The DOI matches its Crossref record; 74 of the 74 references it cites were found in a registry or an index.
Cellular and subcellular distribution of monocarboxylate transporters in cultured brain cells and in the adult brain
Abstract
Monocarboxylate transporters (MCTs) are involved in the uptake and release of lactate, pyruvate, and ketone bodies. Studies of their distribution at both the mRNA and protein levels have highlighted the specific expression of MCT1, MCT2, and more recently MCT4 in the central nervous system. MCT1 was found strongly expressed by cortical astrocytes both in vitro and in vivo. It was also found at high levels on blood vessels, ependymocytes, and glia limitans. A subset of neurons in vitro exhibited a weak but significant MCT1 expression. In contrast, it was determined that MCT2 represents the predominant neuronal MCT on cultured neurons as well as on neurons throughout the brain parenchyma. At the subcellular level, part of MCT2 is located in postsynaptic densities. Specific populations of astrocytes in the white matter also exhibited MCT2 expression in the rat, but not in the mouse brain. MCT4 was found exclusively in astrocytes in several areas including the cortex, the hippocampus, and the cerebellum. MCT2 expression increased in cultured neurons with days in vitro commensurate with increased synapse formation. Moreover, a significant increase in MCT2 expression was observed in cultured neurons exposed to noradrenaline, an effect involving a regulation at the translational level. The description of MCTs on different cell types in the central nervous system together with clear evidence for regulation of their expression further emphasize the important role that monocarboxylates, and particularly lactate, might play in brain energy metabolism not only during development but also in the adult. © 2004 Wiley‐Liss, Inc.
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Pellerin, L., & Magistretti, P. J. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.22.10625 · Cited by 2,927
Self-citationThe proton-linked monocarboxylate transporter (MCT) family: structure, function and regulation
Halestrap, A. P., & Price, N. T. (1999) · Biochemical Journal · doi:10.1042/0264-6021:3430281 · Cited by 1,348
Self-citationThe glucose oxidase-DAB-nickel method in peroxidase histochemistry of the nervous system
Shu, S., Ju, G., & Fan, L. (1988) · Neuroscience Letters · doi:10.1016/0304-3940(88)90346-1 · Cited by 1,227
Halestrap, A. P., & Meredith, D. (2004) · Pfl�gers Archiv European Journal of Physiology · doi:10.1007/s00424-003-1067-2 · Cited by 1,058
Self-citationLactate rise detected by 1H NMR in human visual cortex during physiologic stimulation.
Prichard, J., Rothman, D., Novotny, E., Petroff, O., Kuwabara, T., Avison, M., Howseman, A., Hanstock, C., & Shulman, R. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.13.5829 · Cited by 614
Garcia, C. K., Goldstein, J. L., Pathak, R. K., Anderson, R. G. W., & Brown, M. S. (1994) · Cell · doi:10.1016/0092-8674(94)90361-1 · Cited by 587
DIMMER, K.-S., Friedrich, B., Lang, F. J. W., Deitmer, J. W., & Bröer, S. (2000) · Biochemical Journal · doi:10.1042/0264-6021:3500219 · Cited by 577
Wenthold, R. J., Yokotani, N., Doi, K., & Wada, K. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)48523-7 · Cited by 521
Sappey-Marinier, D., Calabrese, G., Fein, G., Hugg, J. W., Biggins, C., & Weiner, M. W. (1992) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1992.82 · Cited by 413
Billat, V. L., Sirvent, P., Py, G., Koralsztein, J.-P., & Mercier, J. (2003) · Sports Medicine · doi:10.2165/00007256-200333060-00003 · Cited by 397
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Metadata
- Authors
- Pellerin, L., Halestrap, A. P., & Pierre, K.
- Venue
- Journal of Neuroscience Research
- Publisher
- Wiley
- Published
- 2004-11-30
- Volume
- 79
- Issue
- 1-2
- Pages
- 55-64
- ISSN
- 0360-4012 (ISSN-L)
- 1097-4547
- OpenAlex
- W1982422255
- Cited by
- 270
- References
- 74
- FWCI
- 3.50
- Type
- journal article
- Language
- en
- Open access
- closed
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