Mitochondrial outer membrane permeabilization during apoptosis: the innocent bystander scenario
Abstract
Mitochondrial outer membrane permeabilization (MOMP) is considered the 'point of no return' as this event is responsible for engaging the apoptotic cascade in numerous cell death pathways. MOMP is directly governed by a subset of the BCL-2 family of proapoptotic proteins, which induce disruptions in the outer mitochondrial membrane (OMM) and subsequent release of death-promoting proteins like cytochrome c. The proposal here is centered on our hypothesis that MOMP is dictated by an interaction between the cytosol and the OMM, and although proteins of the OMM may be important in the process, the 'decision' to undergo apoptosis originates within the cytosol with no participation (in terms of yes, no and when) by mitochondria.
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Although nonmitochondrial sources of ROS exist during ischemia, the majority of ROS are likely derived from the mitochondrial respiratory complexes.
“Although nonmitochondrial sources of ROS exist during ischemia [e.g., NAD(P)H oxidase (141, 188, 328) and xanthine oxidase (25) in vasculature], the majority of ROS are likely derived from the mitochondrial respiratory complexes, as shown by the damage to respiratory complexes (212, 213, 245) and the effect of mitochondrial inhibitors (5, 28, 71, 81–86).”
From Mitochondrial reactive oxygen species production in excitable cells: Modulators of mitochondrial and cell function (2009) · cites this paper as [83]
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- Authors
- Chipuk, J. E., Bouchier-Hayes, L., & Green, D. R.
- Affiliations
- St. Jude Children's Research Hospital (US)
- Corresponding author
- Green, D R
- Venue
- Cell Death & Differentiation
- Published
- 2006-05-19
- Volume
- 13
- Issue
- 8
- Pages
- 1396-1402
- ISSN
- 1350-9047 (ISSN-L)
- 1476-5403
- OpenAlex
- W2014999693
- Cited by
- 631
- References
- 62
- Citations by year
- 2026: 32 · 2025: 29 · 2024: 33 · 2023: 29 · 2022: 44 · 2021: 26 · 2020: 27 · 2019: 22 · 2018: 41 · 2017: 33 · 2016: 29 · 2015: 29 · 2014: 30 · 2013: 26 · 2012: 25
- FWCI
- 2.84
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Cell Death and Differentiation (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Keywords
- mitochondrial outer membrane permeabilization, apoptosis, Bcl-2 family proteins, cytochrome c release, mitochondrial outer membrane, mitochondrial permeability transition pore
- MeSH terms
- Animals, Humans, Permeability, Apoptosis, Proto-Oncogene Proteins c-bcl-2, Caspases, Bystander Effect, Mitochondrial Membranes
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