Effect of Ecdysterone on Histamine Release from Rat Peritoneal Mast Cells
Abstract
Ecdysterone dose-dependently inhibited anti-IgE-induced histamine release from mast cells. Moreover, the rate and extent of histamine release from mast cells induced by Concanavalin A (Con A) are significantly diminished in samples incubated with ecdysterone. Ecdysterone inhibited both the initial and gradual rise in fluorescent response by anti-IgE and Con A. The effects of ecdysterone on the fluorescence response was correlated with the inhibition of histamine release. These results suggest the possibility that the inhibition of histamine release from rat mast cells by ecdysterone might be due to inhibition of Ca2+ mobilization from intracellular Ca2+ storage.
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In vitro data suggest that ecdysterone's biological effects are associated with histamine release inhibition and neuroprotective effects and show promising therapeutic potential in Alzheimer's disease.
“The data suggest that ecdysterone’s biological effects are associated with histamine release inhibition [54] and neuroprotective effects [55] and show promising therapeutic potential in Alzheimer's disease [55].”
From Ecdysterone and Turkesterone—Compounds with Prominent Potential in Sport and Healthy Nutrition (2024) · cites this paper as [54]
Within the in vitro studies of ecdysterone, no serious effects were reported.
“Within these studies, no serious effects were reported [52,53,54,55,56,57,58,60,61,62,63,64,65,66,67,68,69,70,71,72,73].”
From Ecdysterone and Turkesterone—Compounds with Prominent Potential in Sport and Healthy Nutrition (2024) · cites this paper as [54]
In vitro studies associate ecdysterone with endothelial dysfunction prevention, osteoporosis prevention, glucose regulation, cytotoxic effects, antibacterial properties, immunomodulatory effects, and anti-inflammatory activities.
“Moreover, the effects on cell lines are associated with endothelial dysfunction prevention, osteoporosis prevention, glucose regulation, cytotoxic effects, antibacterial properties, immunomodulatory effects, and anti-inflammatory activities [52,53,54,55,56,57,58,60,61,62,63,64,65,66,67,68,69,70,71,72,73].”
From Ecdysterone and Turkesterone—Compounds with Prominent Potential in Sport and Healthy Nutrition (2024) · cites this paper as [54]
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- Authors
- Takei, M., Endo, K., Nishimoto, N., Shiobara, Y., Inoue, S.-S., & Matsuo, S.
- Affiliations
- La Jolla Institute for Immunology (US)
- Tokushima Bunri University (JP)
- Corresponding author
- Takei, Masao
- Venue
- Journal of Pharmaceutical Sciences
- Publisher
- Elsevier BV
- Published
- 1991-04
- Volume
- 80
- Issue
- 4
- Pages
- 309-310
- ISSN
- 0022-3549 (ISSN-L)
- OpenAlex
- W2165322353
- Cited by
- 8
- References
- 10
- Citations by year
- 2024: 1 · 2021: 1 · 2018: 1 · 2017: 2
- FWCI
- 0.17
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Pharmaceutical Sciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Mast cells and histamine
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Health Sciences › Medicine › Immunology and Allergy › Food Allergy and Anaphylaxis Research
- Keywords
- 20-hydroxyecdysone, histamine release, mast cells, anti-IgE, concanavalin A, calcium mobilization, intracellular calcium stores, mast cell degranulation
- MeSH terms
- Animals, Antibodies, Anti-Idiotypic, Calcium, Cells, Cultured, Concanavalin A, Ecdysterone, Histamine Release, Immunoglobulin E, Mast Cells, Peritoneal Cavity, Rats
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