The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Proposal for the regulatory mechanism of Wolff's law
Open accessAbstract
It is currently believed that the trabecular structure in bone is the result of a dynamic remodeling process controlled by mechanical loads. We propose a regulatory mechanism based on the hypothesis that osteocytes located within the bone sense mechanical signals and that these cells mediate osteoclasts and osteoblasts in their vicinity to adapt bone mass. A computer‐simulation model based on these assumptions was used to investigate if the adaptation of bone, in the sense of Wolff's law, and remodeling phenomena, as observed in reality, can be explained by such a local control process. The model produced structures resembling actual trabecular architectures. The architecture transformed after the external loads were changed, aligning the trabeculae with the actual principal stress orientation, in accordance with Wolff's trajectorial hypothesis. As in reality, the relative apparent density of the structure depended on the magnitude of the applied stresses. Osteocyte density influenced the remodeling rate, which also is consistent with experimental findings. Furthermore, the results indicated that the domain of influence of the osteocytes affects the refinement of the structure as represented by separation and thickness of the struts. We concluded that the trabecular adaptation to mechanical load, as described by Wolff, can be explained by a relatively simple regulatory model. The model is useful for investigating the effects of physiological parameters on the development, maintenance, and adaptation of bone.
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Parfitt, A. M., Drezner, M. K., Glorieux, F. H., Kanis, J. A., Malluche, H., Meunier, P. J., Ott, S. M., & Recker, R. R. (1987) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650020617 · Cited by 5,016
Parfitt, A. M., Mathews, C. H., Villanueva, A. R., Kleerekoper, M., Frame, B., & Rao, D. S. (1983) · Journal of Clinical Investigation · doi:10.1172/jci111096 · Cited by 1,545
Young's modulus of trabecular and cortical bone material: Ultrasonic and microtensile measurements
Rho, J. Y., Ashman, R. B., & Turner, C. H. (1993) · Journal of Biomechanics · doi:10.1016/0021-9290(93)90042-d · Cited by 1,283
A model for the excitation of osteocytes by mechanical loading-induced bone fluid shear stresses
Weinbaum, S., Cowin, S. C., & Zeng, Y. (1994) · Journal of Biomechanics · doi:10.1016/0021-9290(94)90010-8 · Cited by 1,277
Adaptive bone-remodeling theory applied to prosthetic-design analysis
Huiskes, R., Weinans, H., Grootenboer, H. J., Dalstra, M., Fudala, B., & Slooff, T. J. (1987) · Journal of Biomechanics · doi:10.1016/0021-9290(87)90030-3 · Cited by 1,173
Self-citationvan Rietbergen, B., Weinans, H., Huiskes, R., & Odgaard, A. (1995) · Journal of Biomechanics · doi:10.1016/0021-9290(95)80008-5 · Cited by 865
Self-citationWolff, J. (1986) · Springer eBooks · doi:10.1007/978-3-642-71031-5 · Cited by 802
The effect of porosity and mineral content on the Young's modulus of elasticity of compact bone
Currey, J. D. (1988) · Journal of Biomechanics · doi:10.1016/0021-9290(88)90006-1 · Cited by 799
Sensitivity of osteocytes to biomechanical stress in vitro
Klein‐Nulend, J., Van Der Plas, A., Semeins, C. M., Ajubi, N. E., Erangos, J. A., Nijweide, P. J., & Burger, E. H. (1995) · The FASEB Journal · doi:10.1096/fasebj.9.5.7896017 · Cited by 783
Bone remodeling I: theory of adaptive elasticity
Cowin, S. C., & Hegedus, D. H. (1976) · Journal of Elasticity · doi:10.1007/bf00041724 · Cited by 665
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Fritton, S. P., J. McLeod, K., & Rubin, C. T. (2000) · Journal of Biomechanics · doi:10.1016/s0021-9290(99)00210-9 · Cited by 401
A theoretical framework for strain-related trabecular bone maintenance and adaptation
Ruimerman, R., Hilbers, P., van Rietbergen, B., & Huiskes, R. (2005) · Journal of Biomechanics · doi:10.1016/j.jbiomech.2004.03.037 · Cited by 300
Self-citationOsteocyte density changes in aging and osteoporosis
Mullender, M. G., van der Meer, D. D., Huiskes, R., & Lips, P. (1996) · Bone · doi:10.1016/8756-3282(95)00444-0 · Cited by 265
Self-citationFinite element models in tissue mechanics and orthopaedic implant design
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Metadata
- Authors
- Mullender, M. G., & Huiskes, R.
- Venue
- Journal of Orthopaedic Research
- Publisher
- Wiley
- Published
- 1995-07
- Volume
- 13
- Issue
- 4
- Pages
- 503-512
- ISSN
- 0736-0266 (ISSN-L)
- 1554-527X
- OpenAlex
- W2134162450
- Cited by
- 408
- References
- 38
- FWCI
- 6.53
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
