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Detection of lunasin in quinoa ( Chenopodium quinoa Willd.) and the in vitro evaluation of its antioxidant and anti‐inflammatory activities
Abstract
Abstract BACKGROUND Lunasin is a novel cancer‐preventive peptide that has been detected in various plants. However, the presence and bioactivity of lunasin in quinoa have not been demonstrated. RESULTS Lunasin was detected in quinoa using ultrahigh‐pressure liquid chromatography–electrosparay ionization–mass spectrometry. The content in 15 quinoa samples ranged from 1.01 × 10 −3 g kg −1 dry seed to 4.89 × 10 −3 g kg −1 dry seed. Significant differences ( P < 0.05) in lunasin content among different cultivars (yy22, xsg86, xsg59, yy30 and yy19) from the same area and the same cultivar from different areas (Hainan, Hebei and Shanxi provinces) were observed. The lunasin isolated and purified from quinoa ( QLP ) exhibited a weak DPPH radical scavenging activity (no IC 50 value), but a strong ABTS + radical scavenging activity ( IC 50 value, 1.45 g L −1 ) and oxygen radical scavenging activity (40.06 µmol L −1 Trolox equivalents/g QLP when the concentration was 3.20 g L −1 ). In addition, QLP inhibited the production of nitric oxide ( NO ), tumor necrosis factor‐α and interleukin‐6 on lipopolysaccharide‐stimulated RAW264 .7 macrophages by up to 44.77%, 39.81% and 33.50%, respectively, at a concentration of 0.40 g L −1 . CONCLUSION Taken together, these findings indicate that lunasin presents in quinoa and is bioactive, which strengthens the recommendations for the development of quinoa‐based functional foods. © 2017 Society of Chemical Industry
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“The in vitro studies presented in Table 7 reported quinoa’s effects on gut microbiota and cancer cells, antioxidant and antidiabetic properties, platelet activity, and modulating collagenase activity [201,202,203,204,205,206,207].”
From Ecdysterone and Turkesterone—Compounds with Prominent Potential in Sport and Healthy Nutrition (2024) · cites this paper as [204]
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Daliri, E. B., Oh, D., & Lee, B. H. (2017) · Foods · doi:10.3390/foods6050032 · Cited by 593
Chai, K. F., Voo, A. Y. H., & Chen, W. N. (2020) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.12651 · Cited by 310
Functional and food application of plant proteins – a review
Tan, M., Nawaz, M. A., & Buckow, R. (2021) · Food Reviews International · doi:10.1080/87559129.2021.1955918 · Cited by 227
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Metadata
- Authors
- Ren, G., Zhu, Y., Shi, Z., & Li, J.
- Affiliations
- Chengdu University (CN)
- University of Liège (BE)
- Beijing Entry‐Exit Inspection and Quarantine Bureau Beijing China
- Corresponding author
- Ren, Guixing
- Venue
- Journal of the Science of Food and Agriculture
- Publisher
- Wiley
- Published
- 2017-04-06
- Volume
- 97
- Issue
- 12
- Pages
- 4110-4116
- ISSN
- 0022-5142 (ISSN-L)
- 1097-0010
- OpenAlex
- W2589718528
- Cited by
- 67
- References
- 26
- Citations by year
- 2026: 2 · 2025: 11 · 2024: 10 · 2023: 9 · 2022: 8 · 2021: 11 · 2020: 6 · 2019: 3 · 2018: 5 · 2017: 2
- FWCI
- 4.92
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of the Science of Food and Agriculture (publishedVersion)
- PubMed (publishedVersion)
- Open Repository and Bibliography (University of Liège) (submittedVersion)
- Funders
- International Science and Technology Cooperation Program of China (KY20142023)
- Hong Kong, Macao, and Taiwan Science and Technology Cooperation Program of China (2013DFH30050)
- Science and Technology Planning Project of General Administration of Quality Supervision, Inspection and Quarantine (AQSIQ) of P.R. China (2015IK012, 2016IK021)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Seed and Plant Biochemistry
- Life Sciences › Agricultural and Biological Sciences › Food Science › Protein Hydrolysis and Bioactive Peptides
- Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
- Keywords
- lunasin, quinoa, antioxidant activity, anti-inflammatory activity, cultivar differences, nitric oxide inhibition, TNF-α, interleukin-6, macrophages, functional foods
- MeSH terms
- RAW 264.7 Cells, Animals, Anti-Inflammatory Agents, Antioxidants, Chromatography, High Pressure Liquid, Macrophages, Nitric Oxide, Plant Extracts, Seeds, Mass Spectrometry, Tumor Necrosis Factor-alpha, Interleukin-6, Chenopodium quinoa, Mice
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- Ren, G., Zhu, Y., Shi, Z., & Li, J. (2017). Detection of lunasin in quinoa ( Chenopodium quinoa Willd.) and the in vitro evaluation of its antioxidant and anti‐inflammatory activities. Journal of the Science of Food and Agriculture. https://doi.org/10.1002/jsfa.8278
