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Cited by 16Clinical Nutrition and GastroenterologyIntensive Care Unit Cognitive DisordersEnhanced Recovery After Surgery

Nutrition in the Intensive Care Unit and Early Recovery Influence Functional Outcomes for Survivors of Critical Illness: A Prospective Cohort Study

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Jubina, Lindsey E., Locke, Alleyna, Fedder, Kelly R., Slone, Stacey A., Soper, Melissa K., Kalema, Anna G., Montgomery‐Yates, Ashley A., Mayer, Kirby P.·2023·Journal of Parenteral and Enteral Nutrition
DOI 10.1002/jpen.2538PMC PMC11210604
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Abstract

Background: Patients who are critically ill may receive suboptimal nutrition that leads to weight loss and increased risk of functional deficits. Methods: Our overarching hypothesis is that nutrition in the intensive care unit (ICU) and the early recovery phase associates with functional outcomes at short‐term follow‐up. We enrolled adult patients who attended the University of Kentucky ICU recovery clinic (ICU‐RC) from November 2021 to June 2022. Patients participated in muscle and functional assessments. Nutrition intake and status during the ICU stay were analyzed. The Subjective Global Assessment and a nutrition questionnaire were used to identify changes in intake, ongoing gastrointestinal symptoms, and patient's access to food at the ICU‐RC appointment. Results: Forty‐one patients enrolled with a median hospital length of stay (LOS) of 23 days. Patients with 0 days of nil per os (NPO) status throughout hospitalization had a shorter LOS (P = 0.05), were able to complete the five times sit‐to‐stand test (P = 0.02), and were less likely to experience ICU‐acquired weakness (P = 0.04) at short‐term follow‐up compared with patients with ≥1 day of NPO status. Twenty (48%) patients reported changes in nutrition intake in early recovery compared with before hospitalization. Eight (20%) patients reported symptoms leading to decreased intake and four (10%) reported access to food as a barrier to intake. Conclusion: Barriers to nutrition exist during critical illness and persist after discharge, with almost half of patients reporting a change in intake. Inpatient nutrition intake is associated with functional outcomes and warrants further exploration.

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  • Maintaining adequate nutrition has been associated with improved patient outcomes.

    “Maintaining adequate nutrition has been associated with improved patient outcomes, and guidelines recommend that nutritional support be initiated within 48 h of admission to the intensive care unit [25].”

    From Non-Diabetic Hypoglycemia: Evaluation and Management in Adults (2025) · cites this paper as [25]

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Cited by

Sorted by citations

Authors
Jubina, L. E., Locke, A., Fedder, K. R., Slone, S. A., Soper, M. K., Kalema, A. G., Montgomery‐Yates, A. A., & Mayer, K. P.
Affiliations
  • University of Kentucky (US)
  • University of Kentucky HealthCare (US)
  • Division of Pulmonary, Critical Care and Sleep Medicine, Internal Medicine, College of Medicine University of Kentucky Lexington Kentucky USA
Corresponding author
Jubina, Lindsey E.
ORCID
Venue
Journal of Parenteral and Enteral Nutrition
Publisher
Wiley
Published
2023-07-21
Volume
47
Issue
7
Pages
888-895
ISSN
  • 0148-6071 (ISSN-L)
  • 1941-2444
DOI
10.1002/jpen.2538
PMC
PMC11210604
OpenAlex
W4381597615
Cited by
16
References
2
Citations by year
2026: 1 · 2025: 8 · 2024: 6 · 2023: 1
FWCI
2.81
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Journal of Parenteral and Enteral Nutrition (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institute of Arthritis and Musculoskeletal and Skin Diseases (K23AR079583)
  • National Institute on Minority Health and Health Disparities (L32 MD017732)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
  • Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Intensive Care Unit Cognitive Disorders
  • Health Sciences › Medicine › Surgery › Enhanced Recovery After Surgery
Keywords
critical illness, intensive care nutrition, functional outcome, ICU-acquired weakness, nil per os, nutrition intake, food access, sit-to-stand test, muscle strength, post-ICU recovery, length of hospital stay
MeSH terms
Adult, Humans, Intensive Care Units, Length of Stay, Nutritional Status, Prospective Studies, Critical Illness, Survivors

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