Modulation of normal and altered hippocampal excitability states by septal networks
Abstract
The septal region of the basal forebrain plays a dual role: 1) It modulates hippocampal excitability, facilitating synaptic plasticity within hippocampal circuits. Through this mechanism, the septum facilitates diverse cognitive processes that involve hippocampal circuits. 2) Additionally, the septum maintains the hippocampal networks working within normal ranges, decreasing the probability of abnormal excitability states. Through this second mechanism, the septum prevents the occurrence of epileptic discharges. Thus, septal alterations may lead to both decreased cognitive functions and epilepsy, as observed in elderly patients affected with Alzheimer's disease. © 2007 Wiley‐Liss, Inc.
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The dorsal hippocampus-septal network contributes to cognitive functions.
“The dorsal hippocampus-septal network contributes to cognitive functions,119,120”
From Preferential loss of dorsal-hippocampus synapses underlies memory impairments provoked by short, multimodal stress (2014) · cites this paper as [119]
Cites
The Organization of Behavior: A Neuropsychological Theory
(1950) · JAMA · doi:10.1001/jama.1950.02910470083028 · Cited by 4,271 · see citing works
The physiology and pharmacology of hippocampal formation theta rhythms
Bland, B. H. (1986) · Progress in Neurobiology · doi:10.1016/0301-0082(86)90019-5 · Cited by 1,039 · see citing works
Larson, J., Wong, D., & Lynch, G. (1986) · Brain Research · doi:10.1016/0006-8993(86)90579-2 · Cited by 1,037 · see citing works
Loss of Hippocampal Theta Rhythm Results in Spatial Memory Deficit in the Rat
Winson, J. (1978) · Science · doi:10.1126/science.663646 · Cited by 857 · see citing works
(1997) · Neuroscience · doi:10.1016/s0306-4522(97)00239-x · Cited by 707 · see citing works
Huerta, P. T., & Lisman, J. E. (1993) · Nature · doi:10.1038/364723a0 · Cited by 564 · see citing works
Bland, B. H., & Oddie, S. D. (2001) · Behavioural Brain Research · doi:10.1016/s0166-4328(01)00358-8 · Cited by 520 · see citing works
Hippocampal theta activity following selective lesion of the septal cholinergic systeM
Lee, M., Chrobak, J. J., Attila Gabor, S. I. K., Wiley, R. G., & Buzsáki, G. (1994) · Neuroscience · doi:10.1016/0306-4522(94)90341-7 · Cited by 501 · see citing works
Organization of Behavior : A Neuropsychological Theory
MacCorquodale, K. (1951) · American Journal of Psychiatry · doi:10.1176/ajp.108.1.73-a · Cited by 481 · see citing works
Expression, control, and probable functional significance of the neuronal theta-rhythm
Vinogradova, O. S. (1995) · Progress in Neurobiology · doi:10.1016/0301-0082(94)00051-i · Cited by 383 · see citing works
Torres, E. M., Perry, T., Blokland, A., Wilkinson, L. S., Wiley, R. G., Lappi, D. A., & Dunnett, S. B. (1994) · Neuroscience · doi:10.1016/0306-4522(94)90010-8 · Cited by 329 · see citing works
Extrinsic and intrinsic properties underlying oscillation and synchrony in limbic cortex
Bland, B. H., & Colom, L. V. (1993) · Progress in Neurobiology · doi:10.1016/0301-0082(93)90007-f · Cited by 321 · see citing works
Self-citationSotty, F., Danik, M., Manseau, F., Laplante, F., Quirion, R., & Williams, S. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2003.046847 · Cited by 256 · see citing works
Glutamatergic systems in Alzheimer's disease
Francis, P. T. (2003) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.934 · Cited by 242 · see citing works
Involvement of GABAergic and cholinergic medial septal neurons in hippocampal theta rhythm
Yoder, R. M., & Pang, K. C. H. (2005) · Hippocampus · doi:10.1002/hipo.20062 · Cited by 237 · see citing works
Reversible inactivation of the medial septum differentially affects two forms of learning in rats
Mizumori, S. J. Y., Perez, G. M., Alvarado, M. C., Barnes, C. A., & McNaughton, B. L. (1990) · Brain Research · doi:10.1016/0006-8993(90)90188-h · Cited by 227 · see citing works
Stumpf, C., Petsche, H., & Gogolák, G. (1962) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(62)90031-7 · Cited by 205 · see citing works
Characterization of medial septal glutamatergic neurons and their projection to the hippocampus
Colom, L. V., Castaneda, M. T., Reyna, T. A., Hernandez, S., & Garrido-Sanabria, E. R. (2005) · Synapse · doi:10.1002/syn.20184 · Cited by 191 · see citing works
Self-citationManns, I. D., Mainville, L., & Jones, B. E. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00302-5 · Cited by 182 · see citing works
Wu, M., Shanabrough, M., Léránth, C., & Alreja, M. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-10-03900.2000 · Cited by 171 · see citing works
Septal networks: relevance to theta rhythm, epilepsy and Alzheimer's disease
Colom, L. V. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03630.x · Cited by 142 · see citing works
Self-citationA functional glutamatergic neurone network in the medial septum and diagonal band area
Manseau, F., Danik, M., & Williams, S. (2005) · The Journal of Physiology · doi:10.1113/jphysiol.2005.089664 · Cited by 139 · see citing works
Leutgeb, S., & Mizumori, S. J. Y. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-15-06661.1999 · Cited by 116 · see citing works
Macadar, O., Roig, J. A., Monti, J. M., & Budelli, R. (1970) · Physiology & Behavior · doi:10.1016/0031-9384(70)90134-4 · Cited by 114 · see citing works
Colom, L. V., García-Hernández, A., Castañeda, M. T., Perez-Cordova, M. G., & Garrido-Sanabria, E. R. (2006) · Journal of Neurophysiology · doi:10.1152/jn.00040.2006 · Cited by 108 · see citing works
Self-citationAnticonvulsant effects of the experimental induction of hippocampal theta activity
Miller, J. W., Turner, G. M., & Gray, B. C. (1994) · Epilepsy Research · doi:10.1016/0920-1211(94)90040-x · Cited by 103 · see citing works
Bland, B. H., Oddie, S., & Colom, L. V. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-08-03223.1999 · Cited by 93 · see citing works
Self-citationIntraseptal muscarinic ligands and galanin: influence on hippocampal acetylcholine and cognition
Elvander-Tottie, E., Schött, P. A., Sandin, J., Bjelke, B., Kehr, J., Yoshitake, T., & Ögren, S. O. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.03.058 · Cited by 89 · see citing works
Relationships of hippocampal theta cycles with bar pressing during self-stimulation
Buño, W., & Velluti, J. C. (1977) · Physiology & Behavior · doi:10.1016/0031-9384(77)90035-x · Cited by 74 · see citing works
Glutamatergic synaptic transmission participates in generating the hippocampal EEG
Leung, L.-W. S., & Bixia Shen, A. (2004) · Hippocampus · doi:10.1002/hipo.10199 · Cited by 70 · see citing works
Garrido Sanabria, E. R., Castañeda, M. T., Banuelos, C., Perez-Cordova, M. G., Hernandez, S., & Colom, L. V. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.06.057 · Cited by 68 · see citing works
Self-citationSeptohippocampal properties of N ‐methyl‐ D ‐aspartate‐induced theta‐band oscillation and synchrony
Bland, B. H., Declerck, S., Jackson, J., Glasgow, S. D., & Oddie, S. (2006) · Synapse · doi:10.1002/syn.20357 · Cited by 57 · see citing works
Bonansco, C., & Buño, W. (2002) · Hippocampus · doi:10.1002/hipo.10067 · Cited by 36 · see citing works
Natsume, K., & Kometani, K. (1997) · Neuroscience Research · doi:10.1016/s0168-0102(97)01167-x · Cited by 34 · see citing works
Interactions between hippocampal penicillin spikes and theta rhythm
Lerma, J., Herreras, Ó., Muñoz, M.-D., & Solís, J. M. (1984) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(84)90089-0 · Cited by 30 · see citing works
Hippocampal rhythm generation: Gamma-related theta-frequency resonance in CA3 interneurons
Orbán, G., Kiss, T., Lengyel, M., & Érdi, P. (2001) · Biological Cybernetics · doi:10.1007/s004220000199 · Cited by 30 · see citing works
Silveira, D. C., Holmes, G. L., Schachter, S. C., Geula, C., & Schomer, D. L. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02703-7 · Cited by 24 · see citing works
Age-Related Changes in Rat Hippocampal Theta Rhythms: A Difference between Type 1 and Type 2 Theta.
Abe, Y., & Toyosawa, K. (1999) · Journal of Veterinary Medical Science · doi:10.1292/jvms.61.543 · Cited by 24 · see citing works
Age-related changes in rhythmically bursting activity in the medial septum of rats
Apartis, E., Poindessous‐Jazat, F., Epelbaum, J., & Bassant, M. H. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02571-3 · Cited by 22 · see citing works
Puma, C., Monmaur, V., Sharif, A., & Monmaur, P. (1996) · Experimental Brain Research · doi:10.1007/bf00229622 · Cited by 21 · see citing works
Bonansco, C., de la Vega, A. G., Gonzalez‐Alegre, P., Borde, M., García‐Segura, L. M., & Buño, W. (2002) · Hippocampus · doi:10.1002/hipo.10023 · Cited by 20 · see citing works
Hippocampal theta rhythm in anesthetized rats
Puma, C., & Bizot, J. (1999) · Neuroreport · doi:10.1097/00001756-199908020-00014 · Cited by 16 · see citing works
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Remote Effects of Focal Hippocampal Seizures on the Rat Neocortex
Englot, D. J., Mishra, A. M., Mansuripur, P. K., Hermán, P., Hyder, F., & Blumenfeld, H. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.2014-08.2008 · Cited by 152 · see citing works
Consciousness and epilepsy: why are complex-partial seizures complex?
Englot, D. J., & Blumenfeld, H. (2009) · Progress in brain research · doi:10.1016/s0079-6123(09)17711-7 · Cited by 119 · see citing works
“Thus, the septal nuclei play an important role in regulating normal hippocampal rhythms (Cavazos et al., 1997;Colom, 2006), and may also contribute anti-epileptogenic effects by preventing hyperexcitable limbic states (Colom et al., 2006;Colom and Garrido-Sanabria, 2007).”
BackgroundMaras, P. M., Molet, J., Chen, Y., Rice, C., Ji, S. G., Solodkin, A., & Baram, T. Z. (2014) · Molecular Psychiatry · doi:10.1038/mp.2014.12 · Cited by 118 · see citing works
“The dorsal hippocampus-septal network contributes to cognitive functions, 119,120 and PVT is considered a “stress memory” center.”
Nava-Mesa, M. O., Jiménez‐Díaz, L., Yajeya, J., & Navarro‐López, J. D. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00167 · Cited by 105 · see citing works
“The function of septal neurons of the basal forebrain is to modulate hippocampus and neocortex circuits’ activity in order to maintain sensory information and memory processes (Colom, 2006; Colom and Garrido-Sanabria, 2007).”
BackgroundButler, T., Weisholtz, D. S., Isenberg, N., Harding, E., Epstein, J., Stern, E. R., & Silbersweig, D. (2011) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2011.11.004 · Cited by 58 · see citing works
“Septal nuclei are highly interconnected with hippocampi and are known to inhibit hippocampal seizures [48].”
Kitchigina, V. F., & Butuzova, M. V. (2009) · Experimental Neurology · doi:10.1016/j.expneurol.2009.01.001 · Cited by 52 · see citing works
Disturbances of septohippocampal theta oscillations in the epileptic brain: Reasons and consequences
Kitchigina, V. F., Popova, I. Y., Sinel'nikova, V. V., Malkov, A., Astasheva, E., Shubina, L., & Aliev, R. R. (2013) · Experimental Neurology · doi:10.1016/j.expneurol.2013.01.029 · Cited by 50 · see citing works
Savage, L. M., Hall, J. M., & Vetreno, R. P. (2011) · Learning & Memory · doi:10.1101/lm.023887.111 · Cited by 32 · see citing works
“The MS/DB modulates hippocampal excitability through the interactions of ACh, GABA, and glutamate (Colom and Garrido-Sanabria 2007).”
Volume of the Human Septal Forebrain Region Is a Predictor of Source Memory Accuracy
Butler, T., Blackmon, K., Záborszky, L., Wang, X. H., DuBois, J. M., Carlson, C., Barr, W., French, J. A., Devinsky, O., Kuzniecky, R., et al. (2011) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617711001421 · Cited by 29 · see citing works
“The medial septal nuclei (medial septum and diagonal band of Broca) provide the major cholinergic input to the hippocampus (Colom & Garrido-Sanabria, 2007; Mesulam, Mufson, Wainer, & Levey, 1983) and drive hippocampal theta oscillations involved in memory encoding (Huerta & Lisman, 1993).”
BackgroundLinking brain structure, cognition, and sleep: insights from clinical data
Wei, R., Ganglberger, W., Sun, H., Hadar, P., Gollub, R. L., Pieper, S., Billot, B., Au, R., Iglesias, J. E., Cash, S. S., et al. (2023) · SLEEP · doi:10.1093/sleep/zsad294 · Cited by 28 · see citing works
“…is associated with impaired cognition [65–67], (3) specific sleep macro and microstructure are associated with specific brain volumes and cognition [68–70], and (4) the combination of sleep electroencephalogram (EEG) from PSG and brain MRI data are better predictors of cognition than either…”
Mysin, I. E., Kitchigina, V. F., & Kazanovich, Y. B. (2015) · Journal of Computational Neuroscience · doi:10.1007/s10827-015-0564-6 · Cited by 20 · see citing works
Davidson, C. A., Kuroki, N., Alvarado, J. L., Niznikiewicz, M. A., McCarley, R. W., & Levitt, J. J. (2011) · Schizophrenia Research · doi:10.1016/j.schres.2011.11.012 · Cited by 18 · see citing works
“The hippocampus and fornix are morphologically, developmentally, and functionally linked to the SP, and abnormalities of these structures may be related to SP development and schizophrenia (Colom and Garrido-Sanabria, 2007; Fitzsimmons et al., 2009; Rakic and Yakovlev, 1968).”
BackgroundAstasheva, E., Astashev, M., & Kitchigina, V. F. (2014) · Epilepsy Research · doi:10.1016/j.eplepsyres.2014.10.022 · Cited by 14 · see citing works
Developmental anomalies of the medial septal area: possible implication for limbic epileptogenesis
Iannetti, P., Papetti, L., Nicita, F., Castronovo, A., Ursitti, F., Parisi, P., Spalice, A., & Verrotti, A. (2010) · Child s Nervous System · doi:10.1007/s00381-010-1322-8 · Cited by 8 · see citing works
“Degeneration of septal neurons may have a role in increasing epileptic activity [1].”
BackgroundOptogenetic dissection of septohippocampal neural circuitry for the treatment of epilepsy
Laxpati, N. G. (2015) · SMARTech Repository (Georgia Institute of Technology)
Sandi, C. (2014) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.718297966.793492714
Communication in the Depressed Brain
Sunzeri, F. (2026) · Springer eBooks · doi:10.1007/978-3-032-14465-2_7
- Authors
- Colom, L. V., & Garrido‐Sanabria, E.
- Affiliations
- The University of Texas System (US)
- Corresponding author
- Colom, Luis V.
- Venue
- Journal of Neuroscience Research
- Publisher
- Wiley
- Published
- 2007-03-28
- Volume
- 85
- Issue
- 13
- Pages
- 2839-2843
- ISSN
- 0360-4012 (ISSN-L)
- 1097-4547
- OpenAlex
- W2008456424
- Cited by
- 17
- References
- 42
- Citations by year
- 2026: 1 · 2023: 1 · 2015: 2 · 2014: 4 · 2013: 1
- FWCI
- 0.10
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neuroscience Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- septal nuclei, hippocampal excitability, basal forebrain, synaptic plasticity, hippocampal circuitry, epilepsy, epileptiform discharges, Alzheimer's disease, cognitive impairment, hippocampal network
- MeSH terms
- Animals, Hippocampus, Nerve Net, Neuronal Plasticity, Septum of Brain
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