The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Members of several gene families influence survival of rat motoneurons in vitro and in vivo
Open accessAbstract
The survival and functional maintenance of spinal motoneurons, both during the period of developmental cell death and in adulthood, have been shown to be dependent on trophic factors. In vitro experiments have previously been used to identify several survival factors for motoneurons, including CNTF, LIF, and members of the neurotrophin, FGF, and IGF gene families. Some of these factors have also been shown to be active in vivo, either on chick motoneurons during embryonic development or on lesioned facial and spinal motoneurons of the newborn rat. Here we demonstrate that lesioned newborn rat facial motoneurons can be rescued by NT‐4/5, IGF‐I and LIF. Furthermore, in contrast to chick motoneurons, the survival of isolated embryonic rat motoneurons can be maintained by the neurotrophins BDNF, NT‐3, and NT‐4/5. IGF‐I and FGF‐5 were also active in this system, each supporting more than 50% of the originally plated neurons. The responsiveness of motoneurons to multiple factors in vitro and in vivo suggests that motoneuron survival and function are regulated by the coordinated actions of members of different gene families. © 1993 Wiley‐Liss, Inc.
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Cites
Trophic factors and neuronal survival
Barde, Y.-A. (1989) · Neuron · doi:10.1016/0896-6273(89)90040-8 · Cited by 1,625
Cell death and control of cell survival in the oligodendrocyte lineage
Barres, B. A., Hart, I. K., Coles, H. S. R., Burne, J. F., Voyvodic, J. T., Richardson, W. D., & Raff, M. C. (1992) · Cell · doi:10.1016/0092-8674(92)90531-g · Cited by 1,345
Neurotrophin-3: a Neurotrophic Factor Related to NGF and BDNF
Maisonpierre, P. C., Belluscio, L., Squinto, S., Ip, N. Y., Furth, M. E., Lindsay, R. M., & Yancopoulos, G. D. (1990) · Science · doi:10.1126/science.2321006 · Cited by 1,322
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Multiple extracellular signals are required for long-term oligodendrocyte survival
Barres, B. A., Schmid, R., Sendnter, M., & Raff, M. C. (1993) · Development · doi:10.1242/dev.118.1.283 · Cited by 712
Cited by
Peripheral Infusion of IGF-I Selectively Induces Neurogenesis in the Adult Rat Hippocampus
Åberg, M. A. I., Åberg, N. D., Hedbäcker, H., Oscarsson, J., & Eriksson, P. S. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-08-02896.2000 · Cited by 852
Beck, K. D., Powell-Braxtont, L., Widmer, H.-R., Valverde, J., & Hefti, F. (1995) · Neuron · doi:10.1016/0896-6273(95)90216-3 · Cited by 636
O'Kusky, J. R., Ye, P., & D'Ercole, A. J. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-22-08435.2000 · Cited by 358
Liu, M.-L., Zang, T., Zou, Y., Chang, J. C., Gibson, J. R., Huber, K. M., & Zhang, C.-L. (2013) · Nature Communications · doi:10.1038/ncomms3183 · Cited by 343
Arsenijevic, Y., & Weiss, S. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-06-02118.1998 · Cited by 243
“IGF-I and BDN F recently have been demonstrated to have important neurotrophic actions in both motor neuron and striatal neurons (Hughes et al., 1993; Neff et al., 1993; Li et al., 1994; Ventimiglia et al., 1995; Nakao et al., 1996).”
BackgroundMethodInfluential
Metadata
- Authors
- Hughes, R. A., Sendtner, M., & Thoenen, H.
- Venue
- Journal of Neuroscience Research
- Publisher
- Wiley
- Published
- 1993-12-15
- Volume
- 36
- Issue
- 6
- Pages
- 663-671
- ISSN
- 0360-4012 (ISSN-L)
- 1097-4547
- OpenAlex
- W2095454466
- Cited by
- 273
- References
- 6
- FWCI
- 7.00
- Type
- journal article
- Language
- en
- Open access
- green
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