Movement impairment: Focus on the brain
Abstract
The saying "mens sana in corpore sano" has a particular resonance these days because, for the majority who have a very sedentary occupation, the everyday rhythms of life do not compel us to do much physical exercise. Recently published data indicate that exercise can counteract the effects of neurological diseases such as Alzheimer's disease and have prompted research on the beneficial effects of movement on the brain and brain neurogenesis. This might lead us to hypothesize that the absence or reduction of movements, especially those with antigravity effects, could induce a deterioration of the brain. This Review discusses current knowledge of the relationship between neurogenic capacity and the lack of motor activity in human and animal models.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In rodents, voluntary exercise impacts the rate of neurogenesis.
“Moderate amounts of exercise can make a meaningful difference to brain structures and their function; for example, in rodents, voluntary exercise impacts the rate of neurogenesis (Adami and Bottai, 2016;van Praag et al., 1999).”
From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Adami and Bottai, 2016
Cites
Evidence for a release of brain-derived neurotrophic factor from the brain during exercise
Rasmussen, P., Brassard, P., Adser, H., Pedersen, M. V., Leick, L., Hart, E., Secher, N. H., Pedersen, B. K., & Pilegaard, H. (2009) · Experimental Physiology · doi:10.1113/expphysiol.2009.048512 · Cited by 914 · see citing works
Essential role of brain-derived neurotrophic factor in adult hippocampal function
Monteggia, L. M., Barrot, M., Powell, C. M., Berton, O., Galanis, V., Gemelli, T., Meuth, S., Nagy, A., Greene, R. W., & Nestler, E. J. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402141101 · Cited by 685 · see citing works
Effect of treatment on serum brain–derived neurotrophic factor levels in depressed patients
Gonul, A. S., Akdeniz, F., Taneli, F., Donat, O., Eker, Ç., & Vahip, S. (2005) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-005-0578-6 · Cited by 375 · see citing works
Huh, J. Y., Mougios, V., Kabasakalis, A., Fatouros, I., Siopi, A., Douroudos, I. I., Filippaios, A., Panagiotou, G., Park, K. H., & Mantzoros, C. S. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-1437 · Cited by 363 · see citing works
Low plasma BDNF is associated with suicidal behavior in major depression
Kim, Y.-K., Lee, H.-P., Won, S.-D., Park, E.-Y., Lee, H.-Y., Lee, B.-H., Lee, S.-W., Yoon, D., Han, C., Kim, D.-J., et al. (2007) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2006.06.024 · Cited by 300 · cited 1× · see citing works
“A similar result was observed in patients with suicidal behavior (Kim et al., 2007).”
ResultLLorens-Martín, M., Torres-Alemán, I., & Trejo, J. L. (2010) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2010.02.006 · Cited by 135 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Cryan, J. F., O'Riordan, K. J., Cowan, C. S. M., Sandhu, K. V., Bastiaanssen, T. F. S., Boehme, M., Codagnone, M. G., Cussotto, S., Fulling, C., Golubeva, A. V., et al. (2019) · Physiological Reviews · doi:10.1152/physrev.00018.2018 · Cited by 5,286 · see citing works
- Authors
- Adami, R., & Bottai, D.
- Affiliations
- University of Milan (IT)
- Corresponding author
- Bottai, Daniele
- Venue
- Journal of Neuroscience Research
- Publisher
- Wiley
- Published
- 2016-01-13
- Volume
- 94
- Issue
- 4
- Pages
- 310-317
- ISSN
- 0360-4012 (ISSN-L)
- 1097-4547
- OpenAlex
- W2238545713
- Cited by
- 7
- References
- 6
- Citations by year
- 2025: 1 · 2023: 2 · 2020: 2 · 2019: 1 · 2018: 1
- FWCI
- 0.08
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neuroscience Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Asamsi ONLUS
- Vertical Foundation
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Keywords
- motor impairment, sedentary lifestyle, physical activity, neurogenesis, brain, neurological disorders, Alzheimer's disease, motor activity
- MeSH terms
- Animals, Brain, Humans, Motor Activity, Neurogenesis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
