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Cited by 148Inflammasome and immune disordersOral microbiology and periodontitis researchAdipokines, Inflammation, and Metabolic Diseases

The DOI matches its Crossref record; 52 of the 53 references it cites were found in a registry or an index.

Periodontitis activates the NLRP3 inflammasome in serum and saliva

Isola, Gaetano, Polizzi, Alessandro, Santonocito, Simona, Alibrandi, Angela, Williams, Ray C.·2022·Journal of Periodontology
DOI 10.1002/jper.21-0049
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Abstract

BACKGROUND: Nod-like receptor family pyrin domain-containing protein-3 (NLRP3) complex inflammasome has potentially been shown to play an important role in the development of periodontitis and diabetes. The objective of this study was to analyze the association between serum and salivary NLRP3 concentrations in patients with periodontitis and type-II diabetes mellitus (DM) and to evaluate whether this association was influenced by potential confounders. METHODS: For the present study, a cohort of healthy controls (n = 32), and patients with periodontitis (n = 34), type-II DM (n = 33), and a combination of periodontitis + type-II DM (n = 34) were enrolled. Patients were characterized on the basis of their periodontal status and analyzed for demographic characteristics, serum mediators, and for serum and salivary concentrations of NLRP3. A uni- and multivariate model was established to analyze whether periodontitis, type-II DM, and CRP influenced serum and salivary NLRP3 concentrations. RESULTS: In comparison to type-II DM patients and healthy controls, patients with periodontitis (serum, P = 0.003; saliva P = 0.012) and periodontitis + type-II DM (serum, P = 0.028; saliva, P = 0.003) had elevated serum and salivary NLRP3 concentrations. The multivariate regression model showed that periodontitis (P = 0.029) and HDL-cholesterol (P = 0.012) were significant predictors of serum NLRP3 concentrations whereas periodontitis (P = 0.036) and CRP (P = 0.012) were significant predictors of salivary NLRP3. CONCLUSION: The results of the present study showed that periodontitis and periodontitis + type-II DM patients had higher serum and salivary NLRP3 concentrations in comparison to healthy controls and patients with type-II DM. Periodontitis was demonstrated to be a significant predictor of both serum and salivary NLRP3 concentrations.

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Research works printed but not linked: 1

  1. Liang L, 2016, ET‐1 promotes differentiation of periodontal ligament stem cells into osteoblasts through ETR, MAPK, and Wnt/β‐Catenin signaling pathways under inflammatory microenvironment, Mediat Inflammat

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Metadata

Authors
Isola, G., Polizzi, A., Santonocito, S., Alibrandi, A., & Williams, R. C.
Affiliations
  • University of Catania (IT)
  • University of Messina (IT)
  • University of North Carolina at Chapel Hill (US)
Corresponding author
Isola, Gaetano
ORCID
Venue
Journal of Periodontology
Publisher
Wiley
Published
2021-06-02
Volume
93
Issue
1
Pages
135-145
ISSN
  • 0022-3492 (ISSN-L)
  • 1943-3670
DOI
10.1002/jper.21-0049
OpenAlex
W3161768710
Cited by
148
References
53
Citations by year
2026: 11 · 2025: 19 · 2024: 29 · 2023: 25 · 2022: 46 · 2021: 18
FWCI
9.26
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Journal of Periodontology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
  • Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Keywords
periodontitis, NLRP3 inflammasome, type 2 diabetes, salivary biomarkers, serum biomarkers, C-reactive protein, HDL cholesterol, inflammation
MeSH terms
NLR Family, Pyrin Domain-Containing 3 Protein, Diabetes Mellitus, Type 2, Humans, Periodontitis, Saliva, Inflammasomes

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