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Cited by 265Bone health and osteoporosis researchBone Metabolism and DiseasesAlkaline Phosphatase Research Studies

Osteocyte density changes in aging and osteoporosis

Open access
Mullender, M.G., van der Meer, D.D., Huiskes, R., Lips, P.·1996·Bone
DOI 10.1016/8756-3282(95)00444-0
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Abstract

Recently, it was suggested that osteocytes are involved in the regulation of bone remodeling. We have examined human trabecular bone of the iliac crest of fracture patients and control subjects to determine if osteoporosis is associated with changes in osteocyte density or osteocyte death. The relationships of these parameters with age was also investigated. It was found that osteocyte death was not related to age, nor was it increased in osteoporosis compared with the controls. In healthy adults ranging from 30 to 91 years, lacunar number per bone area decreases with advancing age, from about 210/mm(2) to 150/mm(2). Significantly higher lacunar and osteocyte numbers per bone tissue volume were found in osteoporotics than in controls (17,100 lacunae/mm(3) and 13,300 osteocytes/mm(3) vs. 12,900 lacunae/mm(3) and 10,500 osteocytes/mm(3), respectively), whereas lacunar area was significantly reduced in osteoporotics (from 44.1 mu m(3) to 39.1 mu m(2)). These findings are compatible with the hypothesis that, in osteoporosis, osteoblasts produce less bone per cell. This can in turn explain the reduced wall thickness, which has previously been described as characteristic for osteoporosis.

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  • Osteocyte surface is 400-fold larger than that of all Haversian and Volkmann systems and more than 100-fold larger than the trabecular bone surface.

    “It has been estimated that osteocyte surface is 400-fold larger than that of the all Haversian and Volkmann systems and more than 100-fold larger than the trabecular bone surface [67, 68].”

    From Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells (2015) · cites this paper as [68]

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Research works printed but not linked: 1

  1. Eriksen, E. F. and Kassem, M. The cellular basis of bone remodeling. Triangle, Sandoz Journal of Medical Science 31:45-57; 1992.

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Authors
Mullender, M. G., van der Meer, D. D., Huiskes, R., & Lips, P.
Affiliations
  • Radboud University Nijmegen (NL)
  • Vrije Universiteit Amsterdam (NL)
Corresponding author
Huiskes, R.
ORCID
Venue
Bone
Publisher
Elsevier BV
Published
1996-02
Volume
18
Issue
2
Pages
109-113
ISSN
  • 1873-2763 (ISSN-L)
  • 8756-3282
DOI
10.1016/8756-3282(95)00444-0
OpenAlex
W2144447510
Cited by
265
References
34
Citations by year
2026: 9 · 2025: 9 · 2024: 7 · 2023: 10 · 2022: 11 · 2021: 9 · 2020: 6 · 2019: 11 · 2018: 12 · 2017: 5 · 2016: 13 · 2015: 16 · 2014: 12 · 2013: 15 · 2012: 15
FWCI
5.38
Type
journal article
Language
en
Open access
Licence
Locations
  • Bone (publishedVersion)
  • PubMed (publishedVersion)
  • Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
  • TU/e Research Portal (submittedVersion, other-oa)
  • TU/e Research Portal (submittedVersion)
  • Pure Amsterdam UMC (submittedVersion)
  • Radboud Repository (Radboud University) (submittedVersion)
  • Radboud Repository (Radboud University) (submittedVersion, other-oa)
  • Data Archiving and Networked Services (DANS) (submittedVersion)
Funders
  • Procter and Gamble
  • Nederlandse Organisatie voor Wetenschappelijk Onderzoek
Topics
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Alkaline Phosphatase Research Studies
Keywords
osteocytes, osteocyte density, osteoporosis, aging, trabecular bone, osteocyte death, bone remodeling, iliac crest bone
MeSH terms
Adult, Aged, Aging, Cell Count, Female, Humans, Male, Middle Aged, Osteocytes, Osteoporosis, Reproducibility of Results

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