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Cited by 299Nerve injury and regenerationNeurogenesis and neuroplasticity mechanismsNeuroscience and Neuropharmacology Research

The DOI matches its Crossref record; 216 of the 216 references it cites were found in a registry or an index.

Revenge of the “Sit”: How lifestyle impacts neuronal and cognitive health through molecular systems that interface energy metabolism with neuronal plasticity

Vaynman, Shoshanna, Gomez‐Pinilla, Fernando·2006·Journal of Neuroscience Research
DOI 10.1002/jnr.20979
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Abstract

Exercise, a behavior that is inherently associated with energy metabolism, impacts the molecular systems important for synaptic plasticity and learning and memory. This implies that a close association must exist between these systems to ensure proper neuronal function. This review emphasizes the ability of exercise and other lifestyle implementations that modulate energy metabolism, such as diet, to impact brain function. Mechanisms believed to interface metabolism and cognition seem to play a critical role with the brain derived neurotrophic factor (BDNF) system. Behaviors concerned with activity and metabolism may have developed simultaneously and interdependently during evolution to determine the influence of exercise and diet on cognition. Alook into our evolutionary past indicates that our genome remains unchanged from the times of our hunter‐gatherer ancestors, whose active lifestyle predominated throughout almost 100% of humankind's existence. Consequently, the sedentary lifestyle and eating behaviors enabled by the comforts of technologic progress may be reaping “revenge” on the health of both our bodies and brains. In the 21st century we are confronted by the ever‐increasing incidence of metabolic disorders in both the adult and child population. The ability of exercise and diet to impact systems that promote cell survival and plasticity may be applicable for combating the deleterious effects of disease and ageing on brain health and cognition. © 2006 Wiley‐Liss, Inc.

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Research works printed but not linked: 8

  1. American Diabetes Association, 1996, Vital statistics
  2. American Heart Association, 1999, Heart and stroke statistical update
  3. 10.1097/00019052-199310000-00015 · DOI
  4. Center for Disease Control and Prevention, 2001, Behavioral risk factor surveillance system survey data
  5. 10.1210/jc.85.9.3077 · DOI
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  7. Reaven P, 2004, Metabolic syndrome, J Insur Med, 36, 132
  8. 10.1017/S002187829900713X · DOI

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Metadata

Authors
Vaynman, S., & Gomez‐Pinilla, F.
Affiliations
University of California, Los Angeles (US)
Venue
Journal of Neuroscience Research
Publisher
Wiley
Published
2006-07-21
Volume
84
Issue
4
Pages
699-715
ISSN
  • 0360-4012 (ISSN-L)
  • 1097-4547
DOI
10.1002/jnr.20979
OpenAlex
W2106085375
Cited by
299
References
216
Citations by year
2026: 3 · 2025: 6 · 2024: 20 · 2023: 7 · 2022: 16 · 2021: 20 · 2020: 12 · 2019: 12 · 2018: 15 · 2017: 19 · 2016: 12 · 2015: 23 · 2014: 20 · 2013: 16 · 2012: 21
FWCI
1.37
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Journal of Neuroscience Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
physical activity, lifestyle, energy metabolism, neuroplasticity, synaptic plasticity, learning and memory, brain-derived neurotrophic factor, diet, sedentary lifestyle, metabolic disorders, brain health, aging
MeSH terms
Aging, Animals, Brain, Cognition, Energy Metabolism, Humans, Learning, Life Style, Models, Biological, Neuronal Plasticity, Exercise, Brain-Derived Neurotrophic Factor

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