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Biomechanical consequences of an isolated overload on the human vertebral body
Abstract
The biomechanical consequences of an isolated overload to the vertebral body may play a role in the etiology of vertebral fracture. In this context, we quantified residual strains and reductions in stiffness and ultimate load when vertebral bodies were loaded to various levels beyond the elastic regimen and related these properties to the externally applied strain and bone density. Twenty‐three vertebral bodies (T11‐L4, from 23 cadavers aged 20–90 years) were loaded once in compression to a randomized nominal strain level between 0.37 and 4.5%, unloaded, and then reloaded to 10% strain. Residual strains of up to 1.36% developed on unloading and depended on the applied strain (r 2 = 0.85) but not on density (p = 0.25). Percentage reductions in stiffness and ultimate load of up to 83.7 and 52.5%, respectively, depended on both applied strain (r 2 = 0.90 and r 2 = 0.32, respectively) and density (r 2 = 0.23 and r 2 = 0.22, respectively). Development of residual strains is indicative of permanent deformations, whereas percentage reductions in stiffness are direct measures of effective mechanical damage. These results therefore demonstrate that substantial mechanical damage—which is not visible from radiographs—can develop in the vertebral body after isolated overloads, as well as subtle but significant permanent deformations. This behavior is similar to that observed previously for cylindrical cores of trabecular bone. Taken together, these findings indicate that the damage behavior of the lumbar and lower thoracic vertebral body is dominated by the trabecular bone and may be an important factor in the etiology of vertebral fracture.
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“These effects occur in trabecular samples and in the entire vertebral body (81)”
From Bone Mechanical Properties in Healthy and Diseased States (2018) · cites this paper as [81]
Citations
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Research works printed but not linked: 1
- KopperdahlDL:Structural Consequences of Damage on the Mechanical Behavior of the Human Vertebral Body[Ph.D.dissertation]. Department of Mechanical Engineering Berkeley California University of California Berkeley 1998
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Sorted by citations
Bone Mechanical Properties in Healthy and Diseased States
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“These effects occur in trabecular samples and in the entire vertebral body (81), indicating that isolated overloads that do not cause overt fracture of the bone may cause subtle but cumulative permanent deformations that could lead to clinical fractures.”
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“Such behavior has also been found for bovine bone (93, 94) and for the entire vertebral body (95) and appears therefore to be independent of density, anatomic site, and even species.”
Self-citationBiomechanics and Mechanobiology of Trabecular Bone: A Review
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MethodSelf-citationStructural Determinants of Vertebral Fracture Risk
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Self-citationDental implant induced bone remodeling and associated algorithms
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The vertebral fracture cascade in osteoporosis: a review of aetiopathogenesis
Briggs, A. M., Greig, A. M., & Wark, J. D. (2007) · Osteoporosis International · doi:10.1007/s00198-006-0304-x · Cited by 165
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Finite Element Modeling of the Human Thoracolumbar Spine
Liebschner, M. A. K., Kopperdahl, D. L., Rosenberg, W. S., & Keaveny, T. M. (2003) · Spine · doi:10.1097/01.brs.0000049923.27694.47 · Cited by 158
“An upper limit for EZZ of 1 GPa was used for the trabecular bone.(19) The remaining orthotropic elastic constants for the trabecular bone were assigned based on data from Ulrich et al(37) as fixed ratios of the longitudinal modulus for human Figure 1.”
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MethodSelf-citationRole of Trabecular Microarchitecture in Whole-Vertebral Body Biomechanical Behavior
Fields, A. J., Eswaran, S. K., Jekir, M. G., & Keaveny, T. M. (2009) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.090317 · Cited by 121
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Self-citationRiggs, B. L., Melton, L. J., Robb, R. A., Camp, J. J., Atkinson, E. J., Oberg, A. L., Rouleau, P. A., McCollough, C. H., Khosla, S., & Bouxsein, M. (2006) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.051022 · Cited by 118
Compressive fatigue behavior of human vertebral trabecular bone
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“This asymptomatic characteristic suggests that repetitive loading lower than ultimate loads, associated with low bone mass and microarchitectural deterioration, may be causing these fractures (Keaveny et al., 1999; Kopperdahl et al., 2000).”
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Haddock, S. M., Yeh, O. C., Mummaneni, P. V., Rosenberg, W. S., & Keaveny, T. M. (2003) · Journal of Biomechanics · doi:10.1016/s0021-9290(03)00245-8 · Cited by 112
Self-citationBouxsein, M., Uchiyama, T., Rosen, C. J., Shultz, K. L., Donahue, L. R., Turner, C. H., Sen, Ś., Churchill, G. A., Müller, R., & Beamer, W. G. (2004) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.0301255 · Cited by 107
A review of anatomical and mechanical factors affecting vertebral body integrity
Briggs, A. M., Greig, A. M., Wark, J. D., Fazzalari, N. L., & Bennell, K. L. (2004) · International Journal of Medical Sciences · doi:10.7150/ijms.1.170 · Cited by 103
“Ex vivo investigations demonstrate that mechanical characteristics of vertebral bone to strain is dominated by trabecular bone properties [43, 81].”
BackgroundThe effect of osteoporotic vertebral fracture on predicted spinal loads in vivo
Briggs, A. M., Wrigley, T. V., van Dieën, J. H., Phillips, B. A., Lo, S. K., Greig, A. M., & Bennell, K. L. (2006) · European Spine Journal · doi:10.1007/s00586-006-0158-0 · Cited by 101
Perilli, E., Briggs, A. M., Kantor, S., Codrington, J. D., Wark, J. D., Parkinson, I. H., & Fazzalari, N. L. (2012) · Bone · doi:10.1016/j.bone.2012.03.002 · Cited by 89
“The loading conditions for biomechanical tests were chosen to provide controlled boundary conditions common in laboratory testing, and might not be fully representative of in vivo loading conditions [20,48].”
Lambers, F. M., Bouman, A. R., Rimnac, C. M., & Hernandez, C. J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0083662 · Cited by 86
“Cancellous bone is the primary load-carrying component in human vertebral bodies, suggesting that damage accumulation and related degradation in biomechanical performance of vertebral cancellous bone is part of the development of vertebral fractures [5].”
BackgroundInfluence of vertical trabeculae on the compressive strength of the human vertebra
Fields, A. J., Lee, G. L., Liu, X. S., Jekir, M. G., Guo, X.-D. E., & Keaveny, T. M. (2010) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.207 · Cited by 85
“Details of the biomechanical tests are described elsewhere in more detail.((12,14,15)) Briefly, these experiments were conducted using a screw-driven load frame with a lockable ball joint to allow the top platen of the load frame to rest flat on the vertebrae during compression.”
MethodSelf-citationLuo, J., Skrzypiec, D. M., Pollintine, P., Adams, M. A., Annesley-Williams, D. J., & Dolan, P. (2007) · Bone · doi:10.1016/j.bone.2006.11.021 · Cited by 84
“Low BMD leads to greater height loss and to greater changes in load-sharing after fracture because less dense vertebrae have a reduced stiffness, and tend to be more brittle [62], so that more extensive damage can be sustained when the elastic limit is exceeded [63].”
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“For the 12 specimens, simulations showed the expected nonlinear behaviour for vertebral bodies in compression and flexion observed experimentally (Kopperdahl et al. 2000; Buckley et al. 2007).”
BackgroundEswaran, S. K., Gupta, A. K., & Keaveny, T. M. (2007) · Bone · doi:10.1016/j.bone.2007.05.017 · Cited by 79
“Our finding of a large amount of high-risk tissue in the trabecular bone is consistent with previous laboratory observations that the damage behavior of the whole vertebral body is dominated by that of the trabecular bone [14].”
ResultSelf-citationDamage accumulation in vertebral trabecular bone depends on loading mode and direction
Wolfram, U., Wilke, H., & Zysset, P. K. (2011) · Journal of Biomechanics · doi:10.1016/j.jbiomech.2011.01.018 · Cited by 78
“Qualitatively, this damage accumulation appears to be independent on site, species and density (Keaveny et al., 1994; Zysset and Curnier, 1996; Kopperdahl et al., 2000).”
BackgroundÖzçivici, E., Garman, R., & Judex, S. (2007) · Journal of Biomechanics · doi:10.1016/j.jbiomech.2007.05.015 · Cited by 76
“Considering the association between bone stiffness and strength (Kopperdahl et al., 2000; Ammann and Rizzoli, 2003) and the accuracy of linear FE models to predict failure events in bone (Bozic et al.”
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Sun, G., Wei, D., Liu, X., Chen, Y., Li, M., He, D., & Zhong, J. Q. (2013) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2012.12.003 · Cited by 63
Distribution of anterior cortical shear strain after a thoracic wedge compression fracture
Kayanja, M. M., Ferrara, L., & Lieberman, I. H. (2004) · The Spine Journal · doi:10.1016/j.spinee.2003.07.003 · Cited by 61
““Potting” specimens for compressive testing is a standard technique used in biomechanical testing described in numerous studies [26–39].”
MethodMicrodamage propagation in trabecular bone due to changes in loading mode
Wang, X., & Niebur, G. L. (2005) · Journal of Biomechanics · doi:10.1016/j.jbiomech.2005.02.007 · Cited by 60
“Changes in trabecular bone stiffness in even a small region can cause large differences in whole bone strength (Kopperdahl et al., 2000; Oden et al., 1999).”
BackgroundQuantitative Computed Tomography-Based Predictions of Vertebral Strength in Anterior Bending
Buckley, J. M., Cheng, L. C., Loo, K., Slyfield, C. R., & Xu, Z. K. (2007) · Spine · doi:10.1097/01.brs.0000260979.98101.9c · Cited by 57
“Axial (KA,exp) and bending (KB,exp) stiffness measures were calculated using the methods of Kopperdahl et al.(28) This method involved taking the maximum of the tangent moduli at each”
MethodInfluentialRelationship Between Axial and Bending Behaviors of the Human Thoracolumbar Vertebra
Crawford, R. P., & Keaveny, T. M. (2004) · Spine · doi:10.1097/01.brs.0000142435.90314.3b · Cited by 55
“Data from 23 isolated vertebral bodies from 23 cadavers (T11–L4; age, 37–90 years; males 11, females 7) were used from a previous experiment.(25) The soft tissues were removed with a scalpel and the posterior elements were removed with an autopsy saw.”
MethodSelf-citationBiomechanics of Prophylactic Vertebral Reinforcement
Sun, K., & Liebschner, M. A. K. (2004) · Spine · doi:10.1097/01.brs.0000128760.94173.90 · Cited by 52
“7, 6 females, 2 males), were prepared and scanned with quantitative computer tomography (QCT) in a previous study by Kopperdahl et al.(18) The average QCT densities of the vertebral bodies ranged from 0.”
MethodInfluentialDouble-bar application decreases postoperative pain after the Nuss procedure
Nagaso, T., Miyamoto, J., Kokaji, K., Yozu, R., Jiang, H., Jin, H., & Tamaki, T. (2010) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2009.12.027 · Cited by 49
“7 þ 3230 QCT, where E and QCT mean Young’s modulus [in mega-pascals] and CT density [in grams per milliliter], respectively) and were allotted to each component of the thorax.(8) Thus-obtained, Young’s moduli were 1580 to 1920 kg/mm(2) (mean 1750 kg/mm(2)) for cortical bone, 160 to 200 kg/mm(2) (mean 180 kg/mm(2)) for…”
MethodHussein, A. I., & Morgan, E. F. (2012) · Osteoporosis International · doi:10.1007/s00198-012-2039-1 · Cited by 43
Dynamic effects of the Nuss procedure on the spine in asymmetric pectus excavatum
Nagasao, T., Noguchi, M., Miyamoto, J., Jiang, H., Ding, W., Shimizu, Y., & Kishi, K. (2010) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2010.06.025 · Cited by 43
Vertebral fragility and structural redundancy
Fields, A. J., Nawathe, S., Eswaran, S. K., Jekir, M. G., Adams, M. F., Papadopoulos, P., & Keaveny, T. M. (2012) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.1664 · Cited by 42
“This same mechanism may explain why the reduction in vertebral strength following an isolated overload is greater in vertebrae with lower BV/TV and fewer trabeculae.((20,43)) However, given the challenge of relating finite element predictions of failed tissue with direct observations of microdamage,((44,45)) additiona…”
BackgroundSelf-citationContinuum damage interactions between tension and compression in osteonal bone
Mirzaali, M. J., Bürki, A., Schwiedrzik, J. J., Zysset, P. K., & Wolfram, U. (2015) · Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials · doi:10.1016/j.jmbbm.2015.05.007 · Cited by 41
“…bone’s stiffness, strength, and toughness26 and eventually leads to collapse of whole bones (Fyhrie and Schaffler, 1994; Burr et al.,27 1997; Kopperdahl et al., 2000; Nalla et al., 2005; Ritchie et al., 2005; Ritchie, 2011).28 Bone microdamage can be classified into microcracks and diffuse…”
BackgroundHussein, A. I., Louzeiro, D. T., Unnikrishnan, G. U., & Morgan, E. F. (2017) · Journal of Biomechanical Engineering · doi:10.1115/1.4038609 · Cited by 41
Relative strength of thoracic vertebrae in axial compression versus flexion
Buckley, J. M., Kuo, C. C., Cheng, L. C., Loo, K., Motherway, J. A., Slyfield, C. R., Deviren, V., & Ames, C. P. (2009) · The Spine Journal · doi:10.1016/j.spinee.2009.02.010 · Cited by 40
“[33].”
Vertebral body integrity: a review of various anatomical factors involved in the lumbar region
Prakash, Prabhu, L. V., Saralaya, V., Pai, M. M., Ranade, A. V., Singh, G., & Madhyastha, S. P. (2007) · Osteoporosis International · doi:10.1007/s00198-007-0373-5 · Cited by 39
“[38] reported that the damage behavior of the lumbar and lower thoracic vertebral body is dominated by the trabecular bone and may be an important factor in the etiology of vertebral fracture.”
BackgroundDeterminants of bone damage: An ex-vivo study on porcine vertebrae
Mirzaali, M. J., Libonati, F., Ferrario, D., Rinaudo, L., Messina, C., Ulivieri, F. M., Cesana, B. M., Strano, M., & Vergani, L. M. (2018) · PLoS ONE · doi:10.1371/journal.pone.0202210 · Cited by 38
Evolution of Vertebroplasty: A Biomechanical Perspective
Sun, K., & Liebschner, M. A. K. (2003) · Annals of Biomedical Engineering · doi:10.1023/b:abme.0000007793.49771.6d · Cited by 37
Strain distribution in the lumbar vertebrae under different loading configurations
Cristofolini, L., Brandolini, N., Danesi, V., Juszczyk, M., Erani, P., & Viceconti, M. (2013) · The Spine Journal · doi:10.1016/j.spinee.2013.06.014 · Cited by 35
Characterizing microcrack orientation distribution functions in osteonal bone samples
Wolfram, U., Schwiedrzik, J. J., Mirzaali, M. J., Bürki, A., Varga, P., Olivier, C., Peyrin, F., & Zysset, P. K. (2016) · Journal of Microscopy · doi:10.1111/jmi.12440 · Cited by 33
“…is not detectable using conventional clinical imaging modalities but decreases bone’s stiffness, strength and toughness and eventually leads to a collapse of whole bones (Fyhrie & Schaffler, 1994; Burr et al., 1997; Kopperdahl et al., 2000; Nalla et al., 2005; Ritchie et al., 2005; Ritchie, 2011).”
Premature Adjacent Vertebral Fracture After Vertebroplasty: A Biomechanical Study
Fahim, D. K., Sun, K., Tawackoli, W., Mendel, E., Rhines, L. D., Burton, A. W., Kim, D. H., Ehni, B. L., & Liebschner, M. A. K. (2011) · Neurosurgery · doi:10.1227/neu.0b013e31821cc499 · Cited by 32
“The protocols for preparation and scanning of the vertebral segments were reported previously by Kopperdahl et al.37 We used the Model 3 computed tomography calibration phantom based on the original Cann-Genant phantom, composed of a Teflon base material with 5 embedded rods containing varying amounts of K2HPO4 and wa…”
MethodUnnikrishnan, G. U., Barest, G. D., Berry, D. B., Hussein, A. I., & Morgan, E. F. (2013) · Journal of Biomechanical Engineering · doi:10.1115/1.4025179 · Cited by 28
Axial-shear interaction effects on microdamage in bovine tibial trabecular bone
Wang, X., Guyette, J. P., Liu, X., Roeder, R. K., & Niebur, G. L. (2005) · European Journal of Morphology · doi:10.1080/09243860500095570 · Cited by 28
“The aniso- tropy of modulus changes following damage is important, as it would alter the stress field within the trabecular bone, which could in turn decrease the whole bone fracture strength (Kopperdahl et al. 2000).”
BackgroundKim, D., Dong, X. N., Cao, T., Baker, K. C., Shaffer, R. R., Fyhrie, D. P., & Yeni, Y. N. (2005) · Journal of Biomechanical Engineering · doi:10.1115/1.2133770 · Cited by 27
Reproducible reference frame for in vitro testing of the human vertebrae
Danesi, V., Zani, L., Scheele, A., Berra, F., & Cristofolini, L. (2013) · Journal of Biomechanics · doi:10.1016/j.jbiomech.2013.10.005 · Cited by 26
Paraspinal muscle control in people with osteoporotic vertebral fracture
Briggs, A. M., Greig, A. M., Bennell, K. L., & Hodges, P. W. (2007) · European Spine Journal · doi:10.1007/s00586-006-0276-8 · Cited by 26
“Combining higher static vertebral loads with a higher loading rate may be sufficient to cause vertebral failure by increasing trabecular strains [25].”
BackgroundPresence of intervertebral discs alters observed stiffness and failure mechanisms in the vertebra
Hussein, A. I., Mason, Z. D., & Morgan, E. F. (2013) · Journal of Biomechanics · doi:10.1016/j.jbiomech.2013.04.004 · Cited by 26
“Removal of the posterior elements is a common procedure for biomechanical testing of vertebrae, at times because of limitations on the size of test samples (Buckley et al., 2007; Hussein et al., 2011; Kim et al., 2007; Kopperdahl et al., 2000; Mosekilde et al., 1989; Perilli et al., 2012), as was the case herein due t…”
BackgroundKobayashi, N., Ong, K. L., Villarraga, M. L., Schwardt, J. D., Wenz, R., Togawa, D., Fujishiro, T., Turner, A. S., Seim, H. B., & Bauer, T. W. (2007) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.31079 · Cited by 26
Alkalay, R. N. (2014) · Clinical Biomechanics · doi:10.1016/j.clinbiomech.2014.10.001 · Cited by 26
Kim, Y. H., Wu, M., & Kim, K. (2013) · Journal of Applied Mathematics · doi:10.1155/2013/285165 · Cited by 22
“The compressive strengthFc and stiffness kc were compared with those from previous experimental and computational studies [20, 24–27] for the validation of the model.”
ResultYeni, Y. N., Kim, D., Divine, G., Johnson, E. M., & CODY, D. D. (2008) · Bone · doi:10.1016/j.bone.2008.09.002 · Cited by 22
“A progressive damagerelated failure is especially relevant to vertebral fractures in that i) vertebrae lose a portion of their stiffness and strength when loaded beyond their ultimate load but still maintain substantial stiffness and strength when loaded a second time in laboratory experiments [35,60], ii) clinical ve…”
BackgroundAlkalay, R. N., Stechow, D. V., Torres, K., Hassan, S., Sommerich, R., & Zurakowski, D. (2008) · Spine · doi:10.1097/brs.0b013e31817cf7d1 · Cited by 21
“Mechanical Tests In response to the applied deformation, the intact vertebrae exhibited a typical load-displacement curve.(36) The compressive force (Fz), flexion moment (Mx) and, to a lesser extent, the anterior-posterior shear force (Fy) and lateral bending moment (My), monotonically increased during both the nonlin…”
BackgroundKennedy, O. D., Brennan, O., Mahony, N. J., Rackard, S. M., O’Brien, F. J., Taylor, D. M., & Lee, C. T. (2008) · Spine · doi:10.1097/brs.0b013e318186b292 · Cited by 21
“Specimens were then unloaded to 200 N and held for 1 minute to minimize viscoelastic creep and to reach a steady-state displacement.(24,25) They were then reloaded, under the same conditions, to 10% strain.”
MethodKummari, S. R., Davis, A. J., Vega, L. A., Ahn, N. U., Cassinelli, E. H., & Hernandez, C. J. (2009) · Calcified Tissue International · doi:10.1007/s00223-009-9257-3 · Cited by 20
“Microscopic tissue damage has been implicated as a contributor to clinical fractures, particularly those that are not caused by a single loading event, such as stress fractures and vertebral fractures [14, 15 ].”
BackgroundInfluence of Orthogonal Overload on Human Vertebral Trabecular Bone Mechanical Properties
Badiei, A., Bottema, M. J., & Fazzalari, N. L. (2007) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.070706 · Cited by 20
Nekkanty, S., Yerramshetty, J., Kim, D.-G., Zauel, R., Johnson, E., Cody, D. D., & Yeni, Y. N. (2010) · Bone · doi:10.1016/j.bone.2010.07.001 · Cited by 23
“The significance of structural ductility, or the ability of a vertebra to sustain post-damage deformation, as a mechanical property relevant to vertebral fracture may be reinforced by two observations: (1) Vertebrae maintain substantial stiffness and strength when loaded a second time after subjecting them to loads be…”
BackgroundEXPERIMENTAL METHODS FOR THE BIOMECHANICAL INVESTIGATION OF THE HUMAN SPINE: A REVIEW
Brandolini, N., Cristofolini, L., & Viceconti, M. (2013) · Journal of Mechanics in Medicine and Biology · doi:10.1142/s0219519414300026 · Cited by 18
Lee, C.-H., Landham, P. R., Eastell, R., Adams, M. A., Dolan, P., & Yang, L. (2017) · Proceedings of the Institution of Mechanical Engineers Part H Journal of Engineering in Medicine · doi:10.1177/0954411917708806 · Cited by 15
The Mechanical Behavior of Bone
Karim, L., Hussein, A. I., Morgan, E. F., & Bouxsein, M. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-415853-5.00019-4 · Cited by 15
Biomechanics of Vertebral Bone
Keaveny, T. M., & Buckley, J. M. (2006) · Elsevier eBooks · doi:10.1016/b978-012369390-7/50005-8 · Cited by 15
Self-citationYi, W., Feng, W., Li, G., Li, Z., Liu, Z., Cheng, X., & Yang, H. (2021) · Medical Engineering & Physics · doi:10.1016/j.medengphy.2021.05.008 · Cited by 14
Oravec, D. J., Flynn, M. J., Zauel, R. R., Rao, S. D., & Yeni, Y. N. (2019) · Medical Physics · doi:10.1002/mp.13750 · Cited by 14
Erdem, İ., Truumees, E., & van der Meulen, M. C. H. (2011) · Computer Methods in Biomechanics & Biomedical Engineering · doi:10.1080/10255842.2011.636741 · Cited by 12
“…vertebra models, we calculated axial and flexion stiffness to characterise the global behaviour of the vertebra and to validate our results with previous experimental (Kopperdahl et al. 2000; Heini et al. 2001; Buckley et al. 2007) and analytical studies (Crawford et al. 2003; Buckley et al. 2007).”
InfluentialEffects of damage on the orthotropic material symmetry of bovine tibial trabecular bone
Liu, X., Wang, X., & Niebur, G. L. (2003) · Journal of Biomechanics · doi:10.1016/s0021-9290(03)00217-3 · Cited by 12
Kuhn, F., Clausing, R. J., Stiller, A., Ulloa, C. A. F., Fölsch, C., Rickert, M., & Jahnke, A. (2022) · Journal of Orthopaedics · doi:10.1016/j.jor.2022.07.003 · Cited by 11
Oravec, D. J., Zauel, R. R., Flynn, M. J., & Yeni, Y. N. (2020) · Medical Engineering & Physics · doi:10.1016/j.medengphy.2020.08.008 · Cited by 11
Danesi, V., Erani, P., Brandolini, N., Juszczyk, M., & Cristofolini, L. (2016) · Journal of Biomechanical Engineering · doi:10.1115/1.4034383 · Cited by 10
Frontal Bone Fracture Patterns Suggesting Involvement of Optic Canal Damage
Imajo, K., Nagasao, T., Aizezi, N., Morotomi, T., Tamai, M., & Miyake, M. (2018) · Journal of Craniofacial Surgery · doi:10.1097/scs.0000000000004926 · Cited by 10
Yeni, Y. N., Dix, M. R., Xiao, A., & Oravec, D. J. (2022) · Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials · doi:10.1016/j.jmbbm.2022.105334 · Cited by 9
Effects of bone damage on creep behaviours of human vertebral trabeculae
O'Callaghan, P., Szarko, M., Wang, Y., & Luo, J. (2017) · Bone · doi:10.1016/j.bone.2017.10.022 · Cited by 9
“Although vertebral components, including trabecular bone, cortical shell and endplate, all contribute to vertebral creep deformation, trabecular bone plays a dominant role [8, 9].”
BackgroundBone Response to Mechanical Loads
Ramaswamy, G., Bidez, M. W., & Misch, C. E. (2014) · Elsevier eBooks · doi:10.1016/b978-0-323-07845-0.00006-3 · Cited by 9
Creating Physiologically Realistic Vertebral Fractures in a Cervine Model
Corbiere, N. C., Lewicki, K. A., Issen, K. A., & Kuxhaus, L. (2014) · Journal of Biomechanical Engineering · doi:10.1115/1.4027059 · Cited by 8
“Specimens were preconditioned in load control from 100 N to 250 N for 10 cycles [9,10].”
BackgroundMethodEswaran, S. K., Bevill, G. R., Nagarathnam, P., Allen, M. R., Burr, D. B., & Keaveny, T. M. (2009) · Journal of Biomechanics · doi:10.1016/j.jbiomech.2008.11.023 · Cited by 8
“Our analysis used uniform compressive loading via a PMMA layer in order to mimic controlled conditions commonly used in experimental testing of isolated vertebrae (Eriksson et al., 1989;Faulkner et al., 1991;Kopperdahl et al., 2000).”
MethodSelf-citationRoux, J. P., Belghali, S., Wegrzyn, J., Sornay‐Rendu, E., & Chapurlat, R. D. (2016) · Osteoporosis International · doi:10.1007/s00198-016-3558-y · Cited by 8
“Mechanical damage which is not visible from radiographs predominates in trabecular bone, therefore explaining progressive deformations and reduction of vertebral heights [37].”
BackgroundFeng, W., Yi, W., Song, F., Li, Z., Fu, R., Din, R. U., Li, J., Liu, W., Liu, Y., & Yang, H. (2022) · Medical Engineering & Physics · doi:10.1016/j.medengphy.2022.103882 · Cited by 7
Local and global microarchitecture is associated with different features of bone biomechanics
Roux, J.-P., Boutroy, S., Bouxsein, M., Chapurlat, R. D., & Wegrzyn, J. (2020) · Bone Reports · doi:10.1016/j.bonr.2020.100716 · Cited by 7
“…a global approach of exploring “bone strength”, that includes various averaged parameters of the whole volume of interest such as bone geometry, microarchitecture and matrix properties, rather than aBMD measurement alone (SornayRendu et al., 2005; Siris et al., 2004; Bouxsein, 2005; Lester, 2005).”
BackgroundANTERIOR BENDING ON WHOLE VERTEBRAE USING CONTROLLED BOUNDARY CONDITIONS FOR MODEL VALIDATION
de Brosses, E. S. , Chan, F., Ayoub, G., Roux, C., Wafa Skalli, E., & Mitton, D. (2009) · Journal of Musculoskeletal Research · doi:10.1142/s0218957709002250 · Cited by 6
Shore, S. W., Unnikrishnan, G. U., Hussein, A. I., & Morgan, E. F. (2012) · CRC Press eBooks · doi:10.1201/b13733-3 · Cited by 6
Cristofolini, L., Brandolini, N., Danesi, V., Erani, P., Viceconti, M., & Ferguson, S. J. (2016) · Journal of Mechanics in Medicine and Biology · doi:10.1142/s0219519416500743 · Cited by 5
An improved metric for quantifying the stiffnesses of intact human vertebrae
Buckley, J. M., Parmeshwar, R., Deviren, V., & Ames, C. P. (2009) · Proceedings of the Institution of Mechanical Engineers Part H Journal of Engineering in Medicine · doi:10.1243/09544119jeim524 · Cited by 5
Kraxenberger, M., Schröder, C., Geith, T., Büttner, A., Pellengahr, C. V. S., Birkenmaier, C., Müller, P. E., Jansson, V., & Wegener, B. (2017) · Technology and Health Care · doi:10.3233/thc-171086 · Cited by 5
“Consequently, our model includes the advantages of existing testing devices [6–10].”
Zhang, M., Gao, J., Huang, X., Gong, H., Zhang, M., & Liu, B. (2017) · Journal of Healthcare Engineering · doi:10.1155/2017/5707568 · Cited by 5
“Unloading-reloading cycles were repeated five times before the test recording under a compressive preload of 2000N to reduce the viscoelastic effect [27, 28].”
MethodAnalyses of trabecular bone failure
Verhulp, E. (2006) · TU/e Research Portal · doi:10.6100/ir608109 · Cited by 6
“However, the vertebrae can still function and can carry, although reduced, loads (Kopperdahl et al., 2000).”
BackgroundDanesi, V., Faldini, C., & Cristofolini, L. (2017) · Journal of Mechanics in Medicine and Biology · doi:10.1142/s0219519417300022 · Cited by 4
Briggs, A. M., Perilli, E., Codrington, J. D., Reynolds, K. J., Parkinson, I. H., & Wark, J. D. (2014) · Calcified Tissue International · doi:10.1007/s00223-014-9866-3 · Cited by 4
“The specimen preparation and testing procedure were performed based on previously published protocols [18, 37, 38].”
MethodHatano, A., Nagasao, T., Shimizu, Y., Jin, H., Kaneko, T., Cho, Y., Jiang, H., & Kishi, K. (2013) · Computer Aided Surgery · doi:10.3109/10929088.2013.777120 · Cited by 4
A biomechanical study of relationship between sternum defect patterns and thoracic respiration
Nagasao, T., Kasai, S., Shimizu, Y., Sakamoto, Y., Hatano, A., Morotomi, T., Ogata, H., & Kishi, K. (2016) · Computer Assisted Surgery · doi:10.3109/10929088.2015.1076038 · Cited by 4
“7 + 3230QCT.[8] Based on this equation, Young’s modulus was calculated for each cartilage and bone of each thorax.”
MethodLocalized Trabecular Damage Adjacent to Interbody Fusion Devices
WARDEN, K. E., & Davy, D. T. (2010) · Spine · doi:10.1097/brs.0b013e3181ba0003 · Cited by 4
“5% applied structural strain levels were chosen on the basis of the published data because they approximate cancellous yield and an “above yield” condition.(46,47) Force, actuator displacement, and extensometer displacement were recorded at 50 Hz.”
MethodWalterscheid, Z., O’Neill, C. N., Ochs, A., D’Averso, A., Dew, C., Huntington, A., Ma, G., Behrend, C. J., Vita, R. D., & Carmouche, J. J. (2017) · Geriatric Orthopaedic Surgery & Rehabilitation · doi:10.1177/2151458517715739 · Cited by 4
Biomechanics of Vertebral Fracture
Whyne, C. M., McLachlin, S. D., Burke, M., & Hardisty, M. (2017) · Springer eBooks · doi:10.1007/978-3-319-52634-8_2 · Cited by 3
A predictive model for creep deformation following vertebral compression fractures
Luo, J., Dolan, P., Adams, M. A., Annesley-Williams, D. J., & Wang, Y. (2020) · Bone · doi:10.1016/j.bone.2020.115595 · Cited by 2
Metadata
- Authors
- Kopperdahl, D. L., Pearlman, J. L., & Keaveny, T. M.
- Affiliations
- University of California, Berkeley (US)
- University of California, San Francisco (US)
- Corresponding author
- Keaveny, Tony M.
- Venue
- Journal of Orthopaedic Research
- Publisher
- Wiley
- Published
- 2000-09
- Volume
- 18
- Issue
- 5
- Pages
- 685-690
- ISSN
- 0736-0266 (ISSN-L)
- 1554-527X
- OpenAlex
- W2087738478
- Cited by
- 120
- References
- 21
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 1 · 2023: 1 · 2022: 4 · 2021: 3 · 2020: 6 · 2019: 1 · 2018: 3 · 2017: 8 · 2016: 5 · 2015: 3 · 2014: 5 · 2013: 10 · 2012: 5
- FWCI
- 3.69
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Orthopaedic Research® (publishedVersion)
- PubMed (publishedVersion)
- D-Scholarship@Pitt (University of Pittsburgh) (acceptedVersion)
- Funders
- Stryker
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR41481)
- Topics
- Health Sciences › Medicine › Surgery › Spinal Fractures and Fixation Techniques
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Spine and Intervertebral Disc Pathology
- Keywords
- vertebral body, residual strain, bone stiffness, ultimate load, bone mineral density, trabecular bone, mechanical damage, compressive loading, permanent deformation, lumbar vertebrae, thoracic vertebrae
- MeSH terms
- Adult, Aged, Aged, 80 and over, Cadaver, Humans, Lumbar Vertebrae, Middle Aged, Random Allocation, Stress, Mechanical, Thoracic Vertebrae, Tomography, X-Ray Computed, Bone Density, Weight-Bearing, Pliability, Compressive Strength
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