The DOI matches its Crossref record; 216 of the 216 references it cites were found in a registry or an index.
Revenge of the “Sit”: How lifestyle impacts neuronal and cognitive health through molecular systems that interface energy metabolism with neuronal plasticity
Abstract
Exercise, a behavior that is inherently associated with energy metabolism, impacts the molecular systems important for synaptic plasticity and learning and memory. This implies that a close association must exist between these systems to ensure proper neuronal function. This review emphasizes the ability of exercise and other lifestyle implementations that modulate energy metabolism, such as diet, to impact brain function. Mechanisms believed to interface metabolism and cognition seem to play a critical role with the brain derived neurotrophic factor (BDNF) system. Behaviors concerned with activity and metabolism may have developed simultaneously and interdependently during evolution to determine the influence of exercise and diet on cognition. Alook into our evolutionary past indicates that our genome remains unchanged from the times of our hunter‐gatherer ancestors, whose active lifestyle predominated throughout almost 100% of humankind's existence. Consequently, the sedentary lifestyle and eating behaviors enabled by the comforts of technologic progress may be reaping “revenge” on the health of both our bodies and brains. In the 21st century we are confronted by the ever‐increasing incidence of metabolic disorders in both the adult and child population. The ability of exercise and diet to impact systems that promote cell survival and plasticity may be applicable for combating the deleterious effects of disease and ageing on brain health and cognition. © 2006 Wiley‐Liss, Inc.
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Metadata
- Authors
- Vaynman, S., & Gomez‐Pinilla, F.
- Affiliations
- University of California, Los Angeles (US)
- Venue
- Journal of Neuroscience Research
- Publisher
- Wiley
- Published
- 2006-07-21
- Volume
- 84
- Issue
- 4
- Pages
- 699-715
- ISSN
- 0360-4012 (ISSN-L)
- 1097-4547
- OpenAlex
- W2106085375
- Cited by
- 299
- References
- 216
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 20 · 2023: 7 · 2022: 16 · 2021: 20 · 2020: 12 · 2019: 12 · 2018: 15 · 2017: 19 · 2016: 12 · 2015: 23 · 2014: 20 · 2013: 16 · 2012: 21
- FWCI
- 1.37
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neuroscience Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- physical activity, lifestyle, energy metabolism, neuroplasticity, synaptic plasticity, learning and memory, brain-derived neurotrophic factor, diet, sedentary lifestyle, metabolic disorders, brain health, aging
- MeSH terms
- Aging, Animals, Brain, Cognition, Energy Metabolism, Humans, Learning, Life Style, Models, Biological, Neuronal Plasticity, Exercise, Brain-Derived Neurotrophic Factor
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