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Cited by 114

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

5‐Caffeoylquinic acid decreases diet‐induced obesity in rats by modulating PPARα and LXRα transcription

Huang, Kang, Liang, Xiu‐ci, Zhong, Ying‐li, He, Wan‐yan, Wang, Zheng·2015·Journal of the Science of Food and Agriculture
DOI 10.1002/jsfa.6896
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Abstract

Background: Chlorogenic acids ( CGAs ) are widely distributed in plant material, including foods and beverages. 5‐Caffeoylquinic acid (5‐ CQA ) is the most studied CGA , but the mechanism of its hypolipidaemic effect remains unclear. This study aimed to determine the effect of 5‐ CQA on lipid metabolism in the liver of Sprague–Dawley rats fed a high‐fat diet ( HFD ). Results: 5‐ CQA suppressed HFD ‐induced increases in body weight and visceral fat‐pad weight, serum lipid levels, and serum and hepatic free fatty acids in a dose‐dependent manner. Real‐time polymerase chain reaction revealed that 5‐ CQA altered the mRNA expression of the transcription factors peroxisome proliferator‐activated receptor α ( PPARα ) and liver X receptor α ( LXRα ) and target genes involved in hepatic fatty acid uptake, β‐oxidation, fatty acid synthesis, and cholesterol synthesis. Moreover, hepatic tissue sections from HFD ‐fed rats showed many empty vacuoles, suggesting that liver cells were filled with more fat droplets. However, 5‐ CQA significantly ameliorated this effect. Conclusion: 5‐ CQA may improve lipid metabolism disorders by altering the expression of PPARα and LXRα , which are involved in multiple intracellular signalling pathways. © 2014 Society of Chemical Industry

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Cited by

Metadata

Authors
Huang, K., Liang, X., Zhong, Y., He, W., & Wang, Z.
Affiliations
College of Bioscience and Biotechnology Hunan Agricultural University Changsha Hunan 410128 China
Venue
Journal of the Science of Food and Agriculture
Publisher
Wiley
Published
2014-10
Volume
95
Issue
9
Pages
1903-1910
ISSN
  • 0022-5142
  • 1097-0010
DOI
10.1002/jsfa.6896
Cited by
114
References
2
Language
en
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Funders
Scientific Research Fund of Hunan Provincial Education Department (14A071)

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