Effect of treatment on serum brain–derived neurotrophic factor levels in depressed patients
Abstract
Researchers have reported that serum brain-derived neurotrophic factor (sBDNF) of drug-free depressed patients are lower than those of healthy controls and proposed that low sBDNF levels might reflect failure of neuronal plasticity in depression. In this study, we compared sBDNF levels of depressed patients (n = 28) before and after 8 weeks of antidepressant treatment, with those of healthy controls (n = 18) to test the hypothesis that initially low sBDNF levels of drug-free depressed patients will increase parallel with their clinical response to antidepressant treatment. The severity of depression and response to treatment were assessed with Hamilton Rating Scale for Depression (HAM-D). sBDNF was assayed with the sandwich ELISA method. Baseline sBDNF levels of patients (mean, 20.8 ng/ml; [S.D., 6.7]) were significantly lower than those of controls (mean, 26.8 ng/ml; [S.D., 9.3]; p = 0.015), and were negatively correlated with HAM-D scores (r = -0.49, p = 0.007). After 8 weeks of treatment, sBDNF levels of patients had increased significantly (mean, 33.3 ng/ml; [S.D., 9.9]; p < 0.001) and no longer differed from those of controls. These results support the hypothesis that BDNF might play a critical role in the pathophysiology of major depressive disorder and successful antidepressant treatment increases the attenuated BDNF levels in depressed patients.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Both MDD patients and animal models of depression show a remarkable reduction in serum BDNF levels.
“Both MDD patients [57–59] and animal models of depression [60, 61] show a remarkable reduction in serum BDNF levels.”
From Brain-Derived Neurotrophic Factor in Brain Disorders: Focus on Neuroinflammation (2019) · cites this paper as [57]
Cites
Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,841 · see citing works
Hamilton, M. (1960) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.23.1.56 · Cited by 32,817 · see citing works
Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus
Malberg, J. E., Eisch, A. J., Nestler, E. J., & Duman, R. S. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-24-09104.2000 · Cited by 3,111 · see citing works
Nibuya, M., Morinobu, S., & Duman, R. (1995) · The Journal of Neuroscience · doi:10.1523/jneurosci.15-11-07539.1995 · Cited by 2,109 · see citing works
Glucocorticoids and Hippocampal Atrophy in Neuropsychiatric Disorders
Sapolsky, R. M. (2000) · Archives of General Psychiatry · doi:10.1001/archpsyc.57.10.925 · Cited by 2,016 · see citing works
Neurotrophins and Neuronal Plasticity
Thoenen, H. (1995) · Science · doi:10.1126/science.270.5236.593 · Cited by 1,927 · see citing works
Brain-derived neurotrophic factor produces antidepressant effects in behavioral models of depression
Shirayama, Y., Chen, A. C.-H., Nakagawa, S., Russell, D. S., & Duman, R. S. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-08-03251.2002 · Cited by 1,654 · see citing works
(1995) · American Journal of Psychiatry · doi:10.1176/ajp.152.7.973 · Cited by 1,610 · see citing works
Ca2+ Influx Regulates BDNF Transcription by a CREB Family Transcription Factor-Dependent Mechanism
Tao, X., Finkbeiner, S., Arnold, D. B., Shaywitz, A. J., & Greenberg, M. E. (1998) · Neuron · doi:10.1016/s0896-6273(00)81010-7 · Cited by 1,561 · see citing works
Glial reduction in the subgenual prefrontal cortex in mood disorders
Öngür, D., Drevets, W. C., & Price, J. L. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.22.13290 · Cited by 1,525 · see citing works
Gould, E., McEwen, B. S., Tanapat, P., Galea, L. A. M., & Fuchs, E. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-07-02492.1997 · Cited by 1,496 · see citing works
Hippocampal long-term potentiation is impaired in mice lacking brain-derived neurotrophic factor.
Korte, M., Carroll, P., Wolf, E., Brem, G., Thoenen, H., & Bonhoeffer, T. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.19.8856 · Cited by 1,426 · see citing works
Gould, E., Tanapat, P., McEwen, B. S., Flügge, G., & Fuchs, E. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.6.3168 · Cited by 1,395 · see citing works
Sheline, Y. I., Sanghavi, M., Mintun, M. A., & Gado, M. H. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-12-05034.1999 · Cited by 1,382 · see citing works
Transport of brain-derived neurotrophic factor across the blood–brain barrier
Pan, W., Banks, W. A., Fasold, M. B., Bluth, J., & Kastin, A. J. (1998) · Neuropharmacology · doi:10.1016/s0028-3908(98)00141-5 · Cited by 1,354 · see citing works
NEUROTROPHINS AND SYNAPTIC PLASTICITY
McAllister, A. K., Katz, L. C., & Lo, D. C. (1999) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.22.1.295 · Cited by 1,337 · see citing works
Decreased serum brain-derived neurotrophic factor levels in major depressed patients
Karege, F., Perret, G., Bondolfi, G., Schwald, M., Bertschy, G., & Aubry, J.-M. (2002) · Psychiatry Research · doi:10.1016/s0165-1781(02)00005-7 · Cited by 1,232 · see citing works
Nibuya, M., Nestler, E., & Duman, R. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-07-02365.1996 · Cited by 1,206 · see citing works
Increased hippocampal bdnf immunoreactivity in subjects treated with antidepressant medication
Chen, B., Dowlatshahi, D., MacQueen, G. M., Wang, J.-F., & Young, L. T. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01083-6 · Cited by 1,164 · see citing works
Shimizu, E., Hashimoto, K., Okamura, N., Koike, K., Komatsu, N., Kumakiri, C., Nakazato, M., Watanabe, H., Shinoda, N., Okada, S.-I., et al. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00181-1 · Cited by 1,151 · see citing works
Figurov, A., Pozzo-Miller, L. D., Olafsson, P., Wang, T., & Lu, B. (1996) · Nature · doi:10.1038/381706a0 · Cited by 1,106 · see citing works
Magarin˜os, A. M., & McEwen, B. S. (1995) · Neuroscience · doi:10.1016/0306-4522(95)00259-l · Cited by 863 · see citing works
Antidepressant-like effect of brain-derived neurotrophic factor (BDNF)
Siuciak, J. A., Lewis, D. R., Wiegand, S. J., & Lindsay, R. M. (1997) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(96)00169-4 · Cited by 841 · see citing works
Postmortem studies in mood disorders indicate altered numbers of neurons and glial cells
Rajkowska, G. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)00950-1 · Cited by 822 · see citing works
Postnatal Developmental Profile of Brain-Derived Neurotrophic Factor in Rat Brain and Platelets
Karege, F., Schwald, M., & Cisse, M. (2002) · Neuroscience Letters · doi:10.1016/s0304-3940(02)00529-3 · Cited by 799 · see citing works
Brain-derived Neurotrophic Factor Is Stored in Human Platelets and Released by Agonist Stimulation
Fujimura, H., Chen, R., Nakamura, T., Nakahashi, T., Kambayashi, J.-I., Sun, B., Altar, C., & Tandon, N. (2002) · Thrombosis and Haemostasis · doi:10.1055/s-0037-1613072 · Cited by 777 · see citing works
Identification of a Signaling Pathway Involved in Calcium Regulation of BDNF Expression
Shieh, P. B., Hu, S.-C., Bobb, K., Timmusk, T., & Ghosh, A. (1998) · Neuron · doi:10.1016/s0896-6273(00)81011-9 · Cited by 693 · see citing works
Neuronal plasticity and survival in mood disorders
Duman, R. S., Malberg, J., Nakagawa, S., & D’Sa, C. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)00935-5 · Cited by 652 · see citing works
Hippocampal Changes in Patients With a First Episode of Major Depression
Frodl, T., Meisenzahl, E. M., Zetzsche, T., Born, C., Groll, C., Jäger, M., Leinsinger, G. L., Ronald Bottlender, A., Hahn, K. M., & Möller, H. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.7.1112 · Cited by 525 · see citing works
Antidepressants and neuroplasticity
D'Sa, C. M., & Duman, R. S. (2002) · Bipolar Disorders · doi:10.1034/j.1399-5618.2002.01203.x · Cited by 516 · see citing works
cAMP Response Element-Mediated Gene Transcription Is Upregulated by Chronic Antidepressant Treatment
Thome, J., Sakai, N., Shin, K.-H., Steffen, C., Zhang, Y.-J., Impey, S., Storm, D. R., & Duman, R. S. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-11-04030.2000 · Cited by 507 · see citing works
Physiology of BDNF: focus on hypothalamic function
Tapia‐Arancibia, L. (2004) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2004.04.001 · Cited by 367 · see citing works
Radka, S. F., Hoist, P. A., Fritsche, M., & Altar, C. A. (1996) · Brain Research · doi:10.1016/0006-8993(95)01321-0 · Cited by 348 · see citing works
Berchtold, N. C., Kesslak, J. P., Pike, C. J., Adlard, P. A., & Cotman, C. W. (2001) · European Journal of Neuroscience · doi:10.1046/j.0953-816x.2001.01825.x · Cited by 329 · see citing works
Increased temporal cortex CREB concentrations and antidepressant treatment in major depression
Young, L. T., Dowlatshahi, D. D., MacQUEEN, G. M., & Wang, J. F. (1998) · The Lancet · doi:10.1016/s0140-6736(05)79827-5 · Cited by 306 · see citing works
Immobilization stress reduced the expression of neurotrophins and their receptors in the rat brain
Ueyama, T., Kawai, Y., Nemoto, K., Sekimoto, M., Toné, S., & Senba, E. (1997) · Neuroscience Research · doi:10.1016/s0168-0102(97)00030-8 · Cited by 303 · see citing works
Hippocampal mossy fiber sprouting induced by chronic electroconvulsive seizures
Vaidya, V. A., Siuciak, J. A., Du, F., & Duman, R. S. (1999) · Neuroscience · doi:10.1016/s0306-4522(98)00289-9 · Cited by 276 · see citing works
Dias, B. (2003) · Neuropharmacology · doi:10.1016/s0028-3908(03)00198-9 · Cited by 274 · see citing works
Russo‐Neustadt, A. A., Alejandre, H., Garcia, C., Ivy, A. S., & Chen, M. J. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300514 · Cited by 190 · see citing works
Roseboom, P. H., & Klein, D. C. (1995) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)08563-3 · Cited by 156 · see citing works
The APUD concept and hormone production
Pearse, A. G. E. (1980) · Clinics in Endocrinology and Metabolism · doi:10.1016/s0300-595x(80)80030-2 · Cited by 124 · see citing works
Adrenal Steroid Regulation of Neurotrophic Factor Expression in the Rat Hippocampus
Chao, H. M., Sakai, R. R., Li, Y., & McEwen, B. S. (1998) · Endocrinology · doi:10.1210/endo.139.7.6114 · Cited by 107 · see citing works
Bianchi, M., Moser, C., Lazzarini, C., Vecchiato, E., & Crespi, F. (2002) · Experimental Brain Research · doi:10.1007/s00221-001-0979-3 · Cited by 102 · see citing works
Timmusk, T., Belluardo, N., Persson, H., & METSIS, M. L. (1994) · Neuroscience · doi:10.1016/0306-4522(94)90242-9 · Cited by 95 · see citing works
Markstein, R., Matsumoto, M., Kohler, C., Togashi, H., Yoshioka, M., & Hoyer, D. (1999) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/pl00005375 · Cited by 68 · see citing works
CELLULAR MECHANISMS IN THE VULNERABILITY TO DEPRESSION AND RESPONSE TO ANTIDEPRESSANTS
Shelton, R. C. (2000) · Psychiatric Clinics of North America · doi:10.1016/s0193-953x(05)70193-3 · Cited by 55 · see citing works
Schaaf, M. J. M., Sibug, R. M., Duurland, R., Fluttert, M., Oitzl, M. S., de Kloet, E. R., & Vreugdenhil, E. (1999) · Stress · doi:10.3109/10253899909001121 · Cited by 51 · see citing works
Sofuoǧlu, S., Doğan, P., Köse, K., Eşel, E., Baştürk, M., Oǧuz, H., & Gönül, A. S. (1995) · Psychiatry Research · doi:10.1016/0165-1781(95)02631-2 · Cited by 11 · see citing works
(1999) · The MIT Press eBooks · doi:10.7551/mitpress/4632.003.0011 · Cited by 1 · see citing works
Flagged first, then by citations
1 of the 50 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
da Luz, A. C. D. D. S., Dias, G. P., Bevilaqua, M. C. D. N., Cocks, G. D., Gardino, P. F., Thuret, S., & Nardi, A. E. (2013) · Neuropsychobiology · doi:10.1159/000353269 · Cited by 4,012 · see citing works
A Neurotrophic Model for Stress-Related Mood Disorders
Duman, R. S., & Monteggia, L. M. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.02.013 · Cited by 3,375 · see citing works
Sen, S., Duman, R., & Sanacora, G. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.05.005 · Cited by 1,232 · see citing works
Brunoni, A. R., Lopes, M., & Fregni, F. (2008) · International Journal of Neuropsychopharmacology · doi:10.1017/s1461145708009309 · Cited by 972 · see citing works
Interaction between BDNF and Serotonin: Role in Mood Disorders
Martinowich, K., & Lu, B. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301571 · Cited by 793 · see citing works
Brain-Derived Neurotrophic Factor in Brain Disorders: Focus on Neuroinflammation
Lima Giacobbo, B., Doorduin, J., Klein, H. C., Dierckx, R. A. J. O., Bromberg, E., & de Vries, E. F. J. (2019) · Molecular Neurobiology · doi:10.1007/s12035-018-1283-6 · Cited by 750 · see citing works
Molendijk, M. L., Spinhoven, P., Polak, M., Bus, B. A. A., Penninx, B. W. J. H., & Elzinga, B. M. (2014) · Molecular Psychiatry · doi:10.1038/mp.2013.105 · Cited by 702 · see citing works
Schmidt, H. D., & Duman, R. S. (2007) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e3282ee2aa8 · Cited by 649 · see citing works
Brain-Derived Neurotrophic Factor Signaling in Depression and Antidepressant Action
Castrén, E., & Monteggia, L. M. (2021) · Biological Psychiatry · doi:10.1016/j.biopsych.2021.05.008 · Cited by 540 · see citing works
Functional Biomarkers of Depression: Diagnosis, Treatment, and Pathophysiology
Schmidt, H. D., Shelton, R. C., & Duman, R. S. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.151 · Cited by 477 · see citing works
The Roles of BDNF in the Pathophysiology of Major Depression and in Antidepressant Treatment
Lee, B.-H., & Kim, Y. (2010) · Psychiatry Investigation · doi:10.4306/pi.2010.7.4.231 · Cited by 447 · see citing works
Serum and plasma BDNF levels in major depression: A replication study and meta-analyses
Bocchio-Chiavetto, L., Bagnardi, V., Zanardini, R., Molteni, R., Gabriela Nielsen, M., Placentino, A., Giovannini, C., Rillosi, L., Ventriglia, M., Riva, M. A., et al. (2010) · The World Journal of Biological Psychiatry · doi:10.3109/15622971003611319 · Cited by 435 · see citing works
Goodman, A. (2007) · Biochemical Pharmacology · doi:10.1016/j.bcp.2007.07.030 · Cited by 412 · see citing works
Is it time to reassess the BDNF hypothesis of depression?
Groves, J. O. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4002075 · Cited by 403 · see citing works
Peripheral BDNF Produces Antidepressant-Like Effects in Cellular and Behavioral Models
Schmidt, H. D., & Duman, R. S. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.114 · Cited by 403 · see citing works
Hashimoto, K. (2010) · Psychiatry and Clinical Neurosciences · doi:10.1111/j.1440-1819.2010.02113.x · Cited by 388 · see citing works
Neurobiology of depression: an integrated view of key findings
Maletic, V., Robinson, M., Oakes, T. M. M., Iyengar, S., Ball, S. G., & Russell, J. D. (2007) · International Journal of Clinical Practice · doi:10.1111/j.1742-1241.2007.01602.x · Cited by 387 · see citing works
Brain-derived neurotrophic factor: role in depression and suicide
Dwivedi, Y. (2009) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s5700 · Cited by 355 · see citing works
Decreased plasma BDNF level in depressive patients
Lee, B.-H., Kim, H., Park, S., & Kim, Y. (2006) · Journal of Affective Disorders · doi:10.1016/j.jad.2006.11.005 · Cited by 327 · see citing works
Post, R. M. (2007) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2007.04.003 · Cited by 303 · see citing works
Role of BDNF in bipolar and unipolar disorder: Clinical and theoretical implications
Post, R. M. (2007) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2006.09.009 · Cited by 286 · see citing works
Notaras, M., Hill, R., & van den Buuse, M. (2015) · Molecular Psychiatry · doi:10.1038/mp.2015.27 · Cited by 274 · see citing works
Zoladz, J. A., & Pilc, A. (2010) · PubMed · Cited by 268 · see citing works
The Hippocampus, Neurotrophic Factors and Depression
Masi, G., & Brovedani, P. (2011) · CNS Drugs · doi:10.2165/11595900-000000000-00000 · Cited by 262 · see citing works
Hwang, J., Tsai, S., Hong, C., Yang, C.-H., Lirng, J., & Yang, Y.-M. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.10.013 · Cited by 253 · see citing works
Consensus paper of the WFSBP Task Force on Biological Markers: Biological Markers in Depression
Mößner, R., Mikova, O., Koutsilieri, E., Saoud, M., Ehlis, A., Müller, N., Fallgatter, A. J., & Riederer, P. F. (2007) · The World Journal of Biological Psychiatry · doi:10.1080/15622970701263303 · Cited by 248 · see citing works
Matrisciano, F., Bonaccorso, S., Ricciardi, A., Scaccianoce, S., Panaccione, I., Wang, L. H.-C., Ruberto, A., Tatarelli, R., Nicoletti, F., Girardi, P., et al. (2008) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2008.03.014 · Cited by 252 · see citing works
Brain-derived neurotrophic factor (BDNF) changes in the serum of depressed women
Aydemir, Ç., Yalcın, E., Aksaray, S., Kısa, C., Yildirim, S. G., Uzbay, T. I., & Göka, E. (2006) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2006.03.025 · Cited by 210 · see citing works
Kozisek, M. E., Middlemas, D. S., & Bylund, D. B. (2007) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2007.07.001 · Cited by 206 · see citing works
Alterations of Serum Levels of BDNF-Related miRNAs in Patients with Depression
Li, Y., Xu, M., Zong-hua, G., Wang, Y., Yue, Z., Zhang, Y.-X., Li, X., Zhang, C. M., Xie, S., & Wang, P. (2013) · PLoS ONE · doi:10.1371/journal.pone.0063648 · Cited by 204 · see citing works
Zhou, C., Zhong, J., Zou, B., Fang, L., Chen, J., Deng, X., Zhang, L., Zhao, X., Qu, Z., Lei, Y., et al. (2017) · PLOS ONE · doi:10.1371/journal.pone.0172270 · Cited by 187 · see citing works
Research on the Pathological Mechanism and Drug Treatment Mechanism of Depression
Peng, G.-J., Tian, J., Gao, X., Zhou, Y., & Qin, X. (2015) · Current Neuropharmacology · doi:10.2174/1570159x1304150831120428 · Cited by 189 · see citing works
Association of BDNF Val66Met Polymorphism and Brain BDNF Levels with Major Depression and Suicide
Youssef, M. M., Underwood, M. D., Huang, Y.-Y., Hsiung, S.-C., Liu, Y., Simpson, N. R., Bakalian, M. J., Rosoklija, G. B., Dwork, A. J., Arango, V., et al. (2018) · International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyy008 · Cited by 183 · see citing works
Bocchio‐Chiavetto, L., Zanardini, R., Bortolomasi, M., Abate, M., Segala, M., Giacopuzzi, M., Riva, M. A., Marchina, E., Pasqualetti, P., Pérez, J., et al. (2006) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2006.04.010 · Cited by 180 · see citing works
Yoshimura, R., Mitoma, M., Sugita, A., Hori, H., Okamoto, T., Umene, W., Ueda, N., & Nakamura, J. (2007) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2007.03.001 · Cited by 178 · see citing works
Almeida, R. N. D., Galvão, A. C. D. M., da Silva, F. S., Silva, E. A. D. S., Palhano-Fontes, F., Maia-de-Oliveira, J. P., de Araújo, L.-S. B., Lobão-Soares, B., & Galvão-Coelho, N. L. (2019) · Frontiers in Psychology · doi:10.3389/fpsyg.2019.01234 · Cited by 177 · see citing works
Rahbardar, M. G., & Hosseinzadeh, H. (2020) · PubMed Central · doi:10.22038/ijbms.2020.45269.10541 · Cited by 202 · see citing works
Serum BDNF levels before treatment predict SSRI response in depression
Wolkowitz, O. M., Wolf, J. S., Shelly, W. B., Rosser, R., Burke, H. M., Lerner, G. K., Reus, V. I., Nelson, J. C., Epel, E. S., & Mellon, S. H. (2011) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2011.06.013 · Cited by 174 · see citing works
Huang, T.-L., Lee, C.-T., & Liu, Y.-L. (2008) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2007.05.007 · Cited by 190 · see citing works
The biology of burnout: Causes and consequences
Bayes, A. J., Tavella, G., & Parker, G. B. (2021) · The World Journal of Biological Psychiatry · doi:10.1080/15622975.2021.1907713 · Cited by 191 · see citing works
Low brain‐derived neurotrophic factor (BDNF) levels in serum of Huntington's disease patients
Ciammola, A., Sassone, J., Cannella, M., Calza, S., Poletti, B., Frati, L., Squitieri, F., & Silani, V. (2007) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30501 · Cited by 171 · see citing works
Larsen, M. H., Mikkelsen, J. D., Hay-Schmidt, A., & Sandi, C. (2010) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2010.01.005 · Cited by 165 · see citing works
Monteleone, P., Serritella, C., Martiadis, V., & Maj, M. (2008) · Bipolar Disorders · doi:10.1111/j.1399-5618.2008.00459.x · Cited by 162 · see citing works
Teixeira, A. L., Barbosa, I. G., Diniz, B. S., & Kümmer, A. (2010) · Biomarkers in Medicine · doi:10.2217/bmm.10.111 · Cited by 162 · see citing works
Michael, J. R. (2009) · Frontiers in bioscience · doi:10.2741/3585 · Cited by 163 · see citing works
Hu, Y., & Russek, S. J. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05237.x · Cited by 161 · see citing works
Reduced serum BDNF levels in schizophrenic patients on clozapine or typical antipsychotics
GRILLO, R., Ottoni, G. L., Leke, R., Souza, D. O., Portela, L. V., & Lara, D. R. (2006) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2006.01.005 · Cited by 159 · see citing works
Pattwell, S. S., Bath, K. G., Perez-Castro, R., Lee, F. S., Chao, M. V., & Ninan, I. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.5205-11.2012 · Cited by 156 · see citing works
Neurotrophins and Psychiatric Disorders
Castrén, E. (2014) · Handbook of Experimental Pharmacology · doi:10.1007/978-3-642-45106-5_17 · Cited by 150 · see citing works
Dell’Osso, L., Carmassi, C., Debbio, A. D., Dell’Osso, M. C., Bianchi, C., Pozzo, E. D., Origlia, N., Domenici, L., Massimetti, G., Marazziti, D., et al. (2009) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2009.04.018 · Cited by 148 · see citing works
Zanardini, R., Gazzoli, A., Ventriglia, M., PEREZ, J., Bignotti, S., MARIAROSSINI, P., Gennarelli, M., & Bocchio‐Chiavetto, L. (2006) · Journal of Affective Disorders · doi:10.1016/j.jad.2005.12.029 · Cited by 147 · see citing works
Arosio, B., Guerini, F. R., Voshaar, R. C. O., & Aprahamian, I. (2021) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2021.626906 · Cited by 151 · see citing works
Leyhe, T., Stransky, E., Eschweiler, G. W., Buchkremer, G., & Laske, C. (2007) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-007-0764-9 · Cited by 140 · see citing works
Brain-Derived Neurotrophic Factor in Patients with Huntington's Disease
Zuccato, C., Marullo, M., Vitali, B., Tarditi, A., Mariotti, C., Valenza, M., Lahiri, N., Wild, E. J., Sassone, J., Ciammola, A., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0022966 · Cited by 138 · see citing works
Hughes, C. W., Barnes, S., Barnes, C., DeFina, L. F., Nakonezny, P., & Emslie, G. J. (2013) · Mental Health and Physical Activity · doi:10.1016/j.mhpa.2013.06.006 · Cited by 132 · see citing works
The effect of depression, BDNF gene val66met polymorphism and gender on serum BDNF levels
Ozan, E., Okur, H., Eker, M. C., Eker, Ö. D., Gönül, A. S., & Akarsu, N. A. (2009) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2009.06.022 · Cited by 130 · see citing works
Self-citationBalaratnasingam, S., & Janča, A. (2012) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2012.01.006 · Cited by 131 · see citing works
Hurley, L. L., Akinfiresoye, L. R., Nwulia, E. A., Kamiya, A., Kulkarni, A. A., & Tizabi, Y. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.10.049 · Cited by 127 · see citing works
Unfolding the Role of BDNF as a Biomarker for Treatment of Depression
Rana, T., Behl, T., Sehgal, A., Srivastava, P., & BUNGAU, S. G. (2020) · Journal of Molecular Neuroscience · doi:10.1007/s12031-020-01754-x · Cited by 127 · see citing works
Neurobiology of Major Depressive Disorder
Villanueva, R. (2013) · Neural Plasticity · doi:10.1155/2013/873278 · Cited by 127 · see citing works
Lee, H.-Y., & Kim, Y.-K. (2008) · Neuropsychobiology · doi:10.1159/000149817 · Cited by 132 · see citing works
The molecular pathophysiology of depression and the new therapeutics
Tian, H., Hu, Z., Xu, J., & Wang, C. (2022) · MedComm · doi:10.1002/mco2.156 · Cited by 122 · see citing works
Donato, F., de Gomes, M. G., Goes, A. T. R., Filho, C. B., Fabbro, L. D., Antunes, M. S., Souza, L. C., Boeira, S. P., & Jessé, C. R. (2014) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2014.03.004 · Cited by 121 · see citing works
Piccinni, A., Del Debbio, A., Medda, P., Bianchi, C., Roncaglia, I., Veltri, A., Zanello, S., Massimetti, E., Origlia, N., & Domenici, L. (2009) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2009.01.002 · Cited by 120 · see citing works
Inverse Correlation of Brain and Blood BDNF Levels in a Genetic Rat Model of Depression
Elfving, B., Plougmann, P. H., Müller, H. K., Mathé, A. A., Rosenberg, R., & Wegener, G. (2010) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145709990721 · Cited by 119 · see citing works
Depression: Biological markers and treatment
Erjavec, G. N., Šagud, M., Perković, M. N., Štrac, D. Š., Konjevod, M., Tudor, L., Uzun, S., & Pivac, N. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.110139 · Cited by 120 · see citing works
Pandey, G. N., Dwivedi, Y., Rizavi, H. S., Ren, X., Zhang, H., & Pavuluri, M. N. (2010) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.03.003 · Cited by 118 · see citing works
Carniel, B. P., & da Rocha, N. S. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.110151 · Cited by 116 · see citing works
Bus, B. A. A., Tendolkar, I., Franke, B., Graaf, J. D., den Heijer, M., Buitelaar, J. K., & Voshaar, R. C. O. (2011) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2010.545187 · Cited by 114 · see citing works
Biomarkers for major depressive disorder
Hacımusalar, Y., & Eşel, E. (2017) · Nöro Psikiyatri Arşivi · doi:10.5152/npa.2017.19482 · Cited by 120 · see citing works
Antidepressant therapy in epilepsy: can treating the comorbidities affect the underlying disorder?
Cardamone, L., Salzberg, M., O'Brien, T. J., & Jones, N. C. (2012) · British Journal of Pharmacology · doi:10.1111/bph.12052 · Cited by 110 · see citing works
Reduced platelet BDNF level in patients with major depression
Lee, B.-H., & Kim, Y.-K. (2009) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2009.04.002 · Cited by 109 · see citing works
The effects of serotonin manipulations on emotional information processing and mood
Merens, W., van der Does, W. A. J., & Spinhoven, P. (2007) · Journal of Affective Disorders · doi:10.1016/j.jad.2007.01.032 · Cited by 108 · see citing works
Mitoma, M., Yoshimura, R., Sugita, A., Umene, W., Hori, H., Nakano, H., Ueda, N., & Nakamura, J. (2008) · Progress in Neuro-psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2007.11.011 · Cited by 28 · see citing works
Solati, Z., Jazayeri, S., Tehrani-Doost, M., Mahmoodianfard, S., & Gohari, M. R. (2015) · Nutritional Neuroscience · doi:10.1179/1476830513y.0000000105 · Cited by 104 · see citing works
The Neuroendocrinology of Mood Disorders
Rubín, R. T., & Carroll, B. J. (2009) · Elsevier eBooks · doi:10.1016/b978-008088783-8.00092-9 · Cited by 103 · see citing works
Faster, better, stronger: Towards new antidepressant therapeutic strategies
O’Leary, O. F., Dinan, T. G., & Cryan, J. F. (2014) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2014.07.046 · Cited by 100 · see citing works
Anderson, R. J., Hoy, K. E., Daskalakis, Z. J., & Fitzgerald, P. B. (2016) · Clinical Neurophysiology · doi:10.1016/j.clinph.2016.08.015 · Cited by 96 · see citing works
Sensorimotor modulation of mood and depression: An integrative review
Canbeyli, R. S. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.11.002 · Cited by 98 · see citing works
BDNF Val66met polymorphism, white matter abnormalities and remission of geriatric depression
Alexopoulos, G. S., Glatt, C. E., Hoptman, M. J., Kanellopoulos, D., Murphy, C. F., Kelly, R. E., Morimoto, S. S., Lim, K. O., & Gunning, F. M. (2010) · Journal of Affective Disorders · doi:10.1016/j.jad.2010.02.115 · Cited by 97 · see citing works
Okamoto, T., Yoshimura, R., Ikenouchi, A., Hori, H., Umene‐Nakano, W., Inoue, Y., Ueda, N., & Nakamura, J. (2008) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2008.02.009 · Cited by 96 · see citing works
Gorgulu, Y., & Çalıyurt, O. (2009) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2009.06.016 · Cited by 101 · see citing works
Pandey, G. N., Rizavi, H. S., Dwivedi, Y., & Pavuluri, M. N. (2008) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/chi.0b013e31817eecd9 · Cited by 93 · see citing works
Ludka, F. K., Zomkowski, A. D. E., Cunha, M. P., Dal-Cim, T., Zeni, A. L. B., Rodrigues, A. L. S., & Tasca, C. I. (2013) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2012.05.005 · Cited by 92 · see citing works
Magnetic resonance imaging and prediction of outcome in patients with major depressive disorder
MacQUEEN, G. M. (2009) · Journal of Psychiatry and Neuroscience · doi:10.1139/jpn.0945 · Cited by 92 · see citing works
Donoso, F., Egerton, S., Bastiaanssen, T. F. S., Fitzgerald, P., Gite, S., Fouhy, F., Ross, R. P., Stanton, C., Dinan, T. G., & Cryan, J. F. (2020) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2020.104673 · Cited by 92 · see citing works
Dias, V. V., Brissos, S., Frey, B. N., Andreazza, A. C., Cardoso, C., & Kapczinski, F. P. (2009) · Bipolar Disorders · doi:10.1111/j.1399-5618.2009.00733.x · Cited by 92 · see citing works
Positive therapeutic and neurotropic effects of yoga in depression: A comparative study
Thirthalli, J., Naveen, G., Rao, M., Varambally, S. S., Christopher, R., & Gangadhar, B. N. (2013) · Indian Journal of Psychiatry · doi:10.4103/0019-5545.116313 · Cited by 93 · see citing works
Genetic association study of BDNF in depression: Finding from two cohort studies and a meta‐analysis
Chen, L., Lawlor, D. A., Lewis, S. J., Yuan, W., Abdollahi, M. R., Timpson, N. J., Day, I. N. M., Ebrahim, S. B. J., Smith, G. D., & Shugart, Y. Y. (2008) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30686 · Cited by 90 · see citing works
Pilar-Cuéllar, F., Vidal, R., Díaz, Á., Castro, E., dos Anjos, S., Pascual-Brazo, J., Linge, R., Vargas, V., Blanco, H., Martínez-Villayandre, B., et al. (2013) · Journal of Neural Transplantation and Plasticity · doi:10.1155/2013/537265 · Cited by 93 · see citing works
Drzyzga, Ł., Marcinowska, A., & Obuchowicz, E. (2009) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2009.03.009 · Cited by 92 · see citing works
Mosiołek, A., Mosiołek, J., Jakima, S., Pięta, A., & Szulc, A. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10153377 · Cited by 87 · see citing works
Brain-derived neurotrophic factor, stress and depression: A minireview
Yuluğ, B., Ozan, E., Gönül, A. S., & Kılıç, E. (2008) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2008.12.002 · Cited by 89 · see citing works
Nin, M. S. (2011) · Frontiers in Endocrinology · doi:10.3389/fendo.2011.00073 · Cited by 86 · see citing works
Iga, J., Ueno, S., Yamauchi, K., Numata, S., Tayoshi‐Shibuya, S., Kinouchi, S., Nakataki, M., Song, H., Hokoishi, K., Tanabe, H., et al. (2007) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30520 · Cited by 87 · see citing works
Multifunctional aspects of allopregnanolone in stress and related disorders
Bali, A., & Jaggi, A. S. (2013) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2013.09.005 · Cited by 87 · see citing works
Neuropeptides in depression: Role of VGF
Thakker‐Varia, S., & Alder, J. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.10.006 · Cited by 86 · see citing works
Involvement of Brain-Derived Neurotrophic Factor in Late-Life Depression
Dwivedi, Y. (2013) · The American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2012.10.026 · Cited by 86 · see citing works
Gratacòs, M., Soria, V., Urretavizcaya, M., González, J. R., Crespo, J. M., Bayés, M., de Cid, R., Menchón, J. M., Vallejo, J., & Estivill, X. (2007) · The Pharmacogenomics Journal · doi:10.1038/sj.tpj.6500460 · Cited by 85 · see citing works
Sheldrick, A. J., Camara, S., Ilieva, M. S., Riederer, P., & Michel, T. M. (2017) · European Psychiatry · doi:10.1016/j.eurpsy.2017.06.009 · Cited by 85 · see citing works
- Authors
- Gonul, A. S., Akdeniz, F., Taneli, F., Donat, O., Eker, Ç., & Vahip, S.
- Affiliations
- Ege University (TR)
- Manisa Celal Bayar University (TR)
- ORCID
- Venue
- European Archives of Psychiatry and Clinical Neuroscience
- Published
- 2005-04-06
- Volume
- 255
- Issue
- 6
- Pages
- 381-386
- ISSN
- 0003-9373 (ISSN-L)
- 0940-1334
- 1433-8491
- OpenAlex
- W2055040288
- Cited by
- 375
- References
- 50
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 9 · 2023: 12 · 2022: 13 · 2021: 10 · 2020: 14 · 2019: 12 · 2018: 16 · 2017: 11 · 2016: 16 · 2015: 23 · 2014: 18 · 2013: 29 · 2012: 25
- FWCI
- 15.10
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- European Archives of Psychiatry and Clinical Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ege Üniversitesi
- Topics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Keywords
- brain-derived neurotrophic factor, serum BDNF, major depressive disorder, antidepressant response, depression pathophysiology, neuroplasticity, treatment response biomarkers, depression severity
- MeSH terms
- Adult, Antidepressive Agents, Depressive Disorder, Major, Major Depressive Disorder, Enzyme-Linked Immunosorbent Assay, Female, Follow-Up Studies, Humans, Male, Middle Aged, Psychiatric Status Rating Scales, Brain-Derived Neurotrophic Factor
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
