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Cited by 91Periodontal Regeneration and TreatmentsVeterinary Orthopedics and NeurologyKnee injuries and reconstruction techniques

Multiple injections of leukoreduced platelet rich plasma reduce pain and functional impairment in a canine model of ACL and meniscal deficiency

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Cook, James L., Smith, Patrick A., Bozynski, Chantelle C., Kuroki, Keiichi, Cook, Cristi R., Stoker, Aaron M., Pfeiffer, Ferris M.·2016·Journal of Orthopaedic Research
DOI 10.1002/jor.23054
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Abstract

Platelet rich plasma (PRP) is used to treat many musculoskeletal disorders. We used a canine model to determine the effects of multiple intra‐articular injections of leukoreduced PRP (ACP) on anterior cruciate ligament healing, meniscal healing, and progression of osteoarthritis (OA). With Animal Care and Use Committee (ACUC) approval, 12 dogs underwent partial ACL transection and meniscal release in one knee. At weeks 1, 2, 3, 6, and 8 after insult, dogs were treated with intra‐articular injections (2 ml) of either ACP ( n = 6) or saline ( n = 6). Dogs were assessed over 6 months to determine comfortable range of motion (CROM), lameness, pain, effusion, kinetics, and radiographic and arthroscopic assessments. At 6‐month endpoint, dogs were assessed for ACL material properties and histopathology. Saline‐treated dogs had significantly ( p < 0.04) more CROM loss, significantly ( p < 0.01) more pain, significantly ( p < 0.05) more severe lameness, significantly ( p < 0.05) lower function, and significantly ( p < 0.05) lower %Total Pressure Index in affected hindlimbs compared to ACP‐treated dogs. Radiographic OA increased significantly ( p < 0.01) over time within each group. Arthroscopically, saline‐treated knees showed moderate to severe synovitis, further ACL disruption, and medial compartment cartilage loss, and ACP‐treated knees showed evidence of ACL repair and less severe synovitis. ACL material properties in ACP‐treated knees were closer to normal than in saline‐treated knees, however, the differences were not statistically significant. ACL histopathology was significantly ( p < 0.05) less severe in ACP‐treated knees compared to saline‐treated knees. Five intra‐articular injections of leukoreduced PRP had beneficial effects for ACL healing, improved range of motion, decreased pain, and improved limb function for up to 6 months in this model. © 2015 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 34:607–615, 2016.

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  • In a dog partial ACL tear model, LP-PRP showed a beneficial effect on tendon healing and tissue quality compared to saline-injected subjects.

    “The LP-PRP showed a beneficial effect on tendon healing and tissue quality compared to saline-injected subjects.”

    From Molecular and Biologic Effects of Platelet-Rich Plasma (PRP) in Ligament and Tendon Healing and Regeneration: A Systematic Review (2023) · cites this paper as [47]

    The Arthroscopic Assessments and Histology sections (pages not provided) report more evidence of ACL repair and significantly less severe ACL pathology in PRP-treated dogs than in saline-treated dogs. The ACL is a ligament, not a tendon; the paper does not establish a benefit for tendon healing or tendon tissue quality. (LLM, conf=0.88)

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  1. [48]48. PRP IN ACL, MENISCAL HEALING

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Authors
Cook, J. L., Smith, P. A., Bozynski, C. C., Kuroki, K., Cook, C. R., Stoker, A. M., & Pfeiffer, F. M.
Affiliations
  • University of Missouri (US)
  • Columbia Orthopaedic Group (US)
Corresponding author
Cook, James L.
ORCID
Venue
Journal of Orthopaedic Research
Publisher
Wiley
Published
2015-10-02
Volume
34
Issue
4
Pages
607-615
ISSN
  • 0736-0266 (ISSN-L)
  • 1554-527X
DOI
10.1002/jor.23054
OpenAlex
W2130353838
Cited by
91
References
49
Citations by year
2026: 8 · 2025: 12 · 2024: 13 · 2023: 10 · 2022: 5 · 2021: 7 · 2020: 8 · 2019: 7 · 2018: 10 · 2017: 6 · 2016: 5
FWCI
9.02
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Journal of Orthopaedic Research® (publishedVersion)
  • PubMed (publishedVersion)
Funders
Arthrex
Topics
  • Health Sciences › Medicine › Urology › Periodontal Regeneration and Treatments
  • Health Sciences › Veterinary › Small Animals › Veterinary Orthopedics and Neurology
  • Health Sciences › Medicine › Surgery › Knee injuries and reconstruction techniques
Keywords
platelet-rich plasma, anterior cruciate ligament, meniscal deficiency, osteoarthritis, intra-articular injection, canine model, knee pain, lameness, range of motion, synovitis, cartilage destruction
MeSH terms
Anterior Cruciate Ligament Injuries, Tibial Meniscus Injuries, Animals, Arthroscopy, Disease Models, Animal, Dogs, Injections, Intra-Articular, Knee Injuries, Random Allocation, Arthralgia, Osteoarthritis, Knee, Platelet-Rich Plasma

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