016/s0166-4328(97)00142-3 · Cited by 184 · see citing works
Marshall, J. F., Levitan, D., & Stricker, E. M. (1976) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0077230 · Cited by 180 · see citing works
Åkerud, P., Alberch, J., Eketjäll, S., Wagner, J., & Arenas, E. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.0730070.x · Cited by 171 · see citing works
Forced Nonuse in Unilateral Parkinsonian Rats Exacerbates Injury
Tillerson, J. L., Cohen, A. D., Caudle, W. M., Zigmond, M. J., Schallert, T. J., & Miller, G. W. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-15-06790.2002 · Cited by 163 · see citing works
Intervention Strategies for Degeneration of Dopamine Neurons in Parkinsonism
Schallert, T. J., & Tillerson, J. L. (2000) · Humana Press eBooks · doi:10.1007/978-1-59259-691-1_8 · Cited by 160 · see citing works
Wang, L., Muramatsu, S., Lu, Y., Ikeguchi, K., Fujimoto, K., Okada, T., Mizukami, H., Hanazono, Y., Kume, A., Urano, F., et al. (2002) · Gene Therapy · doi:10.1038/sj.gt.3301682 · Cited by 160 · see citing works
Toole, T., Hirsch, M. A., Forkink, A., Lehman, D. A., & Maitland, C. (2000) · Neurorehabilitation · doi:10.3233/nre-2000-14306 · Cited by 147 · see citing works
(2002) · Molecular Therapy · doi:10.1016/s1525-0016(16)43581-1 · Cited by 147 · see citing works
The Role of Physical Exercise in the Occurrence of Parkinson's Disease
Sasco, A. J., Paffenbarger, R. S., Gendre, I., & Wing, A. L. (1992) · Archives of Neurology · doi:10.1001/archneur.1992.00530280040020 · Cited by 146 · see citing works
Spirduso, W. W., Gilliam, P. E., Schallert, T. J., Upchurch, M., Vaughn, D. M., & Wilcox, R. E. (1985) · Brain Research · doi:10.1016/0006-8993(85)90274-4 · Cited by 126 · see citing works
Shen, H., Tong, L., Balázs, R., & Cotman, C. W. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00315-3 · Cited by 124 · see citing works
A Clinically Relevant Unilateral Rat Model of Parkinsonian Akinesia
Schallert, T. J., Norton, D., & Jones, T. A. (1992) · Neural Plasticity · doi:10.1155/np.1992.332 · Cited by 121 · see citing works
Regulation of astrocyte proliferation by FGF-2 and heparan sulfate in vivo
Gomez-Pinilla, F., Vu, L., & Cotman, C. W. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-03-02021.1995 · Cited by 120 · see citing works
An Acid-Treatment Method for the Enhanced Detection of GDNF in Biological Samples
Okragly, A. J., & Haak‐Frendscho, M. (1997) · Experimental Neurology · doi:10.1006/exnr.1997.6500 · Cited by 116 · see citing works
Environmental risk factors of young onset Parkinson's disease: a case-control study
Tsai, C. H., Lo, S. K., See, L., Chen, H. Z., Chen, R., Weng, Y.-H., Chang, F., & Lu, C. (2002) · Clinical Neurology and Neurosurgery · doi:10.1016/s0303-8467(02)00027-6 · Cited by 89 · see citing works
GDNF mRNA levels are induced by FGF-2 in rat C6 glioblastoma cells
Suter‐Crazzolara, C., & Unsicker, K. (1996) · Molecular Brain Research · doi:10.1016/0169-328x(96)00089-7 · Cited by 85 · see citing works
Paradoxical Kinesia in Parkinsonism Is Not Caused by Dopamine Release
Keefe, K. A. (1989) · Archives of Neurology · doi:10.1001/archneur.1989.00520460046012 · Cited by 66 · see citing works
Keefe, K. A., Stricker, E. M., Zigmond, M. J., & Abercrombie, E. D. (1990) · Brain Research · doi:10.1016/0006-8993(90)91158-d · Cited by 59 · see citing works
Miklyaeva, E. I., & Whishaw, I. Q. (1996) · Behavioral Neuroscience · doi:10.1037//0735-7044.110.1.117 · Cited by 50 · see citing works
Dopamine neurons in a simple GDNF-treated meso-striatal organotypic co-culture model
Schatz, D. S., Kaufmann, W. A., Saria, A., & Humpel, C. (1999) · Experimental Brain Research · doi:10.1007/s002210050796 · Cited by 48 · see citing works
Shults, C. W., Ray, J., Tsuboi, K., & Gage, F. H. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02900-0 · Cited by 46 · see citing works
Gong, L., Wyatt, R. J., Baker, I., & Masserano, J. M. (1999) · Neuroscience Letters · doi:10.1016/s0304-3940(99)00148-2 · Cited by 41 · see citing works
Effect of Bilateral 6-Hydroxydopamine Lesions of the Medial Forebrain Bundle on Reaction Time
Smith, A. D. (2002) · Neuropsychopharmacology · doi:10.1016/s0893-133x(01)00420-1 · Cited by 39 · see citing works
Kramer, B. C., Goldman, A., & Mytilineou, C. (1999) · Brain Research · doi:10.1016/s0006-8993(99)02191-5 · Cited by 38 · see citing works
Miklyaeva, E. I., & Whishaw, I. Q. (1996) · Behavioral Neuroscience · doi:10.1037/0735-7044.110.1.117 · Cited by 38 · see citing works
Kwon, Y. K. (1997) · Molecules and Cells · doi:10.1016/s1016-8478(23)13300-0 · Cited by 33 · see citing works
6-Hydroxydopamine as a Tool for Studying Catecholamines in Adult Animals
Zigmond, M. J., & Keefe, K. A. (1998) · Humana Press eBooks · doi:10.1007/978-1-59259-477-1_3 · Cited by 25 · see citing works
Zigmond, M. J., & Keefe, K. A. (2003) · Humana Press eBooks · doi:10.1385/0-89603-465-8:75 · Cited by 10 · see citing works
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Mahncke, H., Bronstone, A., & Merzenich, M. (2006) · Progress in Brain Research · doi:10.1016/s0079-6123(06)57006-2 · Cited by 517 · see citing works
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Vaynman, S., & Gomez-Pinilla, F. (2005) · Neurorehabilitation and Neural Repair · doi:10.1177/1545968305280753 · Cited by 420 · see citing works
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Maswood, N., Young, J., Tilmont, E. M., Zhang, Z., Gash, D. M., Gerhardt, G. A., Grondin, R., Roth, G. S., Mattison, J. A., Lane, M. A., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0405831102 · Cited by 383 · see citing works
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Chen, H., Zhang, S. M., Schwarzschild, M. A., Hernán, M. A., & Ascherio, A. (2005) · Neurology · doi:10.1212/01.wnl.0000151960.28687.93 · Cited by 371 · see citing works
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Friedman, J. H., Brown, R. G., Comella, C. L., Garber, C. E., Krupp, L., Lou, J., Marsh, L., Nail, L. M., Shulman, L. M., & Taylor, C. B. (2006) · Movement Disorders · doi:10.1002/mds.21240 · Cited by 356 · see citing works
Petzinger, G. M., Walsh, J. P., Akopian, G., Hogg, E., Abernathy, A., Arevalo, P., Turnquist, P., Vučković, M., Fisher, B. E., Togasaki, D. M., et al. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.1069-07.2007 · Cited by 329 · see citing works
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Real, C. C., Ferreira, A. F. B., Chaves-Kirsten, G. P., Torrão, A. S., Pires, R. S., & Britto, L. R. G. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.01.060 · Cited by 109 · see citing works
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de Tassigny, X. D., Pascual, A., & López‐Barneo, J. (2015) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2015.00010 · Cited by 99 · see citing works
Yin, W., Cao, G., Johnnides, M. J., Signore, A. P., Luo, Y., Hickey, R. W., & Chen, J. (2005) · Neurobiology of Disease · doi:10.1016/j.nbd.2005.07.015 · Cited by 98 · see citing works
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Enriched environment improves motor function in intact and unilateral dopamine-depleted rats
Jadavji, N. M., Kolb, B. E., & Metz, G. A. S. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.03.027 · Cited by 94 · see citing works
Jakowec, M. W., & Petzinger, G. M. (2004) · PubMed · Cited by 92 · see citing works
Zhao, S., Zhao, M., Xiao, T., Jolkkonen, J., & Zhao, C. (2013) · Stroke · doi:10.1161/strokeaha.111.000361 · Cited by 89 · see citing works
Sääksjärvi, K., Knekt, P., Männistö, S., Lyytinen, J., Jääskeläinen, T., Kanerva, N., & Heliövaara, M. (2014) · European Journal of Epidemiology · doi:10.1007/s10654-014-9887-2 · Cited by 88 · see citing works
Greater Physical Activity Is Associated with Slower Visual Field Loss in Glaucoma
Lee, M. J., Wang, J., Friedman, D. S., Boland, M. V., Moraes, C. G. D., & Ramulu, P. Y. (2018) · Ophthalmology · doi:10.1016/j.ophtha.2018.10.012 · Cited by 88 · see citing works
Lack of exercise, via hindlimb suspension, impedes endogenous neurogenesis
Yasuhara, T., Hara, K., Maki, M., Matsukawa, N., Fujino, H., Date, I., & Borlongan, C. V. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.07.045 · Cited by 87 · see citing works
Neurotrophic factors in Parkinson’s disease are regulated by exercise: Evidence-based practice
da Silva, P. G. C., Domingues, D. D., de Carvalho, L. A., Allodi, S., & Correa, C. L. (2016) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2016.02.017 · Cited by 87 · see citing works
Dyskinesia in Parkinson's disease: mechanisms and current non‐pharmacological interventions
Heumann, R., Moratalla, R., Herrero, M. T., Chakrabarty, K., Drucker-Colı́n, R., García-Montes, J. R., Simola, N., & Morelli, M. (2014) · Journal of Neurochemistry · doi:10.1111/jnc.12751 · Cited by 86 · see citing works
Lehman, D. A., Toole, T., Lofald, D., & Hirsch, M. A. (2005) · Neurology Report · doi:10.1097/01.npt.0000282256.36208.cf · Cited by 83 · see citing works
Intensive Amplitude-specific Therapeutic Approaches for Parkinson's Disease
Farley, B. G., Fox, C., Ramig, L. O., & McFarland, D. H. (2008) · Topics in Geriatric Rehabilitation · doi:10.1097/01.tgr.0000318898.87690.0d · Cited by 82 · see citing works
Physical exercise for people with Parkinson’s disease: a systematic review and network meta-analysis
Ernst, M., Folkerts, A., Gollan, R., Lieker, E., Caro-Valenzuela, J., Adams, A., Cryns, N., Monsef, I., Dresen, A., Roheger, M., et al. (2024) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd013856.pub3 · Cited by 89 · see citing works
Gustavsson, M., Anderson, M. F., Mallard, C. E., & Hagberg, H. (2004) · Pediatric Research · doi:10.1203/01.pdr.0000151122.58665.70 · Cited by 77 · see citing works
Handedness as a predictor of side of onset of Parkinson's disease
Yust‐Katz, S., Tesler, D., Treves, T. A., Melamed, E., & Djaldetti, R. (2008) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2008.01.017 · Cited by 75 · see citing works
Shi, L.-H., Woodward, D. J., Luo, F., Anstrom, K. K., Schallert, T. J., & Chang, J.-Y. (2004) · Brain Research · doi:10.1016/j.brainres.2004.03.053 · Cited by 72 · see citing works
Effectiveness of tai chi for Parkinson's disease: A critical review
Lee, M. S., Lam, P., & Ernst, E. (2008) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2008.02.003 · Cited by 73 · see citing works
Al-Jarrah, M. D., Pothakos, K., Novikova, L., Smirnova, I. V., Kurz, M. J., Stehno‐Bittel, L., & Lau, Y.-S. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.07.038 · Cited by 69 · see citing works
Yasuhara, T., Shingo, T., Muraoka, K., Kobayashi, K., Takeuchi, A., Yano, A., Wenji, Y., Kameda, M., Matsui, T., Miyoshi, Y., et al. (2005) · Journal of neurosurgery · doi:10.3171/jns.2005.102.1.0080 · Cited by 70 · see citing works
Landers, M. R., Navalta, J. W., Murtishaw, A. S., Kinney, J. W., & Richardson, S. P. (2018) · Neurology Report · doi:10.1097/npt.0000000000000249 · Cited by 69 · see citing works
Stress reduces the neuroprotective effect of exercise in a rat model for Parkinson's disease
Howells, F. M., Russell, V. A., Mabandla, M. V., & Kellaway, L. A. (2005) · Behavioural Brain Research · doi:10.1016/j.bbr.2005.06.044 · Cited by 69 · see citing works
Cortical and motor responses to acute forced exercise in Parkinson's disease
Alberts, J. L., Phillips, M., Lowe, M. J., Frankemolle‐Gilbert, A. M., Thota, A. K., Beall, E. B., Feldman, M. S., Ahmed, A. E., & Ridgel, A. L. (2016) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2016.01.015 · Cited by 69 · see citing works
Initial management of Parkinson's disease
Goetz, C. G., & Pal, G. D. (2014) · BMJ · doi:10.1136/bmj.g6258 · Cited by 68 · see citing works
Neuroprotection and neurorestoration as experimental therapeutics for Parkinson's disease
Francardo, V., Schmitz, Y., Sulzer, D. L., & Cenci, M. A. (2017) · Experimental Neurology · doi:10.1016/j.expneurol.2017.10.001 · Cited by 66 · see citing works
Fleming, S. M., Delville, Y., & Schallert, T. J. (2004) · Behavioural Brain Research · doi:10.1016/j.bbr.2004.05.024 · Cited by 65 · see citing works
Chasing Protection in Parkinson’s Disease: Does Exercise Reduce Risk and Progression?
Crotty, G. F., & Schwarzschild, M. A. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.00186 · Cited by 64 · see citing works
O’Dell, S. J., Galvez, B., Ball, A. J., & Marshall, J. F. (2011) · Synapse · doi:10.1002/syn.20989 · Cited by 64 · see citing works
Pröschel, C., Stripay, J. L., Shih, C., Munger, J. C., & Noble, M. (2014) · EMBO Molecular Medicine · doi:10.1002/emmm.201302878 · Cited by 64 · see citing works
Tongue force and timing deficits in a rat model of Parkinson disease
Ciucci, M. R., Russell, J. A., Schaser, A. J., Doll, E. J., Vinney, L. A., & Connor, N. P. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.03.057 · Cited by 62 · see citing works
Schenkman, M. L., Hall, D. A., Kumar, R., & Kohrt, W. M. (2007) · Physical Therapy · doi:10.2522/ptj.20060351 · Cited by 62 · see citing works
Targeted exercise therapy for voice and swallow in persons with Parkinson's disease
Russell, J. A., Ciucci, M. R., Connor, N. P., & Schallert, T. J. (2010) · Brain Research · doi:10.1016/j.brainres.2010.03.029 · Cited by 62 · see citing works
Kaagman, D. G. M., van Wegen, E. E. H., Cignetti, N., Rothermel, E., Vanbellingen, T., & Hirsch, M. A. (2024) · Brain Sciences · doi:10.3390/brainsci14030194 · Cited by 60 · see citing works
Seo, J. H., Yu, J. H., Suh, H., Kim, M., & Cho, S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0074405 · Cited by 60 · see citing works
Villar-Cheda, B., Sousa-Ribeiro, D., Rodriguez-Pallares, J., Rodriguez-Perez, A. I., Guerra, M. J., & Labandeira-Garcia, J. L. (2009) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2008.127 · Cited by 59 · see citing works
Cho, H.-S., Shin, M.-S., Song, W., Jun, T.-W., Lim, B.-V., Kim, Y.-P., & Kim, C.-J. (2013) · Journal of Exercise Rehabilitation · doi:10.12965/jer.130048 · Cited by 58 · see citing works
Dutra, M. F., Jaeger, M. D. C., Ilha, J., Kalil-Gaspar, P. I., Marcuzzo, S., & Achaval, M. (2012) · Neurological Sciences · doi:10.1007/s10072-011-0925-5 · Cited by 58 · see citing works
Running wheel activity restores MPTP-induced functional deficits
Fredriksson, A., Stigsdotter, I. M., Hurtig, A., Ewalds‐Kvist, B. M., & Archer, T. (2010) · Journal of Neural Transmission · doi:10.1007/s00702-010-0474-8 · Cited by 57 · see citing works
Lee, J. Y., Kim, S. H., Ko, A.-R., Lee, J. S., Yu, J. H., Seo, J. H., Cho, B. P., & Cho, S. (2013) · Brain Research · doi:10.1016/j.brainres.2013.08.051 · Cited by 56 · see citing works
Lui, A., & Byl, N. N. (2009) · Neurology Report · doi:10.1097/npt.0b013e31819912d0 · Cited by 55 · see citing works
Exercise alleviates Parkinsonism: clinical and laboratory evidence
Archer, T., Fredriksson, A., & Johansson, B. B. (2010) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.2010.01360.x · Cited by 53 · see citing works
Nasrolahi, A., Mahmoudi, J., Akbarzadeh, A., Karimipour, M., Sadigh‐Eteghad, S., Salehi, R., & Farhoudi, M. (2018) · Reviews in the Neurosciences · doi:10.1515/revneuro-2017-0040 · Cited by 52 · see citing works
Landers, M. R., & Ellis, T. D. (2020) · JMIR mhealth and uhealth · doi:10.2196/18985 · Cited by 49 · see citing works
Döbrössy, M. D., & Dunnett, S. B. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.01.016 · Cited by 48 · see citing works
Lifetime occupational and leisure time physical activity and risk of Parkinson's disease
Shih, I., Liew, Z., Krause, N., & Ritz, B. R. (2016) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2016.05.007 · Cited by 48 · see citing works
Exercise and Physical Therapy in Early Management of Parkinson Disease
Alonso‐Frech, F., Sanahuja, J. J., & Rodriguez, A. M. (2011) · The Neurologist · doi:10.1097/nrl.0b013e31823968ec · Cited by 47 · see citing works
Anstrom, K. K., Schallert, T. J., Woodlee, M. T., Shattuck, A., & Roberts, D. C. S. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2007.01.028 · Cited by 46 · see citing works
Side of symptom onset affects motor dysfunction in Parkinson's disease
Haaxma, C. A., Helmich, R. C. G., Borm, G. F., Kappelle, A. C., Horstink, M. W. I. M., & Bloem, B. R. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.07.030 · Cited by 46 · see citing works
Goldberg, N. R. S., Haack, A. K., & Meshul, C. K. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.09.062 · Cited by 44 · see citing works
RetractedGoldberg, N. R. S., Fields, V. L., Pflibsen, L. R., Salvatore, M. F., & Meshul, C. K. (2011) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.12.024 · Cited by 43 · see citing works
Ciucci, M. R., Ma, S. T., Kane, J. R., Ahrens, A. M., & Schallert, T. J. (2008) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2008.04.027 · Cited by 43 · see citing works
Wang, Z., Guo, Y., Myers, K. G., Heintz, R., & Holschneider, D. P. (2015) · Neurobiology of Disease · doi:10.1016/j.nbd.2015.02.020 · Cited by 42 · see citing works
Kane, J. R., Ciucci, M. R., Jacobs, A., Tews, N., Russell, J. A., Ahrens, A. M., Ma, S. T., Britt, J. M., Cormack, L. K., & Schallert, T. J. (2011) · Journal of Communication Disorders · doi:10.1016/j.jcomdis.2011.04.005 · Cited by 42 · see citing works
Yang, J., Sadler, T. R., Givrad, T. K., Maarek, J.-M. I., & Holschneider, D. P. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2007.03.010 · Cited by 41 · see citing works
- Authors
- Cohen, A. D., Tillerson, J. L., Smith, A. D., Schallert, T., & Zigmond, M. J.
- Affiliations
- University of Pittsburgh (US)
- The University of Texas at Austin (US)
- University of Michigan (US)
- Corresponding author
- Zigmond, Michael J.
- ORCID
- Cohen, Ann D.
- Venue
- Journal of Neurochemistry
- Publisher
- Wiley
- Published
- 2003-04
- Volume
- 85
- Issue
- 2
- Pages
- 299-305
- ISSN
- 0022-3042 (ISSN-L)
- 1471-4159
- OpenAlex
- W2131124574
- Cited by
- 243
- References
- 52
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 5 · 2023: 2 · 2022: 4 · 2021: 4 · 2020: 12 · 2019: 7 · 2018: 11 · 2017: 13 · 2016: 10 · 2015: 11 · 2014: 17 · 2013: 19 · 2012: 5
- FWCI
- 4.27
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neurochemistry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01ns023979-15)
- U.S. Public Health Service
- National Institute of Mental Health (MH-29670)
- National Institute of Neurological Disorders and Stroke (NS 19608, NS 23979, T32NS007433, NS 07433)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- 6-hydroxydopamine, medial forebrain bundle lesion, dopamine depletion, striatum, glial cell line-derived neurotrophic factor, neuroprotection, motor impairment, behavioral asymmetry, dopamine metabolites
- MeSH terms
- Animals, Apomorphine, Behavior, Animal, Casts, Surgical, Corpus Striatum, Disease Models, Animal, Dopamine, Forelimb, Immobilization, Functional Laterality, Male, Medial Forebrain Bundle, Motor Activity, Nerve Growth Factors, Parkinson Disease, Secondary, 3,4-Dihydroxyphenylacetic Acid, Oxidopamine, Rats, Sprague-Dawley, Rats, Long-Evans, Glial Cell Line-Derived Neurotrophic Factor, Rats
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