The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Distinct roles of bone morphogenetic proteins in osteogenic differentiation of mesenchymal stem cells
Abstract
Efficacious bone regeneration could revolutionize the clinical management of many bone and musculoskeletal disorders. Bone morphogenetic proteins (BMPs) can regulate the differentiation of mesenchymal stem cells into cartilage, bone, tendon/ligament, and fat lineages. Early data documented the osteogenic potential of rhBMP2 and rhBMP7/OP‐1. However, prior to this work that summarized several of our recent studies, no comprehensive analysis had been undertaken to characterize relative osteogenic activity of all BMPs. Using recombinant adenoviruses expressing 14 BMPs, we have demonstrated that, besides BMP2 and BMP7, BMP6 and BMP9 exhibit the highest osteogenic activity both in vitro and in vivo. We further demonstrated that several BMPs may exert synergistic effect on osteogenic differentiation, and that osteogenic BMPs produce a distinct set of molecular fingerprints during osteogenic differentiation. The reported work should expand our current understanding of BMP functions during osteogenic differentiation. It is conceivable that osteogenic BMPs (i.e., BMP2, 4, 6, 7, and 9) may be used to formulate synergistic pairs among themselves and/or with other less osteogenic BMPs for efficacious bone regeneration in clinical settings. © 2007 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 25:665–677, 2007
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Cites
ID helix-loop-helix proteins in cell growth, differentiation and tumorigenesis
Norton, J. D. (2000) · Journal of Cell Science · doi:10.1242/jcs.113.22.3897 · Cited by 665
Si, W., Kang, Q., Luu, H. H., Park, J. K., Luo, Q., Song, W.-X., Jiang, W., Luo, X., Li, X., Yin, H., et al. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.26.8.2955-2964.2006 · Cited by 272
Self-citation
Cited by
Liao, J., Wei, Q., Zou, Y., Fan, J., Song, D., Cui, J., Zhang, W., Zhu, Y., Ma, C., Hu, X., et al. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000471945 · Cited by 2,742
Self-citationWu, M., Chen, G., & Li, Y.-P. (2016) · Bone Research · doi:10.1038/boneres.2016.9 · Cited by 1,553
Lee, C. S., Bishop, E. S., Zhang, R., Yu, X., Farina, E. M., Yan, S., Zhao, C., Zeng, Z., Shu, Y., Wu, X., et al. (2017) · Genes & Diseases · doi:10.1016/j.gendis.2017.04.001 · Cited by 691
Self-citationFDA-approved bone grafts and bone graft substitute devices in bone regeneration
Gillman, C. E., & Jayasuriya, A. C. (2021) · Materials Science and Engineering: C · doi:10.1016/j.msec.2021.112466 · Cited by 417
Bone regeneration and stem cells
Arvidson, K., Abdallah, B. M., Applegate, L. A., Baldini, N., Cenni, E., Gomez-Barrena, E., Granchi, D., Kassem, M., Konttinen, Y. T., Mustafa, K., et al. (2011) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2010.01224.x · Cited by 408
Metadata
- Authors
- Luu, H. H., Song, W., Luo, X., Manning, D., Luo, J., Deng, Z., Sharff, K. A., Montag, A. G., Haydon, R. C., & He, T.
- Venue
- Journal of Orthopaedic Research
- Publisher
- Wiley
- Published
- 2007-02-08
- Volume
- 25
- Issue
- 5
- Pages
- 665-677
- ISSN
- 0736-0266 (ISSN-L)
- 1554-527X
- OpenAlex
- W2040121303
- Cited by
- 545
- References
- 2
- FWCI
- 8.32
- Type
- journal article
- Language
- en
- Open access
- closed
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- Luu, H. H., Song, W., Luo, X., Manning, D., Luo, J., Deng, Z., Sharff, K. A., Montag, A. G., Haydon, R. C., & He, T. (2007). Distinct roles of bone morphogenetic proteins in osteogenic differentiation of mesenchymal stem cells. Journal of Orthopaedic Research. https://doi.org/10.1002/jor.20359
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