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Amphiphilic block copolymers for drug delivery
Abstract
Amphiphilic block copolymers (ABCs) have been used extensively in pharmaceutical applications ranging from sustained-release technologies to gene delivery. The utility of ABCs for delivery of therapeutic agents results from their unique chemical composition, which is characterized by a hydrophilic block that is chemically tethered to a hydrophobic block. In aqueous solution, polymeric micelles are formed via the association of ABCs into nanoscopic core/shell structures at or above the critical micelle concentration. Upon micellization, the hydrophobic core regions serve as reservoirs for hydrophobic drugs, which may be loaded by chemical, physical, or electrostatic means, depending on the specific functionalities of the core-forming block and the solubilizate. Although the Pluronics, composed of poly(ethylene oxide)-block-poly(propylene oxide)-block-poly(ethylene oxide), are the most widely studied ABC system, copolymers containing poly(L-amino acid) and poly(ester) hydrophobic blocks have also shown great promise in delivery applications. Because each ABC has unique advantages with respect to drug delivery, it may be possible to choose appropriate block copolymers for specific purposes, such as prolonging circulation time, introduction of targeting moieties, and modification of the drug-release profile. ABCs have been used for numerous pharmaceutical applications including drug solubilization/stabilization, alteration of the pharmacokinetic profile of encapsulated substances…
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“Micelles with lower CMC are preferable in DDSs because of their relatively higher stability and insensitivity to the dilution, which enables their longer circulations in the bloodstream [36].”
From Recent Advances in Nanomicelles Delivery Systems. (2020) · cites this paper as [36]
In the citing paper
“have considerably higher CMC, which is 10−3 to 10−4 M, compared to polymeric amphiphilic molecules, which has a CMC located in the range of 10−6 to 10−7 M.”
From Recent Advances in Nanomicelles Delivery Systems. (2020) · cites this paper as [36]
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Metadata
- Authors
- Adams, M. L., Lavasanifar, A., & Kwon, G. S.
- Affiliations
- University of Wisconsin–Madison (US)
- University of Alberta (CA)
- Corresponding author
- Kwon, Glen S.
- Venue
- Journal of Pharmaceutical Sciences
- Publisher
- Elsevier BV
- Published
- 2003-07
- Volume
- 92
- Issue
- 7
- Pages
- 1343-1355
- ISSN
- 0022-3549 (ISSN-L)
- OpenAlex
- W2002975193
- Cited by
- 1,078
- References
- 90
- Citations by year
- 2026: 18 · 2025: 26 · 2024: 33 · 2023: 54 · 2022: 60 · 2021: 47 · 2020: 56 · 2019: 66 · 2018: 51 · 2017: 51 · 2016: 69 · 2015: 68 · 2014: 62 · 2013: 60 · 2012: 63
- FWCI
- 1.74
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Pharmaceutical Sciences (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases (AI 43346-02)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Chemistry › Organic Chemistry › Advanced Polymer Synthesis and Characterization
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Keywords
- amphiphilic block copolymers, polymeric micelles, drug delivery, poloxamer, micellization, critical micelle concentration, drug solubilization, pharmacokinetics, drug release profile, targeting moieties, circulation time, multidrug resistance
- MeSH terms
- Lactates, Polyethylene Glycols, Polymers, Surface-Active Agents, Drug Delivery Systems
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