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Current status of phthalocyanines in the photodynamic therapy of cancer
Abstract
Photodynamic therapy is a binary treatment now accepted in clinic for various malignancies in several countries around the world. Phthalocyanine molecules are second-generation photosensitizers with enhanced photophysical and photochemical properties over those of porphyrins. They have been shown to be phototoxic against a number of cell types and tumor models. A great deal of research has been devoted to the elucidation of their mechanism of action and mode of cell death. The present paper reviews phthalocyanine pre-clinical anti-cancer research with emphasis on phthalocyanine induced apoptosis using a silicon phthalocyanine, Pc 4. A brief summary of the latest clinical results using phthalocyanines is presented.
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Cited by
Oncologic photodynamic therapy photosensitizers: A clinical review
Allison, R. R., & Sibata, C. H. (2010) · Photodiagnosis and Photodynamic Therapy · doi:10.1016/j.pdpdt.2010.02.001 · Cited by 836
Cheng, Y., Samia, A. C., Meyers, J. D., Panagopoulos, I., Fei, B., & Burda, C. (2008) · Journal of the American Chemical Society · doi:10.1021/ja801631c · Cited by 733
Quest for Novel Chemical Entities through Incorporation of Silicon in Drug Scaffolds
Ramesh, R., & Reddy, D. S. (2018) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.7b00718 · Cited by 624
Nanotechnology-Based Drug Delivery Systems for Photodynamic Therapy of Cancer: A Review
Calixto, G., Bernegossi, J., De Freitas, L., Fontana, C., & Chorilli, M. (2016) · Molecules · doi:10.3390/molecules21030342 · Cited by 538
Li, X., Lee, D., Huang, J., & Yoon, J. (2018) · Angewandte Chemie International Edition · doi:10.1002/anie.201806551 · Cited by 426
Metadata
- Authors
- ALLEN, C. M., SHARMAN, W. M., & VAN LIER, J. E.
- Venue
- Journal of Porphyrins and Phthalocyanines
- Publisher
- World Scientific Pub Co Pte Ltd
- Published
- 2001-02
- Volume
- 05
- Issue
- 02
- Pages
- 161-169
- ISSN
- 1088-4246 (ISSN-L)
- 1099-1409
- OpenAlex
- W2050917604
- Cited by
- 550
- References
- 0
- FWCI
- 14.06
- Type
- journal article
- Language
- en
- Open access
- closed
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- ALLEN, C. M., SHARMAN, W. M., & VAN LIER, J. E. (2001). Current status of phthalocyanines in the photodynamic therapy of cancer. Journal of Porphyrins and Phthalocyanines. https://doi.org/10.1002/jpp.324
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