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Cited by 24Connective tissue disorders researchTendon Structure and TreatmentDermatological and Skeletal Disorders

Elastic fibers in orthopedics: Form and function in tendons and ligaments, clinical implications, and future directions

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Hill, Jeffrey Ryan, Eekhoff, Jeremy D., Brophy, Robert H., Lake, Spencer P.·2020·Journal of Orthopaedic Research
DOI 10.1002/jor.24695PMC PMC7572591
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Abstract

Elastic fibers are an essential component of the extracellular matrix of connective tissues. The focus of both clinical management and scientific investigation of elastic fiber disorders has centered on the cardiovascular manifestations due to their significant impact on morbidity and mortality. As such, the current understanding of the orthopedic conditions experienced by these patients is limited. The musculoskeletal implications of more subtle elastic fiber abnormalities, whether due to allelic variants or age‐related tissue degeneration, are also not well understood. Recent advances have begun to uncover the effects of elastic fiber deficiency on tendon and ligament biomechanics; future research must further elucidate mechanisms governing the role of elastic fibers in these tissues. The identification of population‐based genetic variations in elastic fibers will also be essential. Minoxidil administration, modulation of protein expression with micro‐RNA molecules, and direct injection of recombinant elastic fiber precursors have demonstrated promise for therapeutic intervention, but further work is required prior to consideration for orthopedic clinical application. This review provides an overview of the role of elastic fibers in musculoskeletal tissue, summarizes current knowledge of the orthopedic manifestations of elastic fiber abnormalities, and identifies opportunities for future investigation and clinical application.

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Cited by

Sorted by citations

Authors
Hill, J. R., Eekhoff, J. D., Brophy, R. H., & Lake, S. P.
Affiliations
Washington University in St. Louis (US)
Corresponding author
Hill, Jeffrey Ryan
ORCID
Venue
Journal of Orthopaedic Research
Publisher
Wiley
Published
2020-04-28
Volume
38
Issue
11
Pages
2305-2317
ISSN
  • 0736-0266 (ISSN-L)
  • 1554-527X
DOI
10.1002/jor.24695
PMC
PMC7572591
OpenAlex
W3016125784
Cited by
24
References
2
Citations by year
2026: 6 · 2025: 3 · 2024: 2 · 2023: 5 · 2022: 2 · 2021: 4 · 2020: 2
FWCI
0.46
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Orthopaedic Research® (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • Foundation for the National Institutes of Health (T32AR060719)
  • National Science Foundation (1562107)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Connective tissue disorders research
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Tendon Structure and Treatment
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Dermatological and Skeletal Disorders
Keywords
elastic fibers, tendons, ligaments, extracellular matrix, tendon biomechanics, ligament biomechanics, musculoskeletal manifestations, genetic variants, minoxidil, microRNA, connective tissue
MeSH terms
Animals, Biomechanical Phenomena, Connective Tissue Diseases, Elastic Tissue, Humans, Musculoskeletal Physiological Phenomena, Orthopedics, Mechanotransduction, Cellular

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