CoChat
Sign Up
Cited by 135Neurogenesis and neuroplasticity mechanismsMemory and Neural MechanismsNeuroscience and Neuropharmacology Research

Exercise modulates insulin-like growth factor 1-dependent and -independent effects on adult hippocampal neurogenesis and behaviour.

LLorens-Martín, María, Torres-Alemán, Ignacio, Trejo, José Luis·2010·Molecular and Cellular Neuroscience
DOI 10.1016/j.mcn.2010.02.006
Open this paper in CoChat — free account

Abstract

While physical exercise clearly has beneficial effects on the brain, fomenting neuroprotection as well as promoting neural plasticity and behavioural modifications, the cellular and molecular mechanisms mediating these effects are not yet fully understood. We have analyzed sedentary and exercised animals to examine the effects of activity on behaviour (spatial memory and anxiety--as measured by a fear/exploration conflict test), as well as on adult hippocampal neurogenesis (a well-known form of neural plasticity). We have found that the difference in activity between sedentary and exercised animals induced a decrease in the fear/exploration conflict scores (a measure usually accepted as an anxiolytic effect), while no changes are evident in terms of spatial memory learning. The short-term anxiolytic-like effect of exercise was IGF1-dependent and indeed, the recall of hippocampus-dependent spatial memory is impaired by blocking serum IGF1 (as observed by measuring serum IGF levels in the same animals used to analyze the behaviour), irrespective of the activity undertaken by the animals. On the other hand, activity affected neurogenesis as reflected by counting the numbers of several cell populations, while the dependence of this effect on IGF1 varied according to the differentiation state of the new neurons. Hence, while proliferating precursors and postmitotic immature neurons (measured by means of doublecortin and calretinin) are influenced by serum IGF1 levels in both sedentary and exercised animals, premitotic immature neurons (an intermediate stage) respond to exercise independently of serum IGF1. Therefore, we conclude that physical exercise has both serum IGF1-independent and -dependent effects on neural plasticity. Furthermore, several effects mediated by serum IGF1 are induced by physical activity while others are not (both in terms of behaviour and neural plasticity). These findings help to delimit the role of serum IGF1 as a mediator of the effects of exercise, as well as to extend the role of serum IGF1 in the brain in basal conditions. Moreover, these data reveal the complexity of the interaction between neurogenesis, behaviour, and IGF1 under different levels of physical activity.

Integrity signals

Registry

Crossref · 10.1016/j.mcn.2010.02.006

Cites

58 of 58 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
LLorens-Martín, M., Torres-Alemán, I., & Trejo, J. L.
Venue
Molecular and Cellular Neuroscience
Publisher
Elsevier BV
Published
2010-06
Volume
44
Issue
2
Pages
109-117
ISSN
1044-7431 (ISSN-L)
DOI
10.1016/j.mcn.2010.02.006
OpenAlex
W2012267125
Cited by
135
References
58
Citations by year
2026: 2 · 2025: 7 · 2024: 8 · 2023: 8 · 2022: 9 · 2021: 6 · 2020: 8 · 2019: 5 · 2018: 6 · 2017: 3 · 2016: 13 · 2015: 9 · 2014: 12 · 2013: 9 · 2012: 13
FWCI
3.95
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Molecular and Cellular Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
  • DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
Topics
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
physical activity, insulin-like growth factor I, adult hippocampal neurogenesis, spatial memory, anxiety-like behavior, neuroplasticity, immature neurons, doublecortin, calretinin, sedentary behavior, anxiolytic effects
MeSH terms
Doublecortin Domain Proteins, Animals, Anxiety, Exploratory Behavior, Fear, Hippocampus, Insulin-Like Growth Factor I, Male, Memory, Mice, Inbred C57BL, Microtubule-Associated Proteins, Neuronal Plasticity, Neurons, Neuropeptides, Physical Conditioning, Animal, Stem Cells, Biomarkers, Antibodies, Blocking, Mice, Neurogenesis

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review