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The advantages of ESI‐MS detection in conjunction with HILIC mode separations: Fundamentals and applications
Abstract
The analysis of highly hydrophilic, ionic, and polar compounds has been performed by HILIC‐ESI‐MS for the last few years. The use of low aqueous/high polar organic solvent content in HILIC separation mobile phase is almost ideal for ESI‐MS detection in many cases, resulting in increased sensitivity. Although the addition of modifiers such as acids or salts is necessary in some circumstances for a good separation, the optimum concentrations used are still highly amenable for ESI‐MS analysis, showing few deleterious effects. In this review, the mechanism of HILIC separation and ESI ion generation will be briefly discussed, followed by a summary of method development and applications in several fields of research including pharmaceutical, biomolecular, food, metabolic, and environmental analysis.
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Cites
Metabolomics and systems biology: making sense of the soup
KELL, D. (2004) · Current Opinion in Microbiology · doi:10.1016/j.mib.2004.04.012 · Cited by 529
SHOU, W., & NAIDONG, W. (2005) · Journal of Chromatography B · doi:10.1016/j.jchromb.2005.01.011 · Cited by 136
Cited by
Retention and selectivity of stationary phases for hydrophilic interaction chromatography
Guo, Y., & Gaiki, S. (2011) · Journal of Chromatography A · doi:10.1016/j.chroma.2011.06.052 · Cited by 310
Knoll, S., Rösch, T., & Huhn, C. (2020) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-020-02811-5 · Cited by 91
Johnsen, E., Leknes, S., Wilson, S. R., & Lundanes, E. (2015) · Scientific Reports · doi:10.1038/srep09308 · Cited by 65
Metadata
- Authors
- Nguyen, H. P., & Schug, K. A.
- Venue
- Journal of Separation Science
- Publisher
- Wiley
- Published
- 2008-05
- Volume
- 31
- Issue
- 9
- Pages
- 1465-1480
- ISSN
- 1615-9306 (ISSN-L)
- 1615-9314
- OpenAlex
- W2093664208
- Cited by
- 275
- References
- 2
- FWCI
- 10.05
- Type
- journal article
- Language
- en
- Open access
- closed
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- Nguyen, H. P., & Schug, K. A. (2008). The advantages of ESI‐MS detection in conjunction with HILIC mode separations: Fundamentals and applications. Journal of Separation Science. https://doi.org/10.1002/jssc.200700630
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