The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Biomechanical consequences of an isolated overload on the human vertebral body
Abstract
The biomechanical consequences of an isolated overload to the vertebral body may play a role in the etiology of vertebral fracture. In this context, we quantified residual strains and reductions in stiffness and ultimate load when vertebral bodies were loaded to various levels beyond the elastic regimen and related these properties to the externally applied strain and bone density. Twenty‐three vertebral bodies (T11‐L4, from 23 cadavers aged 20–90 years) were loaded once in compression to a randomized nominal strain level between 0.37 and 4.5%, unloaded, and then reloaded to 10% strain. Residual strains of up to 1.36% developed on unloading and depended on the applied strain (r 2 = 0.85) but not on density (p = 0.25). Percentage reductions in stiffness and ultimate load of up to 83.7 and 52.5%, respectively, depended on both applied strain (r 2 = 0.90 and r 2 = 0.32, respectively) and density (r 2 = 0.23 and r 2 = 0.22, respectively). Development of residual strains is indicative of permanent deformations, whereas percentage reductions in stiffness are direct measures of effective mechanical damage. These results therefore demonstrate that substantial mechanical damage—which is not visible from radiographs—can develop in the vertebral body after isolated overloads, as well as subtle but significant permanent deformations. This behavior is similar to that observed previously for cylindrical cores of trabecular bone. Taken together, these findings indicate that the damage behavior of the lumbar and lower thoracic vertebral body is dominated by the trabecular bone and may be an important factor in the etiology of vertebral fracture.
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“These effects occur in trabecular samples and in the entire vertebral body (81)”
From Bone Mechanical Properties in Healthy and Diseased States (2018) · cites this paper as [81]
Citations
Cites
EPIDEMIOLOGY OF VERTEBRAL FRACTURES IN WOMEN
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In vivo measurement of human tibial strains during vigorous activity
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Epidemiology of Vertebral Fractures
Schousboe, J. T. (2015) · Journal of Clinical Densitometry · doi:10.1016/j.jocd.2015.08.004 · Cited by 459
Prediction of vertebral body compressive fracture using quantitative computed tomography.
McBroom, R., Hayes, W. C., Edwards, W. T., Goldberg, R. P., & White, A. A. (1985) · Journal of Bone and Joint Surgery · doi:10.2106/00004623-198567080-00010 · Cited by 430
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The Bone Mineral Content and Ultimate Compressive Strength of Lumbar Vertebrae
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Research works printed but not linked: 1
- KopperdahlDL:Structural Consequences of Damage on the Mechanical Behavior of the Human Vertebral Body[Ph.D.dissertation]. Department of Mechanical Engineering Berkeley California University of California Berkeley 1998
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Bone Mechanical Properties in Healthy and Diseased States
Morgan, E. F., Unnikrisnan, G. U., & Hussein, A. I. (2018) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-062117-121139 · Cited by 1,026
“These effects occur in trabecular samples and in the entire vertebral body (81), indicating that isolated overloads that do not cause overt fracture of the bone may cause subtle but cumulative permanent deformations that could lead to clinical fractures.”
Biomechanics of Trabecular Bone
Keaveny, T. M., Morgan, E. F., Niebur, G. L., & Yeh, O. C. (2001) · Annual Review of Biomedical Engineering · doi:10.1146/annurev.bioeng.3.1.307 · Cited by 807
“Such behavior has also been found for bovine bone (93, 94) and for the entire vertebral body (95) and appears therefore to be independent of density, anatomic site, and even species.”
Self-citationBiomechanics and Mechanobiology of Trabecular Bone: A Review
Oftadeh, R., Perez‐Viloria, M., Villa‐Camacho, J. C., Vaziri, A., & Nazarian, A. (2014) · Journal of Biomechanical Engineering · doi:10.1115/1.4029176 · Cited by 616
Crawford, R. P., Cann, C. E., & Keaveny, T. M. (2003) · Bone · doi:10.1016/s8756-3282(03)00210-2 · Cited by 549
“15 mm/s between the platens of a screw-driven load frame (Model 5583, Instron Corporation, Canton, MA) to failure [26].”
BackgroundMethodSelf-citationEffects of Bone Cement Volume and Distribution on Vertebral Stiffness After Vertebroplasty
Liebschner, M. A. K., Rosenberg, W. S., & Keaveny, T. M. (2001) · Spine · doi:10.1097/00007632-200107150-00009 · Cited by 470
“An upper limit for EZZ of 1 GPa was used for the trabecular bone.(21) The elastic–plastic material definitions for the trabecular bone elements were derived using 8 points along a normalized (stress divided by modulus) stress–strain curve measured empirically for 40 cylindriFigure 1.”
BackgroundMethodSelf-citation
Metadata
- Authors
- Kopperdahl, D. L., Pearlman, J. L., & Keaveny, T. M.
- Affiliations
- University of California, Berkeley (US)
- University of California, San Francisco (US)
- Corresponding author
- Keaveny, Tony M.
- Venue
- Journal of Orthopaedic Research
- Publisher
- Wiley
- Published
- 2000-09
- Volume
- 18
- Issue
- 5
- Pages
- 685-690
- ISSN
- 0736-0266 (ISSN-L)
- 1554-527X
- OpenAlex
- W2087738478
- Cited by
- 120
- References
- 21
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 1 · 2023: 1 · 2022: 4 · 2021: 3 · 2020: 6 · 2019: 1 · 2018: 3 · 2017: 8 · 2016: 5 · 2015: 3 · 2014: 5 · 2013: 10 · 2012: 5
- FWCI
- 3.69
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Orthopaedic Research® (publishedVersion)
- PubMed (publishedVersion)
- D-Scholarship@Pitt (University of Pittsburgh) (acceptedVersion)
- Funders
- Stryker
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR41481)
- Topics
- Health Sciences › Medicine › Surgery › Spinal Fractures and Fixation Techniques
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Spine and Intervertebral Disc Pathology
- Keywords
- vertebral body, residual strain, bone stiffness, ultimate load, bone mineral density, trabecular bone, mechanical damage, compressive loading, permanent deformation, lumbar vertebrae, thoracic vertebrae
- MeSH terms
- Adult, Aged, Aged, 80 and over, Cadaver, Humans, Lumbar Vertebrae, Middle Aged, Random Allocation, Stress, Mechanical, Thoracic Vertebrae, Tomography, X-Ray Computed, Bone Density, Weight-Bearing, Pliability, Compressive Strength
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