Practical uses for ecdysteroids in mammals including humans: And update

Lafont, R.; Dinan, L.

doi:10.1673/031.003.0701

Cited by 197Hormonal and reproductive studiesSteroid Chemistry and BiochemistryAdrenal Hormones and Disorders

Practical uses for ecdysteroids in mammals including humans: And update

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Lafont, R., Dinan, L.·2003·Journal of Insect Science

DOI 10.1673/031.003.0701

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Abstract

Ecdysteroids are widely used as inducers for gene-switch systems based on insect ecdysteroid receptors and genes of interest placed under the control of ecdysteroid-response elements. We review here these systems, which are currently mainly used in vitro with cultured cells in order to analyse the role of a wide array of genes, but which are expected to represent the basis for future gene therapy strategies. Such developments raise several questions, which are addressed in detail.First, the metabolic fate of ecdysteroids in mammals, including humans, is only poorly known, and the rapid catabolism of ecdysteroids may impede their use as in vivo inducers.A second set of questions arose in fact much earlier with the pioneering “heterophylic” studies of Burdette in the early sixties on the pharmacological effects of ecdysteroids on mammals. These and subsequent studies showed a wide range of effects, most of them being beneficial for the organism (e.g. hypoglycaemic, hypocholesterolaemic, anabolic). These effects are reviewed and critically analysed, and some hypotheses are proposed to explain the putative mechanisms involved.All of these pharmacological effects have led to the development of a wide array of ecdysteroid-containing preparations, which are primarily used for their anabolic and/or “adaptogenic” properties on humans (or horses or dogs). In the same way, increasing numbers of patents have been deposited concerning various beneficial effects of ecdysteroids in many medical or cosmetic domains, which make ecdysteroids very attractive candidates for several practical uses.It may be questioned whether all these pharmacological actions are compatible with the development of ecdysteroid-inducible gene switches for gene therapy, and also if ecdysteroids should be classified among doping substances.

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20-hydroxyecdysone (20-OHE) is the most abundant and most studied ecdysteroid.
“among which 20‐hydroxyecdysone (ecdysterone, 20‐OHE) is the most abundant and the most studied.”
From Analytical strategy for the detection of ecdysterone and its metabolites in vivo in uPA(+/+)-SCID mice with humanized liver, human urine samples, and estimation of prevalence of its use in anti-doping samples (2021) · cites this paper as [2]
The Metabolic conversions section reviews studies of 20-hydroxyecdysone (20E) in rats and humans, and Some recent data describes sources of phytoecdysteroids. The paper thus supports that 20E is studied, but the passages do not establish that it is the most studied or the most abundant ecdysteroid; the Conclusion’s abundance statement concerns ecdysteroids as a group, not 20E specifically. Page numbers were not available in our copy. (LLM, conf=0.75)
Experimental — accuracy not yet measured
20E has low toxicity.
“One of the most intriguing properties of 20E in mammals is its anabolic effect, which is similar to that of anabolic steroids, yet it lacks an androgenic effect [14] and has low toxicity [15,16].”
From Beneficial Effects of Asparagus officinalis Extract Supplementation on Muscle Mass and Strength following Resistance Training and Detraining in Healthy Males (2023) · cites this paper as [16]
Ingestion of 20HE reportedly increases the size of muscle fibers in rats and increased lean body mass in sheep, pigs and quail.
“Ingestion of 20HE reportedly increases the size of muscle fibers in rats (Toth et al. 2008) as well as increased lean body mass in sheep, pigs and quail (Chermnykh et al. 1988;Lafont and Dinan 2003) and is associated with antidiabetic effects in obese mice (Kizelsztein et al. 2009).”
From Evaluating the effect of 20-hydroxyecdysone (20HE) on mechanistic target of rapamycin complex 1 (mTORC1) signaling in the skeletal muscle and liver of rats (2015) · cites this paper as Lafont and Dinan 2003
Dietary supplements containing ecdysteroids, especially 20-hydroxyecdysone, are being marketed in the United States.
“Because of such claimed multifactorial activities20, dietary supplements containing ecdysteroids, especially 20-HE, are being marketed in the United States.”
From The Phytochemical, Biological, and Medicinal Attributes of Phytoecdysteroids: An Updated Review (2021) · cites this paper as [20]
PEs have beneficial effects on mammals: anabolic, adaptogenic, antidiabetic, anti-inflammatory, antioxidant, antitumor, antimicrobial, and anti-arthritic activity; they also act as hepatoprotectors and immunomodulators.
“PEs have several beneficial effects on mammals: they play roles in anabolic, adaptogenic, antidiabetic, anti-inflammatory, antioxidant, antitumor, antimicrobial, and anti-arthritic activity. They also act as hepatoprotectors and immunomodulators [3,8,12,15,155].”
From Phytoecdysteroids: Distribution, Structural Diversity, Biosynthesis, Activity, and Crosstalk with Phytohormones (2022) · cites this paper as [155]

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Ten years of protein kinase B signalling: a hard Akt to follow
Brazil, D. P., & Hemmings, B. A. (2001) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(01)01958-2 · Cited by 1,177 · see citing works
The drosophila EcR gene encodes an ecdysone receptor, a new member of the steroid receptor superfamily
Koelle, M. R., Talbot, W. S., Segraves, W. A., Bender, M. T., Cherbas, P. T., & Hogness, D. S. (1991) · Cell · doi:10.1016/0092-8674(91)90572-g · Cited by 978 · see citing works
Oxysterols: Modulators of Cholesterol Metabolism and Other Processes
Schroepfer, G. J. (2000) · Physiological Reviews · doi:10.1152/physrev.2000.80.1.361 · Cited by 972 · see citing works
Functional ecdysone receptor is the product of EcR and Ultraspiracle genes
Yao, T., FORMAN, B. M., Jiang, Z., Cherbas, L., Chen, J.-D., McKeown, M., Cherbas, P. T., & Evans, R. M. (1993) · Nature · doi:10.1038/366476a0 · Cited by 947 · see citing works
Structural requirements of ligands for the oxysterol liver X receptors LXRα and LXRβ
Janowski, B. A., Grogan, M. J., Jones, S. A., Wisely, G. B., Kliewer, S. A., Corey, E. J., & Mangelsdorf, D. J. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.1.266 · Cited by 946 · see citing works
New insecticides with ecdysteroidal and juvenile hormone activity
Dhadialla, T. S., Carlson, G. R., & Le, D. P. (1998) · Annual Review of Entomology · doi:10.1146/annurev.ento.43.1.545 · Cited by 912 · cited 5× · see citing works
“In the context of this review, the identification of bisacylhydrazines as non-steroidal ecdysteroid agonists (Wing, 1988; Dhadialla et al., 1998) is particularly worth mentioning as, in addition to several of these molecules being commercialised as insecticides, other analogues appear appropriate as gene switching eli…”
Influential
Ecdysone-inducible gene expression in mammalian cells and transgenic mice.
No, D. B., Yao, T. P., & Evans, R. M. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.8.3346 · Cited by 852 · see citing works
Cloning, expression, and characterization of a membrane progestin receptor and evidence it is an intermediary in meiotic maturation of fish oocytes
Zhu, Y., Rice, C. D., Pang, Y., Pace, M. C., & Thomas, P. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0336132100 · Cited by 798 · see citing works
Drosophila ultraspiracle modulates ecdysone receptor function via heterodimer formation
Yao, T., Segraves, W. A., Oro, A. E., McKeown, M., & Evans, R. M. (1992) · Cell · doi:10.1016/0092-8674(92)90266-f · Cited by 716 · see citing works
Role of Akt/protein kinase B in metabolism.
Whiteman, E. L., Cho, H., & Birnbaum, M. (2002) · Trends in endocrinology and metabolism · doi:10.1016/s1043-2760(02)00662-8 · Cited by 705 · see citing works
The Pregnane X Receptor: A Promiscuous Xenobiotic Receptor That Has Diverged during Evolution
Jones, S. A., Moore, L. B., Shenk, J. L., Wisely, G. B., Hamilton, G. A., McKee, D. D., Tomkinson, N. C. O., LeCluyse, E. L., Lambert, M. H., Willson, T. M., et al. (2000) · Molecular Endocrinology · doi:10.1210/mend.14.1.0409 · Cited by 672 · see citing works
Drosophila tissues with different metamorphic responses to ecdysone express different ecdysone receptor isoforms
Talbot, W. S., Swyryd, E. A., & Hogness, D. S. (1993) · Cell · doi:10.1016/0092-8674(93)90359-x · Cited by 587 · see citing works
Evolution of the nuclear receptor superfamily: early diversification from an ancestral orphan receptor
Laudet, V (1997) · Journal of Molecular Endocrinology · doi:10.1677/jme.0.0190207 · Cited by 557 · see citing works
Heterodimerization of the Drosophila ecdysone receptor with retinoid X receptor and ultraspiracle
Thomas, H. E., Stunnenberg, H. G., & Stewart, A. F. (1993) · Nature · doi:10.1038/362471a0 · Cited by 520 · see citing works
Altered proteasomal function due to the expression of polyglutamine-expanded truncated N-terminal huntingtin induces apoptosis by caspase activation through mitochondrial cytochrome c release
Jana, N. R. (2001) · Human Molecular Genetics · doi:10.1093/hmg/10.10.1049 · Cited by 453 · see citing works
The structure of the nuclear hormone receptors
Kumar, R., & Thompson, E. B. (1999) · Steroids · doi:10.1016/s0039-128x(99)00014-8 · Cited by 433 · see citing works
Relationship between the product of the Drosophila ultraspiracle locus and the vertebrate retinoid X receptor
Oro, A. E., McKeown, M., & Evans, R. M. (1990) · Nature · doi:10.1038/347298a0 · Cited by 406 · cited 1× · see citing works
“One of the most promiscuous heterodimeric partners for vertebrate nuclear receptors is RXR, of which the equivalent in insects is Ultraspiracle (USP; Oro et al., 1990).”
Phytoecdysteroids: Biological aspects
Dinan, L. (2001) · Phytochemistry · doi:10.1016/s0031-9422(01)00078-4 · Cited by 392 · cited 4× · see citing works
“Although they have been detected in ca. 6% of plant species analysed so far (Dinan, 2001), phytoecdysteroids are not so frequent in plant species used as human food (with the noticeable exception of spinach; Bathory et al., 1982; Grebenok et al., 1991).”
InfluentialSelf-citation
RH 5849, a Nonsteroidal Ecdysone Agonist: Effects on a Drosophila Cell Line
Wing, K. D. (1988) · Science · doi:10.1126/science.3393913 · Cited by 358 · see citing works
Emerging diversities in the mechanism of action of steroid hormones
Brann, D. W., Hendry, L. B., & Mahesh, V. B. (1995) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(94)00160-n · Cited by 260 · see citing works
Chemically regulated gene expression in plants.
Padidam, M. (2003) · Current opinion in plant biology · doi:10.1016/s1369-5266(03)00005-0 · Cited by 228 · see citing works
The Impact of Mammalian Gene Regulation Concepts on Functional Genomic Research, Metabolic Engineering, and Advanced Gene Therapies
Fussenegger, M. (2001) · Biotechnology progress (Print) · doi:10.1021/bp000129c · Cited by 179 · see citing works
Cloning of an ecdysone receptor homolog from Manduca sexta and the developmental profile of its mRNA in Wings
Fujiwara, H., Jindra, M., Newitt, R. A., Palli, S. R., Hiruma, K., & Riddiford, L. M. (1995) · Insect Biochemistry and Molecular Biology · doi:10.1016/0965-1748(95)00023-o · Cited by 178 · see citing works
Exploiting semiochemicals in insect control
Agelopoulos, N. G., Birkett, M. A., Hick, A. J., Hooper, A. M., Pickett, J. A., Pow, E. M., Smart, L. E., Smiley, D. W. M., Wadhams, L. J., & Woodcock, C. M. (1999) · Pesticide Science · doi:10.1002/(sici)1096-9063(199903)55:3 · Cited by 161 · see citing works
Ecdysteroid-dependent regulation of genes in mammalian cells by a Drosophila ecdysone receptor and chimeric transactivators.
Christopherson, K. S., Mark, M. R., Bajaj, V., & Godowski, P. J. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.14.6314 · Cited by 160 · see citing works
The mosquito ultraspiracle homologue, a partner of ecdysteroid receptor heterodimer: cloning and characterization of isoforms expressed during vitellogenesis
Kapitskaya, M. Z., Wang, S.-F., Cress, D. E., Dhadialla, T. S., & Raikhel, A. S. (1996) · Molecular and Cellular Endocrinology · doi:10.1016/0303-7207(96)03847-6 · Cited by 145 · see citing works
Bombyx EcR (BmEcR) and Bombyx USP (BmCF1) combine to form a functional ecdysone receptor
Swevers, L., Cherbas, L., Cherbas, P. T., & Iatrou, K. (1996) · Insect Biochemistry and Molecular Biology · doi:10.1016/0965-1748(95)00097-6 · Cited by 139 · see citing works
α-Synuclein Affects the MAPK Pathway and Accelerates Cell Death
Iwata, A., Maruyama, M., Kanazawa, I., & Nukina, N. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m103736200 · Cited by 139 · see citing works
Identification and mRNA developmental profiles of two ultraspiracle isoforms in the epidermis and wings of Manduca sexta
Jindra, M., Huang, J., Malone, F., Asahina, M., & Riddiford, L. M. (1997) · Insect Molecular Biology · doi:10.1046/j.1365-2583.1997.00153.x · Cited by 139 · see citing works
An extensive ecdysteroid CoMFA
Dinan, L. N., Hormann, R. E., & Fujimoto, T. T. (1999) · Journal of Computer-Aided Molecular Design · doi:10.1023/a:1008052320014 · Cited by 137 · see citing works
Self-citation
Inducible gene expression in mammalian cells and transgenic mice.
Saez, E., No, D., West, A. B., & Evans, R. (1997) · Current Opinion in Biotechnology · doi:10.1016/s0958-1669(97)80037-7 · Cited by 126 · see citing works
Mosquito ecdysteroid receptor: Analysis of the cDNA and expression during vitellogenesis
Cho, W.-L., Kapitskaya, M. Z., & Raikhel, A. S. (1995) · Insect Biochemistry and Molecular Biology · doi:10.1016/0965-1748(94)00045-j · Cited by 126 · see citing works
The silkmoth homolog of the Drosophila ecdysone receptor (BI Isoform): Cloning and analysis of expression during follicular cell differentiation
Swevers, L., Drevet, J. R., Lunke, M. D., & Iatrou, K. (1995) · Insect Biochemistry and Molecular Biology · doi:10.1016/0965-1748(95)00024-p · Cited by 121 · see citing works
Cloning of a Chironomus tentans cDNA encoding a protein (cEcRH) homologous to the Drosophila melanogaster ecdysteroid receptor (dEcR)
Imhof, M. O., Rusconi, S., & Lezzi, M. (1993) · Insect Biochemistry and Molecular Biology · doi:10.1016/0965-1748(93)90089-b · Cited by 121 · see citing works
Progesterone in Conjunction With Estradiol Has Neuroprotective Effects in an Animal Model of Neurodegeneration
Vongher, J. M. (1999) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(99)00140-9 · Cited by 117 · see citing works
Identification of ligands and coligands for the ecdysone-regulated gene switch
Sáez, E., Nelson, M. C., Eshelman, B., Banayo, E., Koder, A., Cho, G. J., & Evans, R. M. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.260499497 · Cited by 114 · see citing works
CHMP1 is a novel nuclear matrix protein affecting chromatin structure and cell-cycle progression
Stauffer, D. R., Howard, T. L., Nyun, T., & Hollenberg, S. M. (2001) · Journal of Cell Science · doi:10.1242/jcs.114.13.2383 · Cited by 112 · see citing works
Characterization of a p75NTR Apoptotic Signaling Pathway Using a Novel Cellular Model
Wang, X., Bauer, J. H., Li, Y., Shao, Z., Zetoune, F. S., Cattaneo, E. F., & Vincenz, C. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m010548200 · Cited by 109 · see citing works
Promoters that respond to chemical inducers
Gatz, C., & Lenk, I. (1998) · Trends in Plant Science · doi:10.1016/s1360-1385(98)01287-4 · Cited by 109 · see citing works
Ecdysone agonist inducible transcription in transgenic tobacco plants
Martínez, A., Sparks, C. A., Hart, C. A., Thompson, J., & Jepson, I. (1999) · The Plant Journal · doi:10.1046/j.1365-313x.1999.00504.x · Cited by 107 · see citing works
4D-QSAR Analysis of a Set of Ecdysteroids and a Comparison to CoMFA Modeling
Ravi, M., Hopfinger, A. J., Hormann, R. E., & Dinan, L. N. (2001) · Journal of Chemical Information and Computer Sciences · doi:10.1021/ci010076u · Cited by 107 · see citing works
Self-citation
Characterization of crab EcR and RXR homologs and expression during limb regeneration and oocyte maturation
Durica, D. S., Wu, X., Anilkumar, G., Hopkins, P. M., & Chung, A. C.-K. (2002) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(01)00740-7 · Cited by 104 · see citing works
High level transactivation by a modified Bombyx ecdysone receptor in mammalian cells without exogenous retinoid X receptor
Suhr, S. T., Gil, E. B., Senut, M., & Gage, F. H. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.14.7999 · Cited by 98 · see citing works
Overexpression of candidate tumor suppressor gene FUS1 isolated from the 3p21.3 homozygous deletion region leads to G1 arrest and growth inhibition of lung cancer cells
Kondo, M., Ji, L., Kamibayashi, C., Tomizawa, Y., Randle, D. E., Sekido, Y., Yokota, J., Kashuba, V. I., Zabarovsky, E. R., Kuzmin, I., et al. (2001) · Oncogene · doi:10.1038/sj.onc.1204832 · Cited by 97 · see citing works
Improved ecdysone receptor‐based inducible gene regulation system
Palli, S. R., Kapitskaya, M. Z., Kumar, M. B., & Cress, D. E. (2003) · European Journal of Biochemistry · doi:10.1046/j.1432-1033.2003.03501.x · Cited by 95 · see citing works
Adenovirus-mediated inducible gene expression in vivo by a hybrid ecdysone receptor.
Hoppe, U. C., Marbán, E., & Johns, D. (2000) · Molecular Therapy · doi:10.1006/mthe.1999.0023 · Cited by 92 · see citing works
The Effect of Thiopurine Methyltransferase Expression on Sensitivity to Thiopurine Drugs
Coulthard, S. A., Hogarth, L., Little, M., Matheson, E. C., Redfern, C. P. F., Minto, L., & Hall, A. G. (2002) · Molecular Pharmacology · doi:10.1124/mol.62.1.102 · Cited by 92 · see citing works
Cloning and developmental expression of the ecdysone receptor gene from the spruce budworm, choristoneura fumiferana
Kothapalli, R., Palli, S. R., Ladd, T. R., Sohi, S. S., Cress, D. E., Dhadialla, T. S., Tzertzinis, G., & Retnakaran, A. (1995) · Developmental Genetics · doi:10.1002/dvg.1020170405 · Cited by 84 · see citing works
p53-independent apoptosis mediated by tachpyridine, an anti-cancer iron chelator
Abeysinghe, R. D. (2001) · Carcinogenesis · doi:10.1093/carcin/22.10.1607 · Cited by 83 · see citing works
A new model for 20‐hydroxyecdysone and dibenzoylhydrazine binding: A homology modeling and docking approach
Wurtz, J., Guillot, B., Fagart, J., Moras, D., Tietjen, K., & Schindler, M. (2000) · Protein Science · doi:10.1110/ps.9.6.1073 · Cited by 79 · see citing works
Overexpression of 5-methylcytosine DNA glycosylase in human embryonic kidney cells EcR293 demethylates the promoter of a hormone-regulated reporter gene
Zhu, B., Benjamin, D., Zheng, Y., Angliker, H., Thiry, S., Siegmann, M., & Jost, J. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.091097298 · Cited by 78 · see citing works
Effect of Ecdysterone on Hyperglycemia in Experimental Animals
Yoshida, T., Otaka, T., Uchiyama, M., & Ogawa, S. (1971) · Biochemical Pharmacology · doi:10.1016/0006-2952(71)90431-x · Cited by 74 · see citing works
Insect hormones in vertebrates: Anabolic effects of 20-hydroxyecdysone in Japanese quail
Sláma, K., Koudela, K., Tenora, J., & Maťhová, A. (1996) · Cellular and Molecular Life Sciences · doi:10.1007/bf01925578 · Cited by 73 · see citing works
The sequence of Locusta RXR, homologous to Drosophila Ultraspiracle, and its evolutionary implications
Hayward, D. C., Bastiani, M. J., Trueman, J. W. H., Truman, J. W., Riddiford, L. M., & Ball, E. E. (1999) · Development Genes and Evolution · doi:10.1007/s004270050290 · Cited by 70 · see citing works
Cloning of Two Putative Ecdysteroid Receptor Isoforms from Tenebrio Molitor and their Developmental Expression in the Epidermis during Metamorphosis
Mouillet, J., Delbecque, J., Quennedey, B., & Delachambre, J. (1997) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1997.00856.x · Cited by 68 · see citing works
A single point mutation in ecdysone receptor leads to increased ligand specificity: Implications for gene switch applications
Kumar, M. B., Fujimoto, T. T., Potter, D. W., Deng, Q., & Palli, S. R. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.222278999 · Cited by 67 · see citing works
Expression of ecdysone receptor is unaffected by pupal diapause in the flesh fly, Sarcophaga crassipalpis, while its dimerization partner, USP, is downregulated
Rinehart, J. P., Cikra-Ireland, R. A., Flannagan, R. D., & Denlinger, D. L. (2001) · Journal of Insect Physiology · doi:10.1016/s0022-1910(01)00064-6 · Cited by 67 · see citing works
Regulation of MDR1 promoter activity in human breast carcinoma cells by protein kinase C isozymes α and θ
Gill, P. K., Gescher, A. J., & Gant, T. W. (2001) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.2001.02326.x · Cited by 66 · see citing works
Mammalian 5′(3′)-Deoxyribonucleotidase, cDNA Cloning, and Overexpression of the Enzyme in Escherichia coli and Mammalian Cells
Rampazzo, C., Johansson, M., Gallinaro, L., Ferraro, P., Hellman, U., Karlsson, A., Reichard, P. A., & Bianchi, V. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.8.5409 · Cited by 63 · see citing works
The ecdysteroid receptor
Bidmon, H. J., & Sliter, T. J. (1990) · Invertebrate Reproduction & Development · doi:10.1080/07924259.1990.9672125 · Cited by 62 · see citing works
Receptor-mediated rapid action of 1 alpha,25-dihydroxycholecalciferol: increase of intracellular cGMP in human skin fibroblasts.
Bársony, J., & Marx, S. J. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.4.1223 · Cited by 61 · see citing works
Molecular Determinants of Differential Ligand Sensitivities of Insect Ecdysteroid Receptors
Wang, S., Ayer, S., Segraves, W. A., Williams, D. R., & Raikhel, A. S. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.11.3870-3879.2000 · Cited by 60 · see citing works
Sustained mammary gland‐directed, ponasterone A‐inducible expression in transgenic mice
Albanese, C., Reutens, A., Bouzahzah, B., Fu, M., D’Amico, M., Link, T., Nicholson, R., DePinho, R., & Pestell, R. (2000) · The FASEB Journal · doi:10.1096/fasebj.14.7.877 · Cited by 59 · see citing works
Drm/Gremlin transcriptionally activates p21Cip1 via a novel mechanism and inhibits neoplastic transformation
Chen, B., Athanasiou, M., Gu, Q., & Blair, D. G. (2002) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)00828-8 · Cited by 58 · see citing works
Functional characterization of two Ultraspiracle forms (CtUSP-1 and CtUSP-2) from Chironomus tentans
Vogtli, M. E. (1999) · Insect Biochemistry and Molecular Biology · doi:10.1016/s0965-1748(99)00068-5 · Cited by 57 · see citing works
Design of a retroviral-mediated ecdysone-inducible system and its application to the expression profiling of the PTEN tumor suppressor
Stolarov, J. P., Chang, K., Reiner, A. H., Rodgers, L., Hannon, G. J., Wigler, M. H., & Mittal, V. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.221450598 · Cited by 57 · see citing works
Different feeding and gustatory responses to ecdysone and 20-hydroxyecdysone by larvae of the silkworm,Bombyx mori
Tanaka, Y., Asaoka, K., & Takeda, S. (1994) · Journal of Chemical Ecology · doi:10.1007/bf02065995 · Cited by 56 · see citing works
Cloning and characterization of LcEcR: A functional ecdysone receptor from the sheep blowfly Lucilia cuprina
Hannan, G. N., & Hill, R. J. (1997) · Insect Biochemistry and Molecular Biology · doi:10.1016/s0965-1748(97)00019-2 · Cited by 54 · see citing works
Generation of a Flexible Cell Line with Regulatable, High-Level Expression of HIV Gag/Pol Particles Capable of Packaging HIV-Derived Vectors
Sparacio, S., Pfeiffer, T., Schaal, H., & Bosch, V. (2001) · Molecular Therapy · doi:10.1006/mthe.2001.0296 · Cited by 54 · see citing works
Comparative Experimental Investigation of the Anabolic Activity of Phytoecdysteroids and Steranabols
Syrov, V. N. (2000) · Pharmaceutical Chemistry Journal · doi:10.1007/bf02524596 · Cited by 53 · see citing works
Dominant Negativec-junInhibits Activation of the Cyclin D1 and Cyclin E Kinase Complexes
Hennigan, R. F., & Stambrook, P. J. (2001) · Molecular Biology of the Cell · doi:10.1091/mbc.12.8.2352 · Cited by 53 · see citing works
Occurrence and levels of ecdysteroids in spinach
Grebenok, R. J., Ripa, P. V., & Adler, J. H. (1991) · Lipids · doi:10.1007/bf02536433 · Cited by 52 · see citing works
Studies on two ecdysone receptor isoforms of the spruce budworm, Choristoneura fumiferana
Perera, S. C., Ladd, T. R., Dhadialla, T. S., Krell, P. J., Sohi, S. S., Retnakaran, A., & Palli, S. R. (1999) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(99)00058-1 · Cited by 52 · see citing works
Considerations on the structural evidence of a ligand-binding function of ultraspiracle, an insect homolog of vertebrate RXR
Jones, G., & Jones, D. (2000) · Insect Biochemistry and Molecular Biology · doi:10.1016/s0965-1748(00)00038-2 · Cited by 50 · see citing works
Calpain Inhibition Decreases the Growth Rate of Mammalian Cell Colonies
Xu, Y., & Mellgren, R. L. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m111689200 · Cited by 50 · see citing works
Tumor suppressor protein VHL is induced at high cell density and mediates contact inhibition of cell growth
Baba, M., Hirai, S.-I., Kawakami, S., Kishida, T., Sakai, N., Kaneko, S., Yao, M., Shuin, T., Kubota, Y., Hosaka, M., et al. (2001) · Oncogene · doi:10.1038/sj.onc.1204397 · Cited by 48 · see citing works
p27Kip1‐mediated controlled proliferation technology increases constitutive sICAM production in CHO‐DUKX adapted for growth in suspension and serum‐free media
Meents, H., Enenkel, B., Werner, R. G., & Fussenegger, M. (2002) · Biotechnology and Bioengineering · doi:10.1002/bit.10322 · Cited by 48 · see citing works
A Chimeric Ecdysone Receptor Facilitates Methoxyfenozide-Dependent Restoration of Male Fertility in ms45 Maize
Unger‐Wallace, E., Cigan, A. M., Trimnell, M. R., Xu, R., Kendall, T., Roth, B., & Albertsen, M. C. (2002) · Transgenic Research · doi:10.1023/a:1020350208095 · Cited by 45 · see citing works
Cloning and characterization of an ecdysone receptor cDNA from Locusta migratoria
Saleh, D. S., Zhang, J., Wyatt, G. R., & Walker, V. K. (1998) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(98)00131-2 · Cited by 45 · see citing works
Creation of ecdysone receptor chimeras in plants for controlled regulation of gene expression
Martinez, A., Sparks, C., Drayton, P., Thompson, J., Greenland, A., & Jepson, I. (1999) · Molecular and General Genetics MGG · doi:10.1007/s004380050999 · Cited by 45 · see citing works
Ecdysteroids in Spinacia oleracea and Chenopodium bonus-henricus
Báthory, M., Tóth, I., Szendrei, K., & Reisch, J. (1982) · Phytochemistry · doi:10.1016/0031-9422(82)80057-5 · Cited by 45 · see citing works
Synthesis and SAR of α-Acylaminoketone ligands for control of gene expression
Tice, C. M., Hormann, R. E., Thompson, C. S., Friz, J. L., Cavanaugh, C. K., Michelotti, E. L., Garcia, J., Nicolás, E., & Alberício, F. (2003) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/s0960-894x(02)00980-0 · Cited by 45 · see citing works
Stimulation of Protein Synthesis in Mouse Liver by Insect-Moulting Steroids
Okui, S., Otaka, T., Uchiyama, M., Takemoto, T., Hikino, H., Ogawa, S., & Nishimoto, N. (1968) · Chemical and Pharmaceutical Bulletin · doi:10.1248/cpb.16.384 · Cited by 44 · see citing works
Polymorphisms in the human xeroderma pigmentosum group A gene and their impact on cell survival and nucleotide excision repair
Mellon, I. (2002) · DNA repair · doi:10.1016/s1568-7864(02)00053-8 · Cited by 43 · see citing works
Phytoecdysteroids effects on mammalians, isolation and analysis
Bathori, M. (2002) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/1389557023406269 · Cited by 42 · cited 2× · see citing works
“…effects of ecdysteroids on vertebrates The pharmacological actions of ecdysteroids on vertebrates have been reviewed in several previous articles (Burdette, 1962, 1972; Ogawa et al., 1974; Syrov, 1984, 1994; Sláma and Lafont, 1995; Xu et al., 1997; Syrov, 2000; Kholodova, 2001; Báthori, 2002).”
Nongenomic effects of ecdysteroids
Tomaschko, K. (1999) · Archives of Insect Biochemistry and Physiology · doi:10.1002/(sici)1520-6327(1999)41:2 · Cited by 42 · see citing works
Ecdysteroids: one potential new anabolic family in breeding animals
Le Bizec, B., Antignac, J.-P., Monteau, F., & Andre, F. (2002) · Analytica Chimica Acta · doi:10.1016/s0003-2670(02)00874-7 · Cited by 41 · see citing works
Evaluation of the tetracycline‐ and ecdysone‐inducible systems for expression of neurotransmitter receptors in mammalian cells
van Craenenbroeck, K., Vanhoenacker, P., Leysen, J., & Haegeman, G. (2001) · European Journal of Neuroscience · doi:10.1046/j.0953-816x.2001.01719.x · Cited by 39 · see citing works
Protection against chemotherapy-induced cytotoxicity by cyclin-dependent kinase inhibitors (CKI) in CKI-responsive cells compared with CKI-unresponsive cells
Schmidt, M., & Fan, Z. (2001) · Oncogene · doi:10.1038/sj.onc.1204814 · Cited by 39 · see citing works
Electrophysiological responses of gustatory sensilla of Mamestra brassicae (Lepidoptera, Noctuidae) larvae to three ecdysteroids: ecdysone, 20-hydroxyecdysone and ponasterone A
Descoins, C., & Marion‐Poll, F. (1999) · Journal of Insect Physiology · doi:10.1016/s0022-1910(99)00057-8 · Cited by 36 · see citing works
Molecular cloning and expression of Tenebrio molitor ultraspiracle during metamorphosis and in vivo induction of its phosphorylation by 20‐hydroxyecdysone
Nicolaı̈, M., Bouhin, H., Quennedey, B., & Delachambre, J. (2000) · Insect Molecular Biology · doi:10.1046/j.1365-2583.2000.00181.x · Cited by 36 · see citing works
Neurotoxic mechanisms triggered by Alzheimer's disease‐linked mutant M146L presenilin 1: involvement of NO synthase via a novel pertussis toxin target
Hashimoto, Y., Ito, Y., Arakawa, E., Kita, Y. A., Terashita, K., Niikura, T., & Nishimoto, I. (2002) · Journal of Neurochemistry · doi:10.1046/j.0022-3042.2001.00722.x · Cited by 36 · see citing works
The use of inducible engrailed fusion proteins to study the cellular functions of eukaryotic transcription factors.
Vickers, E. R., & Sharrocks, A. (2002) · Methods · doi:10.1016/s1046-2023(02)00031-2 · Cited by 36 · see citing works
Involvement of the Fungal Nuclear Migration Gene nudC Human Homolog in Cell Proliferation and Mitotic Spindle Formation
Zhang, M., Huang, N., Clawson, G. A., Osmani, S. A., Pan, W., Xin, P., Razzaque, M. S., & Miller, B. A. (2002) · Experimental Cell Research · doi:10.1006/excr.2001.5414 · Cited by 35 · see citing works
Stimulatory Effect of Insect-Metamorphosing Steroids from Achyranthes and Cyathula on Protein Synthesis in Mouse Liver
Otaka, T., Uchiyama, M., Okui, S., TAKEMOTO, T., Hikino, H., Ogawa, S., & Nishimoto, N. (1968) · Chemical and Pharmaceutical Bulletin · doi:10.1248/cpb.16.2426 · Cited by 35 · see citing works
Hypoglycemic Activity of the Total Ecdysteroid Extract from Ajuga turkestanica
Kutepova, T. A., Syrov, V. N., Khushbaktova, Z. A., & Saatov, Z. (2001) · Pharmaceutical Chemistry Journal · doi:10.1023/a:1015145811009 · Cited by 34 · see citing works
Alterations in Rat Lipid Metabolism Following Ecdysterone Treatment
Catalán, R. E., Martinez, A. M., Aragones, M. D., Miguel, B. G., Robles, A., & Godoy, J. E. (1985) · Comparative Biochemistry and Physiology Part B Comparative Biochemistry · doi:10.1016/0305-0491(85)90403-1 · Cited by 34 · see citing works
Change in gene expression subsequent to induction of Pnn/DRS/memA: increase in p21cip1/waf1
Shi, Y. G., Simmons, M. N., Seki, T., Oh, S. P., & Sugrue, S. P. (2001) · Oncogene · doi:10.1038/sj.onc.1204507 · Cited by 33 · see citing works
20-hydroxyecdysone as a human lymphocyte and neutrophil modulator: In vitro evaluation
Trenin, D. S., & Володин, В. В. (1999) · Archives of Insect Biochemistry and Physiology · doi:10.1002/(sici)1520-6327(1999)41:3 · Cited by 33 · see citing works
Study of excretion of ecdysterone in human urine
Tsitsimpikou, C., Tsamis, G. D., Siskos, P. A., Spyridaki, M. E., & Georgakopoulos, C. G. (2001) · Rapid Communications in Mass Spectrometry · doi:10.1002/rcm.433 · Cited by 33 · see citing works
Inducible Expression of a Constitutively Active Mutant of Mitogen-activated Protein Kinase Kinase 7 Specifically Activates c-JUN NH2-terminal Protein Kinase, Alters Expression of at Least Nine Genes, and Inhibits Cell Proliferation
Wolter, S., Mushinski, J. F., Saboori, A. M., Resch, K., & Kracht, M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m105800200 · Cited by 30 · see citing works
Transcriptional activation of the cloned Heliothis virescens (Lepidoptera) ecdysone receptor (HvEcR) by MuristeroneA
Martínez, A. (1999) · Insect Biochemistry and Molecular Biology · doi:10.1016/s0965-1748(99)00067-3 · Cited by 29 · see citing works
Excretion and metabolism of injected ecdysone in the white mouse
Lafont, R., Girault, J., & Kerb, U. (1988) · Biochemical Pharmacology · doi:10.1016/0006-2952(88)90529-1 · Cited by 28 · see citing works
Self-citation
Ecdysterone induces acetylcholinesterase in mammalian brain
Catalan, R. E., Aragones, M. D., Godoy, J. E., & Martinez, A. M. (1984) · Comparative Biochemistry and Physiology Part C: Comparative Pharmacology · doi:10.1016/0742-8413(84)90068-9 · Cited by 27 · see citing works
Tyrosine phosphorylation of maspin in normal mammary epithelia and breast cancer cells
Odero-Marah, V., Khalkhali‐Ellis, Z., Schneider, G. B., Seftor, E. A., Seftor, R. E. B., Koland, J. G., & Hendrix, M. J. C. (2002) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)00764-7 · Cited by 27 · see citing works
Ecdysone-controlled expression of transgenes
Graham, L. D. (2002) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.2.5.525 · Cited by 26 · see citing works
V642I APP-Inducible Neuronal Cells: A Model System for Investigating Alzheimer's Disorders
Niikura, T., Murayama, N., Hashimoto, Y., Ito, Y., Yamagishi, Y., Matsuoka, M., Takeuchi, Y., Aiso, S., & Nishimoto, I. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.3143 · Cited by 26 · see citing works
Targeted gene regulation and gene ablation
DeMayo, F. J., & Tsai, S. Y. (2001) · Trends in Endocrinology and Metabolism · doi:10.1016/s1043-2760(01)00462-3 · Cited by 26 · see citing works
Study of the Structure—Anabolic Activity Relationship for Phytoecdysteroids Extracted from Some Plants of Central Asia
Syrov, V. N., Saatov, Z., Sagdullaev, S. S., & Mamatkhanov, A. U. (2001) · Pharmaceutical Chemistry Journal · doi:10.1023/a:1015344614064 · Cited by 24 · see citing works
Cloning and characterization of CcEcR
Verras, M., Mavroidis, M., Kokolakis, G., Gourzi, P., Zacharopoulou, A., & Mintzas, A. C. (1999) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.1999.00788.x · Cited by 24 · see citing works
Lcusp, an ultraspiracle gene from the sheep blowfly, Lucilia cuprina: cDNA cloning, developmental expression of RNA and confirmation of function
Hannan, G. N., & Hill, R. J. (2001) · Insect Biochemistry and Molecular Biology · doi:10.1016/s0965-1748(00)00182-x · Cited by 24 · see citing works
Reconstruction of Ligand-Dependent Transactivation of Choristoneura fumiferana Ecdysone Receptor in Yeast
Tran, H. T., Askari, H. B., Shaaban, S. A., Price, L., Palli, S. R., Dhadialla, T. S., Carlson, G. R., & Butt, T. R. (2001) · Molecular Endocrinology · doi:10.1210/mend.15.7.0660 · Cited by 24 · see citing works
Effect of Ecdysone on Incorporation of C14-Leucine into Hepatic Protein in vitro.
Burdette, W. J., & Coda, R. L. (1963) · Experimental Biology and Medicine · doi:10.3181/00379727-112-27996 · Cited by 24 · see citing works
Muristerone A-Induced Nerve Growth Factor Release from Genetically Engineered Human Dermal Fibroblasts for Peripheral Nerve Tissue Engineering
Patrick, C., Zheng, B., Wu, X., Gurtner, G. C., Barlow, M. S., Koutz, C. A., Chang, D. W., Schmidt, M., & Evans, G. R. D. (2001) · Tissue Engineering · doi:10.1089/10763270152044161 · Cited by 23 · see citing works
Ecdysone as A Hypocholesterolemic Agent
Lupien, P. J., Hinse, C., & Chaudhary, K. D. (1969) · Archives Internationales de Physiologie et de Biochimie · doi:10.3109/13813456909109700 · Cited by 23 · see citing works
Characterization of EcR and RXR Homologues in the Ixodid Tick,Amblyomma americanum(L.)
Palmer, M. J., Harmon, M. A., & Laudet, V. (1999) · American Zoologist · doi:10.1093/icb/39.4.747 · Cited by 23 · see citing works
Stimulation of Protein Synthesis in Mouse Liver by Ecdysterone
Otaka, T., Okui, S., & Uchiyama, M. (1969) · Chemical and Pharmaceutical Bulletin · doi:10.1248/cpb.17.75 · Cited by 23 · see citing works
Bicistronic Expression of Ecdysone-Inducible Receptors in Mammalian Cells
Wyborski, D. L., Bauer, J. C., & Vaillancourt, P. (2001) · BioTechniques · doi:10.2144/01313pf02 · Cited by 22 · see citing works
Effect of Pfaffia iresinoides on the experimental inflammatory process in rats
Taniguchi, S. F., Bersani‐Amado, C. A., Sudo, L. S., Caparroz‐Assef, S. M., & Oga, S. (1997) · Phytotherapy Research · doi:10.1002/(sici)1099-1573(199712)11:8 · Cited by 22 · see citing works
Development and characterization of a minimal inducible packaging cell line for simian immunodeficiency virus‐based lentiviral vectors
Kuate, S., Wagner, R., & Überla, K. (2002) · The Journal of Gene Medicine · doi:10.1002/jgm.290 · Cited by 22 · see citing works
α‐Ecdysone, a new bracken fern factor responsible for neoplasm induction in the Egyptian toad (Bufo regularis)
El‐Mofty, M. M., Sadek, I. A., Soliman, A., Mohamed, A. M., & Sakre, S. (1987) · Nutrition and Cancer · doi:10.1080/01635588709513917 · Cited by 22 · see citing works
Cell-Specific Ecdysone-Inducible Expression of FLP Recombinase in Mammalian Cells
Sawicki, J. A., Monks, B. R., & Morris, R. J. (1998) · BioTechniques · doi:10.2144/98255rr01 · Cited by 21 · see citing works
Manipulation of gene expression by an ecdysone-inducible gene switch in tumor xenografts
Karns, L. R., Kisielewski, A. E., Gulding, K. M., & Theodorescu, D. (2001) · BMC Biotechnology · doi:10.1186/1472-6750-1-11 · Cited by 21 · see citing works
Potentiation of GABA-Induced Inhibition by 20-Hydroxyecdysone, a Neurosteroid, in Cultured Rat Cortical Neurons
Tsujiyama, S., Ujihara, H., Ishihara, K., & Sasa, M. (1995) · The Japanese Journal of Pharmacology · doi:10.1254/jjp.68.133 · Cited by 21 · see citing works
Stimulatory Effect of Insect-Metamorphosing Steroids from Ferns on Protein Synthesis in Mouse Liver
Otaka, T., Uchiyama, M., Takemoto, T., & Hikino, H. (1969) · Chemical and Pharmaceutical Bulletin · doi:10.1248/cpb.17.1352 · Cited by 21 · see citing works
[Ecdysterone modulates antitumor activity of cytostatics and biosynthesis of macromolecules in tumor-bearing animals].
Konovalova (2002) · Biology Bulletin · doi:10.1023/a:1021755622981 · Cited by 20 · see citing works
Effect of ecdysterone on the cyclic AMP-protein kinase system in mouse liver
Catalán, R. E., Aragonés, M. D., & Martı́nez, A. M. (1979) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(79)90940-9 · Cited by 20 · see citing works
Pharmacological studies of insect metamorphosing steroids from Achyranthis radix
Matsuda (1970) · Folia Pharmacologica Japonica · doi:10.1254/fpj.66.551 · Cited by 19 · see citing works
Effect of ecdysone on glutamic decarboxylase in rat brain
Chaudhary, K. D., Lupien, P. J., & Hinse, C. (1969) · Cellular and Molecular Life Sciences · doi:10.1007/bf02034373 · Cited by 19 · see citing works
Transfection of p27Kip1 Threonine Residue 187 Mutant Type Gene, Which Is Not Influenced by Ubiquitin-Mediated Degradation, Induces Cell Cycle Arrest in Oral Squamous Cell Carcinoma Cells
Kudo, Y., Kitajima, S., Sato, S., Ogawa, I., Miyauchi, M., & Takata, T. (2002) · Oncology · doi:10.1159/000066222 · Cited by 19 · see citing works
Enhancement of GABA-mediated Inhibition of Rat Medial Vestibular Nucleus Neurons by the Neurosteroid 20-Hydroxyecdysone
MEIKO OKADA, K. I. (1998) · Acta Oto-Laryngologica · doi:10.1080/00016489850155062 · Cited by 19 · see citing works
Drosophila ecdysone receptor functions as a constitutive activator in yeast
Cruz, F. D., & Mak, P. (1997) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(97)00046-0 · Cited by 18 · see citing works
Rapid activation of calcium-sensitive Na+H+ exchange induced by 20-hydroxyecdysone in salivary gland cells of Drosophila melanogaster
Schneider, S. W., Wünsch, S., Schwab, A., & Oberleithner, H. (1996) · Molecular and Cellular Endocrinology · doi:10.1016/0303-7207(95)03699-7 · Cited by 18 · see citing works
Structure of muristerone A, a new phytoecdysone
Canonica, L., Danieli, B., Weisz‐Vincze, I., & Ferrari, G. (1972) · Journal of the Chemical Society Chemical Communications · doi:10.1039/c3972001060b · Cited by 18 · see citing works
Application of Exogenously Regulatable Promoter Systems to Transgenic Models for the Study of Aging
MORGAN, W. W., Richardson, A. G., Sharp, Z. D., & Walter, C. A. (1999) · The Journals of Gerontology Series A · doi:10.1093/gerona/54.1.b30 · Cited by 18 · see citing works
Suppression of the tumorigenicity of mutant p53-transformed rat embryo fibroblasts through expression of a newly cloned rat nonmuscle myosin heavy chain-B
Yam, J. W. P., Chan, K. W., & Hsiao, W. W. (2001) · Oncogene · doi:10.1038/sj.onc.1203982 · Cited by 17 · see citing works
New functions of 20-hydroxyecdysone in lipid peroxidation
I. KUZMENKO, A., NIKI, E., & NOGUCHI, N. (2001) · Journal of Oleo Science · doi:10.5650/jos.50.497 · Cited by 17 · see citing works
Regulated Gene Expression in Glioma Cells: A Comparison of Three Inducible Systems
Senner, V., Sotoodeh, A., & Paulus, W. (2001) · Neurochemical Research · doi:10.1023/a:1010965013113 · Cited by 16 · see citing works
Antiepileptic Effects of 20-Hydroxyecdysone on Convulsive Seizures in Spontaneously Epileptic Rats.
Hanaya, R., Sasa, M., Ishihara, K., Akimitsu, T., Iida, K., Amano, T., Serikawa, T., Arita, K., & Kurisu, K. (1997) · The Japanese Journal of Pharmacology · doi:10.1254/jjp.74.331 · Cited by 15 · see citing works
Reporter-linked monitoring of transgene expression in living cells using the ecdysone-inducible promoter system
Lüers, G. H., Jess, N., & Franz, T. (2000) · European Journal of Cell Biology · doi:10.1078/0171-9335-00086 · Cited by 15 · see citing works
Absorption, Distribution, Metabolism, and Excretion of Insect-Metamorphosing Hormone Ecdysterone in Mice. II
Hikino, H., Ohizumi, Y., & TAKEMOTO, T. (1972) · Chemical and Pharmaceutical Bulletin · doi:10.1248/cpb.20.2454 · Cited by 15 · see citing works
Ecdysone catabolism in the white mouse.
Girault, J., Lafont, R., & Kerb, U. (1988) · Drug Metabolism and Disposition · doi:10.1016/s0090-9556(25)07032-1 · Cited by 15 · see citing works
Self-citation
Effect of ecdysterone on experimental atherosclerosis in rabbits
Matsuda, H., KAWABA, T., Yamamoto, Y., & Ogawa, S. (1974) · Folia Pharmacologica Japonica · doi:10.1254/fpj.70.325 · Cited by 14 · see citing works
Ecdysone-inducible expression of oncogenic Ha-Ras in NIH 3T3 cells leads to transient nuclear localization of activated extracellular signal-regulated kinase regulated by mitogen-activated protein kinase phosphatase-1
Plows, D., Briassouli, P., Carolyn, O. W. E. N., Zoumpourlis, V., Garrett, M. D., & Pintzas, A. (2002) · Biochemical Journal · doi:10.1042/0264-6021:3620305 · Cited by 13 · see citing works
Signal transduction of erythrocytes after specific binding of ecdysterone and cholesterol immobilized on nanodispersed magnetite
Mykhaylyk, O. M., Kotzuruba, A. V., Buchanevich, O. M., Korduban, A. M., Meged, E. F., & Gulaya, N. M. (2001) · Journal of Magnetism and Magnetic Materials · doi:10.1016/s0304-8853(00)01262-2 · Cited by 12 · see citing works
Effect of ecdysterone on cyclic AMP and cyclic GMP in mouse plasma
Catalan, R. E., Aragonés, M. D., & Martı́nez, A. M. (1979) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(79)80009-1 · Cited by 10 · see citing works
Study of ecdysterone metabolites isolated from rat urine
Ramazanov, N. S., Saatov, Z., & Syrov, B. N. (1996) · Chemistry of Natural Compounds · doi:10.1007/bf01372610 · Cited by 10 · see citing works
Effect of Long Term Administration of Insect-Metamorphosing Substances on Higher Animals. I
Hikino, H., NABETANI, S., Nomoto, K., ARAI, T., TAKEMOTO, T., Otaka, T., & Uchiyama, M. (1969) · YAKUGAKU ZASSHI · doi:10.1248/yakushi1947.89.2_235 · Cited by 10 · see citing works
In vitro effect of ecdysterone on protein kinase activity
Catalan, R. E., Martı́nez, A. M., & Aragonés, M. D. (1982) · Comparative Biochemistry and Physiology Part B Comparative Biochemistry · doi:10.1016/0305-0491(82)90259-0 · Cited by 9 · see citing works
Crustecdysone is without estrogenic or antiestrogenic activity in the rat
Prabhu, V. K. K., & Nayar, K. K. (1974) · Experientia · doi:10.1007/bf01924207 · Cited by 8 · see citing works
Method for Screening Ecdysone-Inducible Stable Cell Lines
Wakita, K., McCormick, F. P., & Tetsu, O. (2001) · BioTechniques · doi:10.2144/01312rr03 · Cited by 8 · see citing works
Effect of Ecdysterone on Histamine Release from Rat Peritoneal Mast Cells
Takei, M., Endo, K., Nishimoto, N., Shiobara, Y., Inoue, S.-S., & Matsuo, S. (1991) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.2600800403 · Cited by 8 · see citing works
Transcriptional modulation of foreign gene expression in engineered somatic tissues
Bohl, D., & Heard, J. (1998) · Cell Biology and Toxicology · doi:10.1023/a:1007480419685 · Cited by 7 · see citing works
Transfection of an inducible trout anion exchanger (AE1) into HEK‐EcR cells
Davis, E., Musch, M. W., & Goldstein, L. (2002) · Journal of Experimental Zoology · doi:10.1002/jez.10111 · Cited by 7 · see citing works
Development of a ponasterone A-inducible gene expression system for application in cultured skeletal muscle cells
Xiao, Y.-Y., Beilstein, M. A., Wang, M.-C., Purintrapiban, J., & Forsberg, N. E. (2002) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(02)00122-x · Cited by 7 · see citing works
[Phytoecdysteroids: their biological effects in the body of higher animals and the outlook for their use in medicine].
Syrov, V. N. (1995) · PubMed · Cited by 7 · see citing works
Heterophylic action of ecdysterone
Catal�n, R. E., Mart�nez, A. M., & Aragon�s, M. D. (1980) · Die Naturwissenschaften · doi:10.1007/bf01047642 · Cited by 7 · see citing works
Human cell lines expressing hormone regulated T7 RNA polymerase localized at distinct intranuclear sites
Yarovoi, S. V., & Pederson, T. (2001) · Gene · doi:10.1016/s0378-1119(01)00652-7 · Cited by 5 · see citing works
Influence of Rhaponticum carthamoides Wild on the Growth of Ruminal Bacteria in Vitro and on Fermentation in an Artificial rumen (Rusitec)
Šelepcová, L., Jalč, D., Javorský, P., & Baran, M. (1993) · Archiv für Tierernaehrung · doi:10.1080/17450399309386030 · Cited by 4 · see citing works
Cell surface receptor interactions of C27-steroid hormone ecdysterone immobilized on nanodispersed magnetite
Mykhaylyk, O. M., Kotzuruba, A. V., Buchanevich, O. M., Nm, G., & Bakai, E. A. (1999) · Journal of Magnetism and Magnetic Materials · doi:10.1016/s0304-8853(98)00570-8 · Cited by 4 · see citing works
Hormonal heterophylly, invertebrate endocrinology, and phytohormones.
Burdette, W. J. (1972) · PubMed · Cited by 3 · see citing works
Untitled work
Jepson (1998) · doi:10.1002/(sici)1096-9063(199812)54:4

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Albanese C, Reutens AT, Bouzahzah B, Fu M, D'Amico M, Link Lafont R., Dinan L. 2003. Practical uses for ecdysteroids in mammals including humans: and update. 30pp. Journal of Insect Science, 3:7, Available online: insectscience.org/3.7 Table 5. Continued from previous page heliotrine intoxication. Doklady Akademii Nauk Respubliki Uzbekistana (10) 46-48.
Burdette WJ. 1974. Invertebrate hormones and tumors. In: Burdette, WJ, editor. Invertebrate Endocrinology and Hormonal Heterophylly, 351-367, Springer-Verlag, Berlin.
Carlson GR. 2000. The past, present, and future of EcR and ecdysteroid research in the agrobusiness. Presentation at the 14th Ecdysone Workshop, Rapperswil, Switzerland.
Chabanny VN, Levitsky EL, Gubsky YuI, Kholodova YuD. 1994. Gene-protective effect of the preparation based on ecdysteroids under rat poisoning with tetrachloromethane and chlorphos. Ukrainskii Biokhimicheskii Zhurnal 66(5): 67-77.
Detmar M, Dumas M, Bonté F, Meybeck A, Orfanos CE. 1994. Effects of ecdysterone on the differentiation of normal human keratinocytes in vitro. European Journal of Dermatology 4: 558-562.
Evans R. 2002. Nuclear receptors: lipid physiology and the exotics of xenobiotics. Communication presented at the XVth International Ecdysone Workshop, Kolymbari,Crete, Greece (June 30 -July 6, 2002).
Fomovska GN, Berdyshev AG, Kholodova YuD. 1992. Immunomodulatory effect of ecdysteroids. Ukrainskii Biokhimicheskii Zhurnal 64(2): 56-61.
Gubskii YuI, Levitskii EL, Kholodova YuD, Goriushko AG, Primak RG, Vistunova IE, Sachenko LG 1993. Mechanisms of genoprotective action of a phytoecdysteroid drug (BTK- 8L) in chromatin damage by tetrachloromethane. Ukrainskii Biokhimicheskii Zhurnal 65(6): 75-83.
Guo F. 1989. Ecdysteroids in vertebrates : pharmalogical aspects. In Koolman J, editor. Ecdysone -from chemistry to mode of action, 442-446, Georg Thieme Verlag, Stuttgart.
Heinrich G. 1970. Isolierung, Struktur und Stoffwechsel von Insekten-Häutungshormonen. Dissertation, Mathemathische Naturwissenschaftliche Fakultät, University of Hamburg, Germany.
Khimiko IN, Mitrokin YuI, Efremova OI, Sidorenko LI. 2000. The influence of ecdysterone on the biosynthesis of proteins and nucleic acids in mouse organs. Khimiko- Farmatsevticheskii Zhurnal 34(9): 3-5.
Kotsyuruba AV, Bukhanevich OM, Tarakanov SS, Tuganova AV, Berdyshev AG, Meged OF. 1998a. C27-Steroid hormones calcitriol and ecdysterone activates hydrolysis of neutral lipids) cholesterol esters and triacylglycerols -in its early pregenomic phase of action. Ukrainskii Biokhimicheskii Zhurnal 70(5): 30-36.
Kotsyuruba AV, Bukhanevich OM, Tarakanov SS, Tuganova AV, Berdyshev AG, Meged OF. 1998b. C27-Steroid hormones calcitriol and ecdysterone in its early phase of action activates in target animals tissues the phosphatidylcholine hydrolysis. Ukrainskii Biokhimicheskii Zhurnal 70(5): 30- 36.
Kotsyuruba AV, Bukhanevich OM, Meged OF, Tarakanov SS, Berdyshev AG,Tuganova AV. 1999. C27-Steroid hormones ecdysterone and calcitriol activates phosphoinositide messenger cascade in its early membrane phase of action. Ukrainskii Biokhimicheskii Zhurnal 71(1): 27-32.
Koudela K, Tenora J, Bajer J, Mathova A, Sláma K. 1995. Stimulation of growth and development in Japanese quails after oral administration of ecdysteroid-containing diet. European Journal of Entomology 92: 349-354.
Kuzmenko AI, Morozova RP, Nikolenko IA, Koniets GV, Kholodova YuD. 1997. Effects of vitamin D3 and ecdysterone on free-radical lipid peroxidation. Biochemistry (Moscow) 62(6): 609-612.
Lafont R. 1998. Phytoecdysteroids in the World flora : diversity, distribution, biosynthesis and evolution. Russian Journal of Plant Physiology 45: 276-295.
Lagova ND, Valueva IM. 1981. Effect of ecdysterone isolated from Rhaponticum carthamoides on the growth of experimental tumors. Eksperimental'naya Onkologiya 3(4): 69-71.
Levitskii EL, Gubskii YuI, Primak RG, Goriushko AG, Kholodova YuD, Vistunova IE, Marchenko AN. 1996. Chromatin- protective action of the biological preparation BTK-8L in tetrachloromethane and chlorphos Ukrainskii Biokhimicheskii Zhurnal 68(5): 76-84.
Levitskii EL, Kholodova YuD, Gubskii YuI, Goriushko AG, Primak RG, Vistunova IE, Sachenko LG. 1993a. Mechanism of the genoprotective action of a phytoecdysteroid drug (BTK- 8L) in chromatin damage by chlorphos. Ukrainskii Biokhimicheskii Zhurnal 65(6): 84-91.
Levitsky EL, Kholodova YuD, Gubski I, Primak RG, Chabanny VN, Kindruk NL, Mozzhukina TG, Lenchevskaya LK, Mironova VN, Saad LM, Vitsunova IE, Shabliy VI. 1993b. Biochemical characteristics of rat liver fractionated chromatin under experimental D-hypovitaminosis and after treatment by steroidal preparations. Ukrainskii Biokhimicheskii Zhurnal 65(1): 28-36.
Mironova VN, Kholodova, YuD, Skatchkova TF, Bonda OP, Datsenko ZM, Govseeva NN. 1982. Hypocholesterolemic effects of phytoecdysones in rat experimental hypercholesterolemia. Voprosy Meditsinskoi Khimii 28(3): 101-105.
Ogawa S, Nishimoto N, Matsuda H. 1974. Pharmacology of ecdysones in Vertebrates. In: Burdette, WJ, editor. Invertebrate Endocrinology and Hormonal Heterophylly, 341-344, Springer-Verlag, Berlin.
Osynskaya LF, Saad LM, Kholodova YuD. 1992. Antiradical properties and antioxidative activity of ecdysterone. Ukrainskii Biokhimicheskii Zhurnal 64(1): 114-117.
Padidam M, Gore M, Lu DL, Smirnova O. 2002. Chemical- inducible, ecdysone receptor-based gene expression system for plants. Transgenic Research 11: (in press).
Simon P, Koolman J. 1989. Ecdysteroids in vertebrates : pharmalogical aspects. In Koolman J., editor. Ecdysone - from chemistry to mode of action, 254-259, Georg Thieme Verlag, Stuttgart.
Sláma K, Lafont R. 1995. Insect hormones -ecdysteroids : their presence and actions in vertebrates. European Journal of Entomology 92: 355-377.
Sorensen PW, Hara TJ, Stacey NE, Dulka JG. 1990. Extreme olfactory specificity of male goldfish to the preovulatory steroidal pheromone 17α,20β-dihydroxy-4-pregnen-3-one. Journal of Comparative Physiology, Part A 166: 373-383.
Lafont R., Dinan L. 2003. Practical uses for ecdysteroids in mammals including humans: and update. 30pp. Journal of Insect Science, 3:7, Available online: insectscience.org/3.7 Klinicheskaya Farmakologiya 60: 41-44.
Syrov VN, Osipova S, Khushbaktova ZA. 1990. Influence of prolonged administration of ecdysteron on the spontaneous infection of rabbits with Lamblia duodenalis. Bulletin de la Société Française de Parasitologie 8 (Suppl. 1): 466.
Tuganova AV, Kotsyuruba AV. 1996. The in vitro interaction of C27-steroids with the erythrocyte membranes depends on the sterol structure and concentration. Cellular and Molecular Biology Letters 1: 129-135.
Uchiyama M, Otaka T. 1974. Phytoecdysones and protein metabolism in Mammalia. In Burdette WJ, editor. Invertebrate Endocrinology and Hormonal Heterophylly, 375-398, Springer-Verlag, Berlin.
Uchiyama M, Yoshida T. 1974. Effect of ecdysterone on carbohydrate and lipid metabolism. In Burdette WJ, editor. Invertebrate Endocrinology and Hormonal Heterophylly, 401-416, Springer-Verlag, Berlin.
Wu X, Jiang Y, Fan S. 1997. Effect of ecdysterone on lung contusion from impact. Chinese Journal of Traumatology 13: 295- 296.
Wu X, Jiang Y, Fan S, Wang R, Xiang M, Niu H, Li T. 1998a. Effects of ecdysterone on rat lung reperfusion injury. Zhongguo Yaolixue Tongbao (Chinese Pharmaceutical Bulletin) 14: 256-258.
Wu X, Lin S, Yang Y, Feng S. 1998b. Effects of ecdysterone on human umbilical vein endothelial cells injuried by tumor necrosis factor. Chinese Journal of Pathophysiology 14: 58-62.
Xu N, Guo Y, Li X. 1997. Advances in pharmacological resarch on ecdysterone. Shenyang Yaoke Daxue Xuebao (Journal of Shenyang Pharmaceutical University) 14: 300-302.
Xu WM, Liu LZ, Charles IG. 2001. Microencapsulated iNOS- expressing cells cause tumor suppression in mice. FASEB Journal 15: U131-U148.
Yang G, Hannan GN, Lockett TJ, Hill RJ. 1995. Functional transfer of an elementary ecdysone gene regulatory system to mammalian cells: transient transfections and stable cell lines. European Journal of Entomology 92: 379-389.

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Background
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Csábi, J., Hsieh, T.-J., Hasanpour, F., Martins, A., Kele, Z., Gáti, T., Simon, A., Tóth, G., & Hunyadi, A. (2015) · Journal of Natural Products · doi:10.1021/acs.jnatprod.5b00249 · Cited by 27 · see citing works
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Romaniuk-Drapała, A., Lisiak, N., Totoń, E., Matysiak, A., Nawrot, J., Nowak, G., Kaczmarek, M., Rybczyńska, M., & Rubiś, B. (2021) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2021.109479 · Cited by 27 · see citing works
Ecdysteroids from Polypodium vulgare L.
Simon, A., Ványolós, A., Béni, Z., Dékány, M., Tóth, G., & Báthori, M. (2011) · Steroids · doi:10.1016/j.steroids.2011.07.007 · Cited by 27 · see citing works
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Hu, J., Zhao, T. Z., Chu, W. H., Luo, C. X., Tang, W. H., Yi, L., & Feng, H. (2010) · Journal of Cellular Biochemistry · doi:10.1002/jcb.22877 · Cited by 26 · see citing works
Ecdysterone and its Activity on some Degenerative Diseases
Cahlíková, L., Macáková, K., Chlebek, J., Hošťálková, A., Kulhánková, A., & Opletal, L. (2011) · Natural Product Communications · doi:10.1177/1934578x1100600527 · Cited by 26 · see citing works
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Anthony, T. G., Mirek, E. T., Bargoud, A. R., Phillipson-Weiner, L., DeOliveira, C. M., Wetstein, B., Graf, B. L., Kuhn, P. E., & Raskin, I. (2015) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2015-0301 · Cited by 25 · see citing works
Level and distribution of 20-hydroxyecdysone during Pfaffia glomerata development
Festucci-Buselli, R. A., Contim, L. A. S., Barbosa, L. C. A., Stuart, J. J., Vieira, R. F., & Otoni, W. C. (2008) · Brazilian Journal of Plant Physiology · doi:10.1590/s1677-04202008000400006 · Cited by 25 · see citing works
Revealing the reviving secret of the white dead nettle (Lamium album L.)
Yordanova, Z. P., Zhiponova, M., Iakimova, E. T., Dimitrova, M. A., & Kapchina-Toteva, V. M. (2014) · Phytochemistry Reviews · doi:10.1007/s11101-014-9356-2 · Cited by 25 · see citing works
Biological activity of natural phytoecdysteroids from Ajuga iva against the sweetpotato whitefly Bemisia tabaci and the persea mite Oligonychus perseae
Aly, R., Ravid, U., Abu‐Nassar, J., Botnick, I., Lebedev, G., Gal, S., Ziadna, H., Achdari, G., Smirov, E., Meir, A., et al. (2011) · Pest Management Science · doi:10.1002/ps.2203 · Cited by 26 · see citing works
Effects of 20-hydroxyecdysone, Leuzea carthamoides extracts, dexamethasone and their combinations on the NF-κB activation in HeLa cells
Peschel, W., Kump, A., & Prieto, J. M. (2011) · Journal of Pharmacy and Pharmacology · doi:10.1111/j.2042-7158.2011.01349.x · Cited by 24 · see citing works
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Lapenna, S., Gemen, R., Wollgast, J., Worth, A., Maragkoudakis, P., & Caldeira, S. (2015) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2012.726661 · Cited by 23 · see citing works
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Simon, A., Tóth, G., Liktor‐Busa, E., Kele, Z., Takács, M., Gergely, A., & Báthori, M. (2007) · Steroids · doi:10.1016/j.steroids.2007.06.004 · Cited by 23 · see citing works
Chemical biology of steroid and nuclear hormone receptors
Biggins, J. B., & Koh, J. T. (2006) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2006.10.042 · Cited by 23 · see citing works
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Simon, A., Pongrácz, Z., Tóth, G., Mák, M., Máthé, I., & Báthori, M. (2004) · Steroids · doi:10.1016/j.steroids.2004.03.009 · Cited by 22 · see citing works
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Montemurro, M., Pontonio, E., & Rizzello, C. G. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-814639-2.00036-8 · Cited by 22 · see citing works
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Ishola, I. O., Ochieng, C. O., Olayemi, S. O., Jimoh, M. O., & Lawal, S. M. (2014) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2014.11.005 · Cited by 22 · see citing works
Supercritical fluid extraction of cynaropicrin and 20‐hydroxyecdysone from Leuzea carthamoides DC
Sovová, H., Opletal, L., Sajfrtová, M., & Bártlová, M. (2008) · Journal of Separation Science · doi:10.1002/jssc.200700496 · Cited by 21 · see citing works
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Naresh Kumar, R., Sundaram, R., Shanthi, P., & Sachdanandam, P. (2013) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2012.10.016 · Cited by 21 · see citing works
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Maliński, M. P., Budzianowski, J., Kikowska, M. A., Derda, M., Jaworska, M. M., Młynarczyk, D. T., Szukalska, M., Florek, E., & Thiem, B. (2021) · Molecules · doi:10.3390/molecules26040904 · Cited by 21 · see citing works
Induced polyploidization increases 20-hydroxyecdysone content, in vitro photoautotrophic growth, and ex vitro biomass accumulation in Pfaffia glomerata (Spreng.) Pedersen
Corrêa, J. P. O., Vital, C. E., Pinheiro, M. V. M., Batista, D. S., Saldanha, C. W., da Cruz, A. C. F., Notini, M. M., Freitas, D. M. S., DaMatta, F. M., & Otoni, W. C. (2016) · In Vitro Cellular & Developmental Biology - Plant · doi:10.1007/s11627-016-9746-9 · Cited by 21 · see citing works
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Fang, X., Szołtysik, R., Tang, J., & Bajkacz, S. (2022) · Journal of Food Composition and Analysis · doi:10.1016/j.jfca.2022.104580 · Cited by 20 · see citing works
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Popova, E., Титова, М. В., Тыныкулов, М., Zakirova, R. P., Куличенко, И. Е., Prudnikova, O. N., & Nosov, A. M. (2023) · Nutrients · doi:10.3390/nu15051246 · Cited by 20 · see citing works
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da Rosa, H. S., de Camargo, V. B., Camargo, G. D. S., Garcia, C. V., Fuentefría, A. M., & Mendez, A. S. L. (2015) · Food Chemistry · doi:10.1016/j.foodchem.2015.02.144 · Cited by 20 · see citing works
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Dinan, L. N., Nakagawa, Y., & Hormann, R. E. (2012) · Advances in insect physiology · doi:10.1016/b978-0-12-391500-9.00003-6 · Cited by 20 · see citing works
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Kraiem, S., Al‐Jaber, M. Y., Al‐Mohammed, H., Al‐Menhali, A. S., Al‐Thani, N., Helaleh, M., Samsam, W., Touil, S., Beotra, A., Georgakopoulas, C., et al. (2021) · Drug Testing and Analysis · doi:10.1002/dta.3032 · Cited by 19 · see citing works
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Jian, C.-X., Liu, X.-F., Hu, J., Li, C.-J., Zhang, G., Li, Y., Zhu, J.-W., & Tan, Y.-H. (2013) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2012.07.044 · Cited by 18 · see citing works
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Hunyadi, A., Tóth, G., Simon, A., Mák, M., Kele, Z., Máthé, I., & Báthori, M. (2004) · Journal of Natural Products · doi:10.1021/np030544p · Cited by 19 · see citing works
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Gorelick, J., Iraqi, R. H., & Bernstein, N. (2020) · Plants · doi:10.3390/plants9060727 · Cited by 19 · see citing works
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Maliński, M. P., Kikowska, M., Kruszka, D., Napierała, M., Florek, E., Sliwinska, E., & Thiem, B. (2019) · Plant Cell Tissue and Organ Culture (PCTOC) · doi:10.1007/s11240-019-01660-0 · Cited by 18 · see citing works
Is Strongyloides stercoralis hyperinfection induced by glucocorticoids a result of both suppressed host immunity and altered parasite genetics?
Herbert, D. R., Stoltzfus, J. D. C., Rossi, H. L., & Abraham, D. (2022) · Molecular and Biochemical Parasitology · doi:10.1016/j.molbiopara.2022.111511 · Cited by 18 · see citing works
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Hsieh, C., Ko, W.-C., Ho, W., Chang, C., Chen, G.-J., & Tsai, J.-C. (2016) · Asian Pacific Journal of Tropical Medicine · doi:10.1016/j.apjtm.2016.03.029 · Cited by 18 · see citing works
Hemolin triggers cell survival on fibroblasts in response to serum deprivation by inhibition of apoptosis
Bösch, R. V., Flores, M. P. A., Maria, D. A., & Chudzinski‐Tavassi, A. M. (2016) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2016.05.043 · Cited by 17 · see citing works
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High-protein compound yogurt with quinoa improved clinical features and metabolism of high-fat diet–induced nonalcoholic fatty liver disease in mice
Shi, L., Fang, T., Zhang, C., Deng, X., Zhou, Y., Wang, J., & Wang, L. (2023) · Journal of Dairy Science · doi:10.3168/jds.2022-23045 · Cited by 17 · see citing works
Ragged Robin (Lychnis flos-cuculi) - a plant with potential medicinal value
Maliński, M. P., Michalska‐Falkowska, A., Tomczykowa, M., Tomczyk, M., & Thiem, B. (2014) · Revista Brasileira de Farmacognosia · doi:10.1016/j.bjp.2014.11.004 · Cited by 16 · see citing works
“Brazilian ginseng” (Pfaffia glomerata Spreng. Pedersen, Amaranthaceae) methanolic extract: cytogenotoxicity in animal and plant assays
Neves, C. S., Gomes, S. S. L., dos Santos, T. R., de Almeida, M. M., de Souza, Y. O., Garcia, R. M. G., Otoni, W. C., Chedier, L. M., Raposo, N. R. B., Viccini, L. F., et al. (2016) · South African Journal of Botany · doi:10.1016/j.sajb.2016.07.003 · Cited by 16 · see citing works
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Lapenna, S., Friz, J., Barlow, A., Palli, S. R., Dinan, L., & Hormann, R. E. (2008) · The FEBS Journal · doi:10.1111/j.1742-4658.2008.06687.x · Cited by 15 · see citing works
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Dabire, R. A., Hervé, B. B., & Ouédraogo, S. N. (2017) · Advances in Entomology · doi:10.4236/ae.2018.61001 · Cited by 15 · see citing works
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Hansen, K. Ø., Isaksson, J. M., Glomsaker, E., Andersen, J. H., & Hansen, E. H. (2018) · Molecules · doi:10.3390/molecules23061481 · Cited by 15 · see citing works
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Yamada, E. F., Olin, L. C., Pontel, C. L., da Rosa, H. S., Folmer, V., & da Silva, M. D. (2019) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2019.112277 · Cited by 15 · see citing works
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Kabbash, A. M., & Shoeib, N. A. (2012) · Natural Product Communications · doi:10.1177/1934578x1200701114 · Cited by 15 · see citing works
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Napierała, M., Nawrot, J., Gornowicz-Porowska, J., Florek, E., Moroch, A., Adamski, Z., Kroma, A., Miechowicz, I., & Nowak, G. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17186453 · Cited by 14 · see citing works
A new ecdysteroid and other constituents from two Dioscorea species
Sautour, M., Canon, F., Miyamoto, T., Dongmo, A., & Lacaille-Dubois, M.-A. (2008) · Biochemical Systematics and Ecology · doi:10.1016/j.bse.2008.03.002 · Cited by 17 · see citing works
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Ambrosio, G., Joseph, J. F., Wuest, B., Mazzarino, M., de la Torre, X., Diel, P. R., Botrè, F., & Parr, M. K. (2020) · Steroids · doi:10.1016/j.steroids.2020.108603 · Cited by 14 · see citing works

Practical uses for ecdysteroids in mammals including humans: an update
Lafont, R., & Dinan, L. N. (2003)
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1 REVIEW Effects and applications of arthropod steroid hormones (ecdysteroids) in mammals
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The metabolism of 20-hydroxyecdysone in mice: Relevance to pharmacological effects and gene switch applications of ecdysteroids
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Authors: Lafont, R., & Dinan, L.
Affiliations: Université Pierre-et-Marie-Curie (FR)
University of Exeter (GB)
ORCID: Lafont, R.
Dinan, L.
Venue: Journal of Insect Science
Publisher: Oxford University Press (OUP)
Published: 2003-03
Volume: 3
Issue: 7
Pages: 1-30
ISSN: 1536-2442 (ISSN-L)
0970-3837
DOI: 10.1673/031.003.0701
OpenAlex: W4211150825
Cited by: 196
References: 167
Citations by year: 2026: 6 · 2025: 5 · 2024: 8 · 2023: 11 · 2022: 11 · 2021: 15 · 2020: 11 · 2019: 11 · 2018: 5 · 2017: 6 · 2016: 12 · 2015: 10 · 2014: 11 · 2013: 2 · 2012: 15
FWCI: 2.45
Type: journal article
Language: en
Open access: gold
doi.org
Locations: Journal of Insect Science (publishedVersion)
BioOne Complete (BioOne) (submittedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Steroid Chemistry and Biochemistry
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords: ecdysteroids, ecdysteroid receptor, gene therapy, hypoglycemic effect, hypocholesterolaemic effect, anabolic effects, adaptogenic properties, doping substances, patents

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Practical uses for ecdysteroids in mammals including humans: And update

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