Controlled Release Scaffolds for Bone Tissue Engineering
Abstract
Bone disease and trauma can sometimes create defects that require more than current clinical therapies can provide for effective healing. Scaffolds that release bioactive agents such as drugs offer additional benefits in this regard in comparison to those whose main requirements are space filling and load bearing. This review details a variety of recent research on scaffold carrier systems that release osteogenic drugs for orthopaedic treatment purposes. The controlled release scaffolds presented are created from a variety of materials (such as tricalcium phosphate, hydrogel systems and poly(D,L-lactide)) and release drugs such as statins, bisphosphonates and a variety of growth factors.
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Production of novel scaffolds as carriers for osteogenesis drugs could be an advantageous approach to avoid systemic problems of the drug while improving its therapeutic efficiency.
“It has been reported that the production of novel scaffolds as the carrier for osteogenesis drugs could be an advantageous approach to eschew systemic problems of the drug while improving its therapeutic efficiency (Cartmell, 2009; Xu et al., 2020).”
From Osteogenesis Improvement of Gelatin-Based Nanocomposite Scaffold by Loading Zoledronic Acid (2022) · cites this paper as Cartmell, 2009
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Relationships between degradability of silk scaffolds and osteogenesis
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Osteogenesis Improvement of Gelatin-Based Nanocomposite Scaffold by Loading Zoledronic Acid
Abdulahy, S. B., Esmaeili Bidhendi, M., Vaezi, M. R., & Moosazadeh Moghaddam, M. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.890583 · Cited by 13 · see citing works
“It has been reported that the production of novel scaffolds as the carrier for osteogenesis drugs could be an advantageous approach to eschew systemic problems of the drug while improving its therapeutic efficiency (Cartmell, 2009; Xu et al., 2020).”
Background
- Authors
- Cartmell, S.
- Affiliations
- Keele University (GB)
- Corresponding author
- Cartmell, Sarah
- ORCID
- Cartmell, Sarah
- Venue
- Journal of Pharmaceutical Sciences
- Publisher
- Elsevier BV
- Published
- 2009-02
- Volume
- 98
- Issue
- 2
- Pages
- 430-441
- ISSN
- 0022-3549 (ISSN-L)
- OpenAlex
- W2074556301
- Cited by
- 66
- References
- 87
- Citations by year
- 2024: 2 · 2023: 1 · 2022: 1 · 2021: 2 · 2020: 2 · 2019: 3 · 2018: 1 · 2017: 4 · 2016: 8 · 2015: 3 · 2014: 5 · 2013: 8 · 2012: 9
- FWCI
- 3.76
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Pharmaceutical Sciences (publishedVersion)
- PubMed (publishedVersion)
- Research Explorer (The University of Manchester) (publishedVersion)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Keywords
- bone tissue engineering, drug delivery systems, tricalcium phosphate, hydrogels, poly(D,L-lactide), statins, bisphosphonates, growth factors, bone defects, orthopaedic treatment
- MeSH terms
- Animals, Anti-Bacterial Agents, Bone and Bones, Chemistry, Pharmaceutical, Delayed-Action Preparations, Drug Carriers, Drug Compounding, Humans, Osteogenesis, Bone Remodeling, Bone Substitutes, Tissue Engineering, Intercellular Signaling Peptides and Proteins, Bone Density Conservation Agents, Tissue Scaffolds
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