Cited by 1,078Nanoparticle-Based Drug DeliveryAdvanced Polymer Synthesis and CharacterizationAdvanced Drug Delivery Systems

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Amphiphilic block copolymers for drug delivery

Adams, Monica L., Lavasanifar, Afsaneh, Kwon, Glen S.·2003·Journal of Pharmaceutical Sciences

DOI 10.1002/jps.10397

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Abstract

Amphiphilic block copolymers (ABCs) have been used extensively in pharmaceutical applications ranging from sustained-release technologies to gene delivery. The utility of ABCs for delivery of therapeutic agents results from their unique chemical composition, which is characterized by a hydrophilic block that is chemically tethered to a hydrophobic block. In aqueous solution, polymeric micelles are formed via the association of ABCs into nanoscopic core/shell structures at or above the critical micelle concentration. Upon micellization, the hydrophobic core regions serve as reservoirs for hydrophobic drugs, which may be loaded by chemical, physical, or electrostatic means, depending on the specific functionalities of the core-forming block and the solubilizate. Although the Pluronics, composed of poly(ethylene oxide)-block-poly(propylene oxide)-block-poly(ethylene oxide), are the most widely studied ABC system, copolymers containing poly(L-amino acid) and poly(ester) hydrophobic blocks have also shown great promise in delivery applications. Because each ABC has unique advantages with respect to drug delivery, it may be possible to choose appropriate block copolymers for specific purposes, such as prolonging circulation time, introduction of targeting moieties, and modification of the drug-release profile. ABCs have been used for numerous pharmaceutical applications including drug solubilization/stabilization, alteration of the pharmacokinetic profile of encapsulated substances…

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Authors: Adams, M. L., Lavasanifar, A., & Kwon, G. S.
Affiliations: University of Wisconsin–Madison (US)
University of Alberta (CA)
Corresponding author: Kwon, Glen S.
ORCID: Lavasanifar, Afsaneh
Kwon, Glen S.
Venue: Journal of Pharmaceutical Sciences
Publisher: Elsevier BV
Published: 2003-07
Volume: 92
Issue: 7
Pages: 1343-1355
ISSN: 0022-3549 (ISSN-L)
DOI: 10.1002/jps.10397
OpenAlex: W2002975193
Cited by: 1,078
References: 90
Citations by year: 2026: 18 · 2025: 26 · 2024: 33 · 2023: 54 · 2022: 60 · 2021: 47 · 2020: 56 · 2019: 66 · 2018: 51 · 2017: 51 · 2016: 69 · 2015: 68 · 2014: 62 · 2013: 60 · 2012: 63
FWCI: 1.74
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Journal of Pharmaceutical Sciences (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Institute of Allergy and Infectious Diseases (AI 43346-02)
Topics: Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Physical Sciences › Chemistry › Organic Chemistry › Advanced Polymer Synthesis and Characterization
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Keywords: amphiphilic block copolymers, polymeric micelles, drug delivery, poloxamer, micellization, critical micelle concentration, drug solubilization, pharmacokinetics, drug release profile, targeting moieties, circulation time, multidrug resistance
MeSH terms: Lactates, Polyethylene Glycols, Polymers, Surface-Active Agents, Drug Delivery Systems

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Amphiphilic block copolymers for drug delivery

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