The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Microarray analysis of postmortem temporal cortex from patients with schizophrenia
Abstract
To examine molecular mechanisms associated with schizophrenia this study measured expression of approximately 12,000 genes in the middle temporal gyrus from 12 subjects with schizophrenia and 14 matched normal controls. Among the most consistent changes in genes with robust expression were significant decreases in the expression of myelination‐related genes MAG, PLLP (TM4SF11), PLP1, ERBB3 in subjects with schizophrenia. There was also altered expression of genes regulating neurodevelopment (TRAF4, Neurod1, histone deacetylase 3), a circadian pacemaker (PER1), and several other genes involved in regulation of chromatin function and signaling mechanisms. These findings support the hypothesis that schizophrenia is associated with abnormalities in oligodendroglia and provide initial evidence suggesting a role for epigenetic mechanisms and altered circadian rhythms in this disorder. © 2004 Wiley‐Liss, Inc.
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Cites
Model-based analysis of oligonucleotide arrays: Expression index computation and outlier detection.
Li, C., & Wong, W. H. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.1.31 · Cited by 3,133
Mirnics, K., Middleton, F. A., Marquez, A., Lewis, D. A., & Levitt, P. (2000) · Neuron · doi:10.1016/s0896-6273(00)00085-4 · Cited by 882
Expression of CX 3 CR1 chemokine receptors on neurons and their role in neuronal survival
Meucci, O., Fatatis, A., Simen, A. A., & Miller, R. J. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.090017497 · Cited by 385
Cited by
Sleep and circadian rhythm disruption in psychiatric and neurodegenerative disease
Wulff, K., Gatti, S., Wettstein, J. G., & Foster, R. G. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2868 · Cited by 1,055
Fillman, S. G., Cloonan, N., Catts, V. S., Miller, L. C., Wong, J., McCrossin, T., Cairns, M., & Weickert, C. S. (2013) · Molecular Psychiatry · doi:10.1038/mp.2012.110 · Cited by 609
Evaluating the comparability of gene expression in blood and brain
Sullivan, P. F., Fan, C., & Perou, C. M. (2006) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30272 · Cited by 580
Linking oligodendrocyte and myelin dysfunction to neurocircuitry abnormalities in schizophrenia
Takahashi, N., Sakurai, T., Davis, K. L., & Buxbaum, J. D. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2010.09.004 · Cited by 337
Arion, D., Unger, T., Lewis, D. A., Levitt, P., & Mirnics, K. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.12.021 · Cited by 329
Metadata
- Authors
- Aston, C., Jiang, L., & Sokolov, B. P.
- Venue
- Journal of Neuroscience Research
- Publisher
- Wiley
- Published
- 2004-07
- Volume
- 77
- Issue
- 6
- Pages
- 858-866
- ISSN
- 0360-4012 (ISSN-L)
- 1097-4547
- OpenAlex
- W2065094079
- Cited by
- 283
- References
- 3
- FWCI
- 13.12
- Type
- journal article
- Language
- en
- Open access
- closed
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