The DOI matches its Crossref record; 99 of the 99 references it cites were found in a registry or an index.
Effects of lutein and zeaxanthin on aspects of eye health
Abstract
Lutein and zeaxanthin are members of the oxygenated carotenoids found particularly in egg yolks and dark‐green leafy vegetables. A great deal of research has focused on their beneficial roles in eye health. The present article summarises the current literature related to the bioactivity of these carotenoids, emphasising their effects and possible mechanisms of action in relation to human eye health. Available evidence demonstrates that lutein and zeaxanthin are widely distributed in a number of body tissues and are uniquely concentrated in the retina and lens, indicating that each has a possible specific function in these two vital ocular tissues. Most of epidemiological studies and clinical trials support the notion that lutein and zeaxanthin have a potential role in the prevention and treatment of certain eye diseases such as age‐related macular degeneration, cataract and retinitis pigmentosa. The biological mechanisms for the protective effects of these carotenoids may include powerful blue‐light filtering activities and antioxidant properties. Although most studies point towards significant health benefits from lutein and zeaxanthin, further large‐scale randomised supplementation trials are needed to define their effects on ocular function in health and disease. Copyright © 2009 Society of Chemical Industry
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Cites
Prevalence of Age-Related Macular Degeneration in the United States
(2004) · Archives of Ophthalmology · doi:10.1001/archopht.122.4.564 · Cited by 2,736
The Role of Oxidative Stress in the Pathogenesis of Age-Related Macular Degeneration
Beatty, S., Koh, H.-H., Phil, M., Henson, D., & Boulton, M. (2000) · Survey of Ophthalmology · doi:10.1016/s0039-6257(00)00140-5 · Cited by 2,051
Dietary carotenoids, vitamins A, C, and E, and advanced age-related macular degeneration
Seddon, J. M. (1994) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1994.03520180037032 · Cited by 993
B IOLOGIC M ECHANISMS OF THE P ROTECTIVE R OLE OF L UTEIN AND Z EAXANTHIN IN THE E YE
Krinsky, N. I., Landrum, J. T., & Bone, R. A. (2003) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.23.011702.073307 · Cited by 779
Dietary Factors That Affect the Bioavailability of Carotenoids
van het Hof, K. H., Weststrate, J. A., West, C. E., & Hautvast, J. G. A. J. (2000) · The Journal of Nutrition · doi:10.1093/jn/130.3.503 · Cited by 776
Retinal sensitivity to damage from short wavelength light
HAM, W. T., MUELLER, H. A., & SLINEY, D. H. (1976) · Nature · doi:10.1038/260153a0 · Cited by 703
Antioxidants in Photosynthesis and Human Nutrition
Demmig-Adams, B., & Adams, W. W. (2002) · Science · doi:10.1126/science.1078002 · Cited by 677
The role of carotenoids in the prevention of human pathologies
Tapiero, H., Townsend, D. M., & Tew, K. D. (2004) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2003.12.006 · Cited by 645
The Role of Carotenoids in Human Health
Johnson, E. J. (2002) · Nutrition in Clinical Care · doi:10.1046/j.1523-5408.2002.00004.x · Cited by 569
Sparrow, J. R., Nakanishi, K., & Parish, C. A. (2000) · PubMed · Cited by 566
Cited by
Functional properties of carotenoids originating from algae
Christaki, E., Bonos, E., Giannenas, I., & Florou‐Paneri, P. (2013) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.5902 · Cited by 346
Marine Carotenoids: Biological Functions and Commercial Applications
Vílchez, C., Forján, E., Cuaresma, M., Bédmar, F., Garbayo, I., & Vega, J. M. (2011) · Marine Drugs · doi:10.3390/md9030319 · Cited by 328
Concepts and studies on lipid and pigments of microalgae: A review
D’Alessandro, E. B., & Antoniosi Filho, N. R. (2016) · Renewable and Sustainable Energy Reviews · doi:10.1016/j.rser.2015.12.162 · Cited by 289
Ma, L., Dou, H.-L., Wu, Y.-Q., Huang, Y.-M., Huang, Y.-B., Xu, X.-R., Zou, Z.-Y., & Lin, X.-M. (2012) · British Journal of Nutrition · doi:10.1017/s0007114511004260 · Cited by 237
Self-citationBioactive compounds in microalgae and their potential health benefits
Zhou, L., Li, K., Duan, X., Hill, D., Barrow, C., Dunshea, F., Martin, G., & Suleria, H. (2022) · Food Bioscience · doi:10.1016/j.fbio.2022.101932 · Cited by 150
Metadata
- Authors
- Ma, L., & Lin, X.
- Venue
- Journal of the Science of Food and Agriculture
- Publisher
- Wiley
- Published
- 2009-10-21
- Volume
- 90
- Issue
- 1
- Pages
- 2-12
- ISSN
- 0022-5142 (ISSN-L)
- 1097-0010
- OpenAlex
- W2027452486
- Cited by
- 261
- References
- 99
- FWCI
- 12.04
- Type
- journal article
- Language
- en
- Open access
- closed
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