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Cited by 865Bone health and osteoporosis researchElasticity and Material ModelingComposite Material Mechanics

A new method to determine trabecular bone elastic properties and loading using micromechanical finite-element models

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van Rietbergen, B., Weinans, H., Huiskes, R., Odgaard, A.·1995·Journal of Biomechanics
DOI 10.1016/0021-9290(95)80008-5
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Abstract

The apparent mechanical behavior of trabecular bone depends on properties at the tissue or trabecular level. Many investigators have attempted to determine trabecular tissue properties and loading. However, accuracy and applicability of all methods reported are limited. The small size of the trabeculae and a possible size effect are complicating factors when using traditional testing methods on single trabeculae. Other methods reported, using models that describe the trabecular structure, are of limited value because they consider bone as a repetitive structure in order to describe a reasonably large region of bone. The present study introduces a new finite-element method strategy that enables analysis of reasonably large regions of trabecular bone in full detail. The method uses three-dimensional serial reconstruction techniques to construct a large-scale FE model, by directly converting voxels to elements. A 5 mm cube of trabecular bone was modeled in this way, resulting in a FE model that consists of 296,679 elements. Special strategies were developed to solve the set of equations that results from the FE approach. Using this model in combination with experimental apparent data taken from the literature, the upper and lower boundaries for the tissue modulus were calculated to be 10.1 and 2.23 GPa, respectively. From the local stress and strain distributions it was concluded that the deformation mode of the trabeculae in the present cube was predominantly in bending. It was concluded that the method developed offers new perspectives for the study of trabecular bone.

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  • Micro-FE models, which are FE models built directly from μCT scans of trabecular bone, have become a standard tool in the study of trabecular bone mechanics.

    “In parallel, so-called micro-FE models, which are FE models built directly from μCT scans of trabecular bone (132), have become a standard tool in the study of trabecular bone mechanics.”

    From Bone Mechanical Properties in Healthy and Diseased States (2018) · cites this paper as [132]

    The Introduction describes micro-CT as one way to image trabecular structure, and the paper describes constructing FE models directly from voxel data. But its own model used digitized serial sections rather than μCT scans, so it supports the voxel-to-FE description, not the claim that this model was built directly from μCT scans. The citation is attached to that description, not to the separate statement that micro-FE models have become a standard tool. (LLM, conf=0.86)

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Cites

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Research works printed but not linked: 5

  1. Edidin, A. A., Dawson, J. M., Zhu, M. and Chinchalkar, S. (1993) Direct estimation of the modulus of cancellous bone using a variable-stiffness FE model. Trans. 39th A. Meeting Örthop. Res. Soc., p. 589.
  2. (1992) Direct three-dimensional finite element analysis of human vertebral cancellous bone. Trans. 38th A. Meeting
  3. Fyhrie, D. P. and Hamid, M. S. (1993) The probability distribution of trabecular level strains for vertebral cancellous bone. Trans. 39th A. Meeting Orthop. Res. Soc., p. 175. Fyhrie, D. P., Hamid, M. S., Kuo, R. F. and Lang, S. M.
  4. Hollister, S. J. and Kikuchi, N. (1992) Direct analysis of trabecular bone stiffness and tissue level mechanics using an element-by-element homogenization method. Trans. 38th A. Meeting Orthop. Res. Soc., p. 559.
  5. Jacobs, C. R., Mandell, J. A. and Beauprè, G. S. (1993) A comparative study of automatic finite element mesh generation techniques in orthopaedic biomechanics. Bioengng Conf. ASME, BED-24, 512–514.

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Authors
van Rietbergen, B., Weinans, H., Huiskes, R., & Odgaard, A.
Affiliations
  • Radboud University Nijmegen (NL)
  • Aarhus University (DK)
Corresponding author
Huiskes, R.
ORCID
Venue
Journal of Biomechanics
Publisher
Elsevier BV
Published
1995-01
Volume
28
Issue
1
Pages
69-81
ISSN
0021-9290 (ISSN-L)
DOI
10.1016/0021-9290(95)80008-5
OpenAlex
W2128569032
Cited by
865
References
25
Citations by year
2026: 11 · 2025: 10 · 2024: 16 · 2023: 16 · 2022: 10 · 2021: 24 · 2020: 28 · 2019: 25 · 2018: 37 · 2017: 37 · 2016: 32 · 2015: 30 · 2014: 47 · 2013: 44 · 2012: 41
FWCI
15.29
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Biomechanics (publishedVersion)
  • PubMed (publishedVersion)
  • TU/e Research Portal (submittedVersion, other-oa)
  • TU/e Research Portal (submittedVersion)
  • RePub (Erasmus University Rotterdam) (submittedVersion, other-oa)
  • Radboud Repository (Radboud University) (submittedVersion)
  • RePub (Erasmus University Rotterdam) (submittedVersion)
  • Radboud Repository (Radboud University) (submittedVersion, other-oa)
Funders
  • Gigtforeningen
  • Orthopaedic Research Society
  • Nederlandse Organisatie voor Wetenschappelijk Onderzoek
Topics
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
  • Physical Sciences › Engineering › Biomedical Engineering › Elasticity and Material Modeling
  • Physical Sciences › Engineering › Mechanics of Materials › Composite Material Mechanics
Keywords
trabecular bone, bone elastic properties, micromechanical finite element model, bending deformation, size effect
MeSH terms
Algorithms, Bone and Bones, Computer Simulation, Elasticity, Humans, Image Processing, Computer-Assisted, Models, Biological, Signal Processing, Computer-Assisted, Stress, Mechanical, Tibia, Reproducibility of Results

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