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Postinfectious olfactory loss: A retrospective study on 791 patients
Abstract
Objectives/Hypothesis: Postinfectious olfactory loss is among the most common causes of olfactory impairment and has substantial negative impact on patients' quality of life. Recovery rates have been shown to spontaneously improve in most of patients, usually within 2 to 3 years. However, existing studies are limited by small sample sizes and short follow‐up. We aimed to assess the prognostic factors for recovery in a large sample of 791 patients with postinfectious olfactory disorders. Study Design: Retrospective cohort. Methods: We performed a retrospective analysis of 791 patients with postinfectious olfactory loss. Olfactory functions were assessed using the Sniffin' Sticks test at the first and final visits (mean follow‐up = 1.94 years). Results: Smell test scores improved over time. In particular, patient's age and the odor threshold (T), odor discrimination (D), and odor identification (I) (TDI) score at first visit were significant predictors of the extent of change. The percentage of anosmic and hyposmic patients exhibiting clinically significant improvement was 46% and 35%, respectively. Conclusions: This study provides new evidence within the postinfectious olfactory loss literature, shedding light on the prognostic factors and showing that recovery of olfactory function is very frequent, even many years after the infection. Level of Evidence: 4. Laryngoscope, 128:10–15, 2018
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“recovery from typical post-viral anosmia — which is often caused by direct damage to olfactory sensory neurons (OSNs) — frequently takes months (19-21).”
From Non-neuronal expression of SARS-CoV-2 entry genes in the olfactory system suggests mechanisms underlying COVID-19-associated anosmia (2020) · cites this paper as [21]
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Metadata
- Authors
- Cavazzana, A., Larsson, M., Münch, M., Hähner, A., & Hummel, T.
- Affiliations
- Stockholm University (SE)
- Technische Universität Dresden (DE)
- Smell and Taste Clinic Technical University of Dresden Dresden Germany
- Corresponding author
- Cavazzana, Annachiara
- Venue
- The Laryngoscope
- Publisher
- Wiley
- Published
- 2017-05-29
- Volume
- 128
- Issue
- 1
- Pages
- 10-15
- ISSN
- 0023-852X (ISSN-L)
- 1531-4995
- OpenAlex
- W2617219070
- Cited by
- 109
- References
- 29
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 6 · 2023: 12 · 2022: 23 · 2021: 24 · 2020: 24 · 2019: 6 · 2018: 2 · 2017: 1
- FWCI
- 5.63
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Laryngoscope (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft to T.H. (DFG HU411/18-1)
- Swedish Foundation for Humanities and Social Sciences to M.L. (M14-0375:1)
- Topics
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Health Sciences › Medicine › Otorhinolaryngology › Sinusitis and nasal conditions
- Health Sciences › Medicine › Surgery › Head and Neck Surgical Oncology
- Keywords
- olfactory dysfunction, prognostic factors, odor threshold, odor discrimination, odor identification, Sniffin' Sticks, anosmia, hyposmia, quality of life
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Olfaction Disorders, Female, Humans, Male, Middle Aged, Prognosis, Quality of Life, Respiratory Tract Infections, Retrospective Studies, Risk Factors, Sensory Thresholds, Recovery of Function
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