Cited by 392Physical Activity and HealthNeurotransmitter Receptor Influence on BehaviorExercise and Physiological Responses

Exercise Benefits Brain Function: The Monoamine Connection

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Lin, Tzu-Wei, Kuo, Yu-Min·2013·Brain Sciences

Abstract

The beneficial effects of exercise on brain function have been demonstrated in animal models and in a growing number of clinical studies on humans. There are multiple mechanisms that account for the brain-enhancing effects of exercise, including neuroinflammation, vascularization, antioxidation, energy adaptation, and regulations on neurotrophic factors and neurotransmitters. Dopamine (DA), noradrenaline (NE), and serotonin (5-HT) are the three major monoamine neurotransmitters that are known to be modulated by exercise. This review focuses on how these three neurotransmitters contribute to exercise affecting brain function and how it can work against neurological disorders.

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Crossref · 10.3390/brainsci3010039

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Authors
Lin, T.-W., & Kuo, Y.-M.
Affiliations
National Cheng Kung University (TW)
Corresponding author
Kuo, Yu-Min
Venue
Brain Sciences
Publisher
MDPI AG
Published
2013-01-11
Volume
3
Issue
1
Pages
39-53
ISSN
2076-3425 (ISSN-L)
OpenAlex
W2153823980
Cited by
392
References
141
Citations by year
2026: 33 · 2025: 54 · 2024: 48 · 2023: 58 · 2022: 55 · 2021: 33 · 2020: 35 · 2019: 24 · 2018: 13 · 2017: 13 · 2016: 7 · 2015: 8 · 2014: 8
FWCI
5.34
Type
journal article
Language
en
Open access
Locations
  • Brain Sciences (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Physical Activity and Health
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
Keywords
physical activity, brain function, monoamines, dopamine, norepinephrine, serotonin, neuroinflammation, neurotrophic factors, neurotransmitters, neurological disorders

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