Cited by 320Parkinson's Disease Mechanisms and TreatmentsNuclear Receptors and SignalingMitochondrial Function and Pathology

The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.

Mitochondrial localization of DJ‐1 leads to enhanced neuroprotection

Open access

Junn, Eunsung, Jang, Won Hee, Zhao, Xin, Jeong, Byeong Seon, Mouradian, M. Maral·2009·Journal of Neuroscience Research

DOI 10.1002/jnr.21831PMC PMC2752655

Open this paper in CoChat — free account

Abstract

Mutations in DJ‐1 (PARK7) cause recessively inherited Parkinson's disease. DJ‐1 is a multifunctional protein with antioxidant and transcription modulatory activity. Its localization in cytoplasm, mitochondria, and nucleus is recognized, but the relevance of this subcellular compartmentalization to its cytoprotective activity is not fully understood. Here we report that under basal conditions DJ‐1 is present mostly in the cytoplasm and to a lesser extent in mitochondria and nucleus of dopaminergic neuroblastoma SK‐N‐BE(2)C cells. Upon oxidant challenge, more DJ‐1 translocates to mitochondria within 3 hr and subsequently to the nucleus by 12 hr. The predominant DJ‐1 species in both mitochondria and nucleus is a dimer believed to be the functional form. Mutating cysteine 106, 53, or 46 had no impact on the translocation of DJ‐1 to mitochondria. To study the relative neuroprotective activity of DJ‐1 in mitochondria and nucleus, DJ‐1 cDNA constructs fused to the appropriate localization signal were transfected into cells. Compared with 30% protection against oxidant‐induced cell death in wild‐type DJ‐1‐transfected cells, mitochondrial targeting of DJ‐1 provided a significantly stronger (55%) cytoprotection based on lactate dehydrogenase release. Nuclear targeting of DJ‐1 preserved cells equally as well as the wild‐type protein. These observations suggest that the time frame for the translocation of DJ‐1 from the cytoplasm to mitochondria and to the nucleus following oxidative stress is quite different and that dimerized DJ‐1 in mitochondria is functional as an antioxidant not related to cysteine modification. These findings further highlight the multifaceted functions of DJ‐1 as a cytoprotector in different cellular compartments. © 2008 Wiley‐Liss, Inc.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1002/jnr.21831

Cites

43 of 43 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localization
Canet-Aviles, R., Wilson, M. A., Miller, D. W., Ahmad, R., McLendon, C., Bandyopadhyay, S., Baptista, M. J., Ringe, D., Petsko, G. A., & Cookson, M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402959101 · Cited by 1,115
DJ‐1 has a role in antioxidative stress to prevent cell death
Taira, T., Saito, Y., Niki, T., Iguchi‐Ariga, S. M. M., Takahashi, K., & Ariga, H. (2004) · EMBO Reports · doi:10.1038/sj.embor.7400074 · Cited by 866
Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) and oxidative stress
Kim, R. H., Smith, P. D., Aleyasin, H., Hayley, S. P., Mount, M. P., Pownall, S., Wakeham, A. C., You-Ten, A. J., Kalia, S. K., Horne, P., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0501282102 · Cited by 711
Mitochondrial outer membrane permeabilization during apoptosis: the innocent bystander scenario
Chipuk, J. E., Bouchier-Hayes, L., & Green, D. R. (2006) · Cell Death & Differentiation · doi:10.1038/sj.cdd.4401963 · Cited by 631
DJ-1 Is a Redox-Dependent Molecular Chaperone That Inhibits α-Synuclein Aggregate Formation
Shendelman, S., Jonason, A. S., Martinat, C., Leete, T., & Abeliovich, A. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020362 · Cited by 610
The expression of DJ-1 (PARK7) in normal human CNS and idiopathic Parkinson's disease
Bandopadhyay, R. (2004) · Brain · doi:10.1093/brain/awh054 · Cited by 475
DJ-1( PARK7), a novel gene for autosomal recessive, early onset parkinsonism
Bonifati, V., Rizzu, P., Squitieri, F., Krieger, E., Vanacore, N., Swieten, J. C. V., Brice, A., van Duijn, C. M., Oostra, B. A., Meco, G., et al. (2003) · Neurological Sciences · doi:10.1007/s10072-003-0108-0 · Cited by 427
PIAS Proteins Modulate Transcription Factors by Functioning as SUMO-1 Ligases
Kotaja, N., Karvonen, U., Jänne, O. A., & Palvimo, J. J. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.14.5222-5234.2002 · Cited by 426
Mitochondrial localization of the Parkinson's disease related protein DJ-1: implications for pathogenesis
Zhang, L., Shimoji, M., Thomas, B., Moore, D. J., Yu, S.-W., Marupudi, N. I., Torp, R., Torgner, I. A., Ottersen, O. P., Dawson, T. M., et al. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi211 · Cited by 425
PARK7, a Novel Locus for Autosomal Recessive Early-Onset Parkinsonism, on Chromosome 1p36
van Duijn, C. M., Dekker, M. C. J., Bonifati, V., Galjaard, R. H., Houwing‐Duistermaat, J. J., Snijders, P. J. L. M., Testers, L., Breedveld, G. J., Horstink, M. W. I. M., Sandkuijl, L. A., et al. (2001) · The American Journal of Human Genetics · doi:10.1086/322996 · Cited by 385

Flagged first, then by citations

Show all 43 references

Sorted by citations

Items 101–200 of 320

Manganese-Induced Parkinsonism: Evidence from Epidemiological and Experimental Studies
Lucchini, R. G., & Tieu, K. (2023) · Biomolecules · doi:10.3390/biom13081190 · Cited by 53
Parkinson’s disease-related DJ-1 functions in thiol quality control against aldehyde attack in vitro
Matsuda, N., Kimura, M., Queliconi, B. B., Kojima, W., Mishima, M., Takagi, K., Koyano, F., Yamano, K., Mizushima, T., Ito, Y., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-13146-0 · Cited by 52
The Interplay among PINK1/PARKIN/Dj-1 Network during Mitochondrial Quality Control in Cancer Biology: Protein Interaction Analysis
Salazar, C., Ruiz‐Hincapie, P., & Ruíz, L. M. (2018) · Cells · doi:10.3390/cells7100154 · Cited by 52
Monomer DJ-1 and Its N-Terminal Sequence Are Necessary for Mitochondrial Localization of DJ-1 Mutants
Maita, C., Maita, H., Iguchi‐Ariga, S. M. M., & Ariga, H. (2013) · PLoS ONE · doi:10.1371/journal.pone.0054087 · Cited by 52
Harnessing Redox Cross-Reactivity To Profile Distinct Cysteine Modifications
Majmudar, J. D., Konopko, A. M., Labby, K. J., Tom, C. T. M. B., Crellin, J. E., Prakash, A., & Martin, B. R. (2016) · Journal of the American Chemical Society · doi:10.1021/jacs.5b06806 · Cited by 51
Distribution of oxidized DJ-1 in Parkinson’s disease-related sites in the brain and in the peripheral tissues: effects of aging and a neurotoxin
Mita, Y., Kataoka, Y., Saito, Y., Kashi, T., Hayashi, K., Iwasaki, A., Imanishi, T., Miyasaka, T., & Noguchi, N. (2018) · Scientific Reports · doi:10.1038/s41598-018-30561-z · Cited by 50
Identification of glutathione (GSH)-independent glyoxalase III from Schizosaccharomyces pombe
Zhao, Q., Su, Y., Wang, Z., Chen, C., Wu, T., & Huang, Y. K. (2014) · BMC Evolutionary Biology · doi:10.1186/1471-2148-14-86 · Cited by 49
DJ ‐1 modulates mitochondrial response to oxidative stress: clues from a novel diagnosis of PARK7
Nottia, M. D., Masciullo, M., Verrigni, D., Petrillo, S., Modoni, A., Rizzo, V., Giuda, D. D., Rizza, T., Niceta, M., Torraco, A., et al. (2016) · Clinical Genetics · doi:10.1111/cge.12841 · Cited by 48
DJ ‐1 is not a deglycase and makes a modest contribution to cellular defense against methylglyoxal damage in neurons
Mazza, M. C., Shuck, S. C., Lin, J., Moxley, M. A., Termini, J. S., Cookson, M., & Wilson, M. A. (2022) · Journal of Neurochemistry · doi:10.1111/jnc.15656 · Cited by 48
DJ-1 Interacts with and Regulates Paraoxonase-2, an Enzyme Critical for Neuronal Survival in Response to Oxidative Stress
Parsanejad, M., Bourquard, N., Qu, D., Zhang, Y., Huang, E., Rousseaux, M. W. C., Aleyasin, H., Irrcher, I., Callaghan, S. M., Vaillant, D. C., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0106601 · Cited by 47
Protection Against Dopaminergic Neurodegeneration in Parkinson’s Disease–Model Animals by a Modulator of the Oxidized Form of DJ-1, a Wild-type of Familial Parkinson’s Disease–Linked PARK7
Inden, M., Kitamura, Y., Takahashi, K., Takata, K., Ito, N., Niwa, R., Funayama, R., Nishimura, K., Taniguchi, T., Honda, T., et al. (2011) · Journal of Pharmacological Sciences · doi:10.1254/jphs.11151fp · Cited by 46
DJ-1 Loss by Glutaredoxin but Not Glutathione Depletion Triggers Daxx Translocation and Cell Death
Saeed, U., Ray, A., Valli, R. K., Kumar, A. M. R., & Ravindranath, V. (2009) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.2832 · Cited by 46
Balance is the challenge – The impact of mitochondrial dynamics in Parkinson’s disease
Burbulla, L. F., Krebiehl, G., & Krüger, R. (2010) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.2010.02354.x · Cited by 46
Parkin mitochondria in the autophagosome
McBride, H. M. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200810184 · Cited by 47
The new role of F1Fo ATP synthase in mitochondria-mediated neurodegeneration and neuroprotection
Mnatsakanyan, N., & Jonas, E. A. (2020) · Experimental Neurology · doi:10.1016/j.expneurol.2020.113400 · Cited by 44
Correlation between the biochemical pathways altered by mutated parkinson-related genes and chronic exposure to manganese
Roth, J. A. (2014) · NeuroToxicology · doi:10.1016/j.neuro.2014.08.006 · Cited by 43
DJ-1 promotes the proteasomal degradation of Fis1: implications of DJ-1 in neuronal protection
Zhang, Q., Wu, J., Wu, R., Ma, J., Du, G., Jiao, R., Tian, Y., Zheng, Z., & Yuan, Z. (2012) · Biochemical Journal · doi:10.1042/bj20120598 · Cited by 44
S-Glutathionylation and S-Nitrosylation in Mitochondria: Focus on Homeostasis and Neurodegenerative Diseases
Vrettou, S., & Wirth, B. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232415849 · Cited by 45
A new split-GFP-based probe reveals DJ-1 translocation into the mitochondrial matrix to sustain ATP synthesis upon nutrient deprivation
Calí, T., Ottolini, D., Soriano, M. E., & Brini, M. (2014) · Human Molecular Genetics · doi:10.1093/hmg/ddu519 · Cited by 44
Parkinson's disease‐related DJ ‐1 modulates the expression of uncoupling protein 4 against oxidative stress
Xu, S., Yang, X., Qian, Y., & Xiao, Q. (2018) · Journal of Neurochemistry · doi:10.1111/jnc.14297 · Cited by 43
Reduction of PINK 1 or DJ ‐1 impair mitochondrial motility in neurites and alter ER ‐mitochondria contacts
Parrado‐Fernández, C., Schreiner, B., Ankarcrona, M., Conti, M. M., Cookson, M. R., Kivipelto, M., Cedazo-Mı́nguez, Á., & Matton, A. (2018) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.13815 · Cited by 43
Circadian Rhythm Abnormalities in Parkinson’s Disease from Humans to Flies and Back
Lazzari, F. D., Bisaglia, M., Zordan, M. A., & Sandrelli, F. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19123911 · Cited by 46
Nrf2 Signaling in the Oxidative Stress Response After Spinal Cord Injury
Guo, X., Kang, J., Wang, Z., Wang, Y., Liu, M., Zhu, D., Yang, F., & Kang, X. (2022) · Neuroscience · doi:10.1016/j.neuroscience.2022.06.007 · Cited by 41
Methylglyoxal detoxification by a DJ-1 family protein provides dual abiotic and biotic stress tolerance in transgenic plants
Melvin, P., Bankapalli, K., D’Silva, P., & Shivaprasad, P. V. (2017) · Plant Molecular Biology · doi:10.1007/s11103-017-0613-9 · Cited by 42
BAG1 restores formation of functional DJ-1 L166P dimers and DJ-1 chaperone activity
Deeg, S., Gralle, M., Sroka, K., Bähr, M., Wouters, F. S., & Kermer, P. (2010) · The Journal of Cell Biology · doi:10.1083/jcb.200904103 · Cited by 41
DJ-1 mediates the resistance of cancer cells to dihydroartemisinin through reactive oxygen species removal
Zhu, H., Liao, S., Shi, J.-J., Chang, L.-L., Tong, Y., Cao, J., Fu, Y., Chen, X., Ying, M., Yang, B., et al. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.03.026 · Cited by 40
PARK7/DJ-1 dysregulation by oxidative stress leads to magnesium deficiency: implications in degenerative and chronic diseases
Kolísek, M., Montezano, A. C. I., Sponder, G., Anagnostopoulou, A., Vormann, J., Touyz, R. M., & Aschenbach, J. R. (2015) · Clinical Science · doi:10.1042/cs20150355 · Cited by 42
15-Deoxy-Δ12,14-prostaglandin J2 modulates manganese-induced activation of the NF-κB, Nrf2, and PI3K pathways in astrocytes
Lee, E.-S., Yin, Z., Sidoryk‐Wȩgrzynowicz, M., Jiang, H., & Aschner, M. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.12.016 · Cited by 39
Transcriptional Activation of Low-Density Lipoprotein Receptor Gene by DJ-1 and Effect of DJ-1 on Cholesterol Homeostasis
Yamaguchi, S., Yamane, T., Takahashi-Niki, K., Kato, I., Niki, T., Goldberg, M. S., Shen, J., Ishimoto, K., Doi, T., Iguchi‐Ariga, S. M. M., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0038144 · Cited by 39
Mitochondrial Bioenergy in Neurodegenerative Disease: Huntington and Parkinson
Tassone, A., Meringolo, M., Ponterio, G., Bonsi, P., Schirinzi, T., & Martella, G. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24087221 · Cited by 42
L166P mutant DJ-1 promotes cell death by dissociating Bax from mitochondrial Bcl-XL
Ren, H., Fu, K., Mu, C., Zhen, X., & Wang, G. (2012) · Molecular Neurodegeneration · doi:10.1186/1750-1326-7-40 · Cited by 37
Pro-oxidant status and Nrf2 levels in psoriasis vulgaris skin tissues and dimethyl fumarate-treated HaCaT cells
Lee, Y. J., Bae, J. H., Kang, S. G., Cho, S. W., Chun, D., Nam, S. M., Kim, C. H., Nam, H. S., Lee, S. H., Lee, S.-H., et al. (2017) · Archives of Pharmacal Research · doi:10.1007/s12272-017-0955-5 · Cited by 37
Absence of DJ-1 causes age-related retinal abnormalities in association with increased oxidative stress
Bonilha, V. L., Bell, B. A., Rayborn, M. E., Samuels, I. S., King, A. E., Hollyfield, J. G., Xie, C., & Cai, H. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.01.018 · Cited by 36
DJ-1: A promising therapeutic candidate for ischemia-reperfusion injury
Lazzari, F. D., Prag, H. A., Gruszczyk, A. V., Whitworth, A. J., & Bisaglia, M. (2021) · Redox Biology · doi:10.1016/j.redox.2021.101884 · Cited by 36
DJ-1 deficient mice demonstrate similar vulnerability to pathogenic Ala53Thr human -syn toxicity
Ramsey, C. P., Tsika, E., Ischiropoulos, H., & Giasson, B. I. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq017 · Cited by 37
Dissembled DJ-1 high molecular weight complex in cortex mitochondria from Parkinson's disease patients
Nural, H. F., He, P., Beach, T. G., Sue, L. I., Xia, W., & Shen, Y. (2009) · Molecular Neurodegeneration · doi:10.1186/1750-1326-4-23 · Cited by 36
Warburg effect linked to cognitive‐executive deficits in FMR1 premutation
Napoli, E., Song, G., Schneider, A., Hagerman, R. J., Eldeeb, M. A. A. A., Azarang, A., Tassone, F., & Giulivi, C. (2016) · The FASEB Journal · doi:10.1096/fj.201600315r · Cited by 34
Proteomic analysis of pregnancy-related proteins from pig uterus endometrium during pregnancy
Chae, J., Kim, J., Lee, S. G., Jeon, Y.-J., Kim, D., Soh, Y., Seo, K.-S., Lee, H. K., Choi, N., Ryu, J., et al. (2011) · Proteome Science · doi:10.1186/1477-5956-9-41 · Cited by 34
The effect of cysteine oxidation on DJ-1 cytoprotective function in human alveolar type II cells
Bahmed, K., Boukhenouna, S., Karim, L., Andrews, T., Lin, J., Powers, R., Wilson, M. A., Lin, C.-R., Messier, E. M., Reisdorph, N. A., et al. (2019) · Cell Death and Disease · doi:10.1038/s41419-019-1833-5 · Cited by 36
Small Substrate or Large? Debate Over the Mechanism of Glycation Adduct Repair by DJ-1
Jun, Y. W., & Kool, E. T. (2020) · Cell chemical biology · doi:10.1016/j.chembiol.2020.07.016 · Cited by 37
Microfluidics facilitating the use of small extracellular vesicles in innovative approaches to male infertility
Goss, D. M., Vasilescu, S. A., Sacks, G., Gardner, D. K., & Warkiani, M. E. (2022) · Nature Reviews Urology · doi:10.1038/s41585-022-00660-8 · Cited by 33
Harnessing the Therapeutic Potential of the Nrf2/Bach1 Signaling Pathway in Parkinson’s Disease
Ahuja, M., Kaidery, N. A., Dutta, D., Attucks, O. C., Kazakov, E. H., Gazaryan, I. G., Matsumoto, M., Igarashi, K., Sharma, S. M., & Thomas, B. (2022) · Antioxidants · doi:10.3390/antiox11091780 · Cited by 34
Mitochondrial Aging in the CNS: Unravelling Implications for Neurological Health and Disease
Steffan, D., Pezzini, C., Esposito, M., & Franco‐Romero, A. (2025) · Biomolecules · doi:10.3390/biom15091252 · Cited by 37
The role of DJ-1 in the oxidative stress cell death cascade after stroke
Tajiri, N., Kaneko, Y., Pantcheva, P., Elias, M. N., Duncan, K., & Borlongan, C. (2014) · Neural Regeneration Research · doi:10.4103/1673-5374.139458 · Cited by 31
Surprising behavioral and neurochemical enhancements in mice with combined mutations linked to Parkinson's disease
Hennis, M. R., Marvin, M. A., Taylor, C. M., & Goldberg, M. S. (2013) · Neurobiology of Disease · doi:10.1016/j.nbd.2013.09.009 · Cited by 31
Neurodegeneration: Impact of S-nitrosylated Parkin, DJ-1 and PINK1 on the pathogenesis of Parkinson's disease
Sircar, E., Raj, S. R., Wilson, M. A., Schlossmacher, M. G., & Sengupta, R. (2021) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2021.108869 · Cited by 31
Transduced Tat-DJ-1 Protein Protects against Oxidative Stress-Induced SH-SY5Y Cell Death and Parkinson Disease in a Mouse Model
Jeong, H. J., Kim, D. W., Woo, S. J., Kim, H. R., Kim, S. M., Jo, H. S., Park, M., Kim, D., Kwon, O., Hwang, I. K., et al. (2012) · Molecules and Cells · doi:10.1007/s10059-012-2255-8 · Cited by 31
Reactive Oxygen Species-Mediated DJ-1 Monomerization Modulates Intracellular Trafficking Involving Karyopherin β2
Björkblom, B., Maple‐Grødem, J., Puno, M. R., Odell, M., Larsen, J. P., & Møller, S. G. (2014) · Molecular and Cellular Biology · doi:10.1128/mcb.00286-14 · Cited by 30
PARK7 protein translocating into spermatozoa mitochondria in Chinese asthenozoospermia
Sun, Y. X., Zhang, W.-J., Zhao, X. S., Yuan, R.-P., Jiang, H., & Pu, X. (2014) · Reproduction · doi:10.1530/rep-14-0222 · Cited by 30
Self-citation
PARK7 maintains the stemness of glioblastoma stem cells by stabilizing epidermal growth factor receptor variant III
Kim, J., Kim, H., Jung, C., Choi, B.-I., Lee, D.-H., & Park, M. J. (2020) · Oncogene · doi:10.1038/s41388-020-01543-1 · Cited by 29
DJ-1–Mediated Protective Effect of Protocatechuic Aldehyde Against Oxidative Stress in SH-SY5Y Cells
Gao, J.-W., Yamane, T., Maita, H., Ishikawa, S., Iguchi‐Ariga, S. M. M., Pu, X., & Ariga, H. (2010) · Journal of Pharmacological Sciences · doi:10.1254/jphs.10271fp · Cited by 30
BAG5 Interacts with DJ‐1 and Inhibits the Neuroprotective Effects of DJ‐1 to Combat Mitochondrial Oxidative Damage
Qin, L., Tan, J., Zhang, H., Kousar, R., Lu, J., Tang, J., Jiang, B., Shen, X., Guo, J., Tang, B., et al. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/5094934 · Cited by 31
Mitochondria in aging and age-associated diseases
Pahal, S., Mainali, N., Balasubramaniam, M., Reis, R. J. S., & Ayyadevara, S. (2025) · Mitochondrion · doi:10.1016/j.mito.2025.102022 · Cited by 32
RNAi-mediated knockdown of DJ-1 leads to mitochondrial dysfunction via Akt/GSK-3ß and JNK signaling pathways in dopaminergic neuron-like cells
Zhang, X., Wang, Z., Shao, Q.-H., Zhang, Z., Li, L., Guo, Z., Sun, H., Zhang, Y., & Chen, N. (2019) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2019.01.007 · Cited by 29
Imaging the impact of genes on Parkinson's disease
van der Vegt, J. P. M., van Nuenen, B. F. L., Bloem, B. R., Klein, C., & Siebner, H. R. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.01.055 · Cited by 30
Tracing the Evolution of Plant Glyoxalase III Enzymes for Structural and Functional Divergence
Kumar, B., Kaur, C., Pareek, A., Sopory, S. K., & Singla-Pareek, S. L. (2021) · Antioxidants · doi:10.3390/antiox10050648 · Cited by 27
Tea Polyphenols Prevent Sepsis-Induced Lung Injury via Promoting Translocation of DJ-1 to Mitochondria
Jia, C.-M., Zhang, F., Wang, S., Wang, W., & Li, Y. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.622507 · Cited by 27
DJ-1 as a Therapeutic Target Against Cancer
Cao, J., Chen, X., Ying, M., He, Q., & Yang, B. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-981-10-6583-5_13 · Cited by 27
Understanding role of pesticides in development of Parkinson's disease: Insights from Drosophila and rodent models
Afsheen, S., Rehman, A. S., Jamal, A., Khan, N. H., & Parvez, S. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102340 · Cited by 28
Partially oxidized DJ-1 inhibits α-synuclein nucleation and remodels mature α-synuclein fibrils in vitro
Kumar, R., Kumar, S., Hanpude, P., Singh, A. K., Johari, T., Majumder, S., & Maiti, T. K. (2019) · Communications Biology · doi:10.1038/s42003-019-0644-7 · Cited by 26
Cytoprotective Mechanisms of DJ-1: Implications in Cardiac Pathophysiology
Tsoporis, J. N., Drosatos, I.-A., Gupta, S., Amatullah, H., Izhar, S., dos Santos, C. C., Salpeas, V., Rigopoulos, A. G., Toumpoulis, I. K., Triantafyllis, A. S., et al. (2021) · Molecules · doi:10.3390/molecules26133795 · Cited by 26
DJ-1 mediates paraquat-induced dopaminergic neuronal cell death
Kwon, H. J., Heo, J. Y., Shim, J. H., Park, J. H., Seo, K. S., Ryu, M. J., Han, J., Shong, M., Son, J. H., & Kweon, G. R. (2011) · Toxicology Letters · doi:10.1016/j.toxlet.2011.01.018 · Cited by 26
Reactive Metabolite-induced Protein Glutathionylation: A Potentially Novel Mechanism Underlying Acetaminophen Hepatotoxicity
Chan, J. C. Y., Soh, A. C. K., Kioh, D. Y. Q., Li, J., Verma, C. S., Koh, S. K., Beuerman, R. W., Zhou, L., & Chan, E. C. Y. (2018) · Molecular & Cellular Proteomics · doi:10.1074/mcp.ra118.000875 · Cited by 25
The Pathogenesis of Nodding Syndrome
Johnson, T. P., Sejvar, J. J., Nutman, T. B., & Nath, A. (2020) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathmechdis-012419-032748 · Cited by 26
Retigeric acid B-induced mitophagy by oxidative stress attenuates cell death against prostate cancer cells in vitro
Liu, Y., Ji, Y., Li, X.-Z., Tian, K., Young, C. Y., Lou, H., & Yuan, H. (2013) · Acta Pharmacologica Sinica · doi:10.1038/aps.2013.68 · Cited by 26
Proteomics in Parkinson's disease: An unbiased approach towards peripheral biomarkers and new therapies
Alberio, T., & Fasano, M. (2011) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2011.08.004 · Cited by 25
Evolving paradigms on the interplay of mitochondrial Hsp70 chaperone system in cell survival and senescence
Srivastava, S., Vishwanathan, V., Birje, A., Sinha, D., & D’Silva, P. (2019) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409238.2020.1718062 · Cited by 25
Moving beyond the Tip of the Iceberg: DJ-1 Implications in Cancer Metabolism
Olivo, E., Chimia, M. L., Ceramella, J., Catalano, A. A., Chiaradonna, F., Sinicropi, M. S., Cuda, G., Iacopetta, D., & Scumaci, D. (2022) · Cells · doi:10.3390/cells11091432 · Cited by 25
DJ‐1, an oncogene and causative gene for familial Parkinson's disease, is essential for SV40 transformation in mouse fibroblasts through up‐regulation of c‐Myc
kim, Y. C., Kitaura, H., Iguchi‐Ariga, S. M. M., & Ariga, H. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.08.010 · Cited by 25
Altered Proteins in the Hippocampus of Patients with Mesial Temporal Lobe Epilepsy
Persike, D. S., da Silva, J. E. M. C., Stein, M. L. D. L., Yacubian, E. M. T., Centeno, R. D. S., Canzian, M., & Fernandes, M. J. D. S. (2018) · Pharmaceuticals · doi:10.3390/ph11040095 · Cited by 25
Metals in Alzheimer’s and Parkinson’s Disease: Relevance to Dementia with Lewy Bodies
McAllum, E. J., & Finkelstein, D. I. (2016) · Journal of Molecular Neuroscience · doi:10.1007/s12031-016-0809-5 · Cited by 24
The Tale of DJ-1 (PARK7): A Swiss Army Knife in Biomedical and Psychological Research
Sun, M. E., & Zheng, Q. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24087409 · Cited by 24
2′-Benzoyloxycinnamaldehyde-Mediated DJ-1 Upregulation Protects MCF-7 Cells from Mitochondrial Damage
Ismail, I. A., Kang, H. S., Lee, H., Kwon, B., & Hong, S. (2012) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.35.895 · Cited by 23
Mitochondrial Translocation of DJ-1 Is Mediated by Grp75: Implication in Cardioprotection of Resveratrol Against Hypoxia/Reoxygenation-Induced Oxidative Stress
Zhou, T., Wang, X., Huang, J., Deng, Y., Qiu, L.-J., Liu, H., Xu, X.-W., Ma, Z., Tang, L., & Chen, H. (2020) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0000000000000805 · Cited by 23
Effects of estrogens and androgens on mitochondria under normal and pathological conditions
Mohajeri, M., Martín-Jiménez, C., Barreto, G. E., & Sahebkar, A. (2019) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2019.03.001 · Cited by 23
Mitochondrial and Organellar Crosstalk in Parkinson’s Disease
Ray, B., Bhat, A., Mahalakshmi, A. M., Tuladhar, S., Bishir, M., Mohan, S. K., Veeraraghavan, V. P., Chandra, R., Essa, M. M., Chidambaram, S. B., et al. (2021) · ASN NEURO · doi:10.1177/17590914211028364 · Cited by 26
Elevated expression of DJ-1 (encoded by the human PARK7 gene) protects neuronal cells from sevoflurane-induced neurotoxicity
Zhang, Y., Li, Y., Han, X., Xu, D., Yan, X., & Xing, Q. (2018) · Cell Stress and Chaperones · doi:10.1007/s12192-018-0904-3 · Cited by 24
Mechanism of N-acetylcysteine in alleviating diabetic myocardial ischemia reperfusion injury by regulating PTEN/Akt pathway through promoting DJ-1
Li, W., Li, W., Leng, Y., Xiong, Y., Xue, R., Chen, R., & Xia, Z. (2020) · Bioscience Reports · doi:10.1042/bsr20192118 · Cited by 21
Systematic Review on Saliva Biomarkers in Patients Diagnosed with Morbus Alzheimer and Morbus Parkinson
Wolgin, M., Zobernig, M., Dvornyk, V. M., Braun, R. J., & Kielbassa, A. M. (2022) · Biomedicines · doi:10.3390/biomedicines10071702 · Cited by 21
Stimulation of vesicular monoamine transporter 2 activity by DJ-1 in SH-SY5Y cells
Ishikawa, S., Tanaka, Y., Takahashi-Niki, K., Niki, T., Ariga, H., & Iguchi‐Ariga, S. M. M. (2012) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2012.04.095 · Cited by 21
Natrium Benzoate Alleviates Neuronal Apoptosis via the DJ-1-Related Anti-oxidative Stress Pathway Involving Akt Phosphorylation in a Rat Model of Traumatic Spinal Cord Injury
Gao, L., Zhang, Z., Xu, W., Li, T., Ying, G., Qin, B., Li, J., Zheng, J., Zhao, T., Yan, F., et al. (2019) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2019.00042 · Cited by 21
Mitochondrial respiratory dysfunction and mutations in mitochondrial DNA in PINK1 familial Parkinsonism
Papa, S., Sardanelli, A. M., Capitanio, N., & Piccoli, C. (2009) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-009-9252-4 · Cited by 21
Behavioral and Neurotransmitter Abnormalities in Mice Deficient for Parkin, DJ-1 and Superoxide Dismutase
Hennis, M. R., Seamans, K. W., Marvin, M. A., Casey, B. H., & Goldberg, M. S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0084894 · Cited by 21
Understanding the molecular basis of Parkinson’s disease, identification of biomarkers and routes to therapy
Robinson, P. A. (2010) · Expert Review of Proteomics · doi:10.1586/epr.10.40 · Cited by 20
When safeguarding goes wrong: Impact of oxidative stress on protein homeostasis in health and neurodegenerative disorders
Mesika, R., & Reichmann, D. (2018) · Advances in protein chemistry and structural biology · doi:10.1016/bs.apcsb.2018.11.001 · Cited by 20
DJ-1 promotes energy balance by regulating both mitochondrial and autophagic homeostasis
Lazzari, F. D., Agostini, F., Plotegher, N., Sandre, M., Greggio, E., Megighian, A., Bubacco, L., Sandrelli, F., Whitworth, A. J., & Bisaglia, M. (2022) · Neurobiology of Disease · doi:10.1016/j.nbd.2022.105941 · Cited by 21
Upregulated Parkin expression protects mitochondrial homeostasis in DJ-1 konckdown cells and cells overexpressing the DJ-1 L166P mutation
Chang, C., Wu, G., Gao, P., Yang, L., Liu, W., & Zuo, J. (2013) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-013-1884-3 · Cited by 19
The Parkinson's disease-associated protein DJ-1 plays a positive nonmitochondrial role in endocytosis inDictyosteliumcells
Chen, S., Annesley, S. J., Jasim, R. A. F., Musco, V. J., Sanislav, O., & Fisher, P. R. (2017) · Disease Models & Mechanisms · doi:10.1242/dmm.028084 · Cited by 19
Protein Oxidative Damage in UV-Related Skin Cancer and Dysplastic Lesions Contributes to Neoplastic Promotion and Progression
Tramutola, A., Falcucci, S., Brocco, U., Triani, F., Lanzillotta, C., Donati, M., Panetta, C., Luzi, F., Iavarone, F., Vincenzoni, F., et al. (2020) · Cancers · doi:10.3390/cancers12010110 · Cited by 19
On the Chemical and Biological Characteristics of Multifunctional Compounds for the Treatment of Parkinson’s Disease
García‐Beltrán, O., Urrutia, P. J., & Núñez, M. T. (2023) · Antioxidants · doi:10.3390/antiox12020214 · Cited by 19
Human microsporidian pathogen Encephalitozoon intestinalis impinges on enterocyte membrane trafficking and signaling
Flores, J., Takvorian, P. M., Weiss, L. M., Cali, A., & Gao, N. (2021) · Journal of Cell Science · doi:10.1242/jcs.253757 · Cited by 18
Stepwise oxidations play key roles in the structural and functional regulations of DJ-1
Song, I.-K., Kim, M.-S., Ferrell, J. E., Shin, D. H., & Lee, K. (2021) · Biochemical Journal · doi:10.1042/bcj20210245 · Cited by 17
The mitochondrial metabolic function of DJ‐1 is modulated by 14‐3‐3β
Weinert, M., Millet, A. M. C., Jonas, E. A., & Alavian, K. N. (2019) · The FASEB Journal · doi:10.1096/fj.201802754r · Cited by 18
Diallyl disulfide effect on the invasion and migration ability of HL-60 cells with a high expression of DJ-1 in the nucleus through the suppression of the Src signaling pathway
Liu, R., Yang, Y. F., Yi, L., Qing, J., Li, Q., Wang, W., Wang, J., Tang, Y., & Tan, H. (2018) · Oncology Letters · doi:10.3892/ol.2018.8139 · Cited by 16
Oxidative Stress Regulation and DJ-1 Function in the Retinal Pigment Epithelium: Implications for AMD
Bonilha, V. L. (2018) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-75402-4_1 · Cited by 16
Age-related Mitochondrial Dysfunction in Parkinson's Disease: New Insights Into the Disease Pathology
Rani, L., Sahu, M. R., & Mondal, A. C. (2022) · Neuroscience · doi:10.1016/j.neuroscience.2022.07.007 · Cited by 16
Chapter 24 Quantification, Localization, and Tissue Specificities of Mouse Mitochondrial Reactive Oxygen Species Production
Gusdon, A. M., Chen, J., Votyakova, T. V., & Mathews, C. E. (2009) · Methods in Enzymology · doi:10.1016/s0076-6879(08)04424-8 · Cited by 16
Molecular Alterations in the Cerebellum of Sporadic Creutzfeldt–Jakob Disease Subtypes with DJ-1 as a Key Regulator of Oxidative Stress
Tahir, W., Zafar, S., Llorens, F., Arora, A. S., Thüne, K., Schmitz, M., Gotzmann, N., Kruse, N., Mollenhauer, B., Torres, J. M., et al. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-0294-4 · Cited by 16
ND-13, a DJ-1-Derived Peptide, Attenuates the Renal Expression of Fibrotic and Inflammatory Markers Associated with Unilateral Ureter Obstruction
Miguel, C. D., Kraus, A. C., Saludes, M. A., Konkalmatt, P. R., Domínguez, A. R., Asico, L. D., Latham, P. S., Offen, D., José, P. A., & Cuevas, S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21197048 · Cited by 15
Quantitative reactive cysteinome profiling reveals a functional link between ferroptosis and proteasome-mediated degradation
Wang, Y., & Wang, C. (2022) · Cell Death and Differentiation · doi:10.1038/s41418-022-01050-8 · Cited by 16

Authors: Junn, E., Jang, W. H., Zhao, X., Jeong, B. S., & Mouradian, M. M.
Affiliations: Inje University (KR)
Corresponding author: Mouradian, M. Maral
ORCID: Junn, Eunsung
Jang, Won Hee
Zhao, Xin
Mouradian, M. Maral
Venue: Journal of Neuroscience Research
Publisher: Wiley
Published: 2008-08-18
Volume: 87
Issue: 1
Pages: 123-129
ISSN: 0360-4012 (ISSN-L)
1097-4547
DOI: 10.1002/jnr.21831
PMC: PMC2752655
OpenAlex: W2143048992
Cited by: 320
References: 43
Citations by year: 2026: 6 · 2025: 15 · 2024: 12 · 2023: 18 · 2022: 21 · 2021: 24 · 2020: 19 · 2019: 16 · 2018: 23 · 2017: 16 · 2016: 18 · 2015: 10 · 2014: 24 · 2013: 23 · 2012: 19
FWCI: 11.87
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Journal of Neuroscience Research (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Neurological Disorders and Stroke (NS053517, R01NS059869, NS059869, R21NS053517)
Topics: Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Receptors and Signaling
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Keywords: DJ-1, Parkinson's disease, mitochondrial localization, subcellular compartmentalization, oxidative stress, neuroprotection, protein dimerization, antioxidant activity, nuclear translocation, cysteine modification, dopaminergic neurons
MeSH terms: Protein Deglycase DJ-1, Analysis of Variance, Cell Nucleus, Cysteine, Humans, Hydrogen Peroxide, Mitochondria, Mutation, Neuroblastoma, Transfection, Oncogene Proteins, Oxidants, Cell Death, Apoptosis, Neuroprotective Agents, Cell Line, Tumor, Intracellular Signaling Peptides and Proteins

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Mitochondrial localization of DJ‐1 leads to enhanced neuroprotection

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks