Cited by 320Parkinson's Disease Mechanisms and TreatmentsNuclear Receptors and SignalingMitochondrial Function and Pathology

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Mitochondrial localization of DJ‐1 leads to enhanced neuroprotection

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Junn, Eunsung, Jang, Won Hee, Zhao, Xin, Jeong, Byeong Seon, Mouradian, M. Maral·2009·Journal of Neuroscience Research

DOI 10.1002/jnr.21831PMC PMC2752655

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Abstract

Mutations in DJ‐1 (PARK7) cause recessively inherited Parkinson's disease. DJ‐1 is a multifunctional protein with antioxidant and transcription modulatory activity. Its localization in cytoplasm, mitochondria, and nucleus is recognized, but the relevance of this subcellular compartmentalization to its cytoprotective activity is not fully understood. Here we report that under basal conditions DJ‐1 is present mostly in the cytoplasm and to a lesser extent in mitochondria and nucleus of dopaminergic neuroblastoma SK‐N‐BE(2)C cells. Upon oxidant challenge, more DJ‐1 translocates to mitochondria within 3 hr and subsequently to the nucleus by 12 hr. The predominant DJ‐1 species in both mitochondria and nucleus is a dimer believed to be the functional form. Mutating cysteine 106, 53, or 46 had no impact on the translocation of DJ‐1 to mitochondria. To study the relative neuroprotective activity of DJ‐1 in mitochondria and nucleus, DJ‐1 cDNA constructs fused to the appropriate localization signal were transfected into cells. Compared with 30% protection against oxidant‐induced cell death in wild‐type DJ‐1‐transfected cells, mitochondrial targeting of DJ‐1 provided a significantly stronger (55%) cytoprotection based on lactate dehydrogenase release. Nuclear targeting of DJ‐1 preserved cells equally as well as the wild‐type protein. These observations suggest that the time frame for the translocation of DJ‐1 from the cytoplasm to mitochondria and to the nucleus following oxidative stress is quite different and that dimerized DJ‐1 in mitochondria is functional as an antioxidant not related to cysteine modification. These findings further highlight the multifaceted functions of DJ‐1 as a cytoprotector in different cellular compartments. © 2008 Wiley‐Liss, Inc.

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Santos, R. X., Correia, S. C., Cardoso, S., Carvalho, C., Candeias, E., Plácido, A. I., Duarte, A. I., Santos, M. S., & Moreira, P. I. (2014) · CRC Press eBooks · doi:10.1201/b16653-26 · Cited by 1
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Ciolac, D., & González‐Escamilla, G. (2024) · Neuromethods · doi:10.1007/978-1-0716-4083-8_4 · Cited by 1
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Roth, J. A. (2014) · Royal Society of Chemistry eBooks · doi:10.1039/9781782622383-00221 · Cited by 1
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Russell, A. E., Badr, A., Rai, A., Carafice, C., Rai, A., Daily, K. P., Whitham, O. D., Amer, A. O., Brown, C. M., & Dakhlallah, D. A. (2022) · Nutritional neurosciences · doi:10.1007/978-981-16-9205-5_13 · Cited by 1
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Yu, H. M. (2013) · Purdue e-Pubs (Purdue University System) · Cited by 1
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Shin, M. J., Jeong, H. J., Sohn, E. J., Kim, H. R., Kim, D., Kang, T., Cho, S., Kim, D. W., Park, J., Eum, W. S., et al. (2010) · IEEE International Conference on Bioinformatics and Biomedicine Workshops (BIBMW) · doi:10.1109/bibmw.2010.5703915 · Cited by 1
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Facecchia, K. (2012) · Scholarship at UWindsor (University of Windsor) · Cited by 1
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Ting-Ting, Q. I., Lin, L., Liu, Y., & Jiang, Y. L. (2011) · PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS · doi:10.3724/sp.j.1206.2010.00393 · Cited by 1
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Diec, D. (2009) · TSpace (University of Toronto) · Cited by 1
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Tassone, A., Meringolo, M., Bonsi, P., Schirinzi, T., & Martella, G. (2023) · Preprints.org · doi:10.20944/preprints202302.0015.v1
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Vila, M., & Martínez‐Vicente, M. (2014) · Springer eBooks · doi:10.1007/978-1-4614-5836-4_15
Disorders of mitochondrial DNA polymerase: a clinical, biochemical and structural study
Palin, E. (2013) · Työväentutkimus Vuosikirja
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Farooqı, A. A., Arshad, S., Fayyaz, S., Abbas, S., & Bhatti, S. (2011) · Research in Biotechnology
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Charlesworth, G., & Wood, N. W. (2011) · Springer eBooks · doi:10.1007/978-0-85729-701-3_3
Anatomy of the Cardiovascular Apparatus
Thiriet, M. (2013) · Biomathematical and biomechanical modeling of the circulatory and ventilatory systems · doi:10.1007/978-1-4614-9469-0_1
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Iglesias, S. S. (2011) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)
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Blackinton, J. G. (2008) · Figshare
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Thiriet, M. (2013) · Biomathematical and biomechanical modeling of the circulatory and ventilatory systems · doi:10.1007/978-1-4614-9469-0_5
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Wang, Z., Tang, L., & Gao, T. (2012) · Academic Journal of Second Military Medical University · doi:10.3724/sp.j.1008.2012.00088
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Eltoweissy, M. (2016) · doi:10.53846/goediss-5627
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Schapira, A. H. V. (2012) · Oxidative stress and disease · doi:10.1201/b12308-23
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Sereen, K. (2015) · International Journal of Pharma and Bio Sciences
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Tahir, W. (2017) · doi:10.53846/goediss-6306
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Deol, N. (2016) · TSpace (University of Toronto)
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Sharma, S., Kaur, P., Gupta, S., & Sharma, S. (2018) · Advances in medical diagnosis, treatment, and care (AMDTC) book series · doi:10.4018/978-1-5225-5282-6.ch005
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Hughes, G. L. (2019) · White Rose eTheses Online (University of Leeds, The University of Sheffield, University of York)
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Edson, A. J., Hushagen, H. A., & Fladmark, K. E. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-817780-8.00007-4

Authors: Junn, E., Jang, W. H., Zhao, X., Jeong, B. S., & Mouradian, M. M.
Affiliations: Inje University (KR)
Corresponding author: Mouradian, M. Maral
ORCID: Junn, Eunsung
Jang, Won Hee
Zhao, Xin
Mouradian, M. Maral
Venue: Journal of Neuroscience Research
Publisher: Wiley
Published: 2008-08-18
Volume: 87
Issue: 1
Pages: 123-129
ISSN: 0360-4012 (ISSN-L)
1097-4547
DOI: 10.1002/jnr.21831
PMC: PMC2752655
OpenAlex: W2143048992
Cited by: 320
References: 43
Citations by year: 2026: 6 · 2025: 15 · 2024: 12 · 2023: 18 · 2022: 21 · 2021: 24 · 2020: 19 · 2019: 16 · 2018: 23 · 2017: 16 · 2016: 18 · 2015: 10 · 2014: 24 · 2013: 23 · 2012: 19
FWCI: 11.87
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Journal of Neuroscience Research (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Neurological Disorders and Stroke (NS053517, R01NS059869, NS059869, R21NS053517)
Topics: Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Receptors and Signaling
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Keywords: DJ-1, Parkinson's disease, mitochondrial localization, subcellular compartmentalization, oxidative stress, neuroprotection, protein dimerization, antioxidant activity, nuclear translocation, cysteine modification, dopaminergic neurons
MeSH terms: Protein Deglycase DJ-1, Analysis of Variance, Cell Nucleus, Cysteine, Humans, Hydrogen Peroxide, Mitochondria, Mutation, Neuroblastoma, Transfection, Oncogene Proteins, Oxidants, Cell Death, Apoptosis, Neuroprotective Agents, Cell Line, Tumor, Intracellular Signaling Peptides and Proteins

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Mitochondrial localization of DJ‐1 leads to enhanced neuroprotection

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